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51. 发明申请

US20140213534A1 INTESTINAL HYPERPERMEABILITY AND PREVENTION OF SYSTEMIC DISEASE 审中-公开
公开(公告)号：US20140213534A1
公开(公告)日：2014-07-31
申请号：US14122170
申请日：2012-04-27
申请人： Scott A. Waldman , Adam E. Snook , Peng Li , Jieru Egeria Lin
发明人： Scott A. Waldman , Adam E. Snook , Peng Li , Jieru Egeria Lin
IPC分类号： A61K38/10 , A61K45/06
CPC分类号： A61K38/10 , A61K38/005 , A61K45/06
摘要： Compositions for and methods of preventing or reducing the severity intestinal hyperpermeabilization in an individual are disclosed. Compositions for and methods of preventing or reducing the severity of a disease or condition caused or exacerbated by intestinal hyperpermeabilization in an individual identified as being at risk of a disease or condition caused or exacerbated by intestinal hyperpermeabilization are also disclosed. Compositions for and methods of treating an individual who has been identified as having a disease or condition caused or exacerbated by intestinal hyperpermeabilization are additionally disclosed.
摘要翻译：公开了预防或减轻个体严重性肠过度超敏化的组合物和方法。还公开了预防或降低由被鉴定为处于由肠过度超化引起或加剧的疾病或病症的风险中的个体肠道过度超敏引起或加重的疾病或病症的严重性的组合物和方法。另外还公开了已被鉴定为具有由肠过度超化引起或加剧的疾病或病症的个体的组合物和方法。

52. 发明授权

US08744824B2 Optimization design method for the chassis structure of an electronic device based on mechanical, electrical and thermal three-field coupling 有权
标题翻译：基于机械，电和热三场耦合的电子设备底盘结构的优化设计方法
公开(公告)号：US08744824B2
公开(公告)日：2014-06-03
申请号：US13259262
申请日：2009-09-24
申请人： Baoyan Duan , Hui Qiao , Peng Li , Shibo Jiang , Boyuan Ma , Ning Han , Lizhi Zeng , Yu He
发明人： Baoyan Duan , Hui Qiao , Peng Li , Shibo Jiang , Boyuan Ma , Ning Han , Lizhi Zeng , Yu He
IPC分类号： G06F17/50
CPC分类号： G06F17/5018 , G06F2217/16 , G06F2217/80
摘要： An optimizing design method for a chassis structure of electronic equipment is disclosed, including: investigating from the point of view of mechanical, electric and thermal three-field coupling, determining the preliminary design size of the chassis, performing a mechanical analysis by using a mechanical analysis software such as ANSYS; converting the mesh model among the three-fields, obtaining the mesh model used for the electromagnetic and thermal analyses; setting the thermal analysis parameters, performing the thermal analysis by using an electromagnetic analysis software such as ICEPAK; determining a resonance frequency of the chassis and an electric parameter of the absorbing material, performing an electromagnetic analysis by using a thermal analysis software such as FEKO; correcting the analysis result by sample testing; determining whether the chassis satisfies the design requirement, if it satisfies the requirement, the optimizing design will be finished, otherwise, modifying the preliminary computer assisted design model, the electromagnetic analysis parameter and the thermal analysis parameter, repeating the above processes until the requirement is satisfied.
摘要翻译：公开了一种用于电子设备底盘结构的优化设计方法，包括：从机械，电和热三场耦合的角度考察，确定底盘的初步设计尺寸，通过使用机械分析软件如ANSYS; 在三场中转换网格模型，获得用于电磁和热分析的网格模型; 设置热分析参数，使用ICEPAK等电磁分析软件进行热分析; 确定底盘的共振频率和吸收材料的电参数，通过使用诸如FEKO的热分析软件执行电磁分析; 通过样本测试纠正分析结果; 确定底盘是否满足设计要求，如果满足要求，优化设计将完成，否则，修改初步计算机辅助设计模型，电磁分析参数和热分析参数，重复上述过程，直到要求为满意。

