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51. 发明专利

HRP20000638A2 STEROIDAL SAPOGENINS AND THEIR DERIVATIVES FOR TREATING ALZHEIMER'S DISEASE 未知
公开(公告)号：HRP20000638A2
公开(公告)日：2001-04-30
申请号：HRP20000638
申请日：2000-09-26
申请人： PHYTOPHARM PLC
发明人： XIA ZONGQIN , HU YAER , RUBIN IAN , BROSTOFF JONATHAN , WHITTLE BRIAN , WANG WEIJUN , GUNNING PHIL
IPC分类号： C12N15/09 , A61K20060101 , A61K31/343 , A61K31/352 , A61K31/58 , A61K31/70 , A61K31/704 , A61K35/00 , A61K36/18 , A61K36/896 , A61P9/00 , A61P21/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07D493/10 , C07J71/00 , C12Q1/68 , G01N33/94
摘要： The invention discloses the use of a number of saponins and sapogenins, notably those of steroidal structure, in the treatment of cognitive disfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.

52. 发明专利

AU7538700A 5-hydroxysapogenin derivatives with anti-dementia activity 未知
公开(公告)号：AU7538700A
公开(公告)日：2001-04-30
申请号：AU7538700
申请日：2000-09-29
申请人： PHYTOPHARM PLC
发明人： BARRACLOUGH PAUL , HANSON JIM , GUNNING PHIL , REES DARYL , XIA ZONGQIN , HU YAER , TOBIN ANDREW
IPC分类号： A23L2/52 , A23L1/30 , A61K31/58 , A61K36/18 , A61K36/896 , A61P3/00 , A61P9/02 , A61P21/04 , A61P25/14 , A61P25/16 , A61P25/28 , A61P39/02 , A61P43/00 , C07J71/00
摘要： The invention discloses the use of 5-hydroxysapogenin derivatives in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical composition are also disclosed.

53. 发明专利

AU7538200A Sapogenin derivatives and their use in the treatment of cognitive dysfunction 未知
公开(公告)号：AU7538200A
公开(公告)日：2001-04-30
申请号：AU7538200
申请日：2000-09-29
申请人： PHYTOPHARM PLC
发明人： BARRACLOUGH PAUL , HANSON JIM , GUNNING PHIL , REES DARYL , XIA ZONGQIN , HU YAER , TOBIN ANDREW
IPC分类号： A23L1/30 , A61K31/575 , A61K31/58 , A61K36/18 , A61K36/896 , A61P21/04 , A61P25/14 , A61P25/16 , A61P25/28 , C07J9/00 , C07J71/00

54. 发明专利

NO20004803A 未知
公开(公告)号：NO20004803A
公开(公告)日：2000-11-27
申请号：NO20004803
申请日：2000-09-26
申请人： PHYTOPHARM PLC
发明人： XIA ZONGQIN , HU YAER , RUBIN IAN , BROSTOFF JONATHAN , WHITTLE BRIAN ANTHONY , WANG WEIJUN , GUNNING PHIL
IPC分类号： C12N15/09 , A61K20060101 , A61K31/343 , A61K31/352 , A61K31/58 , A61K31/70 , A61K31/704 , A61K35/00 , A61K36/18 , A61K36/896 , A61P9/00 , A61P21/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07D493/10 , C07J71/00 , C12Q1/68 , G01N33/94 , A61K31/00
CPC分类号： A61K31/704 , A61K31/58 , A61K31/7048 , A61K36/88 , A61K36/896 , A61K36/8964 , A61K36/8965 , A61K36/90 , G01N33/944

55. 发明专利

NO20083993L 未知
公开(公告)号：NO20083993L
公开(公告)日：2000-09-11
申请号：NO20083993
申请日：2008-09-19
申请人： PHYTOPHARM PLC
发明人： XIA ZONGQIN , HU YAER , RUBIN IAN , BROSTOFF JONATHAN , WHITTLE BRIAN , WANG WEIJUN , GUNNING PHIL
IPC分类号： A61K31/58 , C12N15/09 , A61K20060101 , A61K31/343 , A61K31/352 , A61K31/70 , A61K31/704 , A61K35/00 , A61K36/18 , A61K36/896 , A61P9/00 , A61P21/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07D493/10 , C07J71/00 , C12Q1/68 , G01N33/94
摘要： The invention discloses the use of a number of saponins and sapogenins, notably those of steroidal structure, in the treatment of cognitive disfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.

