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51. 发明授权

US07121283B2 Satiation devices and methods 有权
公开(公告)号：US07121283B2
公开(公告)日：2006-10-17
申请号：US10794346
申请日：2004-03-04
申请人： Richard S. Stack , Richard A. Glenn , Trevor J. Moody , Fred E. Silverstein , Nathan Every , William S. Eubanks, Jr.
发明人： Richard S. Stack , Richard A. Glenn , Trevor J. Moody , Fred E. Silverstein , Nathan Every , William S. Eubanks, Jr.
IPC分类号： A61B19/00 , A61F12/04 , A61F5/00
CPC分类号： A61F5/0076 , A61F2/04 , A61F2/07 , A61F2/24 , A61F5/0069 , A61F5/0079 , A61F2002/044 , A61F2002/045 , A61F2002/067 , A61F2002/072 , A61F2002/8483 , A61F2250/0039 , A61F2250/0067
摘要： A device for inducing weight loss in a patient includes a tubular prosthesis self-expandable from a collapsed position in which the prosthesis has a first diameter to an expanded position in which the prosthesis has a second, larger, diameter. In a method for inducing weight loss, the prosthesis is placed in the collapsed position and inserted into a stomach of a patient. The prosthesis is allowed to self-expand from the collapsed position to the expanded position and into contact with the walls of the stomach, where it induces feelings of satiety and/or inhibits modulation of satiety-controlling factors such as Ghrelin.

52. 发明授权

US08934956B2 Intravascular electrodes and anchoring devices for transvascular stimulation 有权
标题翻译：用于血管内刺激的血管内电极和锚定装置
公开(公告)号：US08934956B2
公开(公告)日：2015-01-13
申请号：US13281399
申请日：2011-10-25
申请人： Richard A. Glenn , Jeffrey A. Smith , Geoffrey A. Orth , Kevin Holbrook , Michael S. Williams
发明人： Richard A. Glenn , Jeffrey A. Smith , Geoffrey A. Orth , Kevin Holbrook , Michael S. Williams
IPC分类号： A61B5/04 , A61N1/05 , A61B5/00 , A61B5/042 , A61B5/02 , A61N1/00
CPC分类号： A61N1/05 , A61B5/0422 , A61B5/6862 , A61N1/057
摘要： An intravascular electrode device for use in neuromodulation includes an anchor expandable from a radially compressed position to a radially expanded position. A lead extends from the anchor and has at least one conductor extending through it. A flex circuit is coupled to the anchor and comprises a flexible insulative substrate, a plurality of electrodes carried by the substrate, and a plurality of conductive traces carried by the substrate, each trace electrically coupled to an electrode and a conductor. Expansion of the anchor within a blood vessel biases the electrodes into contact with the surrounding blood vessel wall. An exemplary anchor includes a first portion having expansion forces sufficient to bias the electrodes against the vessel wall for mapping and chronic stimulation, and a second portion having greater radial expansion forces sufficient to chronically engage the vessel wall once an optimal electrode location has been selected.
摘要翻译：用于神经调节的血管内电极装置包括可从径向压缩位置扩展到径向扩张位置的锚固件。引线从锚固体延伸并且具有延伸穿过其的至少一个导体。柔性电路耦合到锚固件并且包括柔性绝缘衬底，由衬底承载的多个电极和由衬底承载的多个导电迹线，每个迹线电耦合到电极和导体。在血管内锚固体的膨胀将电极偏置成与周围的血管壁接触。示例性的锚包括具有足以将电极偏压抵靠血管壁进行映射和慢性刺激的膨胀力的第一部分，以及一旦已经选择最佳电极位置，具有足以长期接合血管壁的较大径向膨胀力的第二部分。

