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51. 发明申请

US20110184485A1 ADAPTIVE RATE PROGRAMMING CONTROL IN IMPLANTABLE MEDICAL DEVICES USING VENTRICULAR-ARTERIAL COUPLING SURROGATES 有权
标题翻译：使用静脉血管连接术的可移植医疗器械中的自适应速率编程控制
公开(公告)号：US20110184485A1
公开(公告)日：2011-07-28
申请号：US12694098
申请日：2010-01-26
申请人： Steve Koh
发明人： Steve Koh
IPC分类号： A61N1/365
CPC分类号： A61N1/36514
摘要： Selection of an appropriate rate programming control (RPC) setting in an implantable medical device (IMD), uses analysis of VA coupling surrogate conditions. The VA coupling surrogate conditions are derived from signals such as cardiogenic impedance, blood pressure, and the pulsatile components of PPG. By analyzing a waveform of the measured surrogate condition, the IMD estimates wall stiffness, through the slope of the waveform, and peripheral arterial pressure, through the reflection time between the main wave and reflection wave of the waveform. These values are plotted against each other on a VA coupling coordinate plane. Based on the location and orientation of the resulting VA coupling plot, the IMD selects an appropriate RPC setting.
摘要翻译：在可植入医疗设备（IMD）中选择适当的速率编程控制（RPC）设置，使用VA耦合替代条件的分析。 VA耦合替代条件来自诸如心源阻抗，血压和PPG脉冲成分的信号。通过分析测量的替代条件的波形，IMD通过波形的波形和反射波之间的反射时间来估计壁面刚度，通过波形斜率和外周动脉压力。这些值在VA耦合坐标平面上相互绘图。根据所得的VA耦合图的位置和方向，IMD选择适当的RPC设置。

52. 发明申请

US20110184304A1 IMPLANTABLE MEDICAL DEVICE WITH SLEEP APNEA DETECTION CONTROL AND METHOD 有权
标题翻译：具有睡眠APNEA检测控制和方法的可植入医疗装置
公开(公告)号：US20110184304A1
公开(公告)日：2011-07-28
申请号：US13080527
申请日：2011-04-05
申请人： Steve Koh
发明人： Steve Koh
IPC分类号： A61B5/08
CPC分类号： A61B5/4818 , A61B5/0809 , A61B5/0826 , A61B5/686 , A61N1/3601 , A61N1/362 , A61N1/3962
摘要： A method for use in an implantable medical device comprises the steps of monitoring respiration with an amplifier having a gain, generating a moving apneic threshold based on recent respiration cycles, accumulating differences between amplitudes of respiration cycles and the moving apnea detection threshold and comparing the accumulated differences against an apnea detection threshold to detect the onset of an episode of apnea. The method further comprises measuring respiration levels upon detecting the onset of apnea, confirming the episode of apnea based upon the respiration levels measured upon detecting the onset of apnea; and adjusting one of the gain of the amplifier and the apnea detection threshold so that the time from the detection of onset of apnea to the time of confirmation of the episode of apnea is within a predetermined time range following the detection of the onset of apnea.
摘要翻译：一种用于可植入医疗装置的方法包括以下步骤：利用具有增益的放大器监测呼吸，基于最近的呼吸循环产生移动呼吸暂停阈值，累积呼吸循环幅度与移动呼吸暂停检测阈值之间的差异，并比较累积与呼吸暂停检测阈值的差异，以检测呼吸暂停发作的发作。该方法还包括在检测呼吸暂停发作时测量呼吸水平，基于在检测呼吸暂停发作时测量的呼吸水平确认呼吸暂停发作; 并调整放大器的增益和呼吸暂停检测阈值之一，使得从检测呼吸暂停发作到呼吸暂停发作时间的时间在检测呼吸暂停发生之后在预定时间范围内。

53. 发明授权

US07894901B1 Apparatus and method for assessing cardiac therapy 有权
标题翻译：心脏治疗评估装置及方法
公开(公告)号：US07894901B1
公开(公告)日：2011-02-22
申请号：US11466074
申请日：2006-08-21
申请人： Steve Koh
发明人： Steve Koh
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61B5/0452 , A61N1/3627 , A61N1/36507 , A61N1/36542 , A61N1/3684
摘要： A patient's response to therapy such as CRT is assessed by cross correlation of a patient's evoked response and physical activity surrogates. Based on the cross correlation, a determination may be made as to whether or how much the therapy is helping the patient's physical activity. For example, the degree of cross correlation index between IEGM parameters and activity threshold parameters may be used to assess whether the patient's heart condition improves the patient's physical activity. The therapy may then be modified as necessary in the event the patient is not sufficiently responding to the therapy.
摘要翻译：患者对治疗如CRT的反应是通过患者的诱发反应和身体活动代理的互相关来评估的。基于互相关，可以确定治疗是否或多少帮助患者的身体活动。例如，可以使用IEGM参数和活动阈值参数之间的互相关指数的程度来评估患者的心脏状况是否改善患者的身体活动。然后可以在患者对治疗没有充分反应的情况下根据需要修改治疗。

