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51. 发明专利

AU2008256348B2 Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans 未知
公开(公告)号：AU2008256348B2
公开(公告)日：2013-08-29
申请号：AU2008256348
申请日：2008-06-02
申请人： CENTRE NAT RECH SCIENT , COMMISSARIAT ENERGIE ATOMIQUE
发明人： LOPEZ ROMAN , SAIDANI NADIA , ROUSSEAU BERNARD , BOTTE CYRILLE , MARECHAL ERIC , MERCIER CORINNE , HARDRE HELENE , BONNEAU ANNE-LAURE , DELIGNY MICHAEL , VIAL HENRI
IPC分类号： C07D211/16 , A61K31/4166 , A61K31/4188 , A61K31/4412 , A61P33/02 , A61P33/06 , C07D211/58 , C07D235/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D409/14 , C07D413/12 , C07D417/14 , C07D471/04 , C07D487/06 , C07D495/04
摘要： The Invention relates to compounds having an antiparasitic activity, and to their use as a drug, in particular as a drug for the prevention and/or treatment of parasitic diseases caused by apicomplexans. The invention also relates to pharmaceutical compositions containing those compounds.

52. 发明专利

CA2491989C COMPOSES A ACTIVITE ANTI-PARASITAIRE ET MEDICAMENTS LES RENFERMANT 未知
公开(公告)号：CA2491989C
公开(公告)日：2012-03-20
申请号：CA2491989
申请日：2003-07-18
申请人： CENTRE NAT RECH SCIENT
发明人： VIAL HENRI , CALAS MICHELE , ESCALE ROGER , VIDAL VALERIE , BRESSOLLE FRANCOISE , ANCELIN MARIE-LAURE
IPC分类号： C07C257/14 , A61K31/155 , A61K31/4245 , A61K31/506 , A61P33/00 , A61P33/06 , C07D271/06 , C07D285/08 , C07D291/04 , C07D403/12 , C07F9/6506
摘要： L'invention vise des composés présentant une activité anti-parasitaire, notamment antipaludique, caractérisés en ce qu'ils répondent à la formule générale : (I) Application notamment comme composés à activité anti-parasitaire.

53. 发明专利

AU2009225272A1 Compounds with antiparasitic activity and medicaments containing them 未知
公开(公告)号：AU2009225272A1
公开(公告)日：2009-10-29
申请号：AU2009225272
申请日：2009-10-09
申请人： CENTRE NAT RECH SCIENT
发明人： BRESSOLLE FRANCOISE , CALAS MICHELE , ANCELIN MARIE-LAURE , VIDAL VALERIE , ESCALE ROGER , VIAL HENRI
IPC分类号： A61K31/4245 , A61K31/506 , A61P33/00 , A61P33/06
摘要： Diamidine derivatives of formula (I) and their salts are new. Amidine derivatives of formula (I) and their salts are new. [Image] X : a group of formula (ii) or R 4; Z : -(CH 2) m-; m : 8 - 21; n : 0 or 1; Y : R 3 or a group of formula (iii); R 1 and R' 1H, alkyl, aryl, OH, O-alkyl, O-aryl, OCO-alkyl, OCO-aryl, O-CO-O-(or S or NH)-alkyl, O-CO-O-(or S or NH)-aryl, PO-(O-alkyl or O-aryl) 2, CO-O-CH 2-aryl, or cycloalkyl; R 2 and R' 2H, alkyl, CO-O-CH 2-aryl, CO-O-alkyl, or cycloalkyl; R 3 and R' 3H, alkyl, aryl, CO-O-alkyl, CO-O-aryl, COO-CH(R)-O-CO-alkyl, PO(O-alkyl, or O-aryl, or ONa) 2, or CO-O-CH(R)-aryl; R : H or alkyl; NR 1R 2, NR' 1R' 2, NR 2R 3, NR' 2R' 3a heterocycle, in which R 2 and R 3 and/or R' 2 and R' 3 may be doubly bonded to the nitrogen atom; R 4 and R' 4H or alkyl; R 1R 4, R' 1R' 4-(CH 2) p-; R 4R 2, R' 4R' 2-(CH 2) p; p : 3 - 5; and provided that: (1) when X is a group of formula (ii), then Y is R 3; and (2) when X is R 4, then Y is a group of formula (iii). [Image] Independent claims are also included for the preparation of compounds of formulae (V), (X), (VI) and (VIII). [Image] R anot defined. ACTIVITY : Protozoacide. 1,12-bis(imidazolin-2-yl) dodecane (Ib) was given orally and intraperitoneally to mice infected with Plasmodium vinckei. The dose that cleared 50 % of the infection (ED50) was 3.4 mg/kg i.p and 62 mg/kg p.o. MECHANISM OF ACTION : Not given in source material.

