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51. 发明授权

US07725148B2 Sensor with layered electrodes 有权
标题翻译：带层状电极的传感器
公开(公告)号：US07725148B2
公开(公告)日：2010-05-25
申请号：US11234523
申请日：2005-09-23
申请人： Rajiv Shah , Rebecca K. Gottlieb
发明人： Rajiv Shah , Rebecca K. Gottlieb
IPC分类号： A61B5/05 , A61B5/00 , G01N31/00 , G01N33/50 , G01N27/26 , C12M1/00 , C12Q1/00
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/0017 , A61B5/14532 , A61B5/6848 , A61B5/6849 , C12Q1/006 , C23C14/20 , C23C14/3414 , G01N27/307 , G01N27/3273 , G01N27/4166 , Y10T29/49002 , Y10T29/49005 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155
摘要： A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.
摘要翻译：提供薄膜传感器，例如葡萄糖传感器，用于经皮放置在患者体内的选定部位。传感器包括几个传感器层，其包括导电层，并且包括限定适于与合适的监视器电连接的导电触点的近端段，以及具有用于经皮放置的传感器电极的远端段。传感器电极层大致彼此上下设置，例如，在工作电极上方的参考电极和对置电极上方的工作电极。电极层由电介质层分离。

52. 发明申请

US20080313896A1 Sensor with layered electrodes 有权
标题翻译：带层状电极的传感器
公开(公告)号：US20080313896A1
公开(公告)日：2008-12-25
申请号：US12229206
申请日：2008-08-20
申请人： Rajiv Shah , Rebecca K. Gottlieb
发明人： Rajiv Shah , Rebecca K. Gottlieb
IPC分类号： H05K3/10
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/0017 , A61B5/14532 , A61B5/6848 , A61B5/6849 , C12Q1/006 , C23C14/20 , C23C14/3414 , G01N27/307 , G01N27/3273 , G01N27/4166 , Y10T29/49002 , Y10T29/49005 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155
摘要： A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.
摘要翻译：提供薄膜传感器，例如葡萄糖传感器，用于经皮放置在患者体内的选定部位。传感器包括几个传感器层，其包括导电层，并且包括限定适于与合适的监视器电连接的导电触点的近端段，以及具有用于经皮放置的传感器电极的远端段。传感器电极层大致彼此上下设置，例如，在工作电极上方的参考电极和对置电极上方的工作电极。电极层由电介质层分离。

53. 发明授权

US09364177B2 Sensor with layered electrodes 有权
标题翻译：带层状电极的传感器
公开(公告)号：US09364177B2
公开(公告)日：2016-06-14
申请号：US12757796
申请日：2010-04-09
申请人： Rajiv Shah , Rebecca K. Gottlieb
发明人： Rajiv Shah , Rebecca K. Gottlieb
IPC分类号： A61B5/05 , A61B5/1486 , A61B5/145 , A61B5/00 , C12Q1/00 , C23C14/20 , C23C14/34
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/0017 , A61B5/14532 , A61B5/6848 , A61B5/6849 , C12Q1/006 , C23C14/20 , C23C14/3414 , G01N27/307 , G01N27/3273 , G01N27/4166 , Y10T29/49002 , Y10T29/49005 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155
摘要： A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.
摘要翻译：提供薄膜传感器，例如葡萄糖传感器，用于经皮放置在患者体内的选定部位。传感器包括几个传感器层，其包括导电层，并且包括限定适于与合适的监视器电连接的导电触点的近端段，以及具有用于经皮放置的传感器电极的远端段。传感器电极层大致彼此上下设置，例如，在工作电极上方的参考电极和对置电极上方的工作电极。电极层由电介质层分离。

