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51. 发明授权

US07972353B2 Removable vena cava filter with anchoring feature for reduced trauma 有权
标题翻译：可拆卸的腔静脉过滤器具有锚固功能，减少创伤
公开(公告)号：US07972353B2
公开(公告)日：2011-07-05
申请号：US11108246
申请日：2005-04-18
申请人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne
发明人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/8483 , A61F2230/005 , A61F2230/008
摘要： The present invention involves a removable filter for capturing thrombi in a blood vessel. The filter comprises a plurality of struts having first ends attached together along a longitudinal axis of the filter. Each strut has a body member extending from the first end along the longitudinal axis to an anchoring hook defining a strut axis. Each strut is configured to move along a strut path relative to the longitudinal axis between an expanded state for engaging with the blood vessel and a collapsed state for filter delivery or retrieval. Each anchoring hook has an angle of up to about 90 degrees relative to the strut axis.
摘要翻译：本发明涉及用于在血管中捕获血栓的可移除过滤器。过滤器包括多个支柱，其具有沿着过滤器的纵向轴线连接在一起的第一端。每个支柱具有主体构件，其从第一端沿着纵向轴线延伸到限定支柱轴线的定位钩。每个支柱构造成在与血管接合的扩张状态和用于过滤器输送或回收的折叠状态之间相对于纵向轴线沿支柱路径移动。每个锚定钩相对于支柱轴线具有高达约90度的角度。

52. 发明授权

US07955376B2 Implantable medical device with constrained expansion 有权
标题翻译：植入式医疗器械具有约束扩张
公开(公告)号：US07955376B2
公开(公告)日：2011-06-07
申请号：US11539925
申请日：2006-10-10
申请人： Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Michael L. Garrison
发明人： Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Michael L. Garrison
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： A medical device comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译：医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植物构件。支撑结构具有第一，未膨胀的构造和第二扩展构型。约束部分适于基本上防止支撑结构实现第二扩张构型。阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

53. 发明授权

US07918882B2 Implantable vascular device comprising a bioabsorbable frame 有权
标题翻译：可植入血管装置，其包括生物可吸收框架
公开(公告)号：US07918882B2
公开(公告)日：2011-04-05
申请号：US11185272
申请日：2005-07-19
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61B17/12022 , A61B17/12172 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/005 , A61F2230/0058 , A61F2230/0095
摘要： A multiple-sided valve for implantation within a body vessel comprising a frame comprising a bioabsorbable material is provided. The devices can be pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material, or a bioabsorbable material, including a collagen-based material such as small intestinal submucosa (SIS), may be attached to the frame to form an occlusion device, a graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：提供了用于植入体内容器的多侧阀，其包括包含生物可吸收材料的框架。装置可以从输送导管推入管道或容器的内腔中，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料或包括基于胶原的材料如小肠粘膜下层（SIS）的生物可吸收材料的全部或部分覆盖物可以附接到框架上以形成闭塞装置，移植物或植入物，腔内瓣膜，如用于矫正小腿和脚部无力静脉。

54. 发明授权

US07901453B2 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US07901453B2
公开(公告)日：2011-03-08
申请号：US11932113
申请日：2007-10-31
申请人： Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma , Brian L. Bates , Thomas A. Osborne
发明人： Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma , Brian L. Bates , Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61K51/1282 , A61F2/24 , A61F2/82 , A61F2250/0068 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppressive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食管，气管，结肠，胆管或尿道中的结构12，以及至少一个位于结构的至少一个表面上的免疫抑制剂层18 任选地，装置10可以包括位于免疫抑制剂的层18上的至少一个多孔的，优选的聚合物层20，并且可以替代地或另外包括至少一个涂覆层16，该涂层16位于结构12的一个表面上，至少一层18的免疫抑制剂依次放置在涂层16的至少一部分上。多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。结构12是优选构造为冠状动脉支架。多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。

55. 发明授权

US07887576B2 Endoluminal device with extracellular matrix material and methods 有权
标题翻译：腔内装置与细胞外基质材料及方法
公开(公告)号：US07887576B2
公开(公告)日：2011-02-15
申请号：US12468383
申请日：2009-05-19
申请人： Clinton D. Bahler , Michael P. DeBruyne , Neal E. Fearnot , Alan R. Leewood , Jason A. Mead , Thomas A. Osborne , Jichao Sun , Lal Ninan
发明人： Clinton D. Bahler , Michael P. DeBruyne , Neal E. Fearnot , Alan R. Leewood , Jason A. Mead , Thomas A. Osborne , Jichao Sun , Lal Ninan
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/0077 , A61F2/848 , A61F2/89 , A61F2/915 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/8483 , A61F2002/8486 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0065
摘要： An endoluminal device comprises a stent and a tubular graft supported by the stent. The graft has a proximal and a distal opening and comprises a synthetic material and a bioremodelable material. The bioremodelable material is disposed on an exterior surface in at least one band adjacent at least one of the proximal and distal openings.
摘要翻译：腔内装置包括支架和由支架支撑的管状移植物。移植物具有近端和远端开口，并且包括合成材料和生物可重构材料。生物可重塑材料设置在邻近近端和远端开口中的至少一个的至少一个带中的外表面上。

