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51. 发明申请

US20060106279A1 Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant having an adjustable bridge stop 审中-公开
公开(公告)号：US20060106279A1
公开(公告)日：2006-05-18
申请号：US11255663
申请日：2005-10-21
申请人： Timothy Machold , David Scott , David Rahdert , David Tholfsen , Robert Chang , John Macoviak
发明人： Timothy Machold , David Scott , David Rahdert , David Tholfsen , Robert Chang , John Macoviak
IPC分类号： A61B17/12 , A61F2/24
CPC分类号： A61F2/2442 , A61B17/00234 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0485 , A61B17/0487 , A61B17/3478 , A61B2017/00243 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/00876 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0451 , A61B2017/0453 , A61B2017/0454 , A61B2017/0458 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0496 , A61B2017/06176 , A61F2/2445 , A61F2/2451 , A61F2/2466 , A61F2/2487 , A61F2210/009 , A61F2250/0012
摘要： Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial adjustability and retrievability years after implant. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize an adjustable bridge stop to secure the implant, and the methods of implantation employ various tools.

52. 发明申请

US20050267573A9 Devices, systems, and methods for supplementing, repairing, or replacing a native heart valve leaflet 有权
标题翻译：用于补充，修复或更换天然心脏瓣膜小叶的装置，系统和方法
公开(公告)号：US20050267573A9
公开(公告)日：2005-12-01
申请号：US10676815
申请日：2003-10-01
申请人： John Macoviak , Robert Chang , David Rahdert , Timothy Machold , Rick Soss
发明人： John Macoviak , Robert Chang , David Rahdert , Timothy Machold , Rick Soss
IPC分类号： A61F20060101 , A61F2/24
CPC分类号： A61F2/2445 , A61F2/2418 , A61F2/2454
摘要： Devices, systems and methods supplement, repair, or replace a native heart valve. The devices, systems, and methods employ an implant that, in use, extends adjacent a valve annulus. The implant includes a mobile neoleaflet element that occupies the space of at least a portion of one native valve leaflet. The implant mimics the one-way valve function of a native leaflet, to resist or prevent retrograde flow. The implant restores normal coaptation of the leaflets to resist retrograde flow, thereby resisting eversion and/or prolapse, which, in turn, reduces regurgitation.
摘要翻译：装置，系统和方法补充，修理或更换原生心脏瓣膜。装置，系统和方法采用在使用中邻近瓣膜环延伸的植入物。植入物包括占据一个天然瓣膜小叶的至少一部分的空间的移动的新叶元件。植入物模拟天然小叶的单向瓣膜功能，以抵抗或防止逆行流动。植入物恢复小叶的正常接合以抵抗逆行流动，从而抵抗外翻和/或脱垂，这进而降低反流。

53. 发明申请

US20050228422A1 Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools 审中-公开
标题翻译：用于重塑心脏瓣膜环的装置，系统和方法，包括使用磁性工具
公开(公告)号：US20050228422A1
公开(公告)日：2005-10-13
申请号：US11089939
申请日：2005-03-25
申请人： Timothy Machold , Robert Chang , John Macoviak , David Rahdert
发明人： Timothy Machold , Robert Chang , John Macoviak , David Rahdert
IPC分类号： A61B17/00 , A61B17/04 , A61B17/14 , A61B17/32 , A61F2/06 , A61F2/82
CPC分类号： A61F2/2451 , A61B17/00234 , A61B17/0401 , A61B2017/00243 , A61B2017/00247 , A61B2017/00292 , A61B2017/00876 , A61B2017/0417 , A61B2018/00392 , A61F2/2487
摘要： Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial retrievability. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize a bridge stop to secure the implant, and the methods of implantation employ various tools.
摘要翻译：植入物或植入物和方法的系统在左心房内或横过左心房施加选定的力向量或力向量的选择组合，这允许二尖瓣小叶更好地适应。植入物和植入物和方法的植入物或系统使得可以快速部署，容易的血管内递送和完全的房内可检索性。植入物或植入物和方法的植入物或系统也利用强荧光检查标志。植入物和植入物和植入物的系统利用可调植入物和固定长度植入物。植入物和植入物的方式的植入物或系统还可以利用桥接止动件来固定植入物，并且植入方法使用各种工具。

54. 发明授权

US6068090A Braking device for a bicycle 失效
标题翻译：自行车制动装置
公开(公告)号：US6068090A
公开(公告)日：2000-05-30
申请号：US345514
申请日：1999-07-01
申请人： Jack Chen , Robert Chang
发明人： Jack Chen , Robert Chang
IPC分类号： B62L1/00 , B62L3/00
CPC分类号： B62L1/005
摘要： A brake device for a bicycle includes a mounting seat having a space and an opening that faces a bicycle wheel. A resilient member is mounted in the space. A brake piece is mounted in front of the space for braking the bicycle wheel. The brake piece is connected to the resilient member to move therewith. A connecting member includes a first end operably connected to the resilient member and a second end actuatable by a brake lever for urging the resilient member and the brake piece to brake the bicycle wheel.
摘要翻译：用于自行车的制动装置包括具有空间的安装座和面向自行车车轮的开口。弹性构件安装在该空间中。制动片安装在空间的前面，用于制动自行车车轮。制动片连接到弹性件以与其一起移动。连接构件包括可操作地连接到弹性构件的第一端和可由制动杆致动的第二端，用于推动弹性构件和制动片以制动自行车车轮。

