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51. 发明授权

US5906633A System for delivering rounded low pain therapeutic electrical waveforms to the heart 失效
标题翻译：向心脏传递圆滑的低疼痛治疗电波形的系统
公开(公告)号：US5906633A
公开(公告)日：1999-05-25
申请号：US64422
申请日：1998-04-22
申请人： Gabriel Mouchawar , Robert J. Sweeney , Mark W. Kroll
发明人： Gabriel Mouchawar , Robert J. Sweeney , Mark W. Kroll
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912 , Y10S128/908
摘要： A system for delivering low pain cardioversion shocks to the heart wherein the system provides a waveform to the heart that is biphasic and has rounded leading and trailing edges. The rounded leading and trailing edges are believed to decrease the discomfort experienced by the patient. In one embodiment, the circuit has a two capacitors connected in parallel with each other and with an H-bridge. The two capacitors are connected via a switch that can be closed so as to simultaneously charge one capacitor from the other while simultaneously applying voltage to the H-bridge. The circuit also includes a dump resistor that can be connected in parallel with the capacitors so as to increase the rounding of the trailing edges of the waveform. In another embodiment, controllable switches can also be included so as to be able to connect the capacitors in series and apply a sharp peak defibrillation waveform to the heart.
摘要翻译：用于向心脏递送低疼痛心脏复律冲击的系统，其中系统向心脏提供双相并具有圆形前缘和后缘的波形。认为圆形的前缘和后缘减少了患者所遭受的不适。在一个实施例中，该电路具有彼此并联并具有H桥的两个电容器。两个电容器通过可以关闭的开关连接，以便同时向另一个电容器充电，同时向H桥施加电压。该电路还包括可与电容器并联连接的转储电阻器，以增加波形后沿的舍入。在另一个实施例中，还可以包括可控开关，以便能够串联连接电容器，并向心脏施加尖锐的除颤波形。

52. 发明授权

US08818495B2 Use of periodicity in medical data analysis 有权
标题翻译：在医学数据分析中使用周期性
公开(公告)号：US08818495B2
公开(公告)日：2014-08-26
申请号：US13437084
申请日：2012-04-02
申请人： Kelly Schatz , Robert J. Sweeney
发明人： Kelly Schatz , Robert J. Sweeney
IPC分类号： A61N5/04
CPC分类号： A61N1/37 , A61N1/08 , A61N1/37211
摘要： A patient management system is described that includes an implantable device for collecting one or more physiological parameter values and associated timestamps indicating the time at which the value is collected. The system is then configured to determine the periodic variation, if any, of a particular physiological parameter and use that periodicity in assessing changes in the parameter values over time.
摘要翻译：描述了一种患者管理系统，其包括用于收集一个或多个生理参数值的可植入装置和指示收集该值的时间的相关联的时间戳。然后将该系统配置为确定特定生理参数的周期性变化（如果有的话），并且使用该周期性来评估参数值随时间的变化。

53. 发明授权

US08768718B2 Between-patient comparisons for risk stratification of future heart failure decompensation 有权
标题翻译：患者对未来心力衰竭代偿失调风险分层的比较
公开(公告)号：US08768718B2
公开(公告)日：2014-07-01
申请号：US11616430
申请日：2006-12-27
申请人： Shelley Cazares , Jon Peterson , Haresh G. Sachanandani , Kevin J. Stalsberg , Robert J. Sweeney , Krzysztof Z. Siejko , Gerrard M. Carlson
发明人： Shelley Cazares , Jon Peterson , Haresh G. Sachanandani , Kevin J. Stalsberg , Robert J. Sweeney , Krzysztof Z. Siejko , Gerrard M. Carlson
IPC分类号： G06Q50/00 , A61B5/00
CPC分类号： G06Q50/22 , A61B5/0031 , A61N1/37282 , G06F19/00 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70
摘要： This document discusses, among other things, systems and methods for using between-patient comparisons for risk stratification of future heart failure decompensation. A method comprises receiving patient data of a current patient, the patient data collected by a patient monitoring device; determining a reference group related to the patient; determining a reference group dataset selected from the reference group, wherein the dataset includes patient data that is of a similar type received from the patient monitoring device; generating a model of the reference group dataset; and automatically comparing the received physiological data to a model to derive an index for the patient.
摘要翻译：本文件除了其他内容之外还讨论了使用患者间比较以预测未来心力衰竭代偿失调的风险分层的系统和方法。一种方法包括接收当前患者的患者数据，由患者监测装置收集的患者数据; 确定与患者相关的参考组; 确定从所述参考组中选择的参考组数据集，其中所述数据集包括从所述患者监视装置接收到的类似类型的患者数据; 生成参考组数据集的模型; 并且将接收到的生理数据自动地与模型进行比较以导出患者的指标。

