专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明授权

US08187834B2 Non-cytotoxic protein conjugates 有权
标题翻译：非细胞毒性蛋白偶联物
公开(公告)号：US08187834B2
公开(公告)日：2012-05-29
申请号：US11791979
申请日：2005-12-01
申请人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
IPC分类号： A61K39/08 , C07K14/00 , C07H21/04
CPC分类号： C07K14/575 , A61K31/711 , A61K38/4893 , A61K47/64 , A61K47/6415 , C07K14/33 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N9/6489 , C12N15/62 , C12Y304/24069
摘要： The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described.
摘要翻译：本发明涉及用于抑制或减少伤害性感觉传入细胞中的胞外融合的非细胞毒性蛋白质缀合物。所述蛋白质缀合物包含：（i）靶向部分（TM），其中所述TM是存在于伤害性感觉传入细胞上的受体的激动剂，并且其中所述受体经受内吞作用以掺入伤害性感觉传入细胞内的内体 ; （ii）非细胞毒性蛋白酶或其片段，其中所述蛋白酶或蛋白酶片段能够切割伤害性感觉传入细胞的胞外融合装置的蛋白质; 易位结构域（Translocation Domain），其中易位域将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入细胞的胞质溶胶中。还描述了编码蛋白质缀合物的核酸序列，其制备方法及其用途。

52. 发明申请

US20110070215A1 METHODS OF TREATING CANCER USING NEUROTROPHIN RETARGETED ENDOPEPTIDASES 审中-公开
标题翻译：使用NEUROTROPHIN RETARGETED ENDOPEPTIASES治疗癌症的方法
公开(公告)号：US20110070215A1
公开(公告)日：2011-03-24
申请号：US12857367
申请日：2010-08-16
申请人： Birgitte P.S. Jacky , Patton E. Garay , Yanira Molina , Dean G. Stathakis , Joseph Francis , Kei Roger Aoki , Ester Fernandez-Salas
发明人： Birgitte P.S. Jacky , Patton E. Garay , Yanira Molina , Dean G. Stathakis , Joseph Francis , Kei Roger Aoki , Ester Fernandez-Salas
IPC分类号： A61K38/43 , A61P35/00
CPC分类号： A61K38/164 , A61K38/4893
摘要： The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
摘要翻译：本说明书公开了TVEMP，包含这样的TVEMP的组合物和使用这种TVEMP组合物治疗哺乳动物癌症的方法。

53. 发明申请

US20110070212A1 Methods of Treating Cancer Using Glucagon-Like Hormone Retargeted Endopeptidases 审中-公开
标题翻译：使用胰高血糖素激素再靶向内肽酶治疗癌症的方法
公开(公告)号：US20110070212A1
公开(公告)日：2011-03-24
申请号：US12856936
申请日：2010-08-16
申请人： Birgitte P.S. Jacky , Patton E. Garay , Yanira Molina , Dean G. Stathakis , Joseph Francis , Kei Roger Aoki , Ester Fernandez-Salas
发明人： Birgitte P.S. Jacky , Patton E. Garay , Yanira Molina , Dean G. Stathakis , Joseph Francis , Kei Roger Aoki , Ester Fernandez-Salas
IPC分类号： A61K38/43 , A61P35/00
CPC分类号： A61K38/48 , A61K38/00 , C07K14/33 , C07K2319/033 , C07K2319/55
摘要： The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
摘要翻译：本说明书公开了TVEMP，包含这样的TVEMP的组合物和使用这种TVEMP组合物治疗哺乳动物癌症的方法。

54. 发明授权

US09139635B2 Non-cytotoxic protein conjugates 有权
标题翻译：非细胞毒性蛋白偶联物
公开(公告)号：US09139635B2
公开(公告)日：2015-09-22
申请号：US13072865
申请日：2011-03-28
申请人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
IPC分类号： A61K38/48 , C07K14/575 , A61K31/711 , A61K47/48 , C07K14/33 , C12N9/64 , C12N15/62
CPC分类号： C07K14/575 , A61K31/711 , A61K38/4893 , A61K47/64 , A61K47/6415 , C07K14/33 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N9/6489 , C12N15/62 , C12Y304/24069
摘要： The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described.
摘要翻译：本发明涉及用于抑制或减少伤害性感觉传入细胞中的胞外融合的非细胞毒性蛋白质缀合物。所述蛋白质缀合物包含：（i）靶向部分（TM），其中所述TM是存在于伤害性感觉传入细胞上的受体的激动剂，并且其中所述受体经受内吞作用以掺入伤害性感觉传入细胞内的内体 ; （ii）非细胞毒性蛋白酶或其片段，其中所述蛋白酶或蛋白酶片段能够切割伤害性感觉传入细胞的胞外融合装置的蛋白质; 易位结构域（Translocation Domain），其中易位域将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入细胞的胞质溶胶中。还描述了编码蛋白质缀合物的核酸序列，其制备方法及其用途。

