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51. 发明专利

PH22959A ANTIFUNGAL 2-AZOLYLMETHYL-3-DIFLUOROBENZYLOXY-2,3-DIHYDROFLUORO-BENZO (B) THIOPHENES 未知
公开(公告)号：PH22959A
公开(公告)日：1989-02-03
申请号：PH33220
申请日：1985-12-19
申请人： SCHERING CORP
发明人： RANE DINANATH F , DESAI JAGDISH A , PIKE RUSSELL E
IPC分类号： A61K31/41 , A61K31/415 , A61P31/04 , C07D333/00 , C07D409/06 , C07D521/00 , A61K31/38 , C07D333/64
摘要： 2-Azolylmethyl-3-difluorobenzyloxy-2,3-dihydro-5- and 6-fluorobenzo [b]thiophen antifungal compounds, especially 2-(1H-imidazolylmethyl-3-(2',6'-difluorobenzyloxy)-2,3-dihydro-5-fluorobenzo[b]thiophene, pharmaceutical compositions containing them and their use in treating fungal infections in animals including humans are disclosed.

52. 发明专利

HU193633B PROCESS FOR PRODUCTION OF NEW BENZO /B/ TIOFENES AND TIOCROMATES 未知
公开(公告)号：HU193633B
公开(公告)日：1987-11-30
申请号：HU107082
申请日：1982-04-07
申请人： SCHERING CORP
发明人： RANE DINANATH F , WRIGHT JOHN J , PIKE RUSSEL E
IPC分类号： A61K31/415 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/14

53. 发明专利

CA1213591A BENZO[B]THIOPHENES, BENZO[B]FURANS, THIOCHROMANS AND CHROMANS HAVING ANTIMICROBIAL ACTIVITY 未知
公开(公告)号：CA1213591A
公开(公告)日：1986-11-04
申请号：CA400570
申请日：1982-04-06
申请人： SCHERING CORP
发明人： RANE DINANATH F , WRIGHT JOHN J , PIKE RUSSELL E
IPC分类号： C07D405/00
摘要： Compounds of the formula I wherein n is 0 or an integer from 1 to 4; p is 0 or 1; q is 0, 1 or 2, R and R1 are independently hydrogen or halogen atoms, or lower alkyl, halolower alkyl, nitro or NR2R3 groups, wherein R2 and R3 are independently hydrogen atoms or lower alkyl groups; or R and R1 together in adjacent positions complete a fused saturated or unsaturated carbocyclic ring that may contain 5 to 7 carbon atoms; X is an oxygen or sulfur atom or a sulphinyl or sulphonyl group; Y is an imidazolyl or 1,2,4-triazolyl group, either of which may be substituted by a lower alkyl or aryl group, wherein said aryl group is a phenyl, halophenyl or lower alkyl phenyl group; Z is an alkyl, alkenyl, alkynyl, cycloalkyl or heterocyclic aromatic group, which may have at least one substituent selected from halogen atoms and lower alkyl, lower alkoxy, lower alkylidenedioxy, phenyl and N-(N'-lower alkanoylpiperazinyl) groups, provided that, when n is 0, Z is not 1-alkynyl; and, when n is 1 to 4, Z can also be an alkoxy, alkylthio, aryl, aryloxy or arylthio group, or an aryl, aryloxy or arylthio group having substituents selected from halogen atoms and lower alkyl, lower alkoxy, lower alkylidenedioxy and N-(N'-lower alkanoylpiperazinyl) groups; where the term "lower" indicates groups having 1 to 6 carbon atoms; and the broken line indicates a single or double bond, with the proviso that it is a double bond only when p is 0 and X is a sulfur atom; and the acid addition salts thereof; have antimicrobial, in particular antifungal, antibacterial and antiprotozoal activity. Compositions, especially pharmaceutical compositions, containing them and processes for their preparation are also disclosed.

54. 发明专利

DE602004018332D1 未知
公开(公告)号：DE602004018332D1
公开(公告)日：2009-01-22
申请号：DE602004018332
申请日：2004-08-04
申请人： SCHERING CORP
发明人： ZHU HUGH Y , COOPER ALAN B , DESAI JAGDISH A , WANG JAMES J-S , RANE DINANATH F , DOLL RONALD J , NJOROGE F GEORGE , GIRIJAVALLABHAN VIYYOOR M
IPC分类号： C07D401/06 , A61K31/415 , A61P35/00 , C07D401/14
摘要： Disclosed are novel tricyclic compounds of the formula: and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.

55. 发明专利

AU2001288451C1 Tricyclic antitumor compounds being farnesyl protein transferase inhibitors 未知
公开(公告)号：AU2001288451C1
公开(公告)日：2008-03-06
申请号：AU2001288451
申请日：2001-08-28
申请人： PHARMACOPEIA INC , SCHERING CORP
发明人： DESAI JAGDISH A , SANTHANAM BAMA , NJOROGE F GEORGE , RANE DINANATH F , HUANG CHIA-YU , ALVAREZ CARMEN S , LI GE , PINTO PATRICK A , WANG JAMES , BALDWIN JOHN J , GUZI TIMOTHY , BISHOP ROBERT W , COOPER ALAN B , ZHU HUGH Y , VIBULBHAN BANCHA , GIRIJAVALLABHAN VIYYOOR MOOPIL , DOLL RONALD J , KEERTIKAR KARTIK M , MINOR KEITH P , JAMES RAY A
IPC分类号： C07D233/61 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/00 , A61P35/00 , A61P43/00 , C07D221/16 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D521/00
摘要： The present invention discloses novel tricyclic compounds represented by the formula (1.0): a prodrug thereof, or a pharmaceutically acceptable salt or solvate of the compound or of said prodrug useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising such compounds their preparation as well as methods of using them to treat proliferative diseases such as cancer.