54. 发明申请

US20110028801A1 CARDIOVASCULAR VESSEL ELASTICITY MONITORING 审中-公开
标题翻译：心血管血管弹性监测
公开(公告)号：US20110028801A1
公开(公告)日：2011-02-03
申请号：US12511484
申请日：2009-07-29
申请人： Steve Koh
发明人： Steve Koh
IPC分类号： A61B5/0205 , A61B5/02
CPC分类号： A61B5/02152 , A61B2562/0247
摘要： Elasticity of a cardiovascular vessel of a patient is monitored to provide an indication of whether the patient's health is changing. In some aspects the elasticity of a cardiovascular vessel is determined irrespective of the current blood pressure level of the patient at the time the elasticity is determined. For example, vessel elasticity may be determined based on a defined set of data that maps vessel elasticity with reflectance times for different blood pressure levels. In some implementations, this set of data corresponds to a set of iso-pressure lines.
摘要翻译：监测患者的心血管血管的弹性以提供患者的健康状况是否变化的指示。在一些方面，确定心血管血管的弹性，而不考虑在确定弹性时患者的当前血压水平。例如，容器弹性可以基于将血管弹性与不同血压水平的反射时间映射的定义的数据组确定。在一些实施方案中，该组数据对应于一组等压线。

55. 发明授权

US07844333B1 Pacing therapy for transient ischemia treatment 有权
标题翻译：起搏治疗短暂性脑缺血治疗
公开(公告)号：US07844333B1
公开(公告)日：2010-11-30
申请号：US11736155
申请日：2007-04-17
申请人： Steve Koh , Euljoon Park , Eric Falkenberg
发明人： Steve Koh , Euljoon Park , Eric Falkenberg
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/365
摘要： Embodiments include methods and devices for detecting ischemia in a patient and treating the ischemia with a pacing therapy that increases cardiac efficiency, output, or both, without substantially increasing myocardial oxygen consumption. Such therapy may also be used to mitigate the adverse effects of decreased blood flow to the ischemic tissue by increasing the blood flow an oxygenation thereto.
摘要翻译：实施方案包括用于检测患者局部缺血的方法和装置，并且通过起搏治疗来治疗缺血，其提高心脏效率，输出或两者，而不显着增加心肌耗氧量。这种治疗也可用于通过增加血流对其的氧合来减轻血液流向缺血组织的不利影响。

56. 发明申请

US20100292747A1 TECHNIQUES FOR DELIVERY OF STEM CELL AND RELATED THERAPIES TO TREAT CARDIAC CONDITIONS 审中-公开
标题翻译：用于输送干细胞的技术和相关治疗以治疗心脏病症状
公开(公告)号：US20100292747A1
公开(公告)日：2010-11-18
申请号：US12841931
申请日：2010-07-22
申请人： Steve Koh
发明人： Steve Koh
IPC分类号： A61N1/00
CPC分类号： A61N1/326 , A61M5/14276 , A61M5/1723 , A61M2210/125 , A61M2230/04 , A61N1/3621 , A61N1/371
摘要： An exemplary method includes acquiring cardiac electrical activity information; detecting an R wave; and based on the detecting, calling for delivery of energy to cells located in a structure outside of the myocardium only during a period time within the QRS complex corresponding to the detected R wave. The energy delivered may be electrical stimulation energy or mechanical energy.
摘要翻译：一种示例性方法包括获取心脏电活动信息; 检测R波; 并且基于检测，仅在对应于检测到的R波的QRS复合体内的周期时间期间呼叫将能量传递到位于心肌外部的结构中的细胞。所传送的能量可能是电刺激能量或机械能。

