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52. 发明专利

ES2584329T3 Utilización cosmética de aceite de Elemí para mejorar la piel áspera resultante del mal funcionamiento del ritmo circadiano 未知
公开(公告)号：ES2584329T3
公开(公告)日：2016-09-27
申请号：ES11762282
申请日：2011-03-30
申请人： SHISEIDO CO LTD
发明人： GOZU YOKO , HAZE SHINICHIRO , MORI KEIKO , UMISHIO KENICHI
IPC分类号： A61K36/185 , A61K31/025 , A61K36/00 , A61K36/05 , A61K36/14 , A61K36/15 , A61K36/324 , A61K36/53 , A61K36/73 , A61K36/75 , A61P25/00 , A61P43/00
摘要： Utilización cosmética de aceite de elemí para modular el ritmo circadiano para mejorar la piel áspera resultante del mal funcionamiento del ritmo circadiano mediante la inducción de los ritmos de expresión de un gen Bmal o la promoción de la expresión de un gen Bmal.

53. 发明专利

ES2567160T3 Modulador de la expresión para el gen reloj Period 未知
公开(公告)号：ES2567160T3
公开(公告)日：2016-04-20
申请号：ES11762283
申请日：2011-03-30
申请人： SHISEIDO CO LTD
发明人： GOZU YOKO , HAZE SHINICHIRO , MORI KEIKO , UMISHIO KENICHI
IPC分类号： A61K36/18 , A61K31/025 , A61K36/00 , A61K36/05 , A61K36/53 , A61K36/73 , A61K36/75 , A61P25/00 , A61P43/00
摘要： Uso cosmético de extracto de Zanthoxylum para modular el ritmo circadiano para mejorar la piel áspera resultante de la disfunción de los ritmos circadianos induciendo ritmos de expresión de un gen Period o promoviendo la expresión de un gen Period.

54. 发明专利

AU2009232715B2 Preparation for preventing or ameliorating wrinkles, to be taken orally, through injection, or through external application to skin, and cosmetic method 未知
公开(公告)号：AU2009232715B2
公开(公告)日：2015-07-09
申请号：AU2009232715
申请日：2009-03-31
申请人： SHISEIDO CO LTD
发明人： HIRUMA TAKUYA , MATSUNAGA YUKIKO , KUSAKARI KEN , AMANO SATOSHI , IRIYAMA SHUNSUKE , UMISHIO KENICHI
IPC分类号： A61K8/46 , A61K8/49 , A61K31/17 , A61K31/4184 , A61K36/00 , A61K36/18 , A61K36/23 , A61K36/73 , A61K36/75 , A61K36/81 , A61K36/896 , A61K45/00 , A61P17/00 , A61Q19/08
摘要： Disclosed is a preparation applied in order to ameliorate wrinkles, said preparation to be taken orally, through injection, or through external application to the skin, and which uses as an active ingredient an agent that controls heparanase.

55. 发明专利

HK1150027A1 PREPARATION FOR PREVENTING OR AMELIORATING WRINKLES, TO BE TAKEN ORALLY, THROUGH INJECTION, OR THROUGH EXTERNAL APPLICATION TO SKIN, AND COSMETIC METHOD 未知
公开(公告)号：HK1150027A1
公开(公告)日：2011-10-28
申请号：HK11104153
申请日：2011-04-26
申请人： SHISEIDO CO LTD
发明人： IRIYAMA SHUNSUKE , MATSUNAGA YUKIKO , AMANO SATOSHI , UMISHIO KENICHI , KUSAKARI KEN , HIRUMA TAKUYA
IPC分类号： A61K20060101