53. 发明申请

US20100211131A1 INTRAVASCULAR SYSTEM AND METHOD FOR BLOOD PRESSURE CONTROL 审中-公开
标题翻译：血管压力控制的血管内系统及方法
公开(公告)号：US20100211131A1
公开(公告)日：2010-08-19
申请号：US12419717
申请日：2009-04-07
申请人： Michael S. Williams , Richard A. Glenn , Daniel W. Fifer
发明人： Michael S. Williams , Richard A. Glenn , Daniel W. Fifer
IPC分类号： A61N1/05
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/056 , A61N1/36117
摘要： An intravascular lead is used to deliver energy for stimulating nervous system targets using energy delivery elements (e.g. electrodes) that are in direct contact with the nervous system targets. The lead may be positioned within the internal jugular vein and the nervous system targets may include the carotid artery/carotid sinus bulb and/or associated baroreceptor afferents, and/or surrounding nervous system targets in the region of the internal jugular vein, such as the carotid sinus nerve and/or associated nerve branches and/or the vagus nerve and/or associated nerve branches. Stimulation energy travels along a conductive bridge that extends from the intravascular lead to the nervous system target, or is relayed from the intravascular lead to another device disposed within or surrounding the target structure.
摘要翻译：血管内铅用于使用与神经系统靶标直接接触的能量递送元件（例如电极）来递送能量以刺激神经系统靶标。铅可以位于颈内静脉内，并且神经系统靶标可以包括颈内动脉/颈动脉窦球和/或相关联的压力感受器传入物，和/或颈内静脉区域周围的神经系统靶标，例如颈动脉窦神经和/或相关神经分支和/或迷走神经和/或相关神经分支。刺激能量沿着从血管内引线延伸到神经系统靶的导电桥传播，或者从血管内引线传递到设置在目标结构内或围绕目标结构的另一个装置。

54. 发明授权

US07617007B2 Method and apparatus for retaining medical implants within body vessels 有权
标题翻译：保留体内血管植入物的方法和装置
公开(公告)号：US07617007B2
公开(公告)日：2009-11-10
申请号：US10977060
申请日：2004-10-29
申请人： Michael S. Williams , Terrance Ransbury , Richard A. Glenn , Kevin Holbrook
发明人： Michael S. Williams , Terrance Ransbury , Richard A. Glenn , Kevin Holbrook
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/37205 , A61N1/375
摘要： The present application describes a retention device for anchoring a medical device within the vasculature. The device may include expandable member coupled to an intravascular medical device and proportioned for receipt within a vessel. At least a portion of the expandable member is expandable to radially engage a vessel wall and to thereby retain the medical device within the vessel. The system is suitable for a variety of intravascular devices, including but not limited to ICD's, pacemakers, and intravascular drug delivery systems.
摘要翻译：本申请描述了用于将医疗装置锚定在脉管系统内的保持装置。该装置可以包括联接到血管内医疗装置并且成比例地用于在容器内接收的可扩张构件。可膨胀构件的至少一部分可扩张以径向接合容器壁并由此将医疗装置保持在容器内。该系统适用于各种血管内装置，包括但不限于ICD，起搏器和血管内药物递送系统。

55. 发明授权

US07141061B2 Photocurable endoprosthesis system 有权
标题翻译：光固化假体内系统
公开(公告)号：US07141061B2
公开(公告)日：2006-11-28
申请号：US10342771
申请日：2003-01-15
申请人： Michael S. Williams , Kevin D. Holbrook , Richard A. Glenn , Jeffrey A. Smith , Joseph M. DeSimone
发明人： Michael S. Williams , Kevin D. Holbrook , Richard A. Glenn , Jeffrey A. Smith , Joseph M. DeSimone
IPC分类号： A61F2/006
CPC分类号： A61F2/90 , A61F2/848 , A61F2002/825 , A61F2220/005 , A61F2220/0058 , A61F2250/0014 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： Novel endoprostheses comprising one or more photocurable materials are disclosed. Said endoprostheses may comprise regions wherein said photocurable materials are selectively disposed about said endoprosthesis and are cured according to desired parameters to achieve varying desired properties. Said properties may include but are not limited to cross-linking density, material density, modulus of elasticity, rate of erosion, extensibility, compressibility, mechanical strength, tensile strength, crystallinity, diffusion coefficient, and permeability.
摘要翻译：公开了包含一种或多种光固化材料的新型内用假体。所述内假体可以包括其中所述可光固化材料围绕所述内假体选择性地设置并且根据期望的参数固化以实现变化的所需性质的区域。所述性质可以包括但不限于交联密度，材料密度，弹性模量，侵蚀速率，伸长率，压缩性，机械强度，拉伸强度，结晶度，扩散系数和渗透性。