54. 发明授权

US09072476B2 Flexible sensor apparatus 有权
标题翻译：灵活的传感器设备
公开(公告)号：US09072476B2
公开(公告)日：2015-07-07
申请号：US11234722
申请日：2005-09-23
申请人： Rajiv Shah , Rebecca K. Gottlieb , Eric A. Larson
发明人： Rajiv Shah , Rebecca K. Gottlieb , Eric A. Larson
IPC分类号： A61B5/05 , A61B5/00 , A61B5/1486 , A61B5/145 , A61B17/34
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6849 , A61B2017/3407 , A61B2562/164
摘要： A flexible mounting base to hold a sensor at an infusion site, the sensor being a removable in vivo sensor for monitoring analyte concentration level in a patient, such as blood glucose (BG) level. The mounting base comprises a flexible adhesive that anchors the flexible sensor set at an infusion site to provide stability for the sensor set in a convenient and comfortable manner. Placement of the mounting base onto the patient's skin causes the insertion needle to pierce the skin for transcutaneous placement of the cannula with the sensor therein. The insertion needle can then be withdrawn to leave the cannula and sensor at the selected insertion position, with the distal segment of the sensor being exposed to patient extracellular fluid via apertures formed in the cannula.
摘要翻译：用于将传感器保持在输注位置的柔性安装基座，所述传感器是可移动的体内传感器，用于监测患者中的分析物浓度水平，例如血糖（BG）水平。安装基座包括柔性粘合剂，其将柔性传感器组固定在输注位置处，以便于和舒适地为传感器组提供稳定性。将安装基座放置在患者皮肤上使得插入针刺穿皮肤，以便将套管与传感器经皮放置在其中。然后可以将插入针抽出以将套管和传感器留在所选择的插入位置，传感器的远端部分通过形成在插管中的孔暴露于患者细胞外液。

55. 发明授权

US08850687B2 Method of making a sensor 有权
标题翻译：制作传感器的方法
公开(公告)号：US08850687B2
公开(公告)日：2014-10-07
申请号：US12980244
申请日：2010-12-28
申请人： Rajiv Shah , Rebecca K. Gottlieb
发明人： Rajiv Shah , Rebecca K. Gottlieb
IPC分类号： H01S4/00 , A61B5/1486 , A61B5/145 , A61B5/00 , C12Q1/00
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/0017 , A61B5/14532 , A61B5/6848 , A61B5/6849 , C12Q1/006 , C23C14/20 , C23C14/3414 , G01N27/307 , G01N27/3273 , G01N27/4166 , Y10T29/49002 , Y10T29/49005 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155
摘要： A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.
摘要翻译：提供薄膜传感器，例如葡萄糖传感器，用于经皮放置在患者体内的选定部位。传感器包括几个传感器层，其包括导电层，并且包括限定适于与合适的监视器电连接的导电触点的近端段，以及具有用于经皮放置的传感器电极的远端段。传感器电极层大致彼此上下设置，例如，在工作电极上方的参考电极和对置电极上方的工作电极。电极层由电介质层分离。

56. 发明授权

US07882611B2 Method of making an analyte sensor 有权
标题翻译：制作分析物传感器的方法
公开(公告)号：US07882611B2
公开(公告)日：2011-02-08
申请号：US12229206
申请日：2008-08-20
申请人： Rajiv Shah , Rebecca K. Gottlieb
发明人： Rajiv Shah , Rebecca K. Gottlieb
IPC分类号： H01S4/00
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/0017 , A61B5/14532 , A61B5/6848 , A61B5/6849 , C12Q1/006 , C23C14/20 , C23C14/3414 , G01N27/307 , G01N27/3273 , G01N27/4166 , Y10T29/49002 , Y10T29/49005 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155
摘要： A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.
摘要翻译：提供薄膜传感器，例如葡萄糖传感器，用于经皮放置在患者体内的选定部位。传感器包括几个传感器层，其包括导电层，并且包括限定适于与合适的监视器电连接的导电触点的近端段，以及具有用于经皮放置的传感器电极的远端段。传感器电极层大致彼此上下设置，例如，在工作电极上方的参考电极和对置电极上方的工作电极。电极层由电介质层分离。

57. 发明申请

US20120097554A1 ANALYTE SENSORS COMPRISING ELECTRODES HAVING SELECTED ELECTROCHEMICAL AND MECHANICAL PROPERTIES 审中-公开
标题翻译：包含选择电化学和机械性质的电极的分析仪传感器
公开(公告)号：US20120097554A1
公开(公告)日：2012-04-26
申请号：US13276183
申请日：2011-10-18
申请人： Rajiv Shah , Eric Allan Larson , Katherine T. Wolfe , Daniel E. Pesantez
发明人： Rajiv Shah , Eric Allan Larson , Katherine T. Wolfe , Daniel E. Pesantez
IPC分类号： G01N33/66 , A61B5/1473 , G01N27/327
CPC分类号： C12Q1/006 , A61B5/076 , A61B5/1473 , G01N27/3274
摘要： Embodiments of the invention disclosed herein comprise amperometric glucose sensor systems that include multiple working electrodes having different material properties as well as algorithms and other elements designed for use with such systems. While embodiments of the innovation can be used in a number of contexts, typical embodiments of the invention include glucose sensors used to facilitate the management of diabetes.
摘要翻译：本文公开的本发明的实施例包括电流葡萄糖传感器系统，其包括具有不同材料性质的多个工作电极以及被设计用于与这种系统一起使用的算法和其它元件。尽管可以在许多情况下使用创新的实施例，但是本发明的典型实施例包括用于促进糖尿病管理的葡萄糖传感器。

