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51. 发明专利

CO2017010583A2 Compuestos de pirazol y método para elaborar y usar los compuestos 未知
公开(公告)号：CO2017010583A2
公开(公告)日：2018-01-05
申请号：CO2017010583
申请日：2017-10-17
申请人： RIGEL PHARMACEUTICALS INC
发明人： SINGH RAJINDER , KELLEY RYAN , LI HUI , HECKRODT THILO , CHEN YAN , MCMURTRIE DARREN , TSO KIN , TAYLOR VANESSA , YEN ROSE , MAUNG JACK
IPC分类号： C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/426 , A61P9/00 , A61P35/00 , A61P43/00 , C07D405/04 , C07D413/04 , C07D417/04 , C07D417/14
摘要： RESUMEN COMPUESTOS DE PIRAZOL Y MÉTODO PARA ELABORAR Y USAR LOS COMPUESTOS Las realizaciones divulgadas tratan de inhibidores de cinasas asociadas con receptores de interleucina (IRAK) y composiciones que comprenden estos inhibidores. También se divulgan métodos para elaborar y usar los compuestos y las composiciones. Los compuestos y/o las composiciones divulgados se pueden usar para tratar o prevenir una enfermedad o afección asociada con IRAK.

52. 发明专利

CA2673125C COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 未知
公开(公告)号：CA2673125C
公开(公告)日：2015-04-21
申请号：CA2673125
申请日：2007-10-19
申请人： RIGEL PHARMACEUTICALS INC
发明人： LI HUI , ARGADE ANKUSH , THOTA SAMBAIAH , CARROLL DAVID , SRAN ARVINDER , COOPER ROBIN , SINGH RAJINDER , TSO KIN , BHAMIDIPATI SOMASEKHAR
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61P37/06 , C07D401/12 , C07D403/12 , C07D417/12 , C07D498/04
摘要： The invention encompasses compounds having formula (I) and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases are therapeutically useful.

53. 发明专利

NZ582485A CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS 未知
公开(公告)号：NZ582485A
公开(公告)日：2012-05-25
申请号：NZ58248508
申请日：2008-07-17
申请人： RIGEL PHARMACEUTICALS INC
发明人： SINGH RAJINDER , LI HUI , ZHAO HAORAN , PAYAN DONALD G , KOLLURI RAO , TSO KIN , RAMPHAL JOHN , GU SHIHAI
IPC分类号： C07D401/12 , A61K31/506 , A61P35/00 , C07D239/48 , C07D401/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D498/04
摘要： Disclosed is a pyrimidine compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are: 5-Fluoro-N2-[3-methoxy-5-(1H-1,2,3,4-tetrazol-1-yl)]phenyl-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-2,4-pyrimidine diamine; N2-[3-Methoxy-5-(1,2,3,4-tetrazol-1-yl)]phenyl-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-5-trifluoromethyl-2,4-pyrimidine diamine and 5-Fluoro-N4-(1,2,2,6, 6-pentamethylpiperidin-4-yl)-N2-(3-tetrazol-1-yl)phenyl-2,4-pyrimidine diamine. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating inflammatory or immune disorder, asthma, atopic dermatitis, allergic rhinitis, systemic anaphylaxis, hypersensitivity responses, drug allergies, insect sting allergies, dermatitis, eczema, urticaria, inflammatory bowel disease, Crohn's disease, ileitis, Celiac disease, non-tropical Sprue, enteritis, enteropathy, colitis, eosinophilic gastroenteritis, ileoanal anastomosis, disorders of the skin, multiple sclerosis, systemic lupus erythermatosus, myasthenia gravis, juvenile onset diabetes, glomerulonephritis, autoimmune thyroiditis, Behcet's disease, graft rejection, stroke, cardiac ischemia, mastitis, vaginitis, cholecystitis, cholangitis, chronic bronchitis, chronic sinusitis, chronic inflammatory diseases of the lung, hypersensitivity pneumonitis, collagen diseases, sarcoidosis, vasculitis, spondyloarthropathies, scleroderma, atherosclerosis, restenosis, myositis pancreatitis, insulin-dependent diabetes mellitus, autoimmune thrombocytopenia, rheumatoid arthritis, osteoarthritis, multiple sclerosis, inflammatory bowel disease, psoriasis, organ transplantation, graft vs. host disease, asthma, chronic obstructive pulmonary disease, osteoarthritis, multiple sclerosis, psoriasis, organ transplantation, insulin-dependent diabetes, a metabolic disorder, insulin resistance, metabolic syndrome, or type II diabetes.

54. 发明专利

NZ563454A 2,4-diaminopyrimidine derivatives for inhibition of the JAK pathway 未知
公开(公告)号：NZ563454A
公开(公告)日：2011-03-31
申请号：NZ56345406
申请日：2006-06-08
申请人： RIGEL PHARMACEUTICALS INC
发明人： SAMBAIAH THOTA , LI HUI , CARROLL DAVID , ARGADE ANKUSH , TSO KIN , SRAN ARVINDER , CLOUGH JEFFREY , KEIM HOLGER , BHAMIDIPATI SOMASEKHAR , TAYLOR VANESSA , COOPER ROBIN , SINGH RAJINDER , WONG BRIAN
IPC分类号： C07D239/48 , A61K31/505
摘要： Disclosed are 2,4-diaryl substituted pyrimidine diamines with a sulphonamide substituted phenyl ring of formula (III), wherein the substituents are as defined in the specification. Also disclosed is their use in treating conditions in which modulation of the JAK pathway or inhibition of the JAK kinases, particularly JAK3, may be useful.

