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51. 发明授权

US07087433B2 7SK RNA regulated transcription 有权
标题翻译： 7SK RNA调节转录
公开(公告)号：US07087433B2
公开(公告)日：2006-08-08
申请号：US10227367
申请日：2002-08-25
申请人： Qiang Zhou , Zhiyuan Yang , Qingwei Zhu , Kunxin Luo
发明人： Qiang Zhou , Zhiyuan Yang , Qingwei Zhu , Kunxin Luo
IPC分类号： A61K48/00 , C07H21/04 , C07H21/02 , C12Q1/68
CPC分类号： C12N15/113
摘要： A method for altering transcription in a cell comprising an amount of active CDK9/cyclin, comprises the steps of: (a) introducing in the cell an agent which modulates the amount of active CDK9/cyclin in the cell, and thereby alters transcription in the cell, wherein the agent comprises an RNA selected from the group consisting of an RNA aptamer that specifically binds CDK9/cyclin, a CDK9/cyclin-binding domain of 7SK RNA, a 7SK RNA-binding antisense 7SK RNA domain, and a 7SK RNA-specific RNAi, and (b) detecting a resultant altering of transcription in the cell.Methods for screening for an agent which modulates 7SK RNA-CDK9/cyclin binding generally comprise the steps of (a) incubating a mixture of 7SK RNA, CDK9/cyclin and a candidate agent under conditions wherein but for the presence of the agent, the 7SK RNA and CDK9/cyclin engage in a reference binding; and (b) detecting an agent-biased binding of the 7SK RNA to the CDK9/cyclin.
摘要翻译：一种用于在包含一定量活性CDK9 /细胞周期蛋白的细胞中改变转录的方法包括以下步骤：（a）在细胞中引入调节细胞中活性CDK9 /细胞周期蛋白的量的试剂，从而改变细胞内的转录细胞，其中所述试剂包含选自特异性结合CDK9 /细胞周期蛋白的RNA适配体，7SK RNA的CDK9 /细胞周期蛋白结合结构域，7SK RNA结合反义7SK RNA结构域和7SK RNA- 特异性RNAi，和（b）检测所得到的细胞转录的变化。用于筛选调节7SK RNA-CDK9 /细胞周期蛋白结合的试剂的方法通常包括以下步骤：（a）在7SK RNA，CDK9 /细胞周期蛋白和候选试剂的混合物的条件下， RNA和CDK9 /细胞周期蛋白参与参考结合; 和（b）检测7SK RNA与CDK9 /细胞周期蛋白的药剂偏置结合。

52. 发明授权

US07078099B1 Drawn gel-spun polyethylene yarns and process for drawing 有权
公开(公告)号：US07078099B1
公开(公告)日：2006-07-18
申请号：US11205939
申请日：2005-08-17
申请人： Thomas Yiu-Tai Tam , Chok B. Tan , Charles R. Arnett, Jr. , Qiang Zhou
发明人： Thomas Yiu-Tai Tam , Chok B. Tan , Charles R. Arnett, Jr. , Qiang Zhou
IPC分类号： D01F6/00
CPC分类号： D01F6/04 , Y10T428/29 , Y10T428/2913 , Y10T428/2967
摘要： Gel-spun multi-filament polyethylene yarns possessing a high degree of molecular and crystalline order, and to the drawing methods by which they are produced. The drawn yarns are useful in impact absorption and ballistic resistance for body armor, helmets, breast plates, helicopter seats, spall shields, and other applications; composite sports equipment such as kayaks, canoes, bicycles and boats; and in fishing line, sails, ropes, sutures and fabrics.

