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51. 发明授权

US5329498A Signal conditioning and interconnection for an acoustic transducer 失效
标题翻译：声换能器的信号调理和互连
公开(公告)号：US5329498A
公开(公告)日：1994-07-12
申请号：US62665
申请日：1993-05-17
申请人： Michael Greenstein
发明人： Michael Greenstein
IPC分类号： A61B8/00 , B06B1/06 , H01L41/08 , H04R3/00 , H04R17/00
CPC分类号： B06B1/0629
摘要： An ultrasonic device having an acoustic transducer with a lamination of parallel integrated circuit chips having active circuitry. A backing member made of a material for attenuating acoustic waves provides Z-axis conduction of signals from the parallel integrated circuit chips to individual piezoelectric elements. Preferably, each piezoelectric element is operatively associated with a particular circuit that is within the acoustic shadow of the element, so that the lamination of chips does not add to the cross sectional area of the transducer. The integrated circuit chips are coterminus at first edges to provide a planar contact surface having a pad grid array of contact pads for connection with conductors extending through the backing member. In one embodiment, the piezoelectric elements provide a two-dimensional array of elements that corresponds to the pad grid array. Circuitry on the integrated circuit chips can include protective diodes, preamplifiers and one or more multiplexers.
摘要翻译：一种具有声学换能器的超声波装置，其具有具有有源电路的并联集成电路芯片的叠层。由用于衰减声波的材料制成的背衬构件将来自并联集成电路芯片的信号的Z轴导通到各个压电元件。优选地，每个压电元件与位于元件的声阴内的特定电路可操作地相关联，使得芯片的层叠不会增加换能器的横截面积。集成电路芯片在第一边缘处是邻接的，以提供具有用于与延伸穿过背衬构件的导体连接的接触垫的焊盘格栅阵列的平面接触表面。在一个实施例中，压电元件提供对应于焊盘格栅阵列的元件的二维阵列。集成电路芯片上的电路可以包括保护二极管，前置放大器和一个或多个多路复用器。

52. 发明申请

US20110177562A1 Portable Preparation, Analysis, and Detection Apparatus for Nucleic Acid Processing 审中-公开
标题翻译：用于核酸加工的便携式制备，分析和检测装置
公开(公告)号：US20110177562A1
公开(公告)日：2011-07-21
申请号：US12973190
申请日：2010-12-20
申请人： Charles S. Vann , Michael Greenstein , Yuh-Min Chiang
发明人： Charles S. Vann , Michael Greenstein , Yuh-Min Chiang
IPC分类号： C12P19/34 , G01N27/447
CPC分类号： G01N27/447 , C12M47/06 , C12Q1/6806 , C12Q1/686
摘要： The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
摘要翻译：本教导包括用于裂解和/或纯化生物样品的装置和方法。该装置可以包括具有包含生物样品接收区域，多个电极和一个或多个筛分基质的腔室的药筒。电极可以被配置成通过产生脉冲电场来裂解生物样品。电极也可以被配置为热裂解生物样品。电极还可以被配置成通过一个或多个筛分基质电泳移动生物样品。样品的一部分可以在膜上分离。可以扩增和检测在膜上分离的样品的部分。样品的一部分可以在存在于盒中的收集区域中分离。分离在收集区域中的样品的部分可以从盒中取出。

53. 发明申请

US20110070587A1 System For Genetic Surveillance and Analysis 审中-公开
标题翻译：遗传监测与分析系统
公开(公告)号：US20110070587A1
公开(公告)日：2011-03-24
申请号：US12868704
申请日：2010-08-25
申请人： Hans FUERNKRANZ , Chirag J. Patel , Michael Greenstein
发明人： Hans FUERNKRANZ , Chirag J. Patel , Michael Greenstein
IPC分类号： C12Q1/68 , C12M1/34 , C40B60/12 , G06F19/00
CPC分类号： G16B30/00 , G06F19/00 , G16B25/00 , G16B50/00 , G16H10/40 , G16H50/80 , Y02A90/22 , Y02A90/24 , Y02A90/26
摘要： A genetic surveillance system comprises a communications network and at least one reader-analyzer instrument. The reader-analyzer instrument has a communication interface to communicate over the network. The reader-analyzer instrument is adapted to perform genetic assay analysis of a sample obtained from a member of a population and to generate detection-related data based upon the analysis. The reader-analyzer instrument is adapted to associate qualifying information with the detection-related data and to communicate the associated qualifying information and detection-related data over the network.
摘要翻译：遗传监测系统包括通信网络和至少一个读取器分析仪器。读取器分析仪具有通过网络进行通信的通信接口。读取器分析仪适于对从群体成员获得的样品进行遗传测定分析，并且基于分析产生检测相关数据。读取器分析仪器适于将限定信息与检测相关数据相关联，并通过网络传送相关联的限定信息和检测相关数据。