56. 发明申请

US20090157169A1 IMPLANTABLE VASCULAR DEVICE 有权
标题翻译：可植入血管装置
公开(公告)号：US20090157169A1
公开(公告)日：2009-06-18
申请号：US12393819
申请日：2009-02-26
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
IPC分类号： A61F2/06
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame using heat or pressure welding crimping, adhesive, or other techniques to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：多面医疗装置包括包括线或其它弹性材料并具有一系列弯曲和互连侧的框架。该装置具有扁平构型和第二折叠构造，其大致蛇形形状。该装置从输送导管推入管道或容器的内腔，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料如DACRON，PTFE或胶原基材料如小肠粘膜下层（SIS）的全部或部分覆盖物可以使用热或压力焊接压接，粘合剂或形成闭塞装置，支架移植物或可植入的腔内瓣膜的其它技术，例如用于矫正小腿和脚部的无能力的静脉。

57. 发明授权

US07520894B2 Implantable vascular device 有权
公开(公告)号：US07520894B2
公开(公告)日：2009-04-21
申请号：US11165600
申请日：2005-06-22
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame using heat or pressure welding crimping, adhesive, or other techniques to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.

58. 发明申请

US20080306509A1 Patent Foramen Ovale Closure Device and Method 有权
标题翻译：专利孔封闭装置及方法
公开(公告)号：US20080306509A1
公开(公告)日：2008-12-11
申请号：US12159829
申请日：2007-01-09
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61B17/068 , A61B17/064
CPC分类号： A61B17/0057 , A61B17/0644 , A61B17/0684 , A61B2017/00349 , A61B2017/00353 , A61B2017/00575
摘要： A device for closure of a patent foramen ovale. The device includes at least one elongated tissue anchor at the distal end of the device. A distal end portion of the tissue anchor is selectively deployable between a closed position in which the distal end portion of the tissue anchor is capable of penetrating the septum and the flap, and a radially extensible position in which the distal end portion of the tissue anchor is capable of engaging the septum or flap so that the septum and flap may be urged into registry. A deployment member is associated with the tissue anchor for selectively deploying the distal end portion of the tissue anchor between the closed position and the radially extensible position. A closure element is disposed at the distal end of the device. The closure element is engageable with the septum and the flap when the septum and flap are in registry, for maintaining such registry. An actuator is associated with the closure element for selectively engaging the closure element with the septum and flap.
摘要翻译：用于闭合卵孔卵泡的设备。该装置包括在装置的远端处的至少一个细长的组织锚。组织锚固件的远端部分可选择性地展开在关闭位置，组合锚固件的远端部分能够穿过隔膜和瓣部之间的封闭位置以及组织锚固件的远端部分的径向可伸展位置能够接合隔膜或瓣片，使得隔膜和皮瓣可被推入注册。展开构件与组织锚固件相关联，用于选择性地将组织锚的远端部分展开在关闭位置和可径向延伸位置之间。闭合元件设置在装置的远端。当隔膜和襟翼处于注册状态时，封闭元件可与隔膜和襟翼接合，以保持这种注册。致动器与闭合元件相关联，用于选择性地将闭合元件与隔膜和瓣片接合。

59. 发明申请

US20080288044A1 Composite Stent Graft 有权
标题翻译：复合支架移植
公开(公告)号：US20080288044A1
公开(公告)日：2008-11-20
申请号：US12092120
申请日：2006-10-31
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/826 , A61F2002/828 , A61F2220/0075 , A61F2230/0054 , A61F2250/0056
摘要： A composite prosthesis (19, 99, 199) and method are disclosed herein. This endoluminal prosthesis is constructed by separately deploying a first prosthesis (9, 201) and a second prosthesis (14, 208), wherein the first prosthesis is deployed and secured to the interior surface of a body lumen (260). In a subsequent step, the second prosthesis is deployed substantially within and secured to the first prosthesis. Although additional prostheses may be deployed within the second prosthesis, in a preferred configuration the first and second prostheses combine to provide all of the necessary attributes associated with a functioning endoluminal prosthesis. Thus, one of the first and second prostheses is permeable to blood and exerts sufficient radial force to cause the composite prosthesis to securely engage an interior surface of the body lumen at one or both of the composite prosthesis's proximal and distal ends, while the other of the first and second prostheses is impermeable to blood flow.
摘要翻译：本文公开了一种复合假体（19,99,199）和方法。该腔内假体通过分开展开第一假体（9,201）和第二假体（14,208）来构造，其中第一假体展开并固定到体腔（260）的内表面。在随后的步骤中，第二假体基本上部署在第一假体内并固定到第一假体。虽然附加的假体可以部署在第二假体内，但是在优选的构造中，第一和第二假体组合以提供与功能性腔内假体相关联的所有必要属性。因此，第一和第二假体中的一个可渗透血液并施加足够的径向力，以使复合假体在复合假体的近端和远端中的一个或两个处牢固地接合体腔的内表面，而另一个第一和第二假体是不透血的。

60. 发明授权

US07452371B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US07452371B2
公开(公告)日：2008-11-18
申请号：US09777091
申请日：2001-02-05
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：多面医疗装置包括包括线或其它弹性材料并具有一系列弯曲和互连侧的框架。该装置具有扁平构型和第二折叠构造，其大致蛇形形状。该装置从输送导管推入管道或容器的内腔，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料如DACRON，PTFE或基于胶原的材料如小肠粘膜下层（SIS）的全部或部分覆盖物可以被缝合或附着到框架上以形成闭塞装置，支架移植物，或可植入的管腔内瓣膜，例如用于矫正小腿和脚部的无能力的静脉。

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