54. 发明专利

AU783267C Quaternary bis-ammonium salt precursors and their uses as prodrugs having an antiparasitic activity 未知
公开(公告)号：AU783267C
公开(公告)日：2006-08-17
申请号：AU7006900
申请日：2000-07-21
申请人： CENTRE NAT RECH SCIENT
发明人： VIAL HENRI , CALAS MICHELE , ANCELIN MARIE-LAURE , BOURGUIGNON JEAN-JACQUES , VIDAL VALERIE , RUBI ERIC
IPC分类号： C07C211/09 , C07D295/08 , A61K31/132 , A61K31/16 , A61K31/39 , A61K31/4025 , A61K31/444 , A61K31/4453 , A61K31/5377 , A61P33/00 , A61P33/02 , A61P33/06 , A61P43/00 , C07C209/74 , C07C319/24 , C07C323/41 , C07C327/30 , C07C327/34 , C07D207/09 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/587 , C07D295/12 , C07D295/14 , C07D295/155 , C07D327/06
摘要： The invention concerns drug precursors with antimalarial effect, characterised in that it consists in quaternary bis-ammonium salts of general formula (I) wherein A and A', identical or different, are respectively either a group A1 and A'1 of formula (1) wherein n=2 to 4; R'1 is hydrogen, C1-C5 alkyl, optionally substituted by an aryl, a hydroxy, an alkoxy, wherein the alkyl comprises 1 to 5 C, or aryloxy and W is halogen or a nucleofuge group; or a group A2 which represents formyl-CHO, or acetyl-COCH3. B and B', identical or different, represent respectively either the group B1 and B'1, if A and A' respectively represent A1, A'1, B1, B'1 representing a group R1 which has the same definition as R'1 above, but cannot be a hydrogen atom; or respectively the groups B2 and B'2, if A and A' represent A2, B2 or B'2 being the group R1 as defined above, or a group of formula (2) wherein -Ra is RS- or RCO-, wherein R is a C1-C6 alkyl, substituted if required, a phenyl or benzyl, wherein the phenyl is substituted if required, the latter being optionally substituted; R2 is hydrogen, C1-C5 alkyl, or a -CH2-COO- (C1-C5)alkyl group; and R3 is hydrogen, C1-C5 alkyl or alkenyl, substituted if required, a phosphate, an alkoxy wherein the alkyl is a C1-C3 alkyl, or aryloxy; or an alkyl (or arylcarbonyloxy; or R2 and R3 form together a cycle with 5 or 6 C; R and R3 can be bound to form a cycle. ± represents: either a single bond when A and A' represent A1 and A'1: or when A and A' represent A2, and B2 and B'2 Represent (3) either, when A and A' are -CHO or -COCH3 and B2 and B'2 are R1, a group of formula (4) or a group of formula (5) wherein (a) represents a bond towards Z and (b) a bond towards the nitrogen atom. Z is a C9-C21 alkyl, if required with insertion of one or several bonds, and/or one or several heteroatoms O and/or S and/or several aromatic cycles, and the pharmaceutically acceptable salts of said compounds. Said precursors and cyclized thiazolium derivatives are useful as antiparasitic medicines in particular antimalarial and antibabesiosis.

