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51. 发明申请

WO2009142810A3 METHODS FOR TREATING OR PREVENTING COLORECTAL CANCER 审中-公开
标题翻译：治疗或预防色素性癌症的方法
公开(公告)号：WO2009142810A3
公开(公告)日：2010-07-15
申请号：PCT/US2009037953
申请日：2009-03-23
申请人： SCHERING CORP , WANG YAOLIN , WANG YAN , LIU MING , BISHOP WALTER ROBERT , SEIDEL-DUGAN CYNTHIA
发明人： WANG YAOLIN , WANG YAN , LIU MING , BISHOP WALTER ROBERT , SEIDEL-DUGAN CYNTHIA
IPC分类号： A61K39/395 , A61K31/404 , A61K31/505 , A61P35/00
CPC分类号： A61K31/505 , A61K31/436 , A61K31/513 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , A61K2300/00
摘要： The present invention provides, for example, methods for treating or preventing colorectal cancer with an anti-IGF1R antibody in association with sunitinib or a combination of leucovorin and 5-fluorouracil.
摘要翻译：本发明提供了例如与舒尼替尼或甲酰四氢叶酸和5-氟尿嘧啶的组合相结合的抗IGF1R抗体治疗或预防结肠直肠癌的方法。

52. 发明申请

WO2007071124A8 PLANETARY CARRIER ASSEMBLY FOR WIND GENERATING APPARATUS, TRANSMISSION FOR WIND GENERATING APPAPATUS AND WIND GENERATING APPARATUS 审中-公开
标题翻译：用于风力发电装置的运输工具组件，用于风力发电装置和风力发电装置的变速器
公开(公告)号：WO2007071124A8
公开(公告)日：2008-09-18
申请号：PCT/CN2006000186
申请日：2006-01-27
申请人： YANG DONG FANG STEAM TURBINE W , ZHANG MINRUI , HU YUNCHENG , WANG YAN , RUAN GUISHENG , ZHENG QIAN , YANG YIRU
发明人： ZHANG MINRUI , HU YUNCHENG , WANG YAN , RUAN GUISHENG , ZHENG QIAN , YANG YIRU
IPC分类号： F03D11/00 , F03B11/00 , F16H57/02 , F16H57/08
CPC分类号： F16H57/082 , F03D15/00 , F05B2260/4031 , Y02E10/722
摘要： A planetary carrier assembly comprises an outer planetary carrier, an inner planetary carrier and a connecting member, a plurality of connecting portions are formed on the respective sides of the outer planetary carrier and inner planetary carrier, a locating hole is provided in said connecting portion, a supporting transmissive portion is uniformly inwardly spaced on an upper end and a lower end of the outer planetary carrier respectively to locate each planetary between each pair of upper and lower supporting portion in an axially symmetric manner by means of a bearing and a supporting shaft, the inner planetary carrier is nestedly engagedinto the outer planetary carrier and a surface contact is formed between said respective connecting portions, the outer planetary carrier may be secured to the inner planetary carrier by means of the connecting member which is inserted into the locating hole, an fixed portion is provided on an end of the inner planetary carrier opposed to the other end thereof which is nestedly engaged into the outer planetary carrier. The present invention also relates to a transmission for a wind generating apparatus and a wind generating apparatus. By means of the apparatuses according to the present invention, the problem of the deflection between the axis of the planetary gear and the axis of the sun gear is solved so that the service life of the planetary gear is significantly improved, the apparatuses according to the present invention are especially suitable used in the application of wind generation and variable torque input.
摘要翻译：行星齿轮架组件包括外行星架，内行星架和连接构件，在外行星架和内行星架的各侧形成有多个连接部，在所述连接部设有定位孔，支撑透射部分在外行星架的上端和下端分别均匀地向内间隔开，以便通过轴承和支撑轴以轴向对称的方式将每个行星齿轮定位在每对上下支撑部分之间，内行星齿轮架嵌套地接合到外行星架，并且在所述各连接部之间形成表面接触，外行星架可以通过插入定位孔的连接构件固定到内行星架上，固定部分设置在与另一个相对的内行星架上其端部嵌套地接合到外行星架。本发明还涉及一种用于风力发电装置和风力发电装置的变速器。通过本发明的装置，解决了行星齿轮的轴线与太阳齿轮的轴线之间的偏转的问题，使得行星齿轮的使用寿命显着提高，根据本发明特别适用于风力发电和可变扭矩输入的应用。

