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51. 发明申请

US20050288671A1 Methods for securing spinal rods 有权
标题翻译：脊椎杆固定方法
公开(公告)号：US20050288671A1
公开(公告)日：2005-12-29
申请号：US11216849
申请日：2005-08-31
申请人： Hansen Yuan , David Nichols , Eric Finley
发明人： Hansen Yuan , David Nichols , Eric Finley
IPC分类号： A61B17/58 , A61B17/00 , A61B17/56 , A61B17/70
CPC分类号： A61B17/7037 , A61B17/7032 , A61B2017/00858
摘要： A device for securing a spinal rod to a spine includes a head adapted to secure the spinal rod, and a locking cap adapted to engage the head and the spinal rod, the locking cap having an unlocked position, an intermediate position, and a locked position. A method of securing the spinal rod to the device includes aligning the spinal rod to a desired position relative to the spine with the locking cap in the unlocked position.
摘要翻译：用于将脊柱杆固定到脊柱的装置包括适于固定脊柱杆的头部和适于接合头部和脊柱杆的锁定帽，锁定帽具有解锁位置，中间位置和锁定位置。将脊柱杆固定到装置的方法包括将脊柱杆相对于脊柱对准到锁定帽处于解锁位置的期望位置。

52. 发明申请

US20050192569A1 Apparatus for spinal stabilization 有权
标题翻译：脊柱稳定装置
公开(公告)号：US20050192569A1
公开(公告)日：2005-09-01
申请号：US11062510
申请日：2005-02-22
申请人： David Nichols , Eric Finley
发明人： David Nichols , Eric Finley
IPC分类号： A61B17/58 , A61B17/70 , A61F5/04
CPC分类号： A61B17/7052
摘要： An apparatus is disclosed for connecting first and second elongated spaced apart spinal rods to one another which includes an elongated body portion, a clamp portion depending from the body portion for engaging a spinal rod, the clamp portion defining a deformable clamp body having opposed clamp arms configured for movement between a first position wherein a spinal rod is received between the opposed clamp arms of the clamp body and a second position wherein the spinal rod is securely engaged by the opposed clamp &ms &the clamp body, and structure operatively associated with the clamp body which h configured to effectuate movement of the opposed clamp arms of the clamp body between the first and second positions.
摘要翻译：公开了一种用于将第一和第二细长间隔开的脊椎杆彼此连接的装置，其包括细长主体部分，从主体部分悬垂以用于接合脊椎杆的夹持部分，夹具部分限定具有相对的夹持臂的可变形夹具体构造成在第一位置和第二位置之间运动，其中脊柱杆被容纳在夹具主体的相对的夹紧臂之间，第二位置，其中脊柱杆通过相对的夹持臂牢固地与夹具主体接合，并且结构与夹具体可操作地相关联其构造成实现夹具本体的相对的夹持臂在第一和第二位置之间的移动。