55. 发明申请

US20140056870A1 FUSION PROTEINS 审中-公开
标题翻译：融合蛋白
公开(公告)号：US20140056870A1
公开(公告)日：2014-02-27
申请号：US13595927
申请日：2012-08-27
申请人： Peter James , Keith Foster , John Chaddock , Kei Roger Aoki , Lance Steward , Joseph Francis
发明人： Peter James , Keith Foster , John Chaddock , Kei Roger Aoki , Lance Steward , Joseph Francis
IPC分类号： C12N9/48 , A61P29/00 , A61K38/48 , C12N15/57 , C12N15/63
摘要： A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, which cleaves a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a galanin Targeting Moiety that binds a Binding Site on the nociceptive sensory afferent, which can undergo endocytosis to be incorporated into an endosome; a protease cleavage site where the fusion protein is cleavable by a protease located between the non-cytotoxic protease and the galanin Targeting Moiety; a translocation domain that translocates the protease from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent; a first spacer from 4 to 25 amino acids between the non-cytotoxic protease and protease cleavage site; and a second spacer comprising from 4 to 35 residues between the galanin Targeting Moiety and translocation domain. Nucleic acid sequences encoding the polypeptide fusion proteins, methods of preparing same and uses thereof are also described.
摘要翻译：一种单链多肽融合蛋白，其包含：非细胞毒性蛋白酶，其切割伤害性感觉传入的胞外融合装置的蛋白质; 将甘露聚糖靶向部位结合到伤害性感觉传入物上的结合位点，其可能经历内吞作用以掺入内体; 蛋白酶切割位点，其中融合蛋白可被位于非细胞毒性蛋白酶和甘丙肽靶向部位之间的蛋白酶切割; 一个易位结构域，其从内体内转移蛋白酶，穿过内体膜并进入伤害性感觉传入体的细胞溶质; 非细胞毒性蛋白酶和蛋白酶切割位点之间的4至25个氨基酸的第一个间隔区; 以及在甘露糖靶向部位和易位结构域之间包含4至35个残基的第二间隔物。还描述了编码多肽融合蛋白的核酸序列，其制备方法及其用途。

56. 发明授权

US08603779B2 Non-cytotoxic protein conjugates 有权
标题翻译：非细胞毒性蛋白偶联物
公开(公告)号：US08603779B2
公开(公告)日：2013-12-10
申请号：US13343892
申请日：2012-01-05
申请人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
IPC分类号： C07K14/00 , A61K38/16 , C12P21/04 , C12P21/06
CPC分类号： A61K38/4893 , A61K38/4886 , C07K14/575 , C07K2319/00 , C07K2319/01 , C12N9/52 , C12Y304/21072
摘要： The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a galanin Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are is also described.
摘要翻译：本发明涉及用于抑制或减少伤害性感觉传入细胞中的胞外融合的非细胞毒性蛋白质缀合物。所述蛋白质缀合物包括：（i）甘丙肽靶向部分（TM），其中所述TM是存在于伤害性感觉传入细胞上的受体的激动剂，并且其中所述受体经受内吞作用以掺入伤害性感觉传入物内的内体细胞; （ii）非细胞毒性蛋白酶或其片段，其中所述蛋白酶或蛋白酶片段能够切割伤害性感觉传入细胞的胞外融合装置的蛋白质; 易位结构域（Translocation Domain），其中易位域将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入细胞的胞质溶胶中。还描述了编码蛋白质缀合物的核酸序列，其制备方法及其用途。

57. 发明授权

US08399400B2 Fusion proteins 有权
公开(公告)号：US08399400B2
公开(公告)日：2013-03-19
申请号：US12862948
申请日：2010-08-25
申请人： Keith Foster , John Chaddock , Philip Marks , Patrick Stancombe , Kei Roger Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Philip Marks , Patrick Stancombe , Kei Roger Aoki , Joseph Francis , Lance Steward
IPC分类号： C07K14/00 , C07H21/02
CPC分类号： C12N9/96 , A61K38/00 , A61K47/64 , C07K2319/01 , C07K2319/33 , C07K2319/50 , C12N9/50
摘要： A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a dynorphin Targeting Moiety that is capable of binding to a Binding Site on the nociceptive sensory afferent, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease or fragment thereof and the dynorphin Targeting Moiety; and a translocation domain that is capable of translocating the protease or protease fragment from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent. Nucleic acid sequences encoding the polypeptide fusion proteins, methods of preparing same and uses thereof are also described.