53. 发明申请

WO2006081190A3 COMPOSITIONS AND METHODS FOR TREATING CARDIAC CONDITIONS 审中-公开
标题翻译：治疗心脏病症的组合物和方法
公开(公告)号：WO2006081190A3
公开(公告)日：2008-02-21
申请号：PCT/US2006002313
申请日：2006-01-25
申请人： FIVE PRIME THERAPEUTICS INC , WILLIAMS LEWIS T , ZHANG HONGBING , WANG YAN , MASUOKA LORIANE , DOBERSTEIN STEPHEN
发明人： WILLIAMS LEWIS T , ZHANG HONGBING , WANG YAN , MASUOKA LORIANE , DOBERSTEIN STEPHEN
IPC分类号： A61K38/18 , A61K38/21 , A61P9/00
CPC分类号： A61K9/0019 , A61K38/1808 , A61K38/1825 , A61K38/1858 , A61K38/1866 , A61K38/2006 , A61K38/2093 , A61K38/212 , A61K38/2285 , A61K38/2292 , A61K38/30 , A61K2300/00
摘要： Pharmaceutical polypeptide compositions promote the survival of cardiac cells, recruit cardiac cells to the cardiac area, stimulate the differentiation of cardiac cells, stimulate the proliferation of cardiac cells, and promote the activity of cardiac cells, thereby treating cardiac conditions. Methods of providing these compositions to the cardiac area include catheterization and direct injection. In preferred embodiements, the compositions comprise one of more of the following growth factors: EGF, bFGF, cardiotrophin-1, thrombin, PDGF-BB, amphiregulin, epiregulin, HB-EGF, TGFalpha, betacellulin, heregulin alpha, NRG-1-betal-HRG-betal, FGF 9.
摘要翻译：药物多肽组合物促进心脏细胞的存活，将心脏细胞募集到心脏区域，刺激心脏细胞的分化，刺激心脏细胞的增殖，并促进心脏细胞的活性，从而治疗心脏病。将这些组合物提供给心脏区域的方法包括导管插入和直接注射。在优选的实施方案中，组合物包含以下生长因子之一：EGF，bFGF，心肌营养因子-1，凝血酶，PDGF-BB，双调蛋白，表孕霉素，HB-EGF，TGFα，细胞素，调节蛋白α，NRG-1-betal -HRG-betal，FGF 9。

54. 发明申请

WO2007047215A2 CONTACT ASSEMBLY CLEANING IN AN ELECTRO-CHEMICAL MECHANICAL PROCESSING APPARATUS 审中-公开
标题翻译：在电化学机械加工设备中接触组件清洁
公开(公告)号：WO2007047215A2
公开(公告)日：2007-04-26
申请号：PCT/US2006039439
申请日：2006-10-10
申请人： APPLIED MATERIALS INC , MANENS ANTOINE P , DUBOUST ALAIN , BUTTERFIELD PAUL D , MARTINEZ RICARDO , WANG YAN , SALAS-VERNIS JOSE
发明人： MANENS ANTOINE P , DUBOUST ALAIN , BUTTERFIELD PAUL D , MARTINEZ RICARDO , WANG YAN , SALAS-VERNIS JOSE
IPC分类号： C25D21/06
CPC分类号： C25F7/00 , B23H5/08 , B24B37/16 , B24B53/017
摘要： Embodiments of the invention generally provide a method and apparatus for cleaning an electrical contact in an electrochemical mechanical planarizing apparatus. In one embodiment, a method for cleaning a contact assembly in an electroprocessing apparatus includes the steps of draining electrolyte from the contact assembly and flowing a rinsing fluid into the contact assembly. In another embodiment, a method for cleaning a contact assembly in an electroprocessing apparatus includes the steps of preventing fluid from passing between an interface of the contact assembly and a pad disposed outward thereof, flowing a rinsing fluid into the contact assembly and draining fluid flowing out of the contact assembly.
摘要翻译：本发明的实施例通常提供用于清洁电化学机械平坦化设备中的电触点的方法和设备。在一个实施例中，一种用于清洁电处理设备中的接触组件的方法包括以下步骤：从接触组件中排出电解质并且使冲洗流体流入接触组件中。在另一个实施例中，一种用于清洁电处理设备中的接触组件的方法包括以下步骤：防止流体在接触组件的接口和设置在接触组件的外部的垫之间流动，使冲洗流体流入接触组件并排出流出的流体的接触组件。

