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51. 发明申请

WO1995006077A2 POLYMERIC MATRICES AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：聚合物基质及其在药物组合物中的应用
公开(公告)号：WO1995006077A2
公开(公告)日：1995-03-02
申请号：PCT/EP1994002833
申请日：1994-08-26
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGELLSCHAFT M.B.H. , ACEMOGLU, Murat , BANTLE, Siegfried , BODMER, David , CAMMISULI, Salvatore , HIESTAND, Peter , NIMMERFALL, Fritz , STOLL, Georg
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGELLSCHAFT M.B.H.
IPC分类号： C08G64/02
CPC分类号： C08G64/183 , A61K9/1647 , A61K9/204 , A61K9/5031 , A61K38/2013 , A61K38/204 , A61K38/31 , C08G64/0208 , C08G64/34 , Y02A50/401 , Y10S514/825 , Y10S514/885 , Y10S514/903 , Y10S514/953 , Y10S514/964
摘要： This invention provides pharmaceutical compositions comprising polymeric matrices, especially those comprising IL-6 as an active ingredient. Specific novel poly(ethylenecarbonate) polymers are also provided for more general use as matrix materials in sustained release compositions containing pharmacologically active compounds, as are methods of using of IL-6 for treatment of conditions mediated by IL-1 and/or TNF alpha , e.g., certain autoimmune and inflammatory conditions, as well as septic shock.
摘要翻译：本发明提供包含聚合物基质，特别是包含IL-6作为活性成分的聚合物基质的药物组合物。还提供特定的新型聚（碳酸亚乙酯）聚合物作为用于在含有药理活性化合物的持续释放组合物中作为基质材料的一般用途，以及使用IL-6用于治疗由IL-1和/或TNFα介导的病症的方法，例如，某些自身免疫和炎症状况以及败血性休克。

52. 发明申请

WO1995001430A1 INSECT DIURETIC HORMONE RECEPTOR, PREFERABLY ISOLATED FROM MANDUCA SEXTA 审中-公开
标题翻译：隐形胆固醇受体，优选分离自曼德拉SEXTA
公开(公告)号：WO1995001430A1
公开(公告)日：1995-01-12
申请号：PCT/EP1994002159
申请日：1994-07-01
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , REAGAN, Jeff, Dale
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12N15/12
CPC分类号： C07K14/72 , C07K2319/00
摘要： Insect diuretic hormone receptors useful in controlling insects, identifying insect control agents and controlling gene expression.
摘要翻译：用于控制昆虫的昆虫利尿激素受体，鉴定昆虫控制剂和控制基因表达。

53. 发明申请

WO1994012659A1 PREVENTING ENDOGENOUS AMINOPEPTIDASE MEDIATED N-TERMINAL AMINO ACID CLEAVAGE DURING EXPRESSION OF FOREIGN GENES IN BACTERIA 审中-公开
标题翻译：在细菌中表达外源基因时，预防内源性氨基酸酶介导的N-末端氨基酸清除
公开(公告)号：WO1994012659A1
公开(公告)日：1994-06-09
申请号：PCT/EP1993003349
申请日：1993-11-29
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , HEITZMANN, Markus , MOVVA, Rao , RAMAGE, Paul
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12P21/06
CPC分类号： C12N15/10 , C07K14/54 , C07K14/5412 , C12P21/06
摘要： A process for the recombinant preparation in a bacterial host of the mature form of a mammalian protein or peptide of formula X-Pro-Z, which is subject to processing by endogenous bacterial aminopeptidases is provided. In the formula X-Pro-Z, X is a single N-terminal amino acid other than proline, and Z is the remaining sequence of amino acid residues of the protein or peptide. The process comprises inserting into a cell of the bacterial host an appropriate vector containing DNA coding for Met-Y-X-Pro-Z, in which Y is a natural amino acid that is specifically cleavable in vitro from X-Pro-Z by an aminopeptidase and that imparts resistance to in vivo processing by endogenous bacterial aminopeptidases. The cell is then induced to express the expression product Met-Y-X-Pro-Z which is then treated with an appropriate aminopeptidase to cleave off Met and Y.
摘要翻译：提供了在细菌宿主中重组制备哺乳动物蛋白质或通过内源性细菌氨基肽酶处理的式X-Pro-Z肽的方法。在式X-Pro-Z中，X是脯氨酸以外的单个N-末端氨基酸，Z是蛋白质或肽的氨基酸残基的剩余序列。该方法包括将含有编码Met-YX-Pro-Z的DNA的适当载体插入到细菌宿主的细胞中，其中Y是天然氨基酸，其可通过氨基肽酶从X-Pro-Z体外特异性切割，其赋予内源性细菌氨基肽酶对体内加工的抵抗力。然后诱导细胞表达表达产物Met-Y-X-Pro-Z，然后用合适的氨基肽酶处理以切割Met和Y.