53. 发明申请

US20140021105A1 NON-LINEAR MAGNETOPHORETIC SEPARATION DEVICE, SYSTEM AND METHOD 有权
标题翻译：非线性磁分离装置，系统和方法
公开(公告)号：US20140021105A1
公开(公告)日：2014-01-23
申请号：US13809091
申请日：2011-07-07
申请人： Gil Lee , Peng Li , Mark Platt , Gemma Cannon
发明人： Gil Lee , Peng Li , Mark Platt , Gemma Cannon
IPC分类号： B03C1/02
CPC分类号： B03C1/02 , B03C1/032 , B03C1/24 , B03C1/288 , B03C2201/18 , B03C2201/24 , B03C2201/26 , G01N27/44756
摘要： A flow enhanced method and system for flow non-linear magnetophoresis (F-NLM) is described. By tuning an external field frequency and the flow rate the migration velocities of different bead types may be caused to differ by several orders of magnitude over an extended range of frequencies to allow for separation of particles. Use of such efficiency in separation in bio-separation and similar assays is described.
摘要翻译：描述了用于流动非线性磁电泳（F-NLM）的流动增强方法和系统。通过调整外场频率和流速，可以使不同珠粒类型的迁移速度在扩展的频率范围内相差几个数量级以允许分离颗粒。描述了在生物分离中的这种效率的使用和类似的测定。

54. 发明申请

US20140002483A1 SYSTEM AND METHOD FOR GENERATING A FLOW BASED ON MULTIPLE TYPES OF INTERACTIONS 有权
标题翻译：基于多种交互类型生成流量的系统和方法
公开(公告)号：US20140002483A1
公开(公告)日：2014-01-02
申请号：US13535336
申请日：2012-06-27
申请人： Jerry Hong , Fenghui Zhang , Lucas Visvikis Pettinati , Zhiting Xu , Lin Liao , Peng Li , Jiajing Wang , Jin Yao , Manuel Frank Martinez
发明人： Jerry Hong , Fenghui Zhang , Lucas Visvikis Pettinati , Zhiting Xu , Lin Liao , Peng Li , Jiajing Wang , Jin Yao , Manuel Frank Martinez
IPC分类号： G09G5/00
CPC分类号： G06T11/206
摘要： A system and method for generating a flow based on multiply types of interactions are provided. Data defining one or more sequences of multiple interactive nodes are received for the multiple interactive nodes, where each of the multiple interactive nodes corresponds to a particular type of interaction. One of the interactive nodes is designated as the starting interactive node and other interactive nodes are designated as intermediary interactive nodes, where the starting interactive node and at least one of the intermediary interactive nodes correspond to different types of interactions. Intermediary interactive nodes are connected to the starting interactive node based on the one or more sequences, where the connection includes one edge corresponding to a direct connection to the starting interactive node or multiple edges corresponding to an indirect connection via at least one other intermediary interactive node. Visualization data for the interactive nodes is generated and provided for display.
摘要翻译：提供了一种基于多种交互类型生成流的系统和方法。为多个交互式节点接收定义多个交互节点的一个或多个序列的数据，其中多个交互节点中的每一个对应于特定类型的交互。其中一个交互节点被指定为起始交互节点，其他交互节点被指定为中间交互节点，其中起始交互节点和至少一个中间交互节点对应于不同类型的交互。中间交互节点基于一个或多个序列连接到起始交互节点，其中连接包括对应于与起始交互节点的直接连接的一个边缘或者经由至少一个其他中间交互节点对应于间接连接的多个边缘。生成交互节点的可视化数据并提供显示。