58. 发明申请

US20110064713A1 Methods of Treating Cancer Using Opioid Retargeted Endopepidases 审中-公开
标题翻译：使用阿片样物质靶向内膜异位症治疗癌症的方法
公开(公告)号：US20110064713A1
公开(公告)日：2011-03-17
申请号：US12855962
申请日：2010-08-13
申请人： Birgitte P.S. Jacky , Patton E. Garay , Yanira Molina , Dean G. Stathakis , Joseph Francis , Kei Roger Aoki , Ester Fernandez-Salas
发明人： Birgitte P.S. Jacky , Patton E. Garay , Yanira Molina , Dean G. Stathakis , Joseph Francis , Kei Roger Aoki , Ester Fernandez-Salas
IPC分类号： A61K38/43 , A61P35/00 , A61P35/02
CPC分类号： A61K38/43 , A61K38/4893 , C07K14/33 , C07K2319/00
摘要： The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
摘要翻译：本说明书公开了TVEMP，包含这样的TVEMP的组合物和使用这种TVEMP组合物治疗哺乳动物癌症的方法。

59. 发明授权

US07659092B2 Fusion proteins 有权
标题翻译：融合蛋白
公开(公告)号：US07659092B2
公开(公告)日：2010-02-09
申请号：US11834311
申请日：2007-08-06
申请人： Keith Foster , John Chaddock , Philip Marks , Patrick Stancombe , Kei Roger Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Philip Marks , Patrick Stancombe , Kei Roger Aoki , Joseph Francis , Lance Steward
IPC分类号： C12P21/06 , C07K14/00
CPC分类号： C12N15/62 , C07K14/575 , C07K2319/06 , G01N33/6848
摘要： A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a Targeting Moiety that is capable of binding to a Binding Site on the nociceptive sensory afferent, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease or fragment thereof and the Targeting Moiety; and a translocation domain that is capable of translocating the protease or protease fragment from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent. Nucleic acid sequences encoding the polypeptide fusion proteins, methods of preparing same and uses thereof are also described.
摘要翻译：一种单链多肽融合蛋白，其包含：非细胞毒性蛋白酶或其片段，所述蛋白酶或蛋白酶片段能够切割伤害性感觉传入的胞外融合装置的蛋白质; 能够结合伤害性感觉传入的结合位点的靶向部位，该结合位点能够经历内吞作用以掺入伤害性感觉传入内的内体; 蛋白酶切割位点，其中融合蛋白可被蛋白酶切割，其中蛋白酶切割位点位于非细胞毒性蛋白酶或其片段与靶向部位之间; 以及易位区域，其能够将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入物的胞质溶胶中。还描述了编码多肽融合蛋白的核酸序列，其制备方法及其用途。

60. 发明申请

US20090035822A1 Fusion Proteins 有权
标题翻译：融合蛋白
公开(公告)号：US20090035822A1
公开(公告)日：2009-02-05
申请号：US11834311
申请日：2007-08-06
申请人： Keith Foster , John Chaddock , Philip Marks , Patrick Stancombe , Kei Roger Aoki , Joseph Francis , Lance Steward
发明人： Keith Foster , John Chaddock , Philip Marks , Patrick Stancombe , Kei Roger Aoki , Joseph Francis , Lance Steward
IPC分类号： C12P21/04 , C07K14/00 , C12N15/11 , C12N15/00
CPC分类号： C12N15/62 , C07K14/575 , C07K2319/06 , G01N33/6848
摘要： A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a Targeting Moiety that is capable of binding to a Binding Site on the nociceptive sensory afferent, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease or fragment thereof and the Targeting Moiety; and a translocation domain that is capable of translocating the protease or protease fragment from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent. Nucleic acid sequences encoding the polypeptide fusion proteins, methods of preparing same and uses thereof are also described.
摘要翻译：一种单链多肽融合蛋白，其包含：非细胞毒性蛋白酶或其片段，所述蛋白酶或蛋白酶片段能够切割伤害性感觉传入的胞外融合装置的蛋白质; 能够结合伤害性感觉传入的结合位点的靶向部位，该结合位点能够经历内吞作用以掺入伤害性感觉传入内的内体; 蛋白酶切割位点，其中融合蛋白可被蛋白酶切割，其中蛋白酶切割位点位于非细胞毒性蛋白酶或其片段与靶向部位之间; 以及易位区域，其能够将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到伤害性感觉传入物的胞质溶胶中。还描述了编码多肽融合蛋白的核酸序列，其制备方法及其用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式