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51. 发明申请

US20110106479A1 METHOD OF AND SYSTEM FOR STABILIZATION OF SENSORS 审中-公开
公开(公告)号：US20110106479A1
公开(公告)日：2011-05-05
申请号：US13004608
申请日：2011-01-11
申请人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundarapajan , David Y. Choy , Peter Schultz , Udo Hoss
发明人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundarapajan , David Y. Choy , Peter Schultz , Udo Hoss
IPC分类号： G06F19/00 , G01R35/00
摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

52. 发明申请

US20110105867A1 OPTICAL SENSOR FOR DETERMINING THE CONCENTRATION OF AN ANALYTE 有权
标题翻译：用于确定分析仪浓度的光学传感器
公开(公告)号：US20110105867A1
公开(公告)日：2011-05-05
申请号：US12741350
申请日：2008-10-31
申请人： Peter Schultz , Arkady Amosov , Natalia Izvarina , Sergey Kravetz
发明人： Peter Schultz , Arkady Amosov , Natalia Izvarina , Sergey Kravetz
IPC分类号： A61B5/1455
CPC分类号： G01N21/49 , A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/7239 , G01N21/1717 , G01N2021/1725
摘要： A method and apparatus for non-invasively determining a concentration of glucose in a subject using optical excitation and detection is provided. The method includes emitting an exciter beam (B1) to irradiate a portion (130) of tissue of the subject, causing physical and chemical changes in the surface, and causing an initial CPU back scattering (D1) of light. The method further includes periodically emitting a probe beam (B2) which irradiates the portion of tissue and causes periodic back scatterings (D2) of light. The initial and periodic back scatterings are detected and converted into electrical signals of at least the amplitude, frequency or decay time of the physical and chemical changes, the back scatterings being modulated by the physical and chemical changes. By differentiating over time at least one of the amplitude, frequency or decay time of the physical and chemical changes, the concentration of glucose may be determined.
摘要翻译：提供了使用光学激发和检测非侵入性地确定受试者中葡萄糖浓度的方法和装置。该方法包括发射激发光束（B1）以照射被检体的组织的一部分（130），引起表面的物理和化学变化，并引起光的初始CPU反向散射（D1）。该方法还包括周期性地发射照射组织部分并产生光的周期性后向散射（D2）的探针束（B2）。初始和周期性后向散射被检测并转换成至少物理和化学变化的振幅，频率或衰减时间的电信号，后向散射由物理和化学变化调制。通过随时间推移物理和化学变化的幅度，频率或衰减时间中的至少一个，可以确定葡萄糖的浓度。

53. 发明申请

US20110027867A1 Methods and compositions for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs 审中-公开
标题翻译：用于产生正交tRNA-aminoacyltRNA合成酶对的方法和组合物
公开(公告)号：US20110027867A1
公开(公告)日：2011-02-03
申请号：US11978217
申请日：2007-10-26
申请人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
IPC分类号： C12N1/00
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in viva
摘要翻译：本发明提供了用于产生蛋白质生物合成机理组分的组合物和方法，包括正交的tRNA，正交氨酰-tRNA合成酶和正向对的tRNA /合成酶。还提供了用于识别正交对的方法。这些组分可用于将非天然氨基酸掺入viva蛋白质中

54. 外观设计

USD628408S1 Table 有权
公开(公告)号：USD628408S1
公开(公告)日：2010-12-07
申请号：US29316167
申请日：2009-08-28
申请人： Peter Schultz
设计人： Peter Schultz

55. 发明授权

US07638300B2 In vivo incorporation of unnatural amino acids 有权
公开(公告)号：US07638300B2
公开(公告)日：2009-12-29
申请号：US11583551
申请日：2006-10-18
申请人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric Meggers , Ryan Aaron Mehl , Miro Pastrnak
发明人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric Meggers , Ryan Aaron Mehl , Miro Pastrnak
IPC分类号： C12P21/06 , C12N15/74 , C12N1/21
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.