55. 发明申请

US20130314828A1 FAULT CURRENT LIMITER 有权
标题翻译：故障电流限制
公开(公告)号：US20130314828A1
公开(公告)日：2013-11-28
申请号：US13479660
申请日：2012-05-24
申请人： Song Chen , Peng Li , Bradley Lehman , Gianfranco de Palma
发明人： Song Chen , Peng Li , Bradley Lehman , Gianfranco de Palma
IPC分类号： H02H9/02
CPC分类号： H02H9/02
摘要： A fault current limiter (FCL) for limiting a fault current in a power line during a fault condition. The FCL includes a magnetic coupling circuit for monitoring current in the power line through magnetic coupling; a sensing circuit for sensing the current in the power line and providing a signal indicative of the sensed current; a control circuit receiving the signal indicative of the sensed current in the power line and determining whether the sensed current indicates that the fault condition exists; and high and low impedance paths that are connected in parallel. The high impedance path includes a discharging impedance circuit for limiting the fault current. The low impedance path includes a reactor circuit and a switching unit having an ON state for conducting current through the low impedance path and an OFF state for conducting current through the high impedance path.
摘要翻译：用于在故障状态期间限制电力线路中的故障电流的故障限流器（FCL）。 FCL包括用于通过磁耦合监测电力线中的电流的磁耦合电路; 感测电路，用于感测电力线中的电流并提供指示感测电流的信号; 控制电路，接收表示电力线中检测到的电流的信号，并确定感测到的电流是否表明存在故障状况; 以及并联连接的高阻抗路径和低阻抗路径。高阻抗路径包括用于限制故障电流的放电阻抗电路。低阻抗路径包括电抗器电路和具有导通电流通过低阻抗路径的导通状态的开关单元和用于导通电流通过高阻抗路径的OFF状态。

56. 发明申请

US20130260049A1 PROCESS FOR CHEMICAL PASSIVATION OF POLYMER SURFACES 有权
标题翻译：化学钝化聚合物表面的方法
公开(公告)号：US20130260049A1
公开(公告)日：2013-10-03
申请号：US13433980
申请日：2012-03-29
申请人： Paul J. Gerroir , Daryl W. Vanbesien , Peng Li
发明人： Paul J. Gerroir , Daryl W. Vanbesien , Peng Li
IPC分类号： B05D7/02 , B05D3/02 , B05D1/18 , C23C14/34
CPC分类号： C08J3/128 , C08L2205/18
摘要： Process for passivating polymeric particles to prevent undesirable interaction with the environment. In particular, sputter coating of metal and surface treatment with aqueous solutions are shown to successfully passivate the particles, such as for example, toner particles, and prevent interaction between the particles and the epoxy embedding resin which causes artifacts, observed by transmission electron microscopy (TEM) imaging.
摘要翻译：用于钝化聚合物颗粒以防止与环境的不期望的相互作用的方法。特别地，金属的溅射涂覆和用水溶液的表面处理显示成功地钝化颗粒，例如调色剂颗粒，并且防止颗粒和环氧树脂包埋树脂之间的相互作用，其引起人为因素，通过透射电子显微镜观察 TEM）成像。

57. 发明申请

US20130091270A1 PAGE LAYOUT IN A FLOW VISUALIZATION 有权
标题翻译：页面布局在流程可视化中
公开(公告)号：US20130091270A1
公开(公告)日：2013-04-11
申请号：US13271199
申请日：2011-10-11
申请人： Fenghui Zhang , Lik Mui , Peng Li , Lin Liao , Zhiting Xu
发明人： Fenghui Zhang , Lik Mui , Peng Li , Lin Liao , Zhiting Xu
IPC分类号： G06F15/173
CPC分类号： H04L41/22 , G06Q30/02 , H04L43/0876
摘要： Systems and methods for generating a flow visualization of network traffic. A scoring function is used to prioritize which traffic paths are displayed in the visualization.
摘要翻译：用于生成网络流量流量可视化的系统和方法。评分功能用于确定在可视化中显示哪些流量路径。

