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51. 发明授权

US06979424B2 Integrated sample analysis device 失效
标题翻译：综合样本分析装置
公开(公告)号：US06979424B2
公开(公告)日：2005-12-27
申请号：US09929270
申请日：2001-08-13
申请人： M. Allen Northrup , Kurt E. Petersen , William A. McMillan , Gregory T. A. Kovacs
发明人： M. Allen Northrup , Kurt E. Petersen , William A. McMillan , Gregory T. A. Kovacs
IPC分类号： B01J19/00 , B01L3/00 , G01N27/447 , G01N30/60 , G01N1/00 , B01J8/00 , C12Q1/68 , G01N15/00
CPC分类号： G01N27/44743 , B01J19/0093 , B01L3/502738 , B01L3/502753 , B01L2300/1883 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0633 , B01L2400/0655 , G01N30/6095
摘要： An analysis device comprises a body having a reaction chamber for chemically reacting a sample, a separation region for separating components of the sample, and a transition region connecting the reaction chamber to the separation region. The transition region includes at least one valve for controlling the flow of fluid between the reaction chamber and the separation region. Further, the transition region thermally isolates the reaction chamber from the separation region. In a preferred embodiment, the reaction chamber is an amplification chamber for amplifying nucleic acid in the sample, and the separation region comprises an electrophoresis channel containing a suitable matrix material, such as electrophoresis gel or buffer, for separating nucleic acid fragments. Electrodes are embedded in the body for separation of sample components. The body may also be surrounded by external, functional components such as an optical detector for detecting separated components of the sample.
摘要翻译：分析装置包括具有用于使样品化学反应的反应室的主体，用于分离样品的组分的分离区域和将反应室连接到分离区域的过渡区域。过渡区域包括用于控制反应室和分离区域之间的流体流动的至少一个阀。此外，过渡区域将反应室与分离区域热隔离。在一个优选的实施方案中，反应室是用于扩增样品中的核酸的扩增室，分离区域包含一个电泳通道，其中含有合适的基质材料，如电泳凝胶或缓冲液，用于分离核酸片段。电极被嵌入在体内用于分离样品组分。身体也可以被外部功能部件包围，例如用于检测样品的分离成分的光学检测器。

52. 发明授权

US06940598B2 Multi-channel optical detection system 有权
标题翻译：多通道光学检测系统
公开(公告)号：US06940598B2
公开(公告)日：2005-09-06
申请号：US10119228
申请日：2002-04-08
申请人： Lee A. Christel , M. Allen Northrup , Kurt E. Petersen , William A. McMillan , Gregory T. A. Kovacs , Steven J. Young , Ronald Chang , Douglas B. Dority , Raymond T. Hebert , Gregory J. Kintz
发明人： Lee A. Christel , M. Allen Northrup , Kurt E. Petersen , William A. McMillan , Gregory T. A. Kovacs , Steven J. Young , Ronald Chang , Douglas B. Dority , Raymond T. Hebert , Gregory J. Kintz
IPC分类号： B01J19/00 , B01L3/00 , B01L3/14 , B01L7/00 , F28F3/12 , F28F21/04 , G01N21/03 , G01N35/00 , G01N21/64
CPC分类号： B01L3/508 , B01J19/0093 , B01L3/5082 , B01L7/52 , B01L2300/042 , B01L2300/0809 , B01L2300/0858 , B01L2300/168 , B01L2300/1805 , F28D2021/0077 , F28F3/12 , F28F21/04 , F28F2280/10 , G01N21/0303 , G01N21/0332 , G01N2035/00326
摘要： An apparatus for thermally controlling and optically interrogating a reaction mixture includes a vessel [2] having a chamber [10] for holding the mixture. The apparatus also includes a heat-exchanging module [37] having a pair of opposing thermal plates [34A, 34B] for receiving the vessel [2] between them and for heating/and or cooling the mixture contained in the vessel. The module [37] also includes optical excitation and detection assemblies [46,48] positioned to optically interrogate the mixture. The excitation assembly [46] includes multiple light sources [100] and a set of filters for sequentially illuminating labeled analytes in the mixture with excitation beams in multiple excitation wavelength ranges. The detection assembly [48] includes multiple detectors [102] and a second set of filters for detecting light emitted from the chamber [10] in multiple emission wavelength ranges. The optics assemblies [46,48] thus provide a multi-channel system for detecting a plurality of different target analytes in the mixture.
摘要翻译：用于热控制和光学询问反应混合物的装置包括具有用于保持混合物的室[10]的容器[2]。该装置还包括具有一对相对的热板[34A，34B]的热交换模块[37]，用于在它们之间接收容器[2]并用于加热和/或冷却容器中所含的混合物。模块[37]还包括定位成光学询问混合物的光学激发和检测组件[46,48]。激发组件[46]包括多个光源[100]和一组用于在多个激发波长范围内用激发光束顺序地照射混合物中的标记分析物的滤光器。检测组件[48]包括多个检测器[102]和第二组滤波器，用于在多个发射波长范围内检测从腔室[10]发射的光。因此，光学组件[46,48]提供用于检测混合物中的多个不同目标分析物的多通道系统。