56. 发明授权

US08771337B2 Endoprostheses and methods of manufacture 失效
标题翻译：内假体和制造方法
公开(公告)号：US08771337B2
公开(公告)日：2014-07-08
申请号：US12660753
申请日：2010-03-03
申请人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
发明人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2/848 , A61F2002/825 , A61F2210/0004 , A61F2250/0014 , A61F2250/0036 , A61F2250/0039 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： A woven tubular endoprosthesis comprising means for locking the endoprosthesis in a deployed configuration is disclosed. The means for locking the endoprosthesis may comprise locking protrusions, notches, a chemical bond, a curable bond, or other mechanism. The woven fibers comprising the endoprosthesis may be hollow and comprise circumferentially oriented polymeric chains, and may be filled with a curable material. A method of treatment using an endoprosthesis according to the invention is also disclosed.
摘要翻译：公开了一种编织管状内假体，其包括用于将内置假体锁定在展开构造中的装置。用于锁定内假体的装置可以包括锁定突起，凹口，化学键，可固化键或其它机构。包含内用假体的编织纤维可以是中空的并且包括周向取向的聚合物链，并且可以用可固化材料填充。还公开了使用根据本发明的内置假体的治疗方法。

57. 发明申请

US20130018444A1 INTRAVASCULAR ELECTRODES FOR TRANSVASCULAR STIMULATION 审中-公开
标题翻译：用于血管扩张的血管内电极
公开(公告)号：US20130018444A1
公开(公告)日：2013-01-17
申请号：US13068866
申请日：2011-07-11
申请人： Richard A. Glenn , Jeffrey A. Smith , Geoffrey A. Orth , Michael S. Williams , Kevin Holbrook
发明人： Richard A. Glenn , Jeffrey A. Smith , Geoffrey A. Orth , Michael S. Williams , Kevin Holbrook
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61B5/0422 , A61B5/6862 , A61N1/057
摘要： An intravascular electrode device for use in neuromodulation includes an anchor expandable from a radially compressed position to a radially expanded position. A lead extends from the anchor and has at least one conductor extending through it. A flex circuit is coupled to the anchor and comprises a flexible insulative substrate, a plurality of electrodes carried by the substrate, and a plurality of conductive traces carried by the substrate, each trace electrically coupled to an electrode and a conductor. Expansion of the anchor within a blood vessel biases the electrodes into contact with the surrounding blood vessel wall.
摘要翻译：用于神经调节的血管内电极装置包括可从径向压缩位置扩展到径向扩张位置的锚。引线从锚固体延伸并且具有延伸穿过其的至少一个导体。柔性电路耦合到锚固件并且包括柔性绝缘衬底，由衬底承载的多个电极和由衬底承载的多个导电迹线，每个迹线电耦合到电极和导体。在血管内锚固体的膨胀将电极偏置成与周围的血管壁接触。

