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51. 发明授权

US06256638B1 Printable interfaces and digital linkmarks 失效
公开(公告)号：US06256638B1
公开(公告)日：2001-07-03
申请号：US09060221
申请日：1998-04-14
申请人： Thomas J. Dougherty , S. Joy Mountford , Daniel Cummings , Allison De Fren
发明人： Thomas J. Dougherty , S. Joy Mountford , Daniel Cummings , Allison De Fren
IPC分类号： G06F1730
CPC分类号： G06K7/10861 , G06K17/0022 , G06K19/06037 , G06K2019/06225 , G06K2019/06253 , Y10S707/99945 , Y10S707/99948
摘要： The present invention improves the human/computer interface by providing printable interfaces that enable a user to invoke and control computer processes. The present invention teaches an encoded physical medium suitable for use in interfacing a computer user and a computer system such that the user can control and/or access a plurality of computer implemented processes such computer applications and web pages. The encoded physical medium has a Linkmark and an instruction mark. Encoded within the Linkmark is machine readable linking information directing to a computer implemented process. Encoded within the instruction mark is a machine readable operating instruction that, when decoded, may be executed by the computer implemented process. The present invention also teaches that the marks can present human readable information related to the nature of the machine readable information stored therein. For example, the Linkmark may have graphical illustrations indicating content found at the web page, media format of the content, user designation, payment and membership requirements, communication speed, duration of content, etc. The present invention further teaches a two-dimensional bar code with a plurality of colored glyphs formed such that the average color of the two-dimensional bar code represents encoded information. The colored glyphs are also arranged such that digital information is encoded within the two-dimensional bar code.

52. 发明授权

US6103751A Carotene analogs of porphyrins, chlorins and bacteriochlorins as therapeutic and diagnostic agents 失效
标题翻译：卟啉类胡萝卜素类似物，二氢卟酚和细菌毒素作为治疗和诊断剂
公开(公告)号：US6103751A
公开(公告)日：2000-08-15
申请号：US102417
申请日：1998-06-22
申请人： Ravindra K. Pandey , William R. Potter , Thomas J. Dougherty
发明人： Ravindra K. Pandey , William R. Potter , Thomas J. Dougherty
IPC分类号： A61K49/00 , C07D487/22 , C07D519/00 , A61K31/40
CPC分类号： A61K49/0036 , A61K49/0052 , C07D487/22 , C07D519/00
摘要： A carotene conjugate of the formula: ##STR1## where R.sup.1 is hydrogen or methyl; R.sup.2 is: ##STR2## R.sup.3, R.sup.4 and R.sup.5 are independently, hydrogen, methyl or ethyl; R.sup.6 and R.sup.7 are independently --R.sup.13, --OR , --C(R.sup.6)(O), --C(R.sup.16).sub.2 OR.sup.13, --CH.dbd.CHR.sup.13, or --(CH.sub.2)R.sup.14 ; R.sup.8 is --R.sup.13, --OR.sup.13, --C(R.sup.16)(O), --C(R.sup.16).sub.2 OR.sup.13, --CH.dbd.CHR.sup.13, or --(CH.sub.2)R.sup.14 or taken with R.sup.10 is .dbd.O; R.sup.9 is --R.sup.13, --OR.sup.13, --C(R.sup.16)(O), --C(R.sup.16).sub.2 OR.sup.13, --CH.dbd.CHR.sup.13, or --(CH.sub.2)R.sup.14 or taken with R.sup.10 is a chemical bond; R.sup.10 is --R.sup.13, --OR.sup.13, --C(R.sup.16)(O) , --C(R.sup.16).sub.2 OR.sup.13, --CH.dbd.CHR.sup.13, or --(CH.sub.2)R.sup.14 or taken together with R.sup.9 is a chemical bond or taken with R.sup.8 is .dbd.O; R.sup.11 is R.sup.13, or --OR.sup.13 ; R.sup.12 is --C(R.sup.13).sub.2 C(Y)--, --C(O)O(O)C--, --C(NR.sup.13)O(O)C--, or --C(O)N(R.sup.15)--C(O)--; R.sup.13 is, independently at each occurrence, hydrogen or lower alkyl of from 1 through about 10 carbon atoms; R.sup.14 is an amino acid residue, R.sup.15 is --R.sup.13, --R.sup.14, or --C(O)NHR.sup.13 ; R.sup.16 is, independently at each occurrence, hydrogen or lower alkyl of 1 to about 4 carbon atoms and Y is .dbd.O, .dbd.S, or 2H--.
摘要翻译：下式的胡萝卜素缀合物：其中R1是氢或甲基; R2是：R3，R4和R5独立地是氢，甲基或乙基; R6和R7独立地是-R13，-OR，-C（R6）（O），-C（R16）2OR13，-CH = CHR13或 - （CH2）R14; R8是-R13，-OR13，-C（R16）（O），-C（R16）2OR13，-CH = CHR13或 - （CH2）R14，或R10为= R9为-R13，-OR13，-C（R16）（O），-C（R16）2OR13，-CH = CHR13或 - （CH2）R14或R10为化学键; R 10为-R 13，-OR 13，-C（R 16）（O），-C（R 16）2 OR 13，-CH = CHR 13或 - （CH 2）R 14或与R 9一起为化学键， O; R11是R13或-OR13; R 12是-C（R 13）2 C（Y） - ， - C（O）O（O）C - ， - C（NR 13）O（O）C-或-C（O）N（R 15） O） - ; R 13在每次出现时独立地为氢或1至约10个碳原子的低级烷基; R14是氨基酸残基，R15是-R13，-R14或-C（O）NHR13; R 16在每次出现时独立地为氢或1至约4个碳原子的低级烷基，Y为= O，= S或2H-。