53. 发明授权

US06836584B1 Optical microswitch 有权
标题翻译：光学微动开关
公开(公告)号：US06836584B1
公开(公告)日：2004-12-28
申请号：US09524727
申请日：2000-03-14
申请人： John H. Jerman , John D. Grade , Joseph D. Drake , Kurt E. Petersen
发明人： John H. Jerman , John D. Grade , Joseph D. Drake , Kurt E. Petersen
IPC分类号： G02B635
CPC分类号： G02B6/3548 , G02B6/3518 , G02B6/357 , G02B6/3582 , G02B6/3584 , G02B6/4216 , G02B26/0833 , G02B26/0841 , G11B7/0037 , G11B7/08564 , G11B7/122 , G11B7/1362 , G11B7/1384 , G11B11/10543 , G11B11/1058 , H02N1/008
摘要： An optical microswitch for use with a laser beam that extends along a path comprising a body having an inlet port adapted to receive the laser beam and a plurality of outlet ports. A plurality of mirrors coupled to a plurality of micromotors carried by the body. The micromotors selectively move the mirrors from a first position out of the path of the laser beam to a second position into the path of the laser beam to direct the laser beam to one of the outlet ports. Each of the micromotors has at least one electrostatically-driven comb drive assembly therein for moving the respective mirror to one of the first and second positions. A controller is electrically coupled to the micromotors for providing control signals to the micromotors.
摘要翻译：一种用于激光束的光学微动开关，其沿着包括具有适于接收激光束的入口端口和多个出口端口的主体的路径延伸。耦合到由身体携带的多个微型马达的多个反射镜。微型电动机选择性地将反射镜从第一位置移出激光束的路径到达激光束的路径的第二位置，以将激光束引导到出口之一。每个微型马达都具有至少一个静电驱动的梳齿驱动组件，用于将相应的反射镜移动到第一和第二位置之一。控制器电耦合到微型马达，用于向微型马达提供控制信号。

54. 发明授权

US06798729B1 Optical head using micro-machined elements 失效
标题翻译：光头使用微加工元件
公开(公告)号：US06798729B1
公开(公告)日：2004-09-28
申请号：US09271440
申请日：1999-03-18
申请人： Jerry E. Hurst, Jr. , Joseph Drake , Jeffrey P. Wilde , Joseph E. Davis , John F. Heanue , Kurt E. Petersen , Terry McDaniel , Jeff Drazan
发明人： Jerry E. Hurst, Jr. , Joseph Drake , Jeffrey P. Wilde , Joseph E. Davis , John F. Heanue , Kurt E. Petersen , Terry McDaniel , Jeff Drazan
IPC分类号： G11B700
CPC分类号： G02B6/3512 , B81B3/0051 , G02B6/105 , G02B6/126 , G02B6/3518 , G02B6/3548 , G02B6/357 , G02B6/3584 , G02B6/4246 , G02B26/0833 , G02B26/0841 , G02B26/085 , G02B26/0866 , G11B7/0037 , G11B7/08564 , G11B7/08576 , G11B7/0901 , G11B7/122 , G11B7/127 , G11B7/1362 , G11B7/1365 , G11B7/1372 , G11B7/1384 , G11B7/14 , G11B7/22 , G11B11/10515 , G11B11/10532 , G11B11/10534 , G11B11/10541 , G11B11/10543 , G11B11/10554 , G11B11/10563 , G11B11/10569 , G11B11/1058 , G11B11/10595 , H02N1/008 , H04B10/2572
摘要： An optical head utilizes a micro-machined element in combination with a light source and a lens to write and read data onto a storage disk. The micro-machined element may include a steerable micro-machined mirror or a micro-actuator. A beam of laser light transmitted from the light source to the optical head and a reflected light from the storage disk is altered by a movement of the micro-machined element. In this manner a focused optical spot is scanned back and forth in a direction which is approximately parallel to the radial direction of the storage disk.
摘要翻译：光学头利用微加工元件与光源和透镜组合来将数据写入和读取到存储盘上。微加工元件可以包括可操纵的微加工镜或微致动器。从光源传输到光学头的激光束和来自存储盘的反射光被微加工元件的移动所改变。以这种方式，聚焦的光点在大致平行于存储盘的径向的方向上来回扫描。