55. 发明申请

WO2006081286A3 MULTI-LAYER POLISHING PAD FOR LOW-PRESSURE POLISHING 审中-公开
标题翻译：多层抛光垫用于低压抛光
公开(公告)号：WO2006081286A3
公开(公告)日：2006-12-14
申请号：PCT/US2006002599
申请日：2006-01-24
申请人： APPLIED MATERIALS INC , MANENS ANTOINE , DUBOUST ALAIN , CHANG SHOU-SUNG , LU WEI , NEO SIWE , WANG YAN , MOON YOUNGSIK
发明人： DUBOUST ALAIN , CHANG SHOU-SUNG , LU WEI , NEO SIWE , WANG YAN , MOON YOUNGSIK
IPC分类号： B24B7/00 , B24B1/00 , B24B7/04 , B24B7/22 , B24B37/013 , B24B37/04 , B24B37/20 , B24B37/22 , B24B37/26 , B24D11/02 , B24D99/00
CPC分类号： B24B37/013 , B24B37/046 , B24B37/205 , B24B37/22 , B24B37/26 , B24D11/02
摘要： A polishing pad has a polishing layer and a backing layer secured to the polishing layer. The polishing layer has a polishing surface, a first thickness, a first compressibility, and a hardness between about 40 to 80 Shore D. The backing layer has a second thickness equal to or less than the first thickness and has a second compressibility greater than the first compressibility. The first thickness, first compressibility, second thickness and second compressibility are such that the polishing surface deflects more than the thickness non-uniformity of the polishing layer under an applied pressure of 1.5 psi or less.
摘要翻译：抛光垫具有抛光层和固定在抛光层上的背衬层。抛光层具有抛光表面，第一厚度，第一可压缩性以及约40至80肖氏D硬度。背衬层具有等于或小于第一厚度的第二厚度并具有大于第一厚度的第二可压缩性第一可压缩性。第一厚度，第一可压缩性，第二厚度和第二可压缩性使得抛光表面在1.5psi或更小的施加压力下偏转大于抛光层的厚度不均匀性。

56. 发明申请

WO2005066211A3 FIBROBLAST GROWTH FACTOR RECEPTORS 1, 2, 3, AND 4 AS TARGETS FOR THERAPEUTIC INTERVENTION 审中-公开
标题翻译：成纤维细胞生长因子受体1,2,3和4作为治疗干预的目标
公开(公告)号：WO2005066211A3
公开(公告)日：2005-11-03
申请号：PCT/US2004042163
申请日：2004-12-17
申请人： FIVE PRIME THERAPEUTICS INC , ZENG CHANGJIANG , HESTIR KEVIN , PIERCE KRISTEN , WILLIAMS LEWIS T , BOSCH ELIZABETH , MASUOKA LORIANNE , WONG JUSTIN G P , WANG YAN , CHU KETING , LEE ERNESTINE
发明人： ZENG CHANGJIANG , HESTIR KEVIN , PIERCE KRISTEN , WILLIAMS LEWIS T , BOSCH ELIZABETH , MASUOKA LORIANNE , WONG JUSTIN G P , WANG YAN , CHU KETING , LEE ERNESTINE
IPC分类号： C07K14/71 , C07K16/28 , C12Q1/68 , G01N33/574 , G01N33/74
CPC分类号： C07K16/2863 , C07K14/71 , G01N33/574 , G01N33/74 , G01N2333/50 , G01N2800/04 , G01N2800/065 , G01N2800/085 , G01N2800/102 , G01N2800/104 , G01N2800/105 , G01N2800/324
摘要： Isolated fibroblast growth factor receptor 1 ("FGFR1"), fibroblast growth factor receptor 2 ("FGFR2"), fibroblast growth factor receptor 3 ("FGFR3"), and fibroblast growth receptor 4 ("FGFR4") polypeptides and polynucleotides encoding the FGFR1-4 polypeptides, respectively, are provided. Additionally, antibodies, directed to the FGFR1-4 polypeptides and polynucleotides, inclusive of all polymorphic forms and variants thereof, are described. These antibodies either specifically activate the polypeptide or specifically interfere with the activity of the polypeptide. Further provided are methods of treating diseases, such as proliferative diseases, inflammatory diseases, and metabolic disorders, and kits and compositions employing the disclosed compositions. Specifically disclosed is a method of treating tumors in a subject where an antagonist of FGFR1, FGFR2, FGFR3, and/or FGFR4 is administered to the subject.
摘要翻译：分离的成纤维细胞生长因子受体1（“FGFR1”），成纤维细胞生长因子受体2（“FGFR2”），成纤维细胞生长因子受体3（“FGFR3”）和成纤维细胞生长受体4（“FGFR4”）多肽和编码FGFR1 -4多肽。另外，描述了针对FGFR1-4多肽和多核苷酸的抗体，包括所有的多态性形式和变体。这些抗体或者特异性激活多肽或者特异性干扰多肽的活性。进一步提供了治疗疾病例如增殖性疾病，炎症性疾病和代谢性疾病的方法，以及使用所公开的组合物的试剂盒和组合物。具体公开的是治疗受试者中施用FGFR1，FGFR2，FGFR3和/或FGFR4的拮抗剂的肿瘤的方法。