53. 再颁专利

USRE36102E Dual lug battery plate construction 失效
公开(公告)号：USRE36102E
公开(公告)日：1999-02-16
申请号：US891827
申请日：1997-07-14
申请人： Thomas J. Dougherty
发明人： Thomas J. Dougherty
IPC分类号： H01M2/24 , H01M2/28 , H01M2/30
CPC分类号： H01M2/28 , H01M2/24 , H01M2/305
摘要： The present invention relates to a unique battery arrangement including battery plates having a pair of spaced apart battery lugs for both the positive and negative plates. While being spaced apart, the lugs are located generally adjacent one top edge of the plates; on opposite sides for the positive and negative plate constructions. The straps used to electrically connect the lugs are lower in height than those used on current battery designs, providing excellent current collection, efficient fusion with smaller lugs and resistance to vibration caused by separation of the lugs from the straps. The present invention also features plates having greater plate surface area, improved current carrying capability and reduced voltage drop. A weld element couples straps of like polarity, and in the preferred embodiment, at least a portion of the weld element is located intermediate the ends of the straps.

54. 发明授权

US5506255A Rhodoporphyrin and phylloerythrin related photosensitizers for photodynamic therapy 失效
标题翻译：铑卟啉和叶绿素相关光敏剂用于光动力疗法
公开(公告)号：US5506255A
公开(公告)日：1996-04-09
申请号：US160384
申请日：1993-12-01
申请人： Kevin M. Smith , Ravindra K. Pandey , Joseph M. Ryan , Nadine Jagerovic , Thomas J. Dougherty
发明人： Kevin M. Smith , Ravindra K. Pandey , Joseph M. Ryan , Nadine Jagerovic , Thomas J. Dougherty
IPC分类号： A61K41/00 , C07D487/22 , A61K31/40
CPC分类号： C07D487/22 , A61K41/0071
摘要： Novel photosensitizers related to rhodoporphyrins and phylloerythrin methyl ester, their preparation and use as photosensitizers for detection and treatment of tumors by photodynamic therapy. The novel photosensitizers accumulate and concentrate preferentially in tumor tissue, have strong light absorption in the 650 to 700 nm region and have reduced skin phototoxicity.
摘要翻译：与紫罗兰卟啉和叶绿菊酯甲酯相关的新型光敏剂，它们的制备和用作光敏剂用于通过光动力学治疗检测和治疗肿瘤。新型光敏剂积聚并优先集中在肿瘤组织中，在650〜700nm区域具有强光吸收，降低皮肤光毒性。