53. 发明申请

US20050187630A1 Modular implant for fusing adjacent bone structure 有权
标题翻译：用于融合相邻骨结构的模块植入物
公开(公告)号：US20050187630A1
公开(公告)日：2005-08-25
申请号：US11112476
申请日：2005-04-22
申请人： Michael Castro , Herb Cohen , David Nichols , R. Graham
发明人： Michael Castro , Herb Cohen , David Nichols , R. Graham
IPC分类号： A61F2/00 , A61F2/30 , A61F2/44
CPC分类号： A61F2/4465 , A61F2002/30126 , A61F2002/30131 , A61F2002/30133 , A61F2002/30357 , A61F2002/30492 , A61F2002/305 , A61F2002/30551 , A61F2002/30599 , A61F2002/30604 , A61F2002/30616 , A61F2002/30747 , A61F2002/30785 , A61F2002/30787 , A61F2002/30841 , A61F2002/30845 , A61F2002/4475 , A61F2220/0025 , A61F2220/0033 , A61F2230/0008 , A61F2230/0013 , A61F2230/0015 , A61F2250/0063 , A61F2310/00017 , A61F2310/00023 , A61F2310/00179
摘要： A method for facilitating fusion of bone structures includes providing an implant member for positioning between opposed bone structures, the implant member having a first end and a second end, and a segmentable portion having an outer wall defining an internal cavity for reception of bone growth inducing substances. The outer wall has at least one groove which extends substantially continuously about the outer wall to define a plurality of discrete ring-like segments. Each ring-like segment includes a plurality of apertures extending therethrough in communication with the internal cavity to permit fusion of vertebral bone tissue. The vertebral space defined between adjacent vertebral bodies is accessed, and the desired implant member length for insertion into the space between adjacent vertebral bodies is determined. The implant member is cut to the desired length and advanced within the vertebral space between the adjacent vertebral bodies.
摘要翻译：用于促进骨结构融合的方法包括提供用于在相对的骨结构之间定位的植入物构件，所述植入构件具有第一端和第二端，以及可分割部分，其具有限定内部空腔的外壁，用于接收骨生长诱导物质外壁具有至少一个凹槽，其围绕外壁基本上连续地延伸以限定多个离散的环状段。每个环形区段包括多个孔，其延伸穿过其与内腔连通，以允许椎骨组织融合。访问相邻椎体之间限定的椎间隙，并且确定用于插入相邻椎体之间的空间的期望的植入物构件长度。将植入物切割成所需长度并在相邻椎体之间的脊椎间隙内前进。

54. 发明授权

US06896074B2 System and method for installation and use of devices in microboreholes 有权
标题翻译：在微孔中安装和使用设备的系统和方法
公开(公告)号：US06896074B2
公开(公告)日：2005-05-24
申请号：US10267487
申请日：2002-10-09
申请人： John Mervyn Cook , Iain Cooper , Benjamin Peter Jeffryes , Richard Timothy Coates , William Li-Tien Wang , Paul Hammond , Philip Christie , David Nichols , Paul Bolchover
发明人： John Mervyn Cook , Iain Cooper , Benjamin Peter Jeffryes , Richard Timothy Coates , William Li-Tien Wang , Paul Hammond , Philip Christie , David Nichols , Paul Bolchover
IPC分类号： E21B33/124 , E21B41/00 , E21B47/00 , E21B49/10 , G01V11/00 , E21B47/01
CPC分类号： G01V11/00 , E21B33/124 , E21B41/0042 , E21B47/00 , E21B49/10 , G01V11/005 , G01V2210/6163
摘要： The present invention provides methods and systems for making measurements associated with a rock formation including a main borehole, a microborehole extending from the main borehole into the rock formation, and one or more sensing devices positioned and arranged to make a measurement at measurement zones being located in the microborehole. A packer can also be installed in the microborehole dimensioned and arranged to hydraulically isolate the measurement zones from conditions present in other parts of the microborehole and/or main borehole. Methods and systems are also provided for taking fluid samples and injecting fluid tracers in a microborehole.
摘要翻译：本发明提供了用于进行与岩层相关联的测量的方法和系统，所述岩层包括主井眼，从主井眼延伸到岩层中的微孔，以及定位和布置成在测量区域处进行测量的一个或多个感测装置在微孔中。封隔器还可以安装在微孔中，其尺寸设计成将测量区与水平孔和/或主钻孔的其它部分中存在的条件水力隔离。还提供了用于采集流体样品并在微孔中注入流体示踪剂的方法和系统。