54. 发明授权

US08738111B2 Cardiac contraction detection using information indicative of lead motion 有权
标题翻译：使用指示引导运动的信息进行心脏收缩检测
公开(公告)号：US08738111B2
公开(公告)日：2014-05-27
申请号：US13168507
申请日：2011-06-24
申请人： Robert J. Sweeney , Allan C. Shuros , Krzysztof Z. Siejko , David C. Olson , Frank Ingle
发明人： Robert J. Sweeney , Allan C. Shuros , Krzysztof Z. Siejko , David C. Olson , Frank Ingle
IPC分类号： A61B5/02 , A61B5/04 , A61B5/05 , A61N1/00
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for cardiac contraction detection using information indicative of lead motion are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include a processor circuit configured to determine whether a cardiac mechanical contraction occurred during a specified interval included in the obtained information indicative of the movement of the implantable lead. The processor circuit can be configured to determine information about the cardiac mechanical contraction using the obtained information indicative of the movement of the implantable lead.
摘要翻译：描述使用指示引导运动的信息进行心脏收缩检测的系统和方法。在一个示例中，可植入医疗设备可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并被配置为获得指示可植入引线的运动的信息，至少部分地由一个心脏。该装置可以包括处理器电路，该处理器电路被配置为确定在所获得的指示可植入引线的运动的信息中包括的指定间隔期间是否发生心脏机械收缩。处理器电路可以被配置为使用获得的指示可植入引线的移动的信息来确定关于心脏机械收缩的信息。

55. 发明授权

US08521276B2 Use of significant point methodology to prevent inappropriate therapy 有权
标题翻译：使用重要的方法来防止不适当的治疗
公开(公告)号：US08521276B2
公开(公告)日：2013-08-27
申请号：US13004582
申请日：2011-01-11
申请人： Robert J. Sweeney , Dan Li
发明人： Robert J. Sweeney , Dan Li
IPC分类号： A61N1/00
CPC分类号： A61N1/36507 , A61B5/0464 , A61N1/3925
摘要： An apparatus example comprises a cardiac signal sensing circuit configured to provide a sensed cardiac signal representative of cardiac depolarization events of a subject, a sampling circuit coupled to the cardiac signal sensing circuit, a therapy circuit, and a controller communicatively coupled to the sampling circuit and the therapy circuit. The controller includes a detection module configured to detect tachyarrhythmia using the cardiac signal and a signal analysis module configured to establish significant points (SPs) of the sampled cardiac signal, estimate heart rate during the tachyarrhythmia using the SPs, and provide an indication of whether noise is present in the cardiac signal using the SPs. The controller is configured to select a therapy for delivery by the therapy circuit in response to the tachyarrhythmia detection and to modify the selected therapy according to the heart rate estimation and the noise indication.
摘要翻译：装置示例包括心脏信号感测电路，其被配置为提供表示对象的心脏去极化事件的感测心脏信号，耦合到心脏信号感测电路的采样电路，治疗电路和通信地耦合到采样电路的控制器，以及治疗电路。所述控制器包括检测模块，所述检测模块被配置为使用所述心脏信号来检测快速性心律失常;以及信号分析模块，所述信号分析模块被配置为建立所述采集的心脏信号的有效点（SP），使用所述SP在所述快速性心律失常期间估计心率，并且提供噪声使用SP存在于心脏信号中。控制器被配置为选择治疗电路响应于快速性心律失常检测的递送的治疗，并且根据心率估计和噪声指示修改所选择的治疗。

56. 发明授权

US08456309B2 Within-patient algorithm to predict heart failure decompensation 有权
公开(公告)号：US08456309B2
公开(公告)日：2013-06-04
申请号：US13539802
申请日：2012-07-02
申请人： Haresh G. Sachanandani , Jon Peterson , Shelley M. Cazares , Robert J. Sweeney , Kevin John Stalsberg
发明人： Haresh G. Sachanandani , Jon Peterson , Shelley M. Cazares , Robert J. Sweeney , Kevin John Stalsberg
IPC分类号： G08B21/00
CPC分类号： A61B5/0031 , A61B5/0205 , A61B5/02455 , A61B5/0402 , A61B5/076 , A61B5/0816 , A61B5/145 , A61B5/14532 , A61B5/7275 , A61B5/746 , A61B2560/0242 , A61N1/3627 , A61N1/37252 , G06F19/00
摘要： This document discusses, among other things, systems and methods for predicting heart failure decompensation using within-patient diagnostics. A method comprises detecting an alert status of each of one or more sensors; calculating an alert score by combining the detected alerts; and calculating a composite alert score, the composite alert score being indicative of a physiological condition and comprising a combination of two or more alert scores.

57. 发明授权

US08326652B2 Optimization of timing for data collection and analysis in advanced patient management system 有权
标题翻译：优化高级患者管理系统数据收集和分析的时间安排
公开(公告)号：US08326652B2
公开(公告)日：2012-12-04
申请号：US13284047
申请日：2011-10-28
申请人： Robert J. Sweeney
发明人： Robert J. Sweeney
IPC分类号： G06Q50/00 , A61B5/02
CPC分类号： A61B5/0031 , G06F19/00 , G06Q50/22 , G06Q50/24
摘要： Advanced patient management systems include a unit for collecting data from a device associated with a patient, and a host in communication with the unit, the host identifying a time for the device to update data on the device. The system can identify a time for the device to update data associated with the device by developing a histogram of the availability of the device for interrogation. The system can also optimize processing loads for the system by developing a histogram of the time at which the caregiver is most likely to access the system to review the collected and processed data. Methods for optimizing device data update and processing times are also included.
摘要翻译：高级患者管理系统包括用于从与患者相关联的设备收集数据的单元以及与该单元通信的主机，主机标识设备更新设备上的数据的时间。系统可以通过开发用于询问的设备的可用性的直方图来识别设备更新与设备相关联的数据的时间。系统还可以通过开发监护人最有可能访问系统的时间的直方图来优化收集和处理的数据来优化系统的处理负荷。还包括优化设备数据更新和处理时间的方法。