57. 发明申请

WO2005002794A3 CELL, SYSTEM AND ARTICLE FOR ELECTROCHEMICAL MECHANICAL PROCESSING (ECMP) 审中-公开
标题翻译：电化学机械加工用电池，系统及其制品（ECMP）
公开(公告)号：WO2005002794A3
公开(公告)日：2005-03-31
申请号：PCT/US2004022722
申请日：2004-07-01
申请人： APPLIED MATERIALS INC , WANG YAN , NEO SIEW S , LIU FENG Q , TSAI STAN D , HU YONGQI , DUBOUST ALAIN , MANENS ANTOINE P , WADENSWEILER RALPH M , MAVLIV RASHID , CHEN LIANG-YUH , OLGADO DONALD J K , BUTTERFIELD PAUL D , TSENG MING-KUEI , CHANG SHOU-SUNG , SUN LIZHONG
发明人： WANG YAN , NEO SIEW S , LIU FENG Q , TSAI STAN D , HU YONGQI , DUBOUST ALAIN , MANENS ANTOINE P , WADENSWEILER RALPH M , MAVLIV RASHID , CHEN LIANG-YUH , OLGADO DONALD J K , BUTTERFIELD PAUL D , TSENG MING-KUEI , CHANG SHOU-SUNG , SUN LIZHONG
IPC分类号： B23H5/08 , B24B37/04 , B24B53/007 , C25F7/00 , H01L21/321
CPC分类号： B24B37/04 , B23H5/08 , B24B53/017 , C25F7/00
摘要： The invention provides a cell, a system and an article for processing a substrate in an electrochemical mechanical polishing system. A cell for polishing a substrate includes a polishing pad disposed on a top surface of a platen assembly. A plurality of conductive elements are arranged in a spaced-apart relation across the upper polishing surface and adapted to bias the substrate relative to an electrode disposed between the pad and the platen assembly. A plurality of passages are formed through the platen assembly between the top surface and a plenum defined within the platen assembly. A system is provided having a bulk polishing cell and a residual polishing cell. The residual polishing cell includes a biased conductive polishing surface. In further embodiments, the conductive element is protected from attack by process chemistries.
摘要翻译：本发明提供一种用于在电化学机械抛光系统中处理基底的电池，系统和制品。用于抛光基板的单元包括设置在压板组件的顶表面上的抛光垫。多个导电元件跨过上抛光表面以间隔的关系布置，并且适于相对于设置在垫和压板组件之间的电极偏置衬底。多个通道通过压板组件形成在顶表面和限定在压板组件内的气室之间。提供了具有大量抛光单元和残余抛光单元的系统。残余抛光单元包括偏置的导电抛光表面。在另外的实施方案中，保护导电元件免受过程化学物质的侵蚀。

58. 发明申请

WO2008076278A8 METHODS OF CANCER TREATMENT WITH IGF1R INHIBITORS 审中-公开
标题翻译：用IGF1R抑制剂治疗癌症的方法
公开(公告)号：WO2008076278A8
公开(公告)日：2013-03-28
申请号：PCT/US2007025398
申请日：2007-12-11
申请人： SCHERING CORP , WANG YAN , ZONG CHEN , SEIDEL-DUGAN CYNTHIA , WANG YAOLIN , YAO SIU-LONG , LU BRIAN DER-HUA , LADHA MOHAMED H
发明人： WANG YAN , ZONG CHEN , SEIDEL-DUGAN CYNTHIA , WANG YAOLIN , YAO SIU-LONG , LU BRIAN DER-HUA , LADHA MOHAMED H
IPC分类号： A61K31/519 , A61K39/395 , A61K45/06 , A61P35/00 , A61P35/02
CPC分类号： A61K31/00 , A61K31/519 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： This invention relates to compositions and methods useful for treating various cancers. Therapeutic combinations and methods of use thereof are also covered in the present application.
摘要翻译：本发明涉及可用于治疗各种癌症的组合物和方法。治疗组合及其使用方法也在本申请中被覆盖。

