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51. 发明专利

CA2128413C FIBER OPTIC ARRAY SENSORS, APPARATUS, AND METHODS FOR CONCURRENTLY VISUALIZING AND CHEMICALLY DETECTING MULTIPLE ANALYTES OF INTEREST INA FLUID SAMPLE 未知
公开(公告)号：CA2128413C
公开(公告)日：2007-04-03
申请号：CA2128413
申请日：1993-11-15
申请人： TUFTS COLLEGE
发明人： WALT DAVID R , BARNARD STEVEN M
IPC分类号： G01N21/00 , A61B6/00 , G01N21/64 , G01N21/75 , G01N21/76 , G01N21/77 , G01N21/78 , G01N21/80 , G01N33/533 , G01N33/543 , G02B6/06
摘要： The present invention provides a unique fiber optic sensor which is able to provide a viewing zone (S14, S18-S24, S39-S46, S51-S58, S63-S70, S75-S82, S89-S96, S100-S106) for visual examination of a sample and its surrounding environment; and is able to conduct multiple assays concurrently using a plurality of different dyes (250, 252, 254, 256) immobilized at individual spatial positions within a dye sensing zone (260A-260D) on the surface of the sensor. The present invention also provides apparatus for making precise optical determinations and measurements for multiple analytes of interest concurrently and provides methods of detection for multiple analytes of interest which can be correlated with specific parameters or other ligands for specific applications and purposes.

52. 发明专利

AU2003200922B8 Self-encoding fiber optic sensor 未知
公开(公告)号：AU2003200922B8
公开(公告)日：2006-08-31
申请号：AU2003200922
申请日：2003-03-05
申请人： TUFTS COLLEGE
发明人： WALT DAVID R , DICKINSON TODD A
IPC分类号： G01N33/50 , G01N21/62 , G01N21/64 , G01N21/77

53. 发明专利

AU746365B2 Fiber optic sensor with encoded microspheres 未知
公开(公告)号：AU746365B2
公开(公告)日：2002-04-18
申请号：AU6464898
申请日：1998-03-13
申请人： TUFTS COLLEGE
发明人： WALT DAVID R , MICHAEL KARRI C
IPC分类号： G01N33/543 , C12Q1/68 , C40B40/10 , G01N15/14 , G01N21/64 , G01N21/77 , G01N33/532 , G01N35/00
摘要： A microsphere-based analytic chemistry system is disclosed in which microspheres carrying different chemical functionalities may be mixed together while the ability is retained to identify the functionality on each bead using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which the separate microsphere may be optically coupled to discrete fibers or groups of fibers within the bundle. The functionalities are encoded on the separate microspheres using fluorescent dyes and then affixed to wells etched in the end of the bundle. Thus, a single sensor may carry thousands of chemistries. Only those microspheres exhibiting reactions then need to be decoded to identify the corresponding functionality.

54. 发明专利

CA2343377A1 TARGET ANALYTE SENSORS UTILIZING MICROSPHERES 未知
公开(公告)号：CA2343377A1
公开(公告)日：2000-03-23
申请号：CA2343377
申请日：1999-09-10
申请人： TUFTS COLLEGE
发明人： WALT DAVID R , MICHAEL KARRI L
IPC分类号： G01N21/64 , B01J19/00 , C12M1/40 , C12Q1/00 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N1/28 , G01N15/14 , G01N21/77 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/532 , G01N33/543 , G01N33/566 , G01N33/58 , G01N35/00 , G01N37/00 , G01N21/75
摘要： A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents ma y be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modifie d substrates may be employed which provide either discrete or non-discrete sit es for accomodating the microspheres in either random or patterned distribution s. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrat e to produce a high density array. The disclosed system and method have utilit y for detecting target analytes and screening large libraries of bioactive age nt.

55. 发明专利

DK1895289T3 Selvkodende sensor med mikrokugler 未知
公开(公告)号：DK1895289T3
公开(公告)日：2018-05-22
申请号：DK07023438
申请日：2000-04-06
申请人： TUFTS COLLEGE
发明人： WALT DAVID R , DICKINSON TODD A
IPC分类号： C12M1/34 , C40B60/14 , G01N21/64 , G01N21/77 , G01N33/00 , G01N33/543

56. 发明专利

CA2734029A1 METHODS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN SOLUTION. 未知
公开(公告)号：CA2734029A1
公开(公告)日：2009-03-05
申请号：CA2734029
申请日：2007-08-30
申请人： TUFTS COLLEGE
发明人： WALT DAVID R , RISSIN DAVID M
IPC分类号： G01N33/543 , G01N33/50 , G01N33/53
摘要： Disclosed is a method for measuring the concentration of an analyte or analytes in a solution. Although the methods can be conducted using a number of different assay formats, in one embodiment, the assays are conducted in reaction vessels defined, at least in part, by the distal ends of fiber optic strands.

57. 发明专利

CA2643993A1 METHODS AND ARRAYS FOR TARGET ANALYTE DETECTION AND DETERMINATION OF TARGET ANALYTE CONCENTRATION IN SOLUTION 未知
公开(公告)号：CA2643993A1
公开(公告)日：2007-08-30
申请号：CA2643993
申请日：2007-02-20
申请人： TUFTS COLLEGE
发明人： GORRIS HANS-HEINER , RISSIN DAVID M , WALT DAVID R
IPC分类号： C12Q1/00 , C12M1/00 , C12M1/36 , C12M1/38 , C12N11/00 , C12Q1/02 , C12Q1/18 , C12Q1/68 , G01N33/00 , G01N33/53 , G01N33/567
摘要： Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection and quantitation. Biomolecules such as enzymes can be addressed at the single molecule level in order to discover function, detect binding partners or inhibitors, and/or measure rate constants.

58. 发明专利

AU2007217819A1 Mthods and arrays for target analyte detection and determination of target analyte concentration in solution 未知
公开(公告)号：AU2007217819A1
公开(公告)日：2007-08-30
申请号：AU2007217819
申请日：2007-02-20
申请人： TUFTS COLLEGE
发明人： GORRIS HANS-HEINER , WALT DAVID R , RISSIN DAVID M
IPC分类号： G01N33/53
摘要： Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection and quantitation. Biomolecules such as enzymes can be addressed at the single molecule level in order to discover function, detect binding partners or inhibitors, and/or measure rate constants.

59. 发明专利

AU2005200653A8 Self-encoding sensor with micropheres 未知
公开(公告)号：AU2005200653A8
公开(公告)日：2005-03-10
申请号：AU2005200653
申请日：2005-02-14
申请人： TUFTS COLLEGE
发明人： DICKINSON TODD A , WALT DAVID R
IPC分类号： G01N21/00

60. 发明专利

AU1308002A Self-encoding sensor with microspheres 未知
公开(公告)号：AU1308002A
公开(公告)日：2002-04-15
申请号：AU1308002
申请日：2001-10-09
申请人： TUFTS COLLEGE
发明人： WALT DAVID R
IPC分类号： C40B60/14 , G01N21/77
摘要： A micro-sphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

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