54. 发明授权

US07303727B1 Microfluidic sample delivery devices, systems, and methods 有权
标题翻译：微流体样品输送装置，系统和方法
公开(公告)号：US07303727B1
公开(公告)日：2007-12-04
申请号：US10369325
申请日：2003-02-19
申请人： Robert S. Dubrow , Michael Greenstein , Luc J. Bousse , Khushroo Gandhi
发明人： Robert S. Dubrow , Michael Greenstein , Luc J. Bousse , Khushroo Gandhi
IPC分类号： B01L3/02 , B32B5/02 , B32B27/04 , B32B27/12 , G01N15/06
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/502715 , B01L3/565 , B01L2200/027 , B01L2200/12 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2400/027 , B01L2400/0415 , B01L2400/0487 , G01N30/6095 , G01N30/84 , G01N35/1095 , G01N2030/847 , G01N2030/8488 , G01N2035/1039 , Y10T436/11 , Y10T436/118339 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： Methods and apparatus for delivering fluidic materials to sample destinations, including mass spectrometers for analysis are provided. In preferred embodiments, sample aliquots are electrosprayed from tapered spray tips of capillary elements into the orifices of mass spectrometric inlet systems. In certain embodiments, fluidic samples are orthogonally sprayed from capillary elements or other fluid conduits, whereas in other embodiments samples are sprayed after devices are rotated or otherwise translocated from sample sources to sample destinations. In still other embodiments, samples are sprayed from flexed or deflected capillary elements at selected sample destinations.
摘要翻译：提供了将流体材料输送到样品目的地的方法和设备，包括用于分析的质谱仪。在优选的实施方案中，将样品等分试样从毛细管元件的锥形喷嘴电喷雾到质谱入口系统的孔中。在某些实施方案中，流体样品从毛细管元件或其他流体导管正交喷射，而在其它实施方案中，在将装置旋转或以其他方式从样品源转移到样品目的地之后，将样品喷雾。在其它实施例中，样品在选定的样品目的地从挠曲或偏转的毛细管元件喷射。

55. 发明授权

US07036667B2 Container providing a controlled hydrated environment 失效
标题翻译：集装箱提供受控的水合环境
公开(公告)号：US07036667B2
公开(公告)日：2006-05-02
申请号：US10837707
申请日：2004-05-04
申请人： Michael Greenstein , Colin Kennedy , Huan Phan , Stephan Bianchi , Jonathan Reed Harris , Daren Walter Hebold , Robert Andrew Howard , Andrew Leonard Zee
发明人： Michael Greenstein , Colin Kennedy , Huan Phan , Stephan Bianchi , Jonathan Reed Harris , Daren Walter Hebold , Robert Andrew Howard , Andrew Leonard Zee
IPC分类号： B65D85/00
CPC分类号： B01L9/527 , B01L2200/025 , B01L2200/0689 , B01L2200/185 , B01L2300/041 , B65D85/70
摘要： A container is provided for shipping and storing a pre-wetted and pre-conditioned microfluidic “sipper” chip. The container contains both dry compartments and wet compartments. A base contains a fluid-filled reservoir configured to house the capillaries. The opening of the reservoir is sealed with an O-ring. The plastic mount of the chip rests on the base in a dry compartment. The upper surface of the chip contains several wells containing fluid. A gasket is provided with plugs configured to be disposed within and seal the wells. Alternatively, the wells are first sealed with a foil film adhered to the well openings with an adhesive and a gasket is disposed between the foil and a cover, which is removably attached to the base. When the cover is closed, the gasket and O-ring seal the wet compartments to prevent leakage and to slow evaporation.
摘要翻译：提供了用于运输和存储预润湿和预调节微流控“吸嘴”芯片的容器。容器包含干燥隔室和湿隔间。基座包含配置成容纳毛细管的流体填充的储存器。储罐的开口用O形圈密封。芯片的塑料安装座位于干燥隔间的底座上。芯片的上表面包含几个含有流体的孔。垫圈设置有被配置为设置在井中并密封井的塞子。或者，孔首先用粘合剂粘附到井口上的箔膜密封，并且垫片设置在箔和盖之间，盖可拆卸地附接到基座。当盖子关闭时，垫圈和O形圈密封湿隔间，以防止泄漏并减缓蒸发。

56. 发明授权

US06966880B2 Universal diagnostic platform 有权
标题翻译：通用诊断平台
公开(公告)号：US06966880B2
公开(公告)日：2005-11-22
申请号：US09981483
申请日：2001-10-16
申请人： Dirk Boecker , Rick Pittaro , Michael Greenstein , Michael C. Higgins , Dominique M. Freeman
发明人： Dirk Boecker , Rick Pittaro , Michael Greenstein , Michael C. Higgins , Dominique M. Freeman
IPC分类号： A61B5/00 , A61B5/15
CPC分类号： A61M5/142 , A61B5/0002 , A61B5/145 , A61B5/14532 , A61B5/150022 , A61B5/150221 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150854 , A61B5/15113 , A61B5/15117 , A61B5/15121 , A61B5/15123 , A61B5/1519 , A61M2205/3576 , G06F19/00 , H04L67/025 , H04L67/1097 , H04L67/12 , Y10S128/903
摘要： A portable medical analyzer comprising a sampling module with a sample port for receiving body fluid, an assay sensor module for analysis of the body fluid, an analytical detector module with detection of information from the assay, and a communications module for transferring the information to a remote location via a wired or wireless network.
摘要翻译：一种便携式医学分析仪，包括具有用于接收体液的采样端口的采样模块，用于分析体液的测定传感器模块，具有来自测定的信息检测的分析检测器模块，以及用于将信息传送到通过有线或无线网络进行远程位置。