53. 发明授权

US07078097B1 Drawn gel-spun polyethylene yarns and process for drawing 有权
标题翻译：拉伸凝胶纺丝聚乙烯纱线和拉丝工艺
公开(公告)号：US07078097B1
公开(公告)日：2006-07-18
申请号：US11205951
申请日：2005-08-17
申请人： Thomas Yiu-Tai Tam , Chok B. Tan , Charles R. Arnett, Jr. , Qiang Zhou
发明人： Thomas Yiu-Tai Tam , Chok B. Tan , Charles R. Arnett, Jr. , Qiang Zhou
IPC分类号： D01F6/00
CPC分类号： D01F6/04 , Y10T428/29 , Y10T428/2913 , Y10T428/2967
摘要： Gel-spun multi-filament polyethylene yarns possessing a high degree of molecular and crystalline order, and to the drawing methods by which they are produced. The drawn yarns are useful in impact absorption and ballistic resistance for body armor, helmets, breast plates, helicopter seats, spall shields, and other applications; composite sports equipment such as kayaks, canoes, bicycles and boats; and in fishing line, sails, ropes, sutures and fabrics.
摘要翻译：具有高分子和结晶度的凝胶纺丝复丝聚乙烯纱线以及它们生产的拉伸方法。拉丝纱可用于身体护甲，头盔，胸板，直升机座椅，防护罩等应用的冲击吸收和防弹性; 复合运动器材如皮划艇，独木舟，自行车和船只; 钓鱼线，帆，绳，缝合线和织物。

54. 发明申请

US20050161854A1 Dimensionally stable yarns 审中-公开
标题翻译：尺寸稳定的纱线
公开(公告)号：US20050161854A1
公开(公告)日：2005-07-28
申请号：US11088020
申请日：2005-03-22
申请人： Peter Rim , Qiang Zhou , Richard Woodlee , Michael Kopplin
发明人： Peter Rim , Qiang Zhou , Richard Woodlee , Michael Kopplin
IPC分类号： D01D5/084 , D01F6/62 , D01D5/096
CPC分类号： D01F6/62 , D01D5/084 , Y10T428/2913 , Y10T428/2969
摘要： An undrawn yarn is produced at increased quench delay and increased take-up speed to achieve improved ultimate elongation at a given crystallinity. Particularly preferred aspects include products comprising such yarns and methods for producing same.
摘要翻译：在提高的淬火延迟和增加的卷取速度下产生未拉伸纱线以在给定的结晶度下实现改进的极限伸长率。特别优选的方面包括包含这种纱线的产品及其制造方法。

55. 发明授权

US5666057A Method of skin effect correction and data quality verification for a multi-frequency induction well logging instrument 失效
标题翻译：多频感应测井仪的皮肤效应校正和数据质量验证方法
公开(公告)号：US5666057A
公开(公告)日：1997-09-09
申请号：US608731
申请日：1996-02-29
申请人： David R. Beard , Qiang Zhou
发明人： David R. Beard , Qiang Zhou
IPC分类号： G01V3/28 , G01V3/18 , G01V3/10
CPC分类号： G01V3/28
摘要： A method of correcting receiver signals in an induction well logging instrument for skin effect. The method includes determining a magnitude of signals induced in an induction receiver at each one of a plurality of different frequencies, determining a relationship of the magnitudes with respect to frequency, and determining a skin effect corrected conductivity by determining a value of the relationship which would obtain when the frequency is equal to zero. In a preferred embodiment, the step of determining the relationship includes calculating a best fit curve of the magnitudes with respect to the frequency, calculating the first derivative of the best fit curve with respect to the frequency, and calculating a correction for the signals at a selected frequency according to the relationship of the first derivative with respect to the frequency. The correction is applied to the signal at the selected frequency to calculate a skin effect corrected signal.In a specific embodiment, the step of curve fitting includes generating a weighting factor for each frequency based on the noise variance of each frequency. The specific embodiment includes constraining the best fit curve so that the first derivative of the best fit curve is generally less than zero and the second derivative of the best fit curve is generally more than zero.
摘要翻译：一种校正感应测井仪器中接收机信号的方法，用于皮肤效应。该方法包括确定在多个不同频率中的每个频率处感应接收机中感应的信号的大小，确定幅度与频率的关系，以及通过确定关系的值来确定皮肤效应校正的电导率当频率等于零时获得。在优选实施例中，确定关系的步骤包括计算相对于频率的幅度的最佳拟合曲线，计算相对于频率的最佳拟合曲线的一阶导数，以及计算对于频率的信号的校正根据一阶导数与频率的关系选择频率。校正被应用于所选频率处的信号，以计算皮肤效应校正信号。在具体实施例中，曲线拟合步骤包括基于每个频率的噪声方差产生每个频率的加权因子。具体实施例包括约束最佳拟合曲线，使得最佳拟合曲线的一阶导数通常小于零，并且最佳拟合曲线的二阶导数通常大于零。

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