58. 发明授权

US08372952B2 Binding proteins that bind to human FGFR1C, human β-klotho and both human FGFR1C and human β-klotho 有权
标题翻译：结合人类FGFR1C，人类和人类klotho以及人类FGFR1C和人类bgr-klotho的结合蛋白
公开(公告)号：US08372952B2
公开(公告)日：2013-02-12
申请号：US12958209
申请日：2010-12-01
申请人： Richard Smith , Alice Bakker , Amy N. Duguay , Peng Li , Yang Li
发明人： Richard Smith , Alice Bakker , Amy N. Duguay , Peng Li , Yang Li
IPC分类号： C07K1/00 , C07K14/00
CPC分类号： C07K14/001 , A61K38/00 , C07K14/50 , C07K14/705 , C07K2319/70 , C07K2319/75
摘要： Binding proteins that specifically bind to β-Klotho or portions thereof, FGFR1c or portions thereof, or both FGFR1c and β-Klotho, and optionally other proteins as well are provided. Coding sequences, methods of treatment and pharmaceutical compositions are also provided.
摘要翻译：提供了特异性结合于其上的结合蛋白-Klotho或其部分，FGFR1c或其部分，或FGFR1c和＆bgr; -Klotho以及任选的其它蛋白质的结合蛋白。还提供编码序列，治疗方法和药物组合物。

59. 发明申请

US20120328569A1 INHIBITORS OF HEPATITIS C VIRUS NS5B POLYMERASE 审中-公开
标题翻译： HEPATITIS C VIRUS NS5B聚合酶抑制剂
公开(公告)号：US20120328569A1
公开(公告)日：2012-12-27
申请号：US13582240
申请日：2011-03-02
申请人： Casey Cameron McComas , Nigel J. Liverton , Richard Soll , Peng Li , Xuanjia Peng , Hao Wu , Frank Narjes , Joerg Habermann , Uwe Koch , Shilan Liu
发明人： Casey Cameron McComas , Nigel J. Liverton , Richard Soll , Peng Li , Xuanjia Peng , Hao Wu , Frank Narjes , Joerg Habermann , Uwe Koch , Shilan Liu
IPC分类号： A61K31/343 , A61K38/21 , A61K31/7056 , C07D407/12 , A61K31/4025 , C07D405/12 , A61K31/4178 , C07D413/10 , A61K31/422 , C07D417/10 , A61K31/428 , A61K31/427 , A61K31/4245 , A61K31/423 , A61K31/41 , C07D471/04 , A61K31/437 , C07D513/04 , C07D498/04 , A61K31/517 , C07D487/04 , A61K31/4985 , A61K31/519 , A61K31/549 , A61K31/5377 , A61P31/14 , C07D307/84
CPC分类号： C07D307/84 , A61K31/343 , A61K45/06 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/10 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D473/00 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译：公开了用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的式（I）化合物，这些化合物的合成，以及这些化合物用于抑制HCV NS5B聚合酶活性的用途，用于治疗或预防HCV感染和抑制在基于细胞的系统中HCV病毒复制和/或病毒生产。

60. 发明授权

US08309722B2 Substituted heterocycle gamma-carbolines synthesis 有权
标题翻译：取代杂环γ-咔啉合成
公开(公告)号：US08309722B2
公开(公告)日：2012-11-13
申请号：US12531016
申请日：2008-03-12
申请人： John Charles Tomesch , Peng Li , Wei Yao , Qiang Zhang , James David Beard , Andrew S. Thompson , Hua Cheng
发明人： John Charles Tomesch , Peng Li , Wei Yao , Qiang Zhang , James David Beard , Andrew S. Thompson , Hua Cheng
IPC分类号： C07D241/36
CPC分类号： C07D471/16 , C07D471/04
摘要： The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines.
摘要翻译：本发明提供了制备取代的杂环稠合的γ-咔啉的方法，可用于制备它们的中间体和制备这种中间体的方法和这种杂环稠合的γ-咔啉。

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