55. 发明申请

US20050088552A1 Image sensor array with substitutional circuit distribution 有权
标题翻译：具有替代电路分布的图像传感器阵列
公开(公告)号：US20050088552A1
公开(公告)日：2005-04-28
申请号：US10691047
申请日：2003-10-22
申请人： Herbert Erhardt , David Nichols
发明人： Herbert Erhardt , David Nichols
IPC分类号： H01L27/146 , H04N5/367 , H04N5/369 , H04N9/64 , H04N3/14 , H04N5/335 , H04N9/04 , H04N9/083
CPC分类号： H04N5/367 , H04N5/3696
摘要： An image sensor includes a plurality of photosensitive sites which convert incident light into a charge for forming a bounded array of active imaging pixels; one or more substitutional pixels sites arranged in predetermined locations and interspersed amongst the boundary of the array of active imaging pixels; wherein the substitutional pixels are of a different design from the active imaging pixels which provides data, information or function different from the active pixels for improving performance, operation, manufacture, and/or assembly of the image sensor.
摘要翻译：图像传感器包括将入射光转换成用于形成有源成像像素的有界阵列的电荷的多个感光部位; 一个或多个替代像素位置布置在预定位置并散布在有源成像像素阵列的边界之间; 其中所述替代像素与所述有源成像像素的设计不同，所述有源成像像素提供与所述有源像素不同的数据，信息或功能，以改善所述图像传感器的性能，操作，制造和/或组装。

56. 发明申请

US20050080266A1 CHROMENO[4,3,2-DE]ISOQUINOLINES AS POTENT DOPAMINE RECEPTOR LIGANDS 失效
标题翻译： CHROMENO [4,3,2-DE]异喹啉作为多巴胺受体配体
公开(公告)号：US20050080266A1
公开(公告)日：2005-04-14
申请号：US10188579
申请日：2002-07-02
申请人： David Nichols , Russell Grubbs , Richard Mailman
发明人： David Nichols , Russell Grubbs , Richard Mailman
IPC分类号： C07D491/052 , A61K31/4741 , A61P5/00 , A61P9/00 , A61P9/12 , A61P11/00 , A61P13/12 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , C07D491/06 , C07D491/02
CPC分类号： C07D491/06
摘要： Novel dopamine receptor ligands of the formula: pharmaceutical formulations of such compounds, and a method using such compounds for treating a patient suffering from dopamine-related dysfunction of the central or peripheral nervous system, are described. The compounds are expected to be useful in treating Parkinson's disease, improving cognition, improving memory, improving the negative symptoms of schizophrenia, improving attention-deficit hyperactivity disorder and related developmental disorders, treating substance abuse disorders, and in treating various peripheral conditions where changes in dopamine receptor occupation affects physiological function, including organ perfusion, cardiovascular function, and selected endocrine and immune system functions.
摘要翻译：描述了下式的新型多巴胺受体配体：这种化合物的药物制剂，以及使用这些化合物治疗患有中枢或周围神经系统的多巴胺相关功能障碍的患者的方法。预期这些化合物可用于治疗帕金森病，改善认知，改善记忆，改善精神分裂症的阴性症状，改善注意力缺陷多动障碍和相关发育障碍，治疗药物滥用障碍，以及治疗各种外周疾病，多巴胺受体占据影响生理功能，包括器官灌注，心血管功能和选择的内分泌和免疫系统功能。

57. 发明申请

US20050036041A1 Method and apparatus to extend the effective dynamic range of an image sensing device 有权
标题翻译：延长图像感测装置的有效动态范围的方法和装置
公开(公告)号：US20050036041A1
公开(公告)日：2005-02-17
申请号：US10946919
申请日：2004-09-22
申请人： Andrew Gallagher , David Nichols
发明人： Andrew Gallagher , David Nichols
IPC分类号： H04N5/235 , H04N3/15 , H04N9/04 , H04N9/07 , H04N5/335
CPC分类号： H04N9/045 , H04N5/235 , H04N5/2355 , H04N5/35563
摘要： An image sensor generates an image signal with a differential response to image light. The image sensor has an array of photosites divided into standard photosites and non-standard photosites. A limiter provides the standard photosites with a predetermined standard response to a light exposure and the non-standard photosites with a predetermined slower response to the same light exposure. The standard photosites and nonstandard photosites both sparsely sample the array in a predetermined pattern.
摘要翻译：图像传感器产生具有对图像光的差分响应的图像信号。图像传感器具有分为标准照片和非标准照片的照片阵列。限制器为具有对曝光的预定标准响应和对相同曝光具有预定的较慢响应的非标准照片提供标准照片。标准照片和非标准照片都以预定的图案稀疏地采样阵列。