55. 发明专利

CA2749248A1 METHODS FOR TREATING INFLAMMATORY DISORDERS USING 2,4-PYRIMIDINEDIAMINE COMPOUNDS 未知
公开(公告)号：CA2749248A1
公开(公告)日：2010-07-22
申请号：CA2749248
申请日：2010-01-13
申请人： RIGEL PHARMACEUTICALS INC
发明人： LI HUI , MASUDA ESTEBAN , YUNG STEPHANIE , KINOSHITA TAISEI , DING RONGXIAN , SINGH RAJINDER , GURURAJA TARIKERE , PAYAN DONALD , TSO KIN
IPC分类号： A61K31/506 , A61K31/505 , A61P29/00
摘要： Methods for treating an inflammatory disorder and for inhibiting the production of IL-23 using 2,4-pyrimidinediamine compounds represented by formula (I):

56. 发明专利

CA2673125A1 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 未知
公开(公告)号：CA2673125A1
公开(公告)日：2008-04-24
申请号：CA2673125
申请日：2007-10-19
申请人： RIGEL PHARMACEUTICALS INC
发明人： LI HUI , ARGADE ANKUSH , CARROLL DAVID , SRAN ARVINDER , THOTA SAMBAIAH , COOPER ROBIN , SINGH RAJINDER , TSO KIN , BHAMIDIPATI SOMASEKHAR
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61P37/06 , C07D401/12 , C07D403/12 , C07D417/12 , C07D498/04
摘要： The invention encompasses compounds having formula (I) and the compositio ns and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases are therapeutica lly useful.

57. 发明专利

SG137989A1 Compositions and methods for inhibition of the JAK pathway 未知
公开(公告)号：SG137989A1
公开(公告)日：2008-01-28
申请号：SG200718255
申请日：2006-06-08
申请人： RIGEL PHARMACEUTICALS INC
发明人： BHAMIDIPATI SOMASEKHAR , LI HUI , CLOUGH JEFFREY , SINGH RAJINDER , TAYLOR VANESSA , CARROLL DAVID , SRAN ARVINDER , KEIM HOLGER , THOTA SAMBAIAH , WONG BRIAN , TSO KIN , COOPER ROBIN , ARGADE ANKUSH
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

58. 发明专利

CA2608367A1 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 未知
公开(公告)号：CA2608367A1
公开(公告)日：2006-12-14
申请号：CA2608367
申请日：2006-06-08
申请人： RIGEL PHARMACEUTICALS INC
发明人： LI HUI , BHAMIDIPATI SOMASEKHAR , TAYLOR VANESSA , THOTA SAMBAIAH , COOPER ROBIN , KEIM HOLGER , SRAN ARVINDER , TSO KIN , CLOUGH JEFFREY , ARGADE ANKUSH , CARROLL DAVID , SINGH RAJINDER , WONG BRIAN
IPC分类号： A61K31/549 , A61K31/505 , A61K31/506 , C07D403/02 , C07D417/02
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.

59. 发明专利

CA2867760C INDOLIZINYL DERIVATIVES AS PROTEIN KINASE C INHIBITORS AND USES THEREOF 未知
公开(公告)号：CA2867760C
公开(公告)日：2021-10-05
申请号：CA2867760
申请日：2013-04-04
申请人： RIGEL PHARMACEUTICALS INC
发明人： SINGH RAJINDER , DUNCTON MATTHEW , ZHANG JING , ALVAREZ SALVADOR , TSO KIN , HOLLAND SACHA , YEN ROSE , KOLLURI RAO , HECKRODT THILO , CHEN YAN , MASUDA ESTEBAN , LI HUI , PAYAN DONALD G , KELLEY RYAN
IPC分类号： C07D471/04 , A61K31/506 , A61K31/538 , A61K31/553 , A61K31/7064
摘要： This disclosure pertains to compounds of formula VI: Such compounds may be useful in inhibiting protein kinase C.

60. 发明专利

SI3286181T1 Spojine pirazola in postopek izdelave in uporabe spojin 未知
公开(公告)号：SI3286181T1
公开(公告)日：2021-07-30
申请号：SI201631128
申请日：2016-04-22
申请人： RIGEL PHARMACEUTICALS INC
发明人： KELLEY RYAN , LI HUI , HECKRODT THILO , CHEN YAN , MCMURTRIE DARREN , TSO KIN , TAYLOR VANESSA , SINGH RAJINDER , YEN ROSE , MAUNG JACK
IPC分类号： C07D405/00 , A61K31/00 , A61P9/00 , A61P35/00 , A61P43/00 , C07D413/00 , C07D417/00

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