59. 发明申请

WO2012003398A1 METHOD FOR USES OF PROTEIN PRECURSORS AS PRODRUGS 审中-公开
标题翻译：使用蛋白质前体作为PRODRUGS的方法
公开(公告)号：WO2012003398A1
公开(公告)日：2012-01-05
申请号：PCT/US2011042708
申请日：2011-06-30
申请人： UNIV SOUTHERN CALIFORNIA , SHEN WEI-CHIANG , WANG YAN
发明人： SHEN WEI-CHIANG , WANG YAN
IPC分类号： C07K14/79 , A61K38/28 , A61K47/48 , C07K14/62 , C12N15/62
CPC分类号： C07K14/79 , A61K38/00 , A61K47/644 , C07K14/62 , C07K2319/00 , C07K2319/31 , C07K2319/33 , C07K2319/74
摘要： The present invention provides compositions useful as prodrugs and methods for making the same. The compositions include a fusion protein having a first delivery domain and a second protein precursor domain linked together via a linker sequence. The delivery domain is a protein capable of facilitating entry to a target cells via the endocytotic pathway, such as transferrin. The protein precursor is a prohormone or a profactor, such as proinsulm. Methods of this invention include the steps of selecting a protein suitable as the delivery domain, constructing a vector to encode the fusion protein, and expressing the fusion protein in a suitable expression host.
摘要翻译：本发明提供可用作前药的组合物及其制备方法。组合物包括具有通过接头序列连接在一起的第一递送结构域和第二蛋白前体结构域的融合蛋白。递送结构域是能够促进通过内吞途径进入靶细胞的蛋白质，例如转铁蛋白。蛋白质前体是前体激素或者一种表面活性剂，如前体蛋白。本发明的方法包括选择适合作为递送结构域的蛋白质，构建编码融合蛋白的载体，并在合适的表达宿主中表达融合蛋白的步骤。

60. 发明申请

WO2011071250A2 METHOD AND APPARATUS FOR PARALLEL PROCESSING TURBO DECODER 审中-公开
标题翻译：并行处理涡轮解码器的方法和装置
公开(公告)号：WO2011071250A2
公开(公告)日：2011-06-16
申请号：PCT/KR2010008136
申请日：2010-11-17
申请人： SAMSUNG ELECTRONICS CO LTD , PISEK ERAN , WANG YAN
发明人： PISEK ERAN , WANG YAN
IPC分类号： H04B7/08
CPC分类号： H04L5/0007 , H03M13/2739 , H03M13/2978 , H03M13/2987 , H03M13/3972 , H03M13/6519 , H03M13/6525 , H03M13/6561 , H04L1/005 , H04L1/0052 , H04L1/0066 , H04L25/03171
摘要： A receiver capable of decoding encoded transmissions. The receiver includes a number of receive antennas configured to receive data; a plurality of memory units that store the received data; and a plurality of decoders configured to perform a Turbo decoding operation. Each of the plurality of decoders decodes at least a portion of the received data using at least a portion of a decoding matrix. The receiver also includes a data switch coupled between the plurality of decoders and the plurality of memory units. The data switch configured to vary a decode operation from an long term evolution (LTE) based operation to a Wideband Code Division Multiple Access (WCDMA) operation.
摘要翻译：一种能够解码编码的传输的接收机。接收机包括被配置为接收数据的多个接收天线; 存储接收到的数据的多个存储单元; 以及多个解码器，被配置为执行Turbo解码操作。多个解码器中的每一个使用解码矩阵的至少一部分来解码所接收的数据的至少一部分。接收机还包括耦合在多个解码器和多个存储器单元之间的数据开关。数据交换机被配置为将解码操作从基于长期演进（LTE）的操作改变为宽带码分多址（WCDMA）操作。

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