55. 发明专利

ZA200500250B Compounds with anti-parasitic activity and medicines containing same 未知
公开(公告)号：ZA200500250B
公开(公告)日：2006-05-31
申请号：ZA200500250
申请日：2005-01-11
申请人： CENTRE NAT RECH SCIENT
发明人： VIAL HENRI , ESCALE ROGER , BRESSOLLE FRANCOISE , CALAS MICHELE , VIDAL VALERIE , ANCELIN MARIE-LAURE
IPC分类号： A61K20060101 , A61K31/4245 , A61K31/506 , A61P20060101 , A61P33/00 , A61P33/06
摘要： Diamidine derivatives of formula (I) and their salts are new. Amidine derivatives of formula (I) and their salts are new. [Image] X : a group of formula (ii) or R 4; Z : -(CH 2) m-; m : 8 - 21; n : 0 or 1; Y : R 3 or a group of formula (iii); R 1 and R' 1H, alkyl, aryl, OH, O-alkyl, O-aryl, OCO-alkyl, OCO-aryl, O-CO-O-(or S or NH)-alkyl, O-CO-O-(or S or NH)-aryl, PO-(O-alkyl or O-aryl) 2, CO-O-CH 2-aryl, or cycloalkyl; R 2 and R' 2H, alkyl, CO-O-CH 2-aryl, CO-O-alkyl, or cycloalkyl; R 3 and R' 3H, alkyl, aryl, CO-O-alkyl, CO-O-aryl, COO-CH(R)-O-CO-alkyl, PO(O-alkyl, or O-aryl, or ONa) 2, or CO-O-CH(R)-aryl; R : H or alkyl; NR 1R 2, NR' 1R' 2, NR 2R 3, NR' 2R' 3a heterocycle, in which R 2 and R 3 and/or R' 2 and R' 3 may be doubly bonded to the nitrogen atom; R 4 and R' 4H or alkyl; R 1R 4, R' 1R' 4-(CH 2) p-; R 4R 2, R' 4R' 2-(CH 2) p; p : 3 - 5; and provided that: (1) when X is a group of formula (ii), then Y is R 3; and (2) when X is R 4, then Y is a group of formula (iii). [Image] Independent claims are also included for the preparation of compounds of formulae (V), (X), (VI) and (VIII). [Image] R anot defined. ACTIVITY : Protozoacide. 1,12-bis(imidazolin-2-yl) dodecane (Ib) was given orally and intraperitoneally to mice infected with Plasmodium vinckei. The dose that cleared 50 % of the infection (ED50) was 3.4 mg/kg i.p and 62 mg/kg p.o. MECHANISM OF ACTION : Not given in source material.

56. 发明专利

AU783267B2 Quaternary bis-ammonium salt precursors and their uses as prodrugs having an antiparasitic activity 未知
公开(公告)号：AU783267B2
公开(公告)日：2005-10-06
申请号：AU7006900
申请日：2000-07-21
申请人： CENTRE NAT RECH SCIENT
发明人： VIAL HENRI , CALAS MICHELE , ANCELIN MARIE-LAURE , BOURGUIGNON JEAN-JACQUES , VIDAL VALERIE , RUBI ERIC
IPC分类号： C07D295/08 , A61K31/132 , A61K31/16 , A61K31/39 , A61K31/4025 , A61K31/444 , A61K31/4453 , A61K31/5377 , A61P33/00 , A61P33/02 , A61P33/06 , A61P43/00 , C07C209/74 , C07C211/09 , C07C319/24 , C07C323/41 , C07C327/30 , C07C327/34 , C07D207/09 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/587 , C07D295/12 , C07D295/14 , C07D295/155 , C07D327/06 , A61K31/14 , A61K31/145 , A61K31/425 , C07C323/27 , C07C323/59
摘要： The invention concerns drug precursors with antimalarial effect, characterised in that it consists in quaternary bis-ammonium salts of general formula (I) wherein A and A', identical or different, are respectively either a group A1 and A'1 of formula (1) wherein n=2 to 4; R'1 is hydrogen, C1-C5 alkyl, optionally substituted by an aryl, a hydroxy, an alkoxy, wherein the alkyl comprises 1 to 5 C, or aryloxy and W is halogen or a nucleofuge group; or a group A2 which represents formyl-CHO, or acetyl-COCH3. B and B', identical or different, represent respectively either the group B1 and B'1, if A and A' respectively represent A1, A'1, B1, B'1 representing a group R1 which has the same definition as R'1 above, but cannot be a hydrogen atom; or respectively the groups B2 and B'2, if A and A' represent A2, B2 or B'2 being the group R1 as defined above, or a group of formula (2) wherein -Ra is RS- or RCO-, wherein R is a C1-C6 alkyl, substituted if required, a phenyl or benzyl, wherein the phenyl is substituted if required, the latter being optionally substituted; R2 is hydrogen, C1-C5 alkyl, or a -CH2-COO- (C1-C5)alkyl group; and R3 is hydrogen, C1-C5 alkyl or alkenyl, substituted if required, a phosphate, an alkoxy wherein the alkyl is a C1-C3 alkyl, or aryloxy; or an alkyl (or arylcarbonyloxy; or R2 and R3 form together a cycle with 5 or 6 C; R and R3 can be bound to form a cycle. ± represents: either a single bond when A and A' represent A1 and A'1: or when A and A' represent A2, and B2 and B'2 Represent (3) either, when A and A' are -CHO or -COCH3 and B2 and B'2 are R1, a group of formula (4) or a group of formula (5) wherein (a) represents a bond towards Z and (b) a bond towards the nitrogen atom. Z is a C9-C21 alkyl, if required with insertion of one or several bonds, and/or one or several heteroatoms O and/or S and/or several aromatic cycles, and the pharmaceutically acceptable salts of said compounds. Said precursors and cyclized thiazolium derivatives are useful as antiparasitic medicines in particular antimalarial and antibabesiosis.