55. 发明授权

US06403037B1 Reaction vessel and temperature control system 有权
标题翻译：反应容器和温度控制系统
公开(公告)号：US06403037B1
公开(公告)日：2002-06-11
申请号：US09497848
申请日：2000-02-04
申请人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Kurt E. Petersen
发明人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Kurt E. Petersen
IPC分类号： G01N1506
CPC分类号： B01L3/502 , B01L3/50825 , B01L7/52 , B01L2200/026 , B01L2200/0642 , B01L2200/0684 , B01L2300/0654 , B01L2300/14 , B01L2400/049 , B01L2400/0644 , G01N2035/0405 , Y10T436/2575
摘要： The invention provides a reaction vessel and temperature control system for performing heat-exchanging chemical reactions, such as nucleic acid amplification. The vessel has a body defining a reaction chamber, and a loading structure extending from the body for loading a sample into the chamber. The loading structure has a loading reservoir, an aspiration port, and respective fluid channels connecting the loading reservoir and aspiration port to the chamber. To load the sample into the vessel, the sample is first dispensed into the loading reservoir and then drawn into the chamber by application of a vacuum to the aspiration port. The vessel also includes a seal aperture extending over the outer ends of the loading reservoir and aspiration port. A plug is inserted into the aperture after loading the sample into the chamber to simultaneously seal the chamber, loading reservoir, and aspiration port from the external environment. The temperature of the sample is controlled by opposing plates positioned to contact opposite sides of the vessel. The system also,includes thermal elements for heating or cooling the plates and optics for detecting one or more analytes in the sample.
摘要翻译：本发明提供了用于进行热交换化学反应如核酸扩增的反应容器和温度控制系统。容器具有限定反应室的主体和从主体延伸以将样品装载到室中的装载结构。装载结构具有装载储存器，抽吸端口和将装载储存器和抽吸端口连接到室的各个流体通道。为了将样品装载到容器中，首先将样品分配到装载容器中，然后通过向抽吸端口施加真空而将其抽吸到室中。容器还包括在装载容器和抽吸端口的外端上延伸的密封孔。将样品装入室后，将插头插入孔中，以同时将腔室，装载储存器和抽吸端口从外部环境密封。样品的温度由位于容器相对侧的相对板控制。该系统还包括用于加热或冷却板的热元件和用于检测样品中的一种或多种分析物的光学元件。