56. 发明专利

GB2335599A Treatment of conditions characterised by a deficiency in the number and function of membrane bound receptors using saponins and sapogenins 未知
公开(公告)号：GB2335599A
公开(公告)日：1999-09-29
申请号：GB9907100
申请日：1999-03-26
申请人： PHYTOPHARM PLC
发明人： XIA ZONGQIN , HU YAER , RUBIN IAN , BROSTOFF JONATHAN , WHITTLE BRIAN ANTHONY , WANG WEIJUN , GUNNING PHIL
IPC分类号： C12N15/09 , A61K20060101 , A61K31/343 , A61K31/352 , A61K31/58 , A61K31/70 , A61K31/704 , A61K35/00 , A61K36/18 , A61K36/896 , A61P9/00 , A61P21/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07D493/10 , C07J71/00 , C12Q1/68 , G01N33/94 , A61K35/78
摘要： A method of treating conditions that are characterised by a deficiency in the number and function of membrane bound receptors. Such conditions include Alzheimer's disease, senile dementia (of the Alzheimer's type), Parkinson's disease, postural hypotension, chronic fatigue syndrome, Lewing-Bedy disease, Gulf War syndrome, autism, Myasthenia Gravis, Lambert Eaton disease, exposure to organo-phosphorus compounds and age-related problems of muscle and heart fibre. The mechanism of how these diseases are related to the number and function of membrane bound receptors is described in detail. Saponins and sapogenins, such as anzurogenin D, diosgenin, hecogenin, prazerigenin, ruscogenin, smilagenin, sisalogenin, sarsasapogenin, tigogenin or astragaloside, exhibit the ability to regulate receptor activity. Their ability to regulate the number and function of membrane bound receptors (muscarinic receptors) was studied in chinese hamster ovary cells and in cultured cardiac cells. Non-oestrogenic saponins and sapogenins are the preferred compounds. Saponins and sapogenins of this type were also claimed to have cognitive function enhancing properties when used to treat age-related cognitive dysfunction. These compounds may be derived from a plant of the genus Agave, Anemarrhena, Asparagus, Smilax or Yucca.

57. 发明专利

PT1246835E SAPOGENINAS SUBSTITUÍDAS E SUA UTILIZAÇÃO 未知
公开(公告)号：PT1246835E
公开(公告)日：2009-04-15
申请号：PT01900185
申请日：2001-01-08
申请人： PHYTOPHARM PLC
发明人： BARRACLOUGH PAUL , HANSON JIM , GUNNING PHIL , REES DARYL , XIA ZONGQIN , HU YAER
IPC分类号： A23L1/30 , A23L2/38 , A23L2/52 , C07J1/00 , A61K31/575 , A61K31/58 , A61P21/04 , A61P25/16 , A61P25/28 , A61P43/00 , C07J9/00 , C07J71/00

58. 发明专利

DE60137307D1 未知
公开(公告)号：DE60137307D1
公开(公告)日：2009-02-26
申请号：DE60137307
申请日：2001-01-08
申请人： PHYTOPHARM PLC GODMANCHESTER
发明人： BARRACLOUGH PAUL , HANSON JIM , GUNNING PHIL , REES DARYL , XIA ZONGQIN , HU YAER
IPC分类号： A23L2/38 , C07J1/00 , A23L1/30 , A23L2/52 , A61K31/575 , A61K31/58 , A61P21/04 , A61P25/16 , A61P25/28 , A61P43/00 , C07J9/00 , C07J71/00
摘要： The invention discloses substituted sapogenins and their use in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical composition are also disclosed