56. 发明申请

US20090137424A1 Selective Posttranslational Modification of Phage-Displayed Polypeptides 有权
标题翻译：噬菌体展示多肽的选择性翻译后修饰
公开(公告)号：US20090137424A1
公开(公告)日：2009-05-28
申请号：US11992341
申请日：2006-10-11
申请人： Meng-Lin Tsao , Feng Tian , Peter Schultz
发明人： Meng-Lin Tsao , Feng Tian , Peter Schultz
IPC分类号： C40B40/02 , C12N7/00
CPC分类号： C12P21/02 , C07K14/005 , C07K2319/00 , C07K2319/50 , C12N7/00 , C12N9/93 , C12N15/1037 , C12N15/67 , C12N2795/14122
摘要： The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such asp-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2]cycloaddition reactions and Staudinger modifications.
摘要翻译：本发明涉及噬菌体展示多肽的翻译后修饰。这些显示的多肽包含至少一个非天然氨基酸，例如芳基叠氮化物氨基酸，例如叠氮基-L-苯丙氨酸，或炔基 - 氨基酸如对 - 炔丙氧基苯丙氨酸，其被并入噬菌体展示的融合多肽通过使用包含合适的正交氨酰-tRNA合成酶和合适的正交tRNA物质的体内正交翻译系统在选定的位置。这些非天然氨基酸有利地提供翻译后修饰的靶标，例如叠氮炔 - 炔[3 + 2]环加成反应和施陶丁格修饰。

57. 发明授权

US07253166B2 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells 有权
标题翻译： 6-苯基-7H-吡咯并[2,3-d]嘧啶化合物，其诱导胚胎干细胞中的神经元分化
公开(公告)号：US07253166B2
公开(公告)日：2007-08-07
申请号：US10829804
申请日：2004-04-22
申请人： Sheng Ding , Tom Wu , Nathanael S. Gray , Peter Schultz
发明人： Sheng Ding , Tom Wu , Nathanael S. Gray , Peter Schultz
IPC分类号： C07D413/10 , C07D487/04 , A61K31/519 , A61K31/5355 , A61P25/28
CPC分类号： C07D487/04
摘要： The invention provides a novel class of compounds and compositions of Formula I: in which R1, R2 and R3 are defined herein, that are useful in the treatment or prevention of diseases or disorders associated with kinases, particularly GSK-3β, c-Abl, HER-1, HER-2, KDR, Flt-3, c-Raf-1, PDGFR-β, c-Kit, Flt-4, Flt-1, Tek, c-src, CDK1, PDK1, FGFR-1, FGFR-2, Fer, MAP3K13, EPHA7 and c-Met kinases. The invention further relates to the use of the compounds of the invention as potent inducers of neurogenesis in embryonic stem cells.
摘要翻译：本发明提供了一类新颖的式I化合物和组合物，其中R 1，R 2和R 3是本文定义的，可用于治疗或预防与激酶相关的疾病或病症，特别是GSK-3β，c-Abl，HER-1，HER-2，KDR，Flt-3，c-Raf-1，PDGFR-β， Kit，Flt-4，Flt-1，Tek，c-src，CDK1，PDK1，FGFR-1，FGFR-2，Fer，MAP3K13，EPHA7和c-Met激酶。本发明还涉及本发明化合物在胚胎干细胞中作为神经发生的有效诱导剂的用途。

58. 发明申请

US20070172915A1 Glycoprotein synthesis 失效
公开(公告)号：US20070172915A1
公开(公告)日：2007-07-26
申请号：US11580203
申请日：2006-10-11
申请人： Peter Schultz , Lei Wang , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , Zhiwen Zhang
IPC分类号： C12P21/06
CPC分类号： C12P21/005
摘要： Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

59. 发明申请

US20070117184A1 In vivo incorporation of unnatural amino acids 有权
标题翻译：体内引入非天然氨基酸
公开(公告)号：US20070117184A1
公开(公告)日：2007-05-24
申请号：US11583551
申请日：2006-10-18
申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
IPC分类号： C07K14/705 , C07K14/82 , C07K14/54 , C07K14/52 , C07H21/04 , C12P21/06 , C12N15/74 , C12N1/21
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
摘要翻译：本发明提供用于体内掺入非天然氨基酸的方法和组合物。还提供了包含具有非天然氨基酸的蛋白质的组合物。

60. 发明授权

US07083970B2 Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs 有权
公开(公告)号：US07083970B2
公开(公告)日：2006-08-01
申请号：US10126931
申请日：2002-04-19
申请人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
IPC分类号： C12N9/10 , C12N15/12 , C12N15/54 , C12P21/00
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.

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