58. 发明申请

US20120046533A1 COMBINED SENSOR AND INFUSION SETS 审中-公开
标题翻译：组合传感器和输液器
公开(公告)号：US20120046533A1
公开(公告)日：2012-02-23
申请号：US13008723
申请日：2011-01-18
申请人： Gayane R. Voskanyan , Katherine T. Wolfe , Brian Chung , Eric Allan Larson , Jose J. Ruelas , Rajiv Shah
发明人： Gayane R. Voskanyan , Katherine T. Wolfe , Brian Chung , Eric Allan Larson , Jose J. Ruelas , Rajiv Shah
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/14865 , A61B5/4839 , A61B5/6849 , A61M5/158
摘要： Embodiments of the invention provide a dual insertion set for supplying a fluid to the body of a patient and for monitoring a body characteristic of the patient. Typical embodiments of the invention include a base, an infusion portion coupled to a first piercing member and a sensor portion coupled to a second piercing member. The infusion portion includes a cannula coupled to the piercing member for supplying a fluid to a placement site. The sensor portion includes a sensor coupled to and extending from the base having at least one sensor electrode formed on a substrate and is coupled to the piercing member in a manner that allows the sensor to be inserted at the placement site. The base is arranged to secure the dual insertion set to the skin of a patient. Typically the infusion portion and sensor portion piercing members are arranged such that when they are operatively coupled to the base, they are disposed in a spatial orientation designed to inhibit sensor interference that may be caused by compounds present in fluids infused through the cannula.
摘要翻译：本发明的实施例提供了一种用于向患者的身体供应流体并用于监测患者的身体特征的双重插入组。本发明的典型实施例包括底座，联接到第一刺穿构件的输注部分和联接到第二穿刺构件的传感器部分。输注部分包括联接到穿刺构件的套管，用于将流体供应到放置位置。所述传感器部分包括传感器，所述传感器耦合到所述底座并且具有至少一个传感器电极并从所述底座延伸并且以允许所述传感器插入所述放置位置的方式联接到所述穿孔构件。基座设置成将双重插入件固定到患者的皮肤上。通常，输注部分和传感器部分刺穿构件被布置成使得当它们可操作地联接到基部时，它们被设置成空间方向，其设计成阻止可能由存在于通过插管注入的流体中的化合物引起的传感器干扰。

59. 发明申请

US20110230735A1 ANALYTE SENSOR APPARATUSES HAVING IMPROVED ELECTRODE CONFIGURATIONS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：具有改进的电极配置的分析仪传感器设备及其制造和使用它们的方法
公开(公告)号：US20110230735A1
公开(公告)日：2011-09-22
申请号：US13047431
申请日：2011-03-14
申请人： Katherine T. Wolfe , Ameya S. Kantak , Eric Allan Larson , Daniel E. Pesantez , Dongjuan Xi , Chia-Hung Chiu , Rajiv Shah
发明人： Katherine T. Wolfe , Ameya S. Kantak , Eric Allan Larson , Daniel E. Pesantez , Dongjuan Xi , Chia-Hung Chiu , Rajiv Shah
IPC分类号： A61B5/145 , G01N27/26 , G01N33/50
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/6848
摘要： Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：本发明的实施例提供了具有优化的元件和/或元件构造的分析物传感器以及用于制造和使用这种传感器的方法。本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

60. 发明授权

US10448872B2 Analyte sensor apparatuses having improved electrode configurations and methods for making and using them 有权
公开(公告)号：US10448872B2
公开(公告)日：2019-10-22
申请号：US13047431
申请日：2011-03-14
申请人： Katherine T. Wolfe , Ameya S. Kantak , Eric Allan Larson , Daniel E. Pesantez , Dongjuan Xi , Chia-Hung Chiu , Rajiv Shah
发明人： Katherine T. Wolfe , Ameya S. Kantak , Eric Allan Larson , Daniel E. Pesantez , Dongjuan Xi , Chia-Hung Chiu , Rajiv Shah
IPC分类号： A61B5/1486 , A61B5/145 , A61B5/00
摘要： Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

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