55. 发明授权

US5488283A Vehicle battery system providing battery back-up and opportunity charging 失效
标题翻译：汽车电池系统提供电池备份和机会充电
公开(公告)号：US5488283A
公开(公告)日：1996-01-30
申请号：US128453
申请日：1993-09-28
申请人： Thomas J. Dougherty , William J. Wruck , Richard J. Johnson
发明人： Thomas J. Dougherty , William J. Wruck , Richard J. Johnson
IPC分类号： H01M2/30 , H01M6/50 , H01M10/04 , H01M10/12 , H01M10/42 , H01M10/44 , H01M10/48 , H02J7/14 , B60L1/02 , H02J7/34
CPC分类号： H01M10/0413 , B60L11/1855 , B60L11/1868 , H01M10/122 , H01M10/425 , H01M10/44 , H01M10/482 , H02J7/1423 , B60L2210/20 , B60L2240/36 , B60L2240/547 , B60L2240/549 , B60L2240/662 , H01M10/0445 , H01M2/305 , H01M6/5016 , Y02E60/126 , Y02T10/7016 , Y02T10/7066 , Y02T10/725 , Y02T10/7291 , Y02T90/16 , Y10T307/625
摘要： A battery system for a vehicle includes a main battery for energizing the vehicle SLI circuits and an auxiliary battery for energizing the vehicle EHC system, the battery system providing back-up of the auxiliary battery by the main battery under certain conditions and back-up of the main battery by the auxiliary battery under certain other conditions, and the battery system providing opportunity charging of the auxiliary battery once the vehicle engine is running whereby the auxiliary battery shares the charging current with the main battery with the auxiliary battery being gradually connected to the source of charging current for the main battery by increasing the duty cycle of the drive circuit that connects the auxiliary battery to the source of charging current while monitoring the state of charge of the main battery and decreasing the duty cycle of the drive circuit to protect the main battery state of charge. In other embodiments, separate sources of charging current are provided for the auxiliary battery.
摘要翻译：一种用于车辆的电池系统包括用于对车辆SLI电路通电的主电池和用于为车辆EHC系统通电的辅助电池，该电池系统在一定条件下提供主电池对辅助电池的备用和备用主电池由辅助电池在某些其他条件下进行，并且一旦车辆发动机运行，电池系统提供辅助电池的充电机会，由此辅助电池与主电池共享充电电流，辅助电池逐渐连接到通过增加将辅助电池连接到充电电流源的驱动电路的占空比，同时监视主电池的充电状态并减小驱动电路的占空比来保护主电池的充电电流源，主电池充电状态。在其他实施例中，为辅助电池提供单独的充电电流源。

56. 发明授权

US5459159A Pyropheophorbides and their use in photodynamic therapy 失效
标题翻译：偏焦异构体及其在光动力疗法中的应用
公开(公告)号：US5459159A
公开(公告)日：1995-10-17
申请号：US239089
申请日：1994-05-05
申请人： Ravindra K. Pandey , Thomas J. Dougherty
发明人： Ravindra K. Pandey , Thomas J. Dougherty
IPC分类号： A61K31/40 , A61K41/00 , A61K51/04 , A61P31/12 , A61P35/00 , C07D487/22 , C07D519/00
CPC分类号： C07D487/22 , A61K41/0071 , A61K51/0485 , C07D519/00 , A61K2123/00
摘要： Pyropheophorbide compounds are injected into a host and accumulate in tumor tissue to a higher degree than surrounding normal tissues. When the pyropheophorbide compounds are exposed to a particular wavelength of light the compounds become cytotoxic and destroy the tumor or diseased tissue without causing irreversible normal tissue damage. The pyropheophorbide compounds have shown improved results as compared to drugs currently used in photodynamic therapy. Further, they absorb light further in the red, optimizing tissue penetration and are retained in the skin for short time periods relative to other drugs used in photodynamic therapy.
摘要翻译：将焦磷偏磷酸酯化合物注射到宿主中并在肿瘤组织中积聚到比周围正常组织更高的程度。当焦偏磷酸酯化合物暴露于特定波长的光时，化合物变成细胞毒性并破坏肿瘤或患病组织而不引起不可逆的正常组织损伤。与目前在光动力疗法中使用的药物相比，焦偏镁离子化合物显示出改善的结果。此外，它们进一步吸收红色的光，优化组织穿透，并相对于光动力疗法中使用的其他药物，在短时间内保留在皮肤中。