55. 发明授权

US5529328A Shock absorbing device for a bicycle 失效
标题翻译：用于自行车的减震装置
公开(公告)号：US5529328A
公开(公告)日：1996-06-25
申请号：US520814
申请日：1995-08-30
申请人： Robert Chang , Tan-jue Hwang
发明人： Robert Chang , Tan-jue Hwang
IPC分类号： B62K25/08 , B62K25/04
CPC分类号： B62K25/08
摘要： A shock absorbing device for a bicycle, which includes a front fork and two cylinders, the front fork including a frame and two columns each of which has a slot defined therein, the frame having two side plates each of which has at least two rollers rotatably disposed thereto and the column movably disposed and guided between the two rollers by extending a bolt through one end of the cylinder, the slot of the column and being engaged to the side plate, the other end of the cylinder fixedly disposed to the column such that when shocks transferred from a wheel of the bicycle the columns moved upwardly and depress the cylinders to absorb the shocks.
摘要翻译：一种用于自行车的减震装置，包括前叉和两个气缸，前叉包括框架和两个柱，每个柱具有限定在其中的狭槽，框架具有两个侧板，每个侧板具有至少两个可旋转的辊通过将螺栓穿过气缸的一端，柱的狭槽并与侧板接合，柱体的另一端固定地设置在柱上，使得柱可移动地设置和引导在两个辊之间，使得当冲击从自行车的车轮转移时，柱向上移动并压下气缸以吸收冲击。

56. 发明授权

US5362127A Bicycle saddle 失效
标题翻译：自行车马鞍
公开(公告)号：US5362127A
公开(公告)日：1994-11-08
申请号：US111177
申请日：1993-08-24
申请人： Robert Chang
发明人： Robert Chang
IPC分类号： B62J1/00 , B62J1/08 , B62J1/28 , A47C7/62
CPC分类号： B62J1/08 , B62J1/00
摘要： A bicycle saddle has a seat body for the posterior of a rider, mechanical parts for fixedly attaching the seat body to a seat post by connecting the a lower wall of the seat body to the seat post, a base has a substantially triangular wall defining a central hole therewithin and a snapping tongue member. The central hole surrounds the seat post and the snapping tongue member extends upwardly and inwardly from the periphery of the wall of the base. The mechanical parts for attaching the bicycle saddle to the seat post are totally enclosed by the base and the seat body; thus, they are hidden from sight.
摘要翻译：自行车鞍座具有用于骑车人后部的座椅主体，用于通过将座椅主体的下壁连接到座椅柱而将座椅主体固定地附接到座椅支柱的机械部件，基座具有基本上三角形的壁，其中的中心孔和咬合舌构件。中心孔围绕座柱，并且卡扣舌构件从底座的壁的周边向上和向内延伸。用于将自行车鞍座附接到座柱的机械部件被基座和座椅主体完全包围; 因此，它们隐藏在视线之内。

57. 发明授权

US5207710A Method for improving implant fixation 失效
标题翻译：改善植入物固定的方法
公开(公告)号：US5207710A
公开(公告)日：1993-05-04
申请号：US819059
申请日：1992-01-10
申请人： George H. Chu , Rosa Armstrong , Robert Chang
发明人： George H. Chu , Rosa Armstrong , Robert Chang
IPC分类号： A61F2/00 , A61F2/28 , A61L27/22 , A61L27/56
CPC分类号： A61F2/28 , A61L27/227 , A61L27/56 , A61F2002/30034 , A61F2002/30677 , A61F2250/0031 , A61F2250/0067 , A61L2430/02 , Y10S623/923
摘要： Stress-bearing prostheses for replacement or partial replacement of stress-bearing bone are fixed in place by bony ingrowth by providing a stress-bearing member having a porous region in combination with an osteogenic factor extract or a purified osteogenic inductive protein, optionally in combination with a TGF-beta cofactor, in a pharmaceutically acceptable carrier. The carrier is preferably either a collagen composition or a ceramic.
摘要翻译：通过提供具有多孔区域的应力承载构件与成骨因子提取物或纯化的成骨诱导性蛋白质组合，可以通过骨髓向内生长来固定应力承载骨的替代或部分替代的应力承载假体，任选地与 TGF-β辅因子，在药学上可接受的载体中。载体优选为胶原组合物或陶瓷。