56. 发明授权

US6084257A Single crystal silicon sensor with high aspect ratio and curvilinear structures 失效
标题翻译：具有高纵横比和曲线结构的单晶硅传感器
公开(公告)号：US6084257A
公开(公告)日：2000-07-04
申请号：US449140
申请日：1995-05-24
申请人： Kurt E. Petersen , Nadim Maluf , Wendell McCulley , John Logan , Erno Klaasen , Jan M. Noworolski
发明人： Kurt E. Petersen , Nadim Maluf , Wendell McCulley , John Logan , Erno Klaasen , Jan M. Noworolski
IPC分类号： G01P15/08 , G01P15/125 , H01L29/82
CPC分类号： G01P15/0802 , G01P15/125 , G01P2015/0814 , Y10S73/01
摘要： In one aspect, the invention provides semiconductor sensor which includes a first single crystal silicon wafer layer. A single crystal silicon structure is formed in the first wafer layer. The structure includes two oppositely disposed substantially vertical major surfaces and two oppositely disposed generally horizontal minor surfaces. The aspect ratio of major surface to minor surface is at least 5:1. A carrier which includes a recessed region is secured to the first wafer layer such that said structure is suspended opposite the recessed region.
摘要翻译：一方面，本发明提供了包括第一单晶硅晶片层的半导体传感器。在第一晶片层中形成单晶硅结构。该结构包括两个相对布置的基本垂直的主表面和两个相对布置的大体水平的小的表面。主表面与次表面的纵横比至少为5：1。包括凹陷区域的载体被固定到第一晶片层，使得所述结构与凹陷区域相对地悬挂。

57. 发明授权

US6061323A Data storage system having an improved surface micro-machined mirror 失效
标题翻译：数据存储系统具有改进的表面微加工镜
公开(公告)号：US6061323A
公开(公告)日：2000-05-09
申请号：US844207
申请日：1997-04-18
申请人： John H. Jerman , Joseph Drake , Joseph E. Davis , Jeffrey P. Wilde , Kurt E. Petersen
发明人： John H. Jerman , Joseph Drake , Joseph E. Davis , Jeffrey P. Wilde , Kurt E. Petersen
IPC分类号： G02B6/10 , G02B6/126 , G02B6/35 , G02B6/42 , G02B26/08 , G11B7/085 , G11B7/09 , G11B7/12 , G11B7/125 , G11B7/135 , G11B7/14 , G11B7/22 , G11B11/105 , H02N1/00 , H04B10/135 , G11B7/00
CPC分类号： G11B7/1362 , G02B26/0833 , G02B26/0841 , G02B26/0866 , G02B6/126 , G02B6/4246 , G11B11/10532 , G11B11/10534 , G11B11/10543 , G11B11/1058 , G11B7/08564 , G11B7/122 , G11B7/127 , G11B7/1365 , G11B7/1372 , G11B7/1384 , G11B7/22 , H02N1/008 , H04B10/2572 , G02B6/105 , G02B6/3518 , G02B6/3584 , G11B11/10515 , G11B11/10554 , G11B11/10563 , G11B7/08576 , G11B7/0901 , G11B7/14
摘要： A data storage and retrieval system includes a micro machined mirror assembly (.mu.MM) having a plate layer defining a surface micro machined mirror supported at a central axis by two opposed torsional frame members connected to inner edges of a surrounding frame.
摘要翻译：数据存储和检索系统包括微加工镜组件（mu MM），其具有限定由连接到周围框架的内边缘的两个相对的扭转框架构件在中心轴线处支撑的表面微加工镜的板层。

58. 发明授权

US5958349A Reaction vessel for heat-exchanging chemical processes 失效
标题翻译：用于热交换化学过程的反应容器
公开(公告)号：US5958349A
公开(公告)日：1999-09-28
申请号：US808325
申请日：1997-02-28
申请人： Kurt E. Petersen , William A. McMillan , Gregory T. A. Kovacs , Steven J. Young
发明人： Kurt E. Petersen , William A. McMillan , Gregory T. A. Kovacs , Steven J. Young
IPC分类号： B01J19/00 , B01L3/00 , B01L7/00 , G01N21/03 , F28D8/04 , G01N21/29 , G01N21/47
CPC分类号： B01L3/505 , B01J19/0093 , B01L7/52 , G01N21/0303 , G01N21/0332 , B01J2219/00873
摘要： A reaction vessel for holding a sample for a heat-exchanging chemical process has two opposing major faces and a plurality of contiguous minor faces joining the major faces to each other. The major and minor faces form an enclosed chamber having a triangular-shaped bottom portion. The ratio of the thermal conductance of the major faces to that of the minor faces is at least 2:1, and the minor faces forming the triangular-shaped bottom portion of the chamber are optically transmissive. The vessel also has a port for introducing a sample into the chamber and a cap for sealing the chamber.
摘要翻译：用于保持用于热交换化学过程的样品的反应容器具有两个相对的主面和将主面彼此连接的多个连续的小面。主面和次面形成具有三角形底部的封闭室。主面与小面的热导率之比至少为2:1，形成腔的三角形底部的小面光学透光。容器还具有用于将样品引入室中的端口和用于密封室的盖。