57. 发明专利

FR2842423A1 未知
公开(公告)号：FR2842423A1
公开(公告)日：2004-01-23
申请号：FR0209156
申请日：2002-07-18
申请人： CENTRE NAT RECH SCIENT
发明人： VIAL HENRI , CALAS MICHELE , ANCELIN MARIE LAURE , ESCALE ROGER , VIDAL VALERIE , BRESSOLLE FRANCOISE
IPC分类号： A61K31/4245 , A61K31/506 , A61P33/00 , A61P33/06
摘要： Diamidine derivatives of formula (I) and their salts are new. Amidine derivatives of formula (I) and their salts are new. [Image] X : a group of formula (ii) or R 4; Z : -(CH 2) m-; m : 8 - 21; n : 0 or 1; Y : R 3 or a group of formula (iii); R 1 and R' 1H, alkyl, aryl, OH, O-alkyl, O-aryl, OCO-alkyl, OCO-aryl, O-CO-O-(or S or NH)-alkyl, O-CO-O-(or S or NH)-aryl, PO-(O-alkyl or O-aryl) 2, CO-O-CH 2-aryl, or cycloalkyl; R 2 and R' 2H, alkyl, CO-O-CH 2-aryl, CO-O-alkyl, or cycloalkyl; R 3 and R' 3H, alkyl, aryl, CO-O-alkyl, CO-O-aryl, COO-CH(R)-O-CO-alkyl, PO(O-alkyl, or O-aryl, or ONa) 2, or CO-O-CH(R)-aryl; R : H or alkyl; NR 1R 2, NR' 1R' 2, NR 2R 3, NR' 2R' 3a heterocycle, in which R 2 and R 3 and/or R' 2 and R' 3 may be doubly bonded to the nitrogen atom; R 4 and R' 4H or alkyl; R 1R 4, R' 1R' 4-(CH 2) p-; R 4R 2, R' 4R' 2-(CH 2) p; p : 3 - 5; and provided that: (1) when X is a group of formula (ii), then Y is R 3; and (2) when X is R 4, then Y is a group of formula (iii). [Image] Independent claims are also included for the preparation of compounds of formulae (V), (X), (VI) and (VIII). [Image] R anot defined. ACTIVITY : Protozoacide. 1,12-bis(imidazolin-2-yl) dodecane (Ib) was given orally and intraperitoneally to mice infected with Plasmodium vinckei. The dose that cleared 50 % of the infection (ED50) was 3.4 mg/kg i.p and 62 mg/kg p.o. MECHANISM OF ACTION : Not given in source material.