58. 发明授权

US07899554B2 Intravascular System and Method 有权
标题翻译：血管内系统和方法
公开(公告)号：US07899554B2
公开(公告)日：2011-03-01
申请号：US11980006
申请日：2007-10-30
申请人： Michael S. Williams , Terrance Ransbury , Richard A. Glenn , Daniel W. Fifer , Kevin Holbrook
发明人： Michael S. Williams , Terrance Ransbury , Richard A. Glenn , Daniel W. Fifer , Kevin Holbrook
IPC分类号： A61N1/02
CPC分类号： A61N1/057 , A61N1/37205 , A61N1/375
摘要： The present application describes an intravascular implantable pacing and/or defibrillation system. The described system includes a pulse generator that is implantable within a blood vessel and proportioned to blood flow through the blood vessel, and at least one electrode attachable to the pulse generator. During implantation, the pulse generator is introduced into a patient's vasculature, advanced to a desired vessel and anchored in place within the vessel. The electrode or electrodes are placed within the heart or surrounding vessels as needed to deliver electrical pulses to the appropriate location.
摘要翻译：本申请描述了血管内可植入起搏和/或除颤系统。所描述的系统包括脉冲发生器，该脉冲发生器可植入血管内并与通过血管的血液流动成比例，以及至少一个可附着到脉冲发生器的电极。在植入期间，将脉冲发生器引入患者的脉管系统中，前进到期望的血管并锚定在血管内的适当位置。根据需要将电极或电极放置在心脏或周围血管内，以将电脉冲传递到适当的位置。

59. 发明申请

US20090281521A1 METHOD AND APPARATUS FOR RETAINING MEDICAL IMPLANTS WITHIN BODY VESSELS 失效
标题翻译：用于在体内保留医用植入物的方法和装置
公开(公告)号：US20090281521A1
公开(公告)日：2009-11-12
申请号：US12506232
申请日：2009-07-20
申请人： Michael S. Williams , Terrance Ransbury , Richard A. Glenn , Kevin Holbrook
发明人： Michael S. Williams , Terrance Ransbury , Richard A. Glenn , Kevin Holbrook
IPC分类号： A61M31/00 , A61N1/05
CPC分类号： A61N1/057 , A61N1/37205 , A61N1/375
摘要： The present application describes a retention device for anchoring a medical device within the vasculature. The device may include expandable member coupled to an intravascular medical device and proportioned for receipt within a vessel. At least a portion of the expandable member is expandable to radially engage a vessel wall and to thereby retain the medical device within the vessel. The system is suitable for a variety of intravascular devices, including but not limited to ICD's, pacemakers, and intravascular drug delivery systems.
摘要翻译：本申请描述了用于将医疗装置锚定在脉管系统内的保持装置。该装置可以包括联接到血管内医疗装置并且成比例地用于在容器内接收的可扩张构件。可膨胀构件的至少一部分可扩张以径向接合容器壁并由此将医疗装置保持在容器内。该系统适用于各种血管内装置，包括但不限于ICD，起搏器和血管内药物输送系统。

60. 发明申请

US20090096137A1 Polymeric endoprostheses with enhanced strength and flexibility and methods of manufacture 审中-公开
标题翻译：具有增强强度和柔韧性的聚合体内用假体和制造方法
公开(公告)号：US20090096137A1
公开(公告)日：2009-04-16
申请号：US12231504
申请日：2008-09-02
申请人： Michael S. Williams , Kevin D. Holbrook , Richard A. Glenn
发明人： Michael S. Williams , Kevin D. Holbrook , Richard A. Glenn
IPC分类号： B29C47/88
CPC分类号： A61F2/82 , A61L29/126 , A61L29/18 , A61L31/128 , A61L31/18
摘要： Improved polymeric endoprostheses and methods of manufacturing endoprostheses are disclosed herein. The endoprostheses may comprise one or more polymers wherein the polymer chains are substantially aligned circumferentially, and comprising increased radial strength and flexibility. An endoprosthesis according to the invention may comprise a smooth surface. Endoprostheses disclosed herein may be used in the treatment of strictures in lumens of the body. Alternatively, endoprostheses disclosed herein may be used as anchors to secure medical devices within lumens of the body. The endoprostheses disclosed herein may comprise one or more erodible polymer.
摘要翻译：本文公开了改进的聚合物内用假体和制造内用假体的方法。内用假体可以包含一种或多种聚合物，其中聚合物链基本上对齐地对准，并且包括增加的径向强度和柔性。根据本发明的内用假体可以包括光滑表面。本文公开的内假体可以用于治疗身体内腔的狭窄。或者，本文公开的假体可以用作锚固件以将身体内腔内的医疗装置固定。本文公开的内用假体可以包含一种或多种可侵蚀的聚合物。

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