56. 发明专利

AU2001288451B2 Tricyclic antitumor compounds being farnesyl protein transferase inhibitors 未知
公开(公告)号：AU2001288451B2
公开(公告)日：2007-05-24
申请号：AU2001288451
申请日：2001-08-28
申请人： SCHERING CORP , PHARMACOPEIA DRUG DISCOVERY
发明人： DESAI JAGDISH A , SANTHANAM BAMA , NJOROGE F GEORGE , RANE DINANATH F , HUANG CHIA-YU , ALVAREZ CARMEN S , LI GE , PINTO PATRICK A , WANG JAMES , BALDWIN JOHN J , GUZI TIMOTHY , BISHOP ROBERT W , COOPER ALAN B , ZHU HUGH Y , VIBULBHAN BANCHA , GIRIJAVALLABHAN VIYYOOR MOOPIL , DOLL RONALD J , KEERTIKAR KARTIK M , MINOR KEITH P , JAMES RAY A
IPC分类号： C07D233/61 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/00 , A61P35/00 , A61P43/00 , C07D221/16 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D521/00
摘要： The present invention discloses novel tricyclic compounds represented by the formula (1.0): a prodrug thereof, or a pharmaceutically acceptable salt or solvate of the compound or of said prodrug useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising such compounds their preparation as well as methods of using them to treat proliferative diseases such as cancer.

57. 发明专利

AT359281T 未知
公开(公告)号：AT359281T
公开(公告)日：2007-05-15
申请号：AT01968188
申请日：2001-08-28
申请人： SCHERING CORP , PHARMACOPEIA DRUG DISCOVERY
发明人： NJOROGE F GEORGE , VIBULBHAN BANCHA , COOPER ALAN B , GUZI TIMOTHY , RANE DINANATH F , MINOR KEITH P , DOLL RONALD J , GIRIJAVALLABHAN VIYYOOR MOOPIL , SANTHANAM BAMA , PINTO PATRICK A , ZHU HUGH Y , KEERTIKAR KARTIK M , ALVAREZ CARMEN S , BALDWIN JOHN J , LI GE , HUANG CHIA-YU , JAMES RAY A , BISHOP ROBERT W , WANG JAMES , DESAI JAGDISH A
IPC分类号： C07D233/61 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/00 , A61P35/00 , A61P43/00 , C07D221/16 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D521/00 , A61K31/435
摘要： The present invention discloses novel tricyclic compounds represented by the formula (1.0): a prodrug thereof, or a pharmaceutically acceptable salt or solvate of the compound or of said prodrug useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising such compounds their preparation as well as methods of using them to treat proliferative diseases such as cancer.

58. 发明专利

BRPI0413384A 未知
公开(公告)号：BRPI0413384A
公开(公告)日：2006-10-17
申请号：BRPI0413384
申请日：2004-08-04
申请人： SCHERING CORP
发明人： ZHU HUGH Y , COOPER ALAN B , DESAI JAGDISH A , WANG JAMES J-S , RANE DINANATH F , DOLL RONALD J , NJOROGE F GEORGE , GIRIJAVALLABHAN VIYYOOR MOOPIL
IPC分类号： A61P35/00 , C07D401/06 , C07D401/14 , A61K31/415
摘要： Disclosed are novel tricyclic compounds of the formula: and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.

59. 发明专利

ECSP066349A INHIBIDORES DE TRANSFERASA DE PROTEÍNA DE FARNESILO NOVEDOSOS COMO AGENTES ANTITUMORALES 未知
公开(公告)号：ECSP066349A
公开(公告)日：2006-08-30
申请号：ECSP066349
申请日：2006-02-06
申请人： SCHERING CORP
发明人： GIRIJAVALLABHN VIYYOOR M , NJOROGE F GEORGE , COOPER ALAN B , RANE DINANATH F , DOLL RONALD J , WANG JAMES J-S , DESAI JAGDISH A , ZHU HUGH Y
IPC分类号： A61K31/415 , A61P35/00 , C07D401/06 , C07D401/14
摘要： Se dan a conocer compuestos tricíclicos novedosos de la fórmulay sales y solvatos farmacéuticamente aceptables de los mismos. Los compuestos son útiles para la inhibición de transferasa de proteína de farnesilo. También se dan a conocer composiciones farmacéuticas que comprenden los compuestos de la fórmula (I). También se dan a conocer usos de los compuestos de la fórmula I para la fabricación de un medicamento para el tratamiento de cáncer.

60. 发明专利

NO20061077L 未知
公开(公告)号：NO20061077L
公开(公告)日：2006-05-05
申请号：NO20061077
申请日：2006-03-06
申请人： SCHERING CORP
发明人： COOPER ALAN BRUCE , GIRIJAVALLABHAN VIYYOOR MOOPIL , WANG JAMES J S , NJOROGE F GEORGE , DOLL RONALD J , ZHU HUGH Y , DESAI JAGDISH A , RANE DINANATH F
IPC分类号： C07D401/06 , A61K31/415 , A61P35/00 , C07D401/14

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