58. 发明专利

ZA200200903B Quaternary bis-ammonium salt precursors and their uses as prodrugs having an antiparasitic activity. 未知
公开(公告)号：ZA200200903B
公开(公告)日：2003-07-30
申请号：ZA200200903
申请日：2002-01-31
申请人： CENTRE NAT RECH SCIENT
发明人： VIAL HENRI , ANCELIN MARIE-LAURE , VIDAL VALERIE , CALAS MICHELE , BOURGUIGNON JEAN-JACQUES , RUBI ERIC
IPC分类号： C07D295/08 , A61K31/132 , A61K31/16 , A61K31/39 , A61K31/4025 , A61K31/444 , A61K31/4453 , A61K31/5377 , A61P33/00 , A61P33/02 , A61P33/06 , A61P43/00 , C07C209/74 , C07C211/09 , C07C319/24 , C07C323/41 , C07C327/30 , C07C327/34 , C07D207/09 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/587 , C07D295/12 , C07D295/14 , C07D295/155 , C07D327/06 , C07C , C07D , A61K , A61P
摘要： The invention concerns drug precursors with antimalarial effect, characterised in that it consists in quaternary bis-ammonium salts of general formula (I) wherein A and A', identical or different, are respectively either a group A1 and A'1 of formula (1) wherein n=2 to 4; R'1 is hydrogen, C1-C5 alkyl, optionally substituted by an aryl, a hydroxy, an alkoxy, wherein the alkyl comprises 1 to 5 C, or aryloxy and W is halogen or a nucleofuge group; or a group A2 which represents formyl-CHO, or acetyl-COCH3. B and B', identical or different, represent respectively either the group B1 and B'1, if A and A' respectively represent A1, A'1, B1, B'1 representing a group R1 which has the same definition as R'1 above, but cannot be a hydrogen atom; or respectively the groups B2 and B'2, if A and A' represent A2, B2 or B'2 being the group R1 as defined above, or a group of formula (2) wherein -Ra is RS- or RCO-, wherein R is a C1-C6 alkyl, substituted if required, a phenyl or benzyl, wherein the phenyl is substituted if required, the latter being optionally substituted; R2 is hydrogen, C1-C5 alkyl, or a -CH2-COO- (C1-C5)alkyl group; and R3 is hydrogen, C1-C5 alkyl or alkenyl, substituted if required, a phosphate, an alkoxy wherein the alkyl is a C1-C3 alkyl, or aryloxy; or an alkyl (or arylcarbonyloxy; or R2 and R3 form together a cycle with 5 or 6 C; R and R3 can be bound to form a cycle. ± represents: either a single bond when A and A' represent A1 and A'1: or when A and A' represent A2, and B2 and B'2 Represent (3) either, when A and A' are -CHO or -COCH3 and B2 and B'2 are R1, a group of formula (4) or a group of formula (5) wherein (a) represents a bond towards Z and (b) a bond towards the nitrogen atom. Z is a C9-C21 alkyl, if required with insertion of one or several bonds, and/or one or several heteroatoms O and/or S and/or several aromatic cycles, and the pharmaceutically acceptable salts of said compounds. Said precursors and cyclized thiazolium derivatives are useful as antiparasitic medicines in particular antimalarial and antibabesiosis.

59. 发明专利

HK1047922A1 Quaternary bis-ammonium salt precursors and their uses as prodrugs having an antiparasitic activity 未知
公开(公告)号：HK1047922A1
公开(公告)日：2003-03-14
申请号：HK02107537
申请日：2002-10-17
申请人： CENTRE NAT RECH SCIENT
发明人： VIAL HENRI , CALAS MICHELE , ANCELIN MARIE-LAURE , BOUGUIGNON JEAN-JACQUES , VIDAL VALERIE , RUBI ERIC
IPC分类号： C07D295/08 , A61K31/132 , A61K31/16 , A61K31/39 , A61K31/4025 , A61K31/444 , A61K31/4453 , A61K31/5377 , A61P33/00 , A61P33/02 , A61P33/06 , A61P43/00 , C07C209/74 , C07C211/09 , C07C319/24 , C07C323/41 , C07C327/30 , C07C327/34 , C07D207/09 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/587 , C07D295/12 , C07D295/14 , C07D295/155 , C07D327/06 , C07C , C07D , A61K , A61P
摘要： The invention concerns drug precursors with antimalarial effect, characterised in that it consists in quaternary bis-ammonium salts of general formula (I) wherein A and A', identical or different, are respectively either a group A1 and A'1 of formula (1) wherein n=2 to 4; R'1 is hydrogen, C1-C5 alkyl, optionally substituted by an aryl, a hydroxy, an alkoxy, wherein the alkyl comprises 1 to 5 C, or aryloxy and W is halogen or a nucleofuge group; or a group A2 which represents formyl-CHO, or acetyl-COCH3. B and B', identical or different, represent respectively either the group B1 and B'1, if A and A' respectively represent A1, A'1, B1, B'1 representing a group R1 which has the same definition as R'1 above, but cannot be a hydrogen atom; or respectively the groups B2 and B'2, if A and A' represent A2, B2 or B'2 being the group R1 as defined above, or a group of formula (2) wherein -Ra is RS- or RCO-, wherein R is a C1-C6 alkyl, substituted if required, a phenyl or benzyl, wherein the phenyl is substituted if required, the latter being optionally substituted; R2 is hydrogen, C1-C5 alkyl, or a -CH2-COO- (C1-C5)alkyl group; and R3 is hydrogen, C1-C5 alkyl or alkenyl, substituted if required, a phosphate, an alkoxy wherein the alkyl is a C1-C3 alkyl, or aryloxy; or an alkyl (or arylcarbonyloxy; or R2 and R3 form together a cycle with 5 or 6 C; R and R3 can be bound to form a cycle. ± represents: either a single bond when A and A' represent A1 and A'1: or when A and A' represent A2, and B2 and B'2 Represent (3) either, when A and A' are -CHO or -COCH3 and B2 and B'2 are R1, a group of formula (4) or a group of formula (5) wherein (a) represents a bond towards Z and (b) a bond towards the nitrogen atom. Z is a C9-C21 alkyl, if required with insertion of one or several bonds, and/or one or several heteroatoms O and/or S and/or several aromatic cycles, and the pharmaceutically acceptable salts of said compounds. Said precursors and cyclized thiazolium derivatives are useful as antiparasitic medicines in particular antimalarial and antibabesiosis.