57. 发明授权

US07787950B1 Techniques for delivery of stem cell and related therapies to treat cardiac conditions 有权
标题翻译：用于输送干细胞和相关疗法以治疗心脏病症的技术
公开(公告)号：US07787950B1
公开(公告)日：2010-08-31
申请号：US11556631
申请日：2006-11-03
申请人： Steve Koh
发明人： Steve Koh
IPC分类号： A61N1/362
CPC分类号： A61N1/326 , A61M5/14276 , A61M5/1723 , A61M2210/125 , A61M2230/04 , A61N1/3621 , A61N1/371
摘要： An exemplary method includes acquiring cardiac electrical activity information, detecting a T wave and, based on the detecting, calling for delivery of matter to the heart where the matter may include one or more of stem cells, progenitor cells, nutrients and drugs. Another exemplary method includes calling for delivery of electrical energy to cells destined for implantation in the body or cells already implanted in the body. Such delivery may be timed according to cardiac electrical activity and/or delivered at an energy level below a capture threshold of neighboring tissue. Various other exemplary technologies are also disclosed.
摘要翻译：一种示例性方法包括获取心脏电活动信息，检测T波，并且基于检测要求将物质递送到心脏，其中物质可以包括干细胞，祖细胞，营养物和药物中的一种或多种。另一个示例性方法包括要求将电能递送到注入体内的细胞或已经植入体内的细胞。这种递送可以根据心脏电活动定时和/或在低于相邻组织的捕获阈值的能量水平下递送。还公开了各种其它示例性技术。

58. 发明授权

US07493164B1 Application of blood pressure profile parameter to assess circadian state of patients 有权
标题翻译：应用血压曲线参数评估患者的昼夜节律状态
公开(公告)号：US07493164B1
公开(公告)日：2009-02-17
申请号：US11237379
申请日：2005-09-27
申请人： Steve Koh
发明人： Steve Koh
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61N1/36542
摘要： A monitoring and/or stimulation device to receive a signal from a lead sensor positioned in the heart of patient. The monitoring and/or stimulation device processes the blood pressure data received from the sensor to determine an augmentation pressure for each heart beat. The augmentation pressure may be tracked over time or compared to a template to determine the circadian state of the patient. The augmentation pressure may be tracked or analyzed over a longer time period to detect other heart conditions such as hypertension.
摘要翻译：一种监测和/或刺激装置，用于从定位在患者心脏中的导联传感器接收信号。监测和/或刺激装置处理从传感器接收的血压数据，以确定每个心跳的增加压力。增加压力可以随时间跟踪或与模板比较以确定患者的昼夜节律状态。可以在更长的时间段内跟踪或分析增加压力以检测其他心脏状况，例如高血压。

59. 发明授权

US07460909B1 Implantable device for monitoring hemodynamic profiles 有权
标题翻译：用于监测血液动力学特征的植入式装置
公开(公告)号：US07460909B1
公开(公告)日：2008-12-02
申请号：US11205694
申请日：2005-08-16
申请人： Steve Koh , Euljoon Park
发明人： Steve Koh , Euljoon Park
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/36521 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3925 , A61N1/3962
摘要： An exemplary method includes providing a filling pressure parameter, providing a perfusion parameter, determining a hemodynamic profile based at least in part on the filling pressure parameter and the perfusion parameter and adjusting a stimulation parameter of an implantable cardiac therapy device based at least in part on the hemodynamic profile. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括提供填充压力参数，提供灌注参数，至少部分地基于填充压力参数和灌注参数确定血液动力学分布，并且至少部分地基于至少部分地调节可植入心脏治疗装置的刺激参数血流动力学特征。还公开了其它示例性方法，装置，系统等。

60. 发明授权

US07363086B1 Capture verification in respiratory diaphragm stimulation 有权
标题翻译：捕获呼吸隔膜刺激的验证
公开(公告)号：US07363086B1
公开(公告)日：2008-04-22
申请号：US11086613
申请日：2005-03-21
申请人： Steve Koh , Mark W. Kroll
发明人： Steve Koh , Mark W. Kroll
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61B5/4818 , A61N1/368
摘要： Improved methods and devices perform respiratory control of a person due to conditions such as sleep apnea. According to one embodiment, a respiratory control method includes delivering stimulation signals according to one or more stimulation parameters to phrenic nerves of a person. The person's chest activity is monitored, e.g., by sensing signals in a chamber of the person's heart, to determine the person's respiratory cycle. The stimulation cycle and respiratory cycle are compared. In response, the one or more stimulation parameters are adjusted. In subsequent stimulation cycle(s), the method delivers the stimulation signals according to the adjusted stimulation parameters. This feedback mechanism may continue until respiratory control is captured.
摘要翻译：由于诸如睡眠呼吸暂停等症状，改进的方法和装置对人进行呼吸控制。根据一个实施例，呼吸控制方法包括将根据一个或多个刺激参数的刺激信号传递给人的膈神经。监测人的胸部活动，例如通过感测人的心脏的腔室中的信号来确定人的呼吸周期。比较刺激周期和呼吸周期。作为响应，调整一个或多个刺激参数。在随后的刺激周期中，该方法根据调整的刺激参数递送刺激信号。这种反馈机制可以持续到捕获呼吸控制。

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