58. 发明申请

US20120238886A1 SYSTEMS AND METHODS TO INDICATE HEART FAILURE CO-MORBIDITY 有权
标题翻译：系统和方法来显示心脏失效的共同性
公开(公告)号：US20120238886A1
公开(公告)日：2012-09-20
申请号：US13408315
申请日：2012-02-29
申请人： Robert J. Sweeney
发明人： Robert J. Sweeney
IPC分类号： A61B5/0205
CPC分类号： A61B5/02055 , A61B5/0031 , A61B5/021 , A61B5/08 , A61B5/11 , A61B5/14551 , A61B5/4836 , A61N1/3627
摘要： Systems and methods to indicate heart failure co-morbidity are described. In an example, one or more physiological signals can be analyzed for a specified time period to determine at least one of an indication of a heart failure event or a characteristic of heart failure co-morbidity, such as a characteristic of a non-heart failure physiological event. At least one of the different physiological signals can be compared to a specified criterion indicative of the heart failure event to provide a comparison value, where the comparison value is indicative of whether the at least one of the different physiological signals contributed towards the indication of the heart failure event. An indication of a non-heart failure physiological event can be determined using the heart failure event indication, the non-heart failure physiological event characteristic, and the comparison value indicative of whether the one or more physiological signals contributed towards the heart failure event.
摘要翻译：描述了指示心力衰竭并发症的系统和方法。在一个示例中，可以在指定的时间段内分析一个或多个生理信号以确定心力衰竭事件的指示或心力衰竭并发特征的至少一个，例如非心力衰竭的特征生理事件。可以将不同生理信号中的至少一个与指示心力衰竭事件的指定标准进行比较以提供比较值，其中比较值指示不同生理信号中的至少一个是否有助于朝向心力衰竭事件。可以使用心力衰竭事件指示，非心力衰竭生理事件特征以及指示一个或多个生理信号是否对心力衰竭事件贡献的比较值来确定非心力衰竭生理事件的指示。

59. 发明授权

US08223023B2 Within-patient algorithm to predict heart failure decompensation 有权
标题翻译：门诊算法预测心力衰竭代偿失调
公开(公告)号：US08223023B2
公开(公告)日：2012-07-17
申请号：US13229110
申请日：2011-09-09
申请人： Haresh G. Sachanandani , Jon Peterson , Shelley M. Cazares , Robert J. Sweeney , Kevin John Stalsberg
发明人： Haresh G. Sachanandani , Jon Peterson , Shelley M. Cazares , Robert J. Sweeney , Kevin John Stalsberg
IPC分类号： G08B21/00
CPC分类号： A61B5/0031 , A61B5/0205 , A61B5/02455 , A61B5/0402 , A61B5/076 , A61B5/0816 , A61B5/145 , A61B5/14532 , A61B5/7275 , A61B5/746 , A61B2560/0242 , A61N1/3627 , A61N1/37252 , G06F19/00
摘要： This document discusses, among other things, systems and methods for predicting heart failure decompensation using within-patient diagnostics. A method comprises detecting an alert status of each of one or more sensors; calculating an alert score by combining the detected alerts; and calculating a composite alert score, the composite alert score being indicative of a physiological condition and comprising a combination of two or more alert scores.
摘要翻译：本文件还讨论了使用病人诊断预测心力衰竭失代偿失调的系统和方法。一种方法包括检测一个或多个传感器中的每一个的警报状态; 通过组合检测到的警报来计算警报评分; 以及计算复合警报评分，所述复合警报评分指示生理状况并且包括两个或更多个警报得分的组合。

60. 发明申请

US20110301660A1 HEART FAILURE MANAGEMENT SYSTEM 有权
标题翻译：心脏失败管理系统
公开(公告)号：US20110301660A1
公开(公告)日：2011-12-08
申请号：US13214564
申请日：2011-08-22
申请人： Imad Libbus , Krzysztof Z. Siejko , Marina V. Brockway , Robert J. Sweeney
发明人： Imad Libbus , Krzysztof Z. Siejko , Marina V. Brockway , Robert J. Sweeney
IPC分类号： A61N1/365
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括适于递送用于心力衰竭治疗的刺激信号的刺激器，适于提供心力衰竭状态的至少第一测量和心力衰竭状态的第二测量的多个传感器以及控制器。控制器连接到刺激器和传感器的数量。控制器适于使用第一和第二测量来创建心力衰竭状态指数，并且使用该索引来控制刺激器来调制信号。本文提供了其它方面和实施例。

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