60. 发明专利

BR0012601A 未知
公开(公告)号：BR0012601A
公开(公告)日：2002-05-21
申请号：BR0012601
申请日：2000-07-21
申请人： CENTRE NAT RECH SCIENT
发明人： VIAL HENRI , CALAS MICHELE , ANCELIN MARIE-LAURE , BOURGUIGNON JEAN-JACQUES , VIDAL VALERIE , RUBI BRIC
IPC分类号： C07D295/08 , A61K31/132 , A61K31/16 , A61K31/39 , A61K31/4025 , A61K31/444 , A61K31/4453 , A61K31/5377 , A61P33/00 , A61P33/02 , A61P33/06 , A61P43/00 , C07C209/74 , C07C211/09 , C07C319/24 , C07C323/41 , C07C327/30 , C07C327/34 , C07D207/09 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/587 , C07D295/12 , C07D295/14 , C07D295/155 , C07D327/06 , C07C323/27 , C07C323/59 , A61K31/14 , A61K31/145 , A61K31/425
摘要： The invention concerns drug precursors with antimalarial effect, characterised in that it consists in quaternary bis-ammonium salts of general formula (I) wherein A and A', identical or different, are respectively either a group A1 and A'1 of formula (1) wherein n=2 to 4; R'1 is hydrogen, C1-C5 alkyl, optionally substituted by an aryl, a hydroxy, an alkoxy, wherein the alkyl comprises 1 to 5 C, or aryloxy and W is halogen or a nucleofuge group; or a group A2 which represents formyl-CHO, or acetyl-COCH3. B and B', identical or different, represent respectively either the group B1 and B'1, if A and A' respectively represent A1, A'1, B1, B'1 representing a group R1 which has the same definition as R'1 above, but cannot be a hydrogen atom; or respectively the groups B2 and B'2, if A and A' represent A2, B2 or B'2 being the group R1 as defined above, or a group of formula (2) wherein -Ra is RS- or RCO-, wherein R is a C1-C6 alkyl, substituted if required, a phenyl or benzyl, wherein the phenyl is substituted if required, the latter being optionally substituted; R2 is hydrogen, C1-C5 alkyl, or a -CH2-COO- (C1-C5)alkyl group; and R3 is hydrogen, C1-C5 alkyl or alkenyl, substituted if required, a phosphate, an alkoxy wherein the alkyl is a C1-C3 alkyl, or aryloxy; or an alkyl (or arylcarbonyloxy; or R2 and R3 form together a cycle with 5 or 6 C; R and R3 can be bound to form a cycle. ± represents: either a single bond when A and A' represent A1 and A'1: or when A and A' represent A2, and B2 and B'2 Represent (3) either, when A and A' are -CHO or -COCH3 and B2 and B'2 are R1, a group of formula (4) or a group of formula (5) wherein (a) represents a bond towards Z and (b) a bond towards the nitrogen atom. Z is a C9-C21 alkyl, if required with insertion of one or several bonds, and/or one or several heteroatoms O and/or S and/or several aromatic cycles, and the pharmaceutically acceptable salts of said compounds. Said precursors and cyclized thiazolium derivatives are useful as antiparasitic medicines in particular antimalarial and antibabesiosis.

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