57. 发明授权

US5381385A Electrical interconnect for multilayer transducer elements of a two-dimensional transducer array 失效
标题翻译：用于二维换能器阵列的多层换能器元件的电互连
公开(公告)号：US5381385A
公开(公告)日：1995-01-10
申请号：US101867
申请日：1993-08-04
申请人： Michael Greenstein
发明人： Michael Greenstein
IPC分类号： A61B8/00 , B06B1/06 , H04R17/00
CPC分类号： B06B1/064
摘要： A multilayer two-dimensional array of ultrasonic transducer elements includes four via segments at the four corners of each transducer element. A first pair of diagonally opposed via segments provide signals to signal electrode layers of each transducer element. A second pair of diagonally opposed via segments interconnect ground electrode layers. Thus, a redundant interconnection scheme is achieved. If the transducer elements include piezoelectric layers having a square cross section parallel to a transducer radiating surface, four-fold symmetry is maintained, despite the formation of the four via segments. Also disclosed is a method of forming a two-dimensional array.
摘要翻译：超声换能器元件的多层二维阵列包括在每个换能器元件的四个角处的四个通路段。第一对对角相对的通孔段向每个换能器元件的信号电极层提供信号。第二对对角相对的通孔段将接地电极层互相连接。因此，实现了冗余互连方案。如果换能器元件包括具有平行于换能器辐射表面的正方形横截面的压电层，则尽管形成了四个通孔段，仍维持四重对称性。还公开了形成二维阵列的方法。

58. 发明授权

US4970198A Antitumor antibiotics (LL-E33288 complex) 失效
标题翻译：抗肿瘤抗生素（LL-E33288复合物）
公开(公告)号：US4970198A
公开(公告)日：1990-11-13
申请号：US9321
申请日：1987-01-30
申请人： May D. Lee , Michael Greenstein , David P. Labeda , Amedeo A. Fantini
发明人： May D. Lee , Michael Greenstein , David P. Labeda , Amedeo A. Fantini
IPC分类号： C07H15/203 , C12P1/06 , C12P19/60
CPC分类号： C07H15/203 , C12P1/06 , C12P19/60 , C12R1/29 , Y10S435/867
摘要： Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora ssp. calichensis NNRL-15839, NRRL-15975 and NRRL-18149, are disclosed.
摘要翻译：名称为LL-E33288复合物的抗菌剂和抗肿瘤剂及其通过新型小单孢菌属 calichensis NNRL-15839，NRRL-15975和NRRL-18149。

59. 发明授权

US4845037A Process for producing antibiotic LL-D42067.alpha. 失效
标题翻译：生产抗生素LL-D42067α的方法
公开(公告)号：US4845037A
公开(公告)日：1989-07-04
申请号：US891082
申请日：1986-07-31
申请人： Taikwang M. Lee , Joseph J. Goodman , Michael Greenstein , Donald B. Borders
发明人： Taikwang M. Lee , Joseph J. Goodman , Michael Greenstein , Donald B. Borders
IPC分类号： C12N1/20 , A61K20060101 , A61K31/535 , A61K35/74 , A61P31/04 , A61P33/10 , C07G11/00 , C12N20060101 , C12N1/00 , C12N1/06 , C12N5/00 , C12N15/00 , C12P1/00 , C12P1/06 , C12P17/16 , C12P17/18 , C12R1/29
CPC分类号： C12R1/29 , Y10S435/867
摘要： A biologically pure culture of Micromonospora purpureochromogenes ssp. Wuxiensis and its use in an aerobic fermentation process to produce the antibacterial and antiparasitic agent LL-D42067.alpha..
摘要翻译：一种生物学纯培养的小单孢菌紫色荧光发生物无锡植物及其在好氧发酵过程中的应用，产生抗菌和抗寄生虫剂LL-D42067α。

60. 发明授权

US4705688A Antibiotic LL-E19020 .alpha. and .beta. 失效
标题翻译：抗生素LL-E19020α和β
公开(公告)号：US4705688A
公开(公告)日：1987-11-10
申请号：US880230
申请日：1986-06-30
申请人： Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
发明人： Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
IPC分类号： C12P1/06 , A61K35/74
CPC分类号： C12P1/06
摘要： This invention relates to antibiotic LL-E19020.alpha. and LL-E19020.beta. derived from the microorganism Streptomyces lydicus subspecies tanzanius NRRL 18036, which are useful as an antibacterial agent.
摘要翻译：本发明涉及衍生自微生物链霉菌属（Streptomyces lydicus subspecies tanzanius）NRRL 18036的抗生素LL-E19020α和LL-E19020ββ，其可用作抗菌剂。

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