54. 发明申请

WO1993016010A1 PRODUCTION OF CEMENT-MORTAR DRY MIX 审中-公开
标题翻译：生产水泥 - 麦芽糖混合物
公开(公告)号：WO1993016010A1
公开(公告)日：1993-08-19
申请号：PCT/EP1992000318
申请日：1992-02-14
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , ELLENBERGER, Peter , SCHMITT, Heinz, W. , VALENTI, Salvatore , YANG, Qiwei
IPC分类号： C04B28/04
CPC分类号： C04B28/04 , C04B24/281 , C04B28/02 , C04B40/06 , C08G59/44 , C08G59/5093 , Y02W30/92 , Y02W30/94 , C04B18/08 , C04B24/121 , C04B40/0028 , C04B2103/0067 , C04B26/14 , C04B18/146 , C04B24/12 , C04B24/28
摘要： A storable cement-mortar dry mix, which comprises the components cement, aggregate, reaction resin and hardener in a single mixture, wherein the hardener is present as the reaction product of the hardener with an organic acid or a functional derivative thereof.
摘要翻译：一种可储存的水泥砂浆干混合物，其包含单一混合物中的水泥，骨料，反应树脂和固化剂组分，其中固化剂作为硬化剂与有机酸或其官能衍生物的反应产物存在。

55. 发明申请

WO1993007150A1 TETRAPHENYLPORPHYN DERIVATIVES 审中-公开
标题翻译：四苯并噻吩衍生物
公开(公告)号：WO1993007150A1
公开(公告)日：1993-04-15
申请号：PCT/EP1992002283
申请日：1992-10-02
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , EHRHARDT, Claus , GIGER, Karl, Andreas, Rudolf
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C07D487/22
CPC分类号： C07D487/22 , Y02P20/55
摘要： A hapten formed of a metalloporphyrin cofactor bound to a residue of a substrate. The hapten is designed to mimic a transition state of a metalloporphyrin catalyst and the substrate in a reaction and is characterised in that the metalloporphyrin cofactor is of formula (II), in which: R1, R2, R2', R3, R3', R8 and R8' are as defined in the specification; R4 is a bridging group connecting the metalloporphyrin catalyst to the residue of the substrate; and M is a metal ion having a co-ordination number of at least 4. Also claimed are metalloporphyrin cofactors in which R4 is H, a linker group or a removable protecting group.
摘要翻译：由与底物残基结合的金属卟啉辅因子形成的半抗原。半抗原被设计为在反应中模拟金属卟啉催化剂和底物的过渡态，其特征在于金属卟啉辅因子具有式（II），其中：R 1，R 2，R 2'，R 3，R 3'，R 8 和R8'如说明书中所定义; R4是连接金属卟啉催化剂与底物残留物的桥连基团; 并且M是具有至少4的配位数的金属离子。还要求的是金属卟啉辅因子，其中R 4是H，连接基团或可除去的保护基团。

56. 发明申请

WO1992020215A1 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的改善或有关
公开(公告)号：WO1992020215A1
公开(公告)日：1992-11-26
申请号：PCT/EP1992001035
申请日：1992-05-11
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , KOOL, Arnoldus, Johannes , VAN-VUURE-RIETVELD, Elizabeth, Mariette , JARL-SUNESSON, Carin, Ingegärd
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH
IPC分类号： A01H01/02
CPC分类号： A01H1/02 , A01H5/08
摘要： A method of preparing fertile, diploid eggplants including a trait found naturally in species of the family Solanaceae, such as reduced susceptibility to the fungal disease caused by Verticillium and/or Fusarium, said trait(s) not being found naturally in eggplants which comprises: i) irradiating a Solanaceae protoplast donor having a desired trait with an irradiating dose sufficient to cause fragmentation of the chromosomes of the donor protoplast, ii) fusing said irradiated donor protoplast with an eggplant protoplast serving as an acceptor wherein the donor protoplast and the acceptor protoplast are derived from different explant types and, iii) regenerating the fused protoplasts obtained to mature plants. Also fertile, diploid eggplants comprising desirable traits found naturally in species of the family Solanaceae other than egg plants.
摘要翻译：一种制备可育的二倍体茄子的方法，其包括茄科科属物种天然存在的性状，例如对由轮枝孢属和/或镰刀菌引起的真菌病的易感性降低，所述性状在茄子中天然存在，其特征包括： i）用足以引起供体原生质体染色体碎裂的照射剂量照射具有所需性状的茄科植物原生质体供体，ii）将所述被照射的供体原生质体与用作受体的茄子原生质体融合，其中供体原生质体和受体原生质体衍生自不同的外植体类型，以及iii）将获得的融合原生质体再生成熟植物。还有肥沃的二倍体茄子，其包含理想的性状，其天然存在于茄科以外的茄科的物种中。