59. 发明专利

AU2002242894B2 Sapogenin derivatives, their synthesis and use 未知
公开(公告)号：AU2002242894B2
公开(公告)日：2008-08-21
申请号：AU2002242894
申请日：2002-03-28
申请人： PHYTOPHARM PLC
发明人： BARRACLOUGH PAUL , GUNNING PHIL , REES DARYL , HU YAER , HANSON JIM , XIA ZONGQIN
IPC分类号： A23L1/30 , C07J71/00 , A61K20060101 , A61K31/58 , A61K31/585 , A61K36/18 , A61P3/02 , A61P9/02 , A61P9/04 , A61P11/06 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/00 , A61P27/02 , C07J41/00 , C07J75/00
摘要： The invention discloses certain steroidal sapogenins and derivatives thereof, and their use in the treatment of cognitive dysfunction, non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, and receptor loss in the absence of cognitive, neural and neuromuscular impairment. Methods of synthesis, treatment and pharmaceutical compositions are also disclosed.

60. 发明专利

NZ547344A Therapeutic methods and uses of sapogenins and their derivatives 未知
公开(公告)号：NZ547344A
公开(公告)日：2007-11-30
申请号：NZ54734403
申请日：2003-03-27
申请人： PHYTOPHARM PLC
发明人： REES DARYL , GUNNING PHIL , ORSI ANTONIA , XIA ZONGQIN , HU YAER
IPC分类号： A61K31/58 , A61K31/585 , A61K31/655 , A61P9/02 , A61P9/04 , A61P11/06 , A61P21/00 , A61P21/04 , A61P25/08 , A61P25/16 , A61P25/28 , A61P27/00 , C07J20060101 , C07J71/00
摘要： Disclosed is a use of one or more active agent selected from compounds of the general formula (Ia): wherein the group Ra is selected from hydrogen; alkylcarbonyl; alkoxycarbonyl; alkyl-carbamoyl; or arylcarbonyl; or sulpho (HO3S); phosphono ((HO)2P(O)-); or a mono-, di- or tri-saccharide; wherein any alkyl group is optionally substituted with aryl, amino, mono- or di-alkyl-amino, a carboxylic acid residue (-COOH), or any combination thereof; and all their steroisomers, unless stereochemically defined above, and racemic mixtures, all their pharmaceutically acceptable salts, and all mixtures and combinations thereof, in the preparation of compositions for the treatment or prevention of any of the following diseases in a human or, where possible, non-human animal suffering therefrom or susceptible thereto: depression, schizophrenia, muscular dystrophy including facioscapulohumeral muscular dystrophy (FSH), Duchenne muscular dystrophy, Becker muscular dystrophy and Bruce's muscular dystrophy, Fuchs' dystrophy, myotonic dystrophy, corneal dystrophy, reflex sympathetic dystrophy syndrome (RSDSA), neurovascular dystrophy, Huntington's disease, motor neurone diseases including amyotrophic lateral sclerosis (ALS), traumatic neurodegeneration e.g. following stroke or following an accident (for example, traumatic 25 head injury or spinal cord injury), Batten's disease, Cockayne syndrome, Down syndrome, corticobasal ganglionic degeneration, multiple system atrophy, cerebral atrophy, olivopontocerebellar atrophy, dentatorubral atrophy, pallidoluysian atrophy, spinobulbar atrophy, optic neuritis, sclerosing pan-encephalitis (SSPE), attention deficit disorder, post- viral encephalitis, post-poliomyelitis syndrome, Fahr's syndrome, Joubert syndrome, Guillain-Barre syndrome, lissencephaly, Moyamoya disease, neuronal migration disorders, polyglutamine disease, Niemann-Pick disease, progressive multifocal leukoencephalopathy, pseudotumor cerebri, Refsum disease, Zellweger syndrome, supranuclear palsy, Friedreich's ataxia, spinocerebellar ataxia type 2, Rhett syndrome, Shy-Drager syndrome, tuberous sclerosis, Pick's disease, neuropathies including hereditary neuropathy, diabetic neuropathy and mitotic neuropathy, prion-based neurodegeneration, including Creutzfeldt-Jakob disease (CJD), variant CJD, new variant CJD, bovine spongiform encephalopathy (BSE), GSS, FFI, kuru and Alper's syndrome, Joseph's disease, acute disseminated encephalomyelitis, arachnoiditis, vascular lesions of the central nervous system, loss of extremity neuronal function, Charcot-Marie-Tooth disease, susceptibility to heart failure, and macular degeneration.

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