56. 发明专利

AU744568B2 1,2-di-substituted piperidine derivative, hair growth promoter and extern al composition for skin using the same 未知
公开(公告)号：AU744568B2
公开(公告)日：2002-02-28
申请号：AU1468899
申请日：1999-02-02
申请人： SHISEIDO CO LTD
发明人： KOBAYASHI KOJI , FUKUNISHI HIROTADA , UMISHIO KENICHI , ISHINO AKIHIRO
IPC分类号： C07D211/22 , C07D211/26 , C07D401/12 , C07D521/00 , C07D211/20 , C07D413/12 , C07D211/58 , C07D211/48 , A61K7/06
摘要： A 1,2-di-substituted piperidine derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C1-30 expressed by R and the other is -(CH2)n-NR R ; Y is -CO-, -CONR - or -COO-; Z is -O-, -OCO-, -OCONR - or -NR -; R and R individually represent a hydrogen a lower alkyl, a phenyl or a benzyl group, or together represent a heterocycle having 3-7 members; -NR -(CH2)n-NR R and -NR -(CH2)n-NR R of -(Y)1-A and -Z-B may be the following Group W: wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R is a hydrogen, a lower alkyl, a phenyl or a benzyl group; R is a hydrogen, a halogen, a lower alkyl, a lower acyl, a nitro, a cyano, a lower alkoxycarbonyl, a carbamoyl, a lower alkylcarbamoyl, a lower alkylamino, a lower acylamino, a lower alkoxy or a lower acyloxy group; each of R and R is a hydrogen, a lower alkyl, a lower acyl, a lower alkylcarbamoyl group, or a part of said ring E; l is 0 or 1; m is an integer of 2-5; and n is an integer of 0-5. The 1,2-di-substituted piperidine derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

57. 发明专利

HK1179897A1 EXPRESSION MODULATOR FOR CLOCK GENE BMAL BMAL 未知
公开(公告)号：HK1179897A1
公开(公告)日：2013-10-11
申请号：HK13107393
申请日：2013-06-25
申请人： SHISEIDO CO LTD
发明人： GOZU YOKO , HAZE SHINICHIRO , MORI KEIKO , UMISHIO KENICHI
IPC分类号： A61K20060101 , A61P20060101

58. 发明专利

HK1177699A1 ARTIFICIAL SKIN AND MANUFACTURING METHOD THEREOF 未知
公开(公告)号：HK1177699A1
公开(公告)日：2013-08-30
申请号：HK13104906
申请日：2013-04-23
申请人： SHISEIDO CO LTD
发明人： IRIYAMA SHUNSUKE , UMISHIO KENICHI , TSUNENAGA MAKOTO , INOMATA SHINJI , ADACHI EIJIRO
IPC分类号： A61L20060101

59. 发明专利

AU2011222243A1 Artificial skin 未知
公开(公告)号：AU2011222243A1
公开(公告)日：2012-09-20
申请号：AU2011222243
申请日：2011-01-19
申请人： SHISEIDO CO LTD
发明人： IRIYAMA SHUNSUKE , UMISHIO KENICHI , TSUNENAGA MAKOTO , INOMATA SHINJI , ADACHI EIJIRO
IPC分类号： A61L27/00
摘要： A process for producing an artificial skin, characterized by adding a matrix metalloprotease inhibitor and a heparanase inhibitor to a culture medium for artificial skin formation purposes which contains keratinocytes derived from a human epidermis and fibroblasts derived from a human dermis and culturing the cells contained in the culture medium, thereby forming the artificial skin.

60. 发明专利

DE69901067D1 未知
公开(公告)号：DE69901067D1
公开(公告)日：2002-05-02
申请号：DE69901067
申请日：1999-02-02
申请人： SHISEIDO CO LTD
发明人： KOBAYASHI KOJI , FUKUNISHI HIROTADA , UMISHIO KENICHI , ISHINO AKIHIRO
IPC分类号： C07D211/22 , C07D211/26 , C07D401/12 , C07D521/00 , A61K7/06
摘要： A 1,2-di-substituted piperidine derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C1-30 expressed by R and the other is -(CH2)n-NR R ; Y is -CO-, -CONR - or -COO-; Z is -O-, -OCO-, -OCONR - or -NR -; R and R individually represent a hydrogen a lower alkyl, a phenyl or a benzyl group, or together represent a heterocycle having 3-7 members; -NR -(CH2)n-NR R and -NR -(CH2)n-NR R of -(Y)1-A and -Z-B may be the following Group W: wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R is a hydrogen, a lower alkyl, a phenyl or a benzyl group; R is a hydrogen, a halogen, a lower alkyl, a lower acyl, a nitro, a cyano, a lower alkoxycarbonyl, a carbamoyl, a lower alkylcarbamoyl, a lower alkylamino, a lower acylamino, a lower alkoxy or a lower acyloxy group; each of R and R is a hydrogen, a lower alkyl, a lower acyl, a lower alkylcarbamoyl group, or a part of said ring E; l is 0 or 1; m is an integer of 2-5; and n is an integer of 0-5. The 1,2-di-substituted piperidine derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

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