57. 发明申请

WO1992007837A1 HETEROCYCLIC DIONE DERIVATIVES AS PESTICIDES AND PLANT GROWTH REGULATORS 审中-公开
标题翻译：作为杀虫剂和植物生长调节剂的杂环二氢衍生物
公开(公告)号：WO1992007837A1
公开(公告)日：1992-05-14
申请号：PCT/EP1991002014
申请日：1991-10-23
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , LEE, Shy-Fuh
IPC分类号： C07D265/02
CPC分类号： A01N43/72 , C07C205/59 , C07D265/02
摘要： The present invention concerns substituted 3,5-dioxo-3,4,5,6-tetrahydrooxazines as herbicides, processes and intermediates for their preparation, compositions containing them and their use as herbicides and acaricides.
摘要翻译：本发明涉及取代的3,5-二氧代-3,4,5,6-四氢恶嗪作为除草剂，其制备方法和中间体，含有它们的组合物及其作为除草剂和杀螨剂的用途。

58. 发明申请

WO1992002543A1 NOVEL IMMUNOSUPPRESSANT PEPTIDES 审中-公开
标题翻译：新型免疫抑制剂
公开(公告)号：WO1992002543A1
公开(公告)日：1992-02-20
申请号：PCT/EP1991001420
申请日：1991-07-29
申请人： CYTEL CORPORATION , SANDOZ LTD. , SANDOZ-PATENT-GMBH , GAETA, Federico, C., A. , POWELL, Michael, F. , GREY, Howard, M. , SETTE, Alessandro, D. , ARRHENIUS, Thomas, S.
发明人： CYTEL CORPORATION , SANDOZ LTD. , SANDOZ-PATENT-GMBH
IPC分类号： C07K07/06
CPC分类号： C07K7/08 , A61K38/00 , C07K14/005 , C12N2760/16022
摘要： Peptide compositions are provided which bind MHC molecules of interest and inhibit T cell activation. The peptides are of 4-25 amino acid residues in length, and have a core binding region comprising, in the direction from the N- to the C- terminus, a hydrophobic L-amino acid or amino acid mimetic, a spacer sequence of 2-6 residues and a Thr or Thr mimetic. At least one residue is a D-amino acid or an amino acid mimetic. The compositions may be used to treat diseases associated with particular Dr alleles, including autoimmune diseases such as rheumatoid arthritis.
摘要翻译：提供了结合感兴趣的MHC分子并抑制T细胞活化的肽组合物。所述肽的长度为4-25个氨基酸残基，并且具有核心结合区，其在从N-至C-末端的方向上包含疏水性L-氨基酸或氨基酸模拟物，间隔序列为2 -6个残基和一个Thr或Thr模拟物。至少一个残基是D-氨基酸或氨基酸模拟物。组合物可用于治疗与特定的Dr等位基因相关的疾病，包括自身免疫性疾病如类风湿性关节炎。

59. 发明申请

WO1991004661A2 MICROENCAPSULATED AGRICULTURAL CHEMICALS 审中-公开
标题翻译：微型农业化学品
公开(公告)号：WO1991004661A2
公开(公告)日：1991-04-18
申请号：PCT/EP1990001618
申请日：1990-09-24
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , CREECH, David, C. , CURTIS, Ralston
IPC分类号： A01N25/28
CPC分类号： B01J13/18 , A01N25/28
摘要： Very sparingly soluble salt forms of rapidly leaching agrochemicals, encapsulated forms thereof, and their method of manufacture and use are disclosed.
摘要翻译：公开了非常微溶盐形式的快速浸出农药，其包封形式及其制造和使用方法。

60. 发明申请

WO1997007218A1 ALLERGEN-XCD32 FUSION PROTEINS 审中-公开
标题翻译： ALLERGEN-XCD32融合蛋白
公开(公告)号：WO1997007218A1
公开(公告)日：1997-02-27
申请号：PCT/EP1996003616
申请日：1996-08-16
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , MUDDE, Geert, C.
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C12N15/62
CPC分类号： C07K14/43531 , A61K38/00 , C07K16/283 , C07K2317/24 , C07K2319/00
摘要： Fusion proteins comprising one or more antigens and one or more moieties interacting with human Fc gamma receptor II (Fc gamma RII) (CD32).
摘要翻译：包含一个或多个抗原和一个或多个与人Fcγ受体II（FcγRII）（CD32）相互作用的部分的融合蛋白。

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