58. 发明申请

US20050021042A1 Instruments and method for inserting an intervertebral implant 有权
标题翻译：用于插入椎间植入物的仪器和方法
公开(公告)号：US20050021042A1
公开(公告)日：2005-01-27
申请号：US10622535
申请日：2003-07-21
申请人： Theirry Marnay , Rudolf Bertagnoli , Frank Magee , Stephan Eckhof , David Nichols , Christophe Geisert
发明人： Theirry Marnay , Rudolf Bertagnoli , Frank Magee , Stephan Eckhof , David Nichols , Christophe Geisert
IPC分类号： A61B17/02 , A61F2/00 , A61F2/30 , A61F2/44 , A61F2/46 , A61B17/58
CPC分类号： A61F2/4611 , A61B2017/0256 , A61F2/30767 , A61F2/4425 , A61F2002/30383 , A61F2002/30616 , A61F2002/30649 , A61F2002/30884 , A61F2002/443 , A61F2002/4622 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00407
摘要： Instruments and methods for inserting an intervertebral implant. Insertion of the implant is accomplished by grasping the implant between the arms of an insertion instrument having arms which separate from each other and close against each other onto the implant, such that the ends of the arms of the insertion instrument engage recesses of the implant. A spacer may be provided between the arms of the insertion instrument to help position the implant while held by the arms.
摘要翻译：用于插入椎间植入物的器械和方法。植入物的插入通过抓住具有彼此分离并且相互靠在植入物上的臂的插入器械的臂之间的植入物来实现，使得插入器械的臂的端部接合植入物的凹部。间隔件可以设置在插入器具的臂之间，以有助于在由臂支撑的同时定位植入物。

59. 发明授权

US06565565B1 Device for securing spinal rods 有权
公开(公告)号：US06565565B1
公开(公告)日：2003-05-20
申请号：US09487942
申请日：2000-01-19
申请人： Hansen Yuan , David Nichols , Eric Finley
发明人： Hansen Yuan , David Nichols , Eric Finley
IPC分类号： A61B1770
CPC分类号： A61B17/7037 , A61B17/7032 , A61B2017/00858
摘要： A device is disclosed for securing a spinal rod to the spine which includes a head portion configured to receive a spinal rod, a locking cap configured to engage the head portion and the spinal rod upon rotation of the locking cap relative to the head portion to secure the position of the head portion relative to the spinal rod, and a fastener portion depending from the head portion and configured to engage the spine.

60. 发明授权

US5989251A Apparatus for spinal stabilization 失效
标题翻译：脊柱稳定装置
公开(公告)号：US5989251A
公开(公告)日：1999-11-23
申请号：US98607
申请日：1998-06-17
申请人： David Nichols
发明人： David Nichols
IPC分类号： A61B17/58 , A61B17/70
CPC分类号： A61B17/7049
摘要： An apparatus is disclosed for connecting first and second elongated spaced apart spinal rods to one another which includes a first connector having structure to engage a first spinal rod at a location along the length thereof and an elongated beam having an axis extending in a direction transverse to the first spinal rod, a second connector having structure to engage a second spinal rod at a location adjacent the first connector and including a reception portion projecting in a direction transverse to the second spinal rod and defining a channel for receiving the elongated beam of the first connector, and a locking member dimensioned and configured to engage the channel along the axis of the beam and secure the position of the beam with respect thereto.
摘要翻译：公开了一种用于将第一和第二细长的间隔开的脊椎杆彼此连接的装置，其包括第一连接器，该第一连接器具有在沿其长度的位置处接合第一脊柱杆的结构，以及具有沿横向于所述第一脊柱杆，具有结构的第二连接器，所述第二连接器具有在邻近所述第一连接器的位置处接合第二脊柱杆，并且包括在横向于所述第二脊柱杆的方向上突出的接收部分，并且限定用于接收所述第一脊柱杆的细长梁的通道连接器和锁定构件，其尺寸和构造成沿着梁的轴线接合通道并且固定梁相对于其的位置。

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