59. 发明授权

US4342227A Planar semiconductor three direction acceleration detecting device and method of fabrication 失效
标题翻译：平面半导体三向加速度检测装置及其制造方法
公开(公告)号：US4342227A
公开(公告)日：1982-08-03
申请号：US219685
申请日：1980-12-24
申请人： Kurt E. Petersen , Anne C. Shartel
发明人： Kurt E. Petersen , Anne C. Shartel
IPC分类号： G01P15/08 , G01P15/125 , G01P15/18 , H01L29/78
CPC分类号： G01P15/125 , G01P15/0802
摘要： This device comprises a v-shaped cavity in a planar semiconductor substrate having a substantially thin-walled v-shaped cantilever beam inset therein. The beam is movable in directions normal to and laterally of the plane of the substrate, whereby acceleration is sensed in both of these directions. A planar substrate of n-type silicon is arranged with the major face oriented in the (100) plane. A v-shaped groove is anisotropically etched in the substrate and capacitor electrode regions are diffused into the sloping walls. An epitaxial layer is grown over this substrate, and over that a layer of insulation is added. A layer of conductive material is laid down on the insulation to define an electrode. The substrate is again subjected to an anisotropic etchant for cutting the epitaxial layer from under the cantilever beam formed of the insulating layer and the conducting layer. The electrodes form two variable capacitors which are connected in parallel or differentially to simple circuitry laid down on the same substrate for resolving the bidirectional movement of the beam. Three such devices appropriately oriented, and compatible electronic circuitry, enable all three spatial coordinates to be probed with a single substrate assembly.
摘要翻译：该装置包括在其中插入有基本上薄壁的V形悬臂梁的平面半导体衬底中的V形空腔。梁可以在垂直于基板的平面和侧面的方向上移动，由此在两个方向上都感测到加速度。 n型硅的平面衬底被布置成主面朝向（100）面。在基板中各向异性地蚀刻V形槽，并且电容器电极区域扩散到倾斜壁中。在该衬底上生长外延层，并且在该层上添加绝缘层。一层导电材料放置在绝缘体上以限定电极。衬底再次经受各向异性蚀刻剂，用于从由绝缘层和导电层形成的悬臂梁下面切割外延层。电极形成两个可并联或差分地连接到放置在同一衬底上的简单电路的可变电容器，用于解决光束的双向移动。三个这样的设备适当地定向和兼容的电子电路，使得能够用单个基板组件探测所有三个空间坐标。

60. 发明授权

US4332000A Capacitive pressure transducer 失效
标题翻译：电容式压力传感器
公开(公告)号：US4332000A
公开(公告)日：1982-05-25
申请号：US193860
申请日：1980-10-03
申请人： Kurt E. Petersen
发明人： Kurt E. Petersen
IPC分类号： G01L9/12 , G01L9/00 , H01L29/84 , H01G7/00
CPC分类号： G01L9/0073
摘要： An integrated semiconductor pressure transducer comprises a central conducting diaphragm located between two frusto-pyramidal recesses defined by contiguous semiconductor body members of conductivity type different from that of the diaphragm. A metal membrane with communicating apertures subtends one cavity and forms a relatively fixed plate of a capacitor, the other plate of which is formed by the diaphragm. A method of making the transducer in semiconductor process steps includes provisions for normal integrated circuit device fabrication whereby a transducer and utilization circuitry are fabricated in the same process into a single integrated semiconductor device.
摘要翻译：一个集成的半导体压力传感器包括一个中心导电隔膜，位于两个截头圆锥形凹槽之间，这两个截头圆锥形凹槽由与隔膜不同的导电类型的连续半导体本体构件限定。具有连通孔的金属膜对着一个空腔并形成电容器的相对固定的板，另一个板由隔膜形成。在半导体工艺步骤中制造换能器的方法包括用于正常集成电路器件制造的设备，由此将换能器和利用电路以相同的工艺制造成单个集成半导体器件。

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