57. 发明授权

US5316868A Dual battery switch circuit 失效
标题翻译：双电池开关电路
公开(公告)号：US5316868A
公开(公告)日：1994-05-31
申请号：US917581
申请日：1992-07-21
申请人： Thomas J. Dougherty , John R. Pierson
发明人： Thomas J. Dougherty , John R. Pierson
IPC分类号： F02N11/08 , B60R16/02 , B60R16/03 , H01M10/04 , H01M10/42 , H02J7/00 , H02J7/14
CPC分类号： H01M10/0413 , H01M10/4207 , H02J7/0063 , H02J7/1423 , B60R16/03 , H01M10/0445 , Y02T10/7005
摘要： A dual-battery switch circuit associated with a load is provided. The switch circuit includes a primary battery, a secondary battery, a circuit disposed to apply energy from the primary battery to the load, and a controller which disposed to sense attempts to apply energy to the load. The controller is configured to couple the secondary battery to the primary battery with respect to the load when a predetermined number of attempts to apply energy to the load occur within a predetermined time period after a first attempt. Alternatively, a controller is provided which couples the secondary battery to the primary battery with respect to the load when an attempt is made to apply energy to the load and the temperature is below a predetermined level.
摘要翻译：提供与负载相关联的双电池开关电路。开关电路包括一次电池，二次电池，被设置为将一次电池的能量施加到负载的电路，以及设置用于感测向负载施加能量的尝试的控制器。控制器被配置为当在第一次尝试之后的预定时间段内发生预定数量的对负载施加能量的尝试时，相对于负载将二次电池耦合到一次电池。或者，提供一种控制器，当试图对负载施加能量并且温度低于预定水平时，提供将二次电池相对于负载耦合到一次电池的控制器。

58. 发明授权

US5257970A In situ photodynamic therapy 失效
标题翻译：原位光动力疗法
公开(公告)号：US5257970A
公开(公告)日：1993-11-02
申请号：US865918
申请日：1992-04-09
申请人： Thomas J. Dougherty
发明人： Thomas J. Dougherty
IPC分类号： A61K9/127 , A61K31/40 , A61K31/50 , A61K31/66 , A61K41/00 , A61N1/30
CPC分类号： A61K9/127 , A61K31/40 , A61K31/50 , A61K31/66 , A61K41/0057 , A61K41/0071
摘要： The process of photodynamic therapy (PDT) is conducted by the step of:1) separately encapsulating at least one activation component for said photodynamic therapy process in a liposome;2) injecting a photosensitizer into a human or animal host;3) injecting the liposome encapsulated components systemically into the same human or animal host; and4) heating the site of the tumor to melt the liposome encapsulated components to permit mixing of the activation components.The mixing of the activation components can result in:a) energy transfer to the previously injected photosensitizer;b) emission of light and absorption of said light by the previously injected photosensitizer; andc) direct formation of at least one cytotoxic species that functions against the tumor.The heating of the site of the tumor is accomplished by one of the following methods: laser, ultra sound, radio-frequency or microwave frequency. Photofrin photosensitizer is a preferred photosensitizer.
摘要翻译：光动力学治疗（PDT）的过程是通过以下步骤进行的：1）在脂质体中分别封装所述光动力学治疗过程的至少一种活化成分; 2）将光敏剂注入人或动物宿主; 3）将脂质体包封的组分全身注入相同的人或动物宿主中; 和4）加热肿瘤部位以熔化脂质体包封的组分以允许活化组分的混合。活化组分的混合可导致：a）能量转移到先前注射的光敏剂; b）通过先前注射的光敏剂发射光和吸收所述光; 和c）直接形成对肿瘤起作用的至少一种细胞毒性物质。通过以下方法之一实现肿瘤部位的加热：激光，超声，射频或微波频率。 Photofrin光敏剂是优选的光敏剂。