58. 发明申请

US20190106674A1 Integrated methods for precision manufacturing of tissue engineering scaffolds 审中-公开
公开(公告)号：US20190106674A1
公开(公告)日：2019-04-11
申请号：US15998685
申请日：2018-08-15
申请人： Filippos Tourlomousis , Robert Chang , Dilhan Kalyon
发明人： Filippos Tourlomousis , Robert Chang , Dilhan Kalyon
IPC分类号： C12N5/00 , A61K35/28 , C12N5/0775 , A61L27/38 , B33Y10/00 , B33Y70/00
摘要： Methods for the development and integration of multiple apparatuses and methods for achieving administration of stem cell therapies include precision manufacturing of tissue scaffolds and/or bioreactor substrates. The nano/microscale fiber material extrusion typifying the electrospinning process is married with the fiber alignment and layering characteristic of an additive manufacturing process. The method generates porous fibrous 3-D meshes with precision controlled structures from biopolymer melts and solutions and gels, blends, and suspensions with and without cells. A method of tracking the migration histories and shapes of stem cells on scaffold surfaces relies on immunofluorescent imaging and automated algorithms based on machine learning. The combination of the precision manufacturing method and the method of cell tracking and cell shape statistics, along with understanding of the intimate relationship between the cell shape/phenotype and scaffold architecture leads to an integrated method for cultivating and harvesting cells having desired phenotypes.

59. 发明申请

US20110136162A1 Compositions and Methods for Functionalized Patterning of Tissue Engineering Substrates Including Bioprinting Cell-Laden Constructs for Multicompartment Tissue Chambers 审中-公开
标题翻译：组织工程底物的功能化图案的组合和方法，包括用于多室组织室的生物印迹细胞 - 拉登构建体
公开(公告)号：US20110136162A1
公开(公告)日：2011-06-09
申请号：US12872992
申请日：2010-08-31
申请人： Wei Sun , Jessica Snyder , Robert Chang , Eda Yildirim , Alexander Fridman , Halim Ayan
发明人： Wei Sun , Jessica Snyder , Robert Chang , Eda Yildirim , Alexander Fridman , Halim Ayan
IPC分类号： C12Q1/02 , C12M1/00 , C12M1/34 , C23C16/50 , C23C16/52
CPC分类号： B01L3/502761 , B01L2300/0877 , B01L2300/0883 , B01L2300/0887 , B01L2300/161 , B01L2400/0418 , B01L2400/0677 , B01L2400/086
摘要： The present invention relates to microfluidic systems and methods for monitoring or detecting a change in a characteristic of an input substance. Specifically, the invention relates to a model for in vitro pharmacokinetic study and other pharmaceutical applications, as well as other uses including computing, sensing, filtration, detoxification, production of chemicals and biomolecules, testing cell/tissue behavior, toxicology, drug metabolism, drug screening, drug discovery, and implantation into a subject. The present invention also relates to systems and methods of a microplasm functionalized surface patterning of a substrate. The present invention represents an improvement over existing plasma systems used to modify the surface of a substrate, as the present invention creates surface patterning without the use of a mask, stamp or a chemical treatment.
摘要翻译：本发明涉及用于监测或检测输入物质的特性变化的微流体系统和方法。具体地说，本发明涉及用于体外药代动力学研究和其他药物应用的模型，以及其它用途，包括计算，感测，过滤，解毒，化学品和生物分子的生产，测试细胞/组织行为，毒理学，药物代谢，药物筛选，药物发现和植入到一个主题。本发明还涉及衬底的微量化学官能化表面图案化的系统和方法。本发明表示对用于改变基材表面的现有等离子体系统的改进，因为本发明在不使用掩模，印模或化学处理的情况下产生表面图案。

60. 发明申请

US20100005103A1 DISTRIBUTED APPLICATION MANAGEMENT SOFTWARE 有权
标题翻译：分布式应用管理软件
公开(公告)号：US20100005103A1
公开(公告)日：2010-01-07
申请号：US12560309
申请日：2009-09-15
申请人： Geoffrey Hager , Robert Chang , Robert Tjia
发明人： Geoffrey Hager , Robert Chang , Robert Tjia
IPC分类号： G06F17/30
CPC分类号： H04L41/048 , H04L41/0213 , H04L41/0233 , H04L41/0266
摘要： A system and method is provided for remote administration and management of a computer network, by installation of distributed software agents in remote network components, such as software agents implemented using encapsulated reusable interfaces such as COM or CORBA interfaces. Remote network management is effected by communication with the distributed agents using a structured language-independent parsable text document, such as a markup language; e.g. XML.
摘要翻译：通过在远程网络组件中安装分布式软件代理，例如使用诸如COM或CORBA接口的封装的可重用接口实现的软件代理，提供了用于远程管理和管理计算机网络的系统和方法。远程网络管理通过使用结构化语言无关的可解析文本文档（例如标记语言）与分布式代理进行通信来实现; 例如 XML。

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