59. 发明授权

US5173504A Bacteriochlorophyll-a derivatives useful in photodynamic therapy 失效
标题翻译：细菌叶绿素a衍生物可用于光动力学治疗
公开(公告)号：US5173504A
公开(公告)日：1992-12-22
申请号：US638172
申请日：1991-01-03
申请人： Thomas J. Dougherty
发明人： Thomas J. Dougherty
IPC分类号： A61K41/00 , C07D487/22
CPC分类号： C07D487/22 , A61K41/0071
摘要： Compounds of formula (1) or formula (2): ##STR1## wherein M is a non-paramagnetic metal selected from Mg.sup.+2, Sn.sup.+2, and Zn.sup.+2, or represents 2 H.sup.30 each H.sup.+ bonded to one of the N atoms connected by the solid lines;R.sup.1 is a saturated of unsaturated hydrocarbyl residue of 8-25 C.;each R.sup.2 is independently selected from the group consisting of vinyl, ethyl, acetyl and 1-hydroxyethyl, andX is COOR.sup.3, wherein R.sup.3 is alkyl (1-C);are useful in photodynamic therapy and diagnosis. These compounds photosensitize target biological substrates to irradiation, and treating said substrates with these sensitizers followed by irradiation leads to the impairment or destruction of the biological substrate. When administered systemically, these compounds accumulate in the undesired target biological substrate. The compounds can also be utilized in vitro, for example to destroy infectious cells or viruses in blood intended for transfusion.
摘要翻译：（1）或式（2）的化合物：其中M是选自Mg + 2，Sn + 2和Zn + 2的非顺磁性金属，或表示2 H30每个H +与通过实线连接的N个原子之一键合; R1是饱和的8-25℃的不饱和烃基残基。每个R 2独立地选自乙烯基，乙基，乙酰基和1-羟乙基，X是COOR 3，其中R 3是烷基（1-C）; 可用于光动力疗法和诊断。这些化合物对目标生物底物进行光敏照射，用这些敏化剂处理所述底物，然后照射导致生物底物的损伤或破坏。当全身施用时，这些化合物积聚在不需要的靶生物底物中。也可以在体外使用这些化合物，例如以破坏用于输血的血液中的感染性细胞或病毒。

60. 发明授权

US4775604A Method and apparatus for sealing a battery terminal post 失效
标题翻译：密封电池端子柱的方法和装置
公开(公告)号：US4775604A
公开(公告)日：1988-10-04
申请号：US80154
申请日：1987-07-29
申请人： Thomas J. Dougherty , Richard A. Hamann , Matthias Geibl
发明人： Thomas J. Dougherty , Richard A. Hamann , Matthias Geibl
IPC分类号： H01M2/06 , H01M2/08 , H01M2/02
CPC分类号： H01M2/08 , H01M2/06
摘要： The interface between the plastic cover of a battery container and the lead or other metal terminal post which extends therethrough is sealed with a rubber bushing which is compressed and extruded along the terminal post during installation and locked tightly in its compressed and extruded state. The bushing preferably has a pair of oppositely angled intersecting frustoconical surfaces on its exterior surface which are adapted to cooperate with mating surfaces surrounding the opening in the cover and on a locking retainer. The assembly provides a flexible seal which will accommodate the inevitable vertical movement of the terminal post as a result of battery element expansion. Most importantly, the assembly provides an extremely effective barrier to the migration of electrolyte along the terminal post to prevent outer terminal corrosion. The rubber bushing is preferably impregnated with silicone oil which, when the bushing is installed, fills the surface voids in the cast terminal post which otherwise provide paths for electrolyte migration. The silicone oil also provides a lubricant for the controlled compression and extrusion of the bushing.
摘要翻译：电池容器的塑料盖和延伸穿过其的导线或其他金属端子柱之间的界面用橡胶衬套密封，橡胶衬套在安装期间沿着端子柱压缩和挤出并且紧密地锁定在其压缩和挤压状态。套管优选地在其外表面上具有一对相对角度的相交的截头圆锥形表面，其适于与围绕盖中的开口的配合表面和锁定保持器协作。组件提供了柔性密封，其将适应由于电池元件膨胀而导致的端子柱的不可避免的垂直运动。最重要的是，该组件为电极沿着端子柱的迁移提供了非常有效的屏障，以防止外部端子腐蚀。橡胶衬套优选地浸渍有硅油，当安装衬套时，填充铸造端子柱中的表面空隙，否则其提供用于电解质迁移的路径。硅油还提供润滑剂用于受控压缩和挤压衬套。

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