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51. 发明申请

US20100196968A1 Polypeptides having beta-glucosidase activity and polynucleotides encoding same 有权
标题翻译：具有β-葡糖苷酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：US20100196968A1
公开(公告)日：2010-08-05
申请号：US12707154
申请日：2010-02-17
申请人： Paul Harris , Elizabeth Golightly
发明人： Paul Harris , Elizabeth Golightly
IPC分类号： C12P19/02
CPC分类号： C12N9/2445 , C12Y302/01021
摘要： The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有β-葡糖苷酶活性的分离多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

52. 发明授权

US07608689B2 Methods for enhancing the degradation or conversion of cellulosic material 有权
公开(公告)号：US07608689B2
公开(公告)日：2009-10-27
申请号：US11541099
申请日：2006-09-29
申请人： Paul Harris , Michael Rey , Hanshu Ding
发明人： Paul Harris , Michael Rey , Hanshu Ding
IPC分类号： C07K1/00 , C12N9/24 , C07H21/04
CPC分类号： C12P7/10 , C12N9/2402 , C12N9/2437 , C12P7/26 , C12P7/40 , C12P13/04 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C13K1/02 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to methods for degrading or converting a cellulosic material and for producing a substance from a cellulosic material.

53. 发明申请

US20080201805A1 Polypeptides Having Beta-Glucosidase Activity and Polynucleotides Encoding Same 有权
标题翻译：具有β-葡萄糖苷酶活性的多肽和编码相同的多核苷酸
公开(公告)号：US20080201805A1
公开(公告)日：2008-08-21
申请号：US11997625
申请日：2006-08-04
申请人： Kristian Krogh , Paul Harris
发明人： Kristian Krogh , Paul Harris
IPC分类号： A01H5/00 , C12N9/00 , C07H21/04 , C12N15/00 , C12P1/00 , D06M16/00 , C12N1/20 , C12P21/04
CPC分类号： C12N9/2477 , C12N9/2437
摘要： The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有β-葡糖苷酶活性的分离多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

54. 发明授权

US07228180B1 Methods for treating victims of cerebrovascular disease 有权
标题翻译：治疗脑血管疾病受害者的方法
公开(公告)号：US07228180B1
公开(公告)日：2007-06-05
申请号：US10682292
申请日：2003-10-09
申请人： Scott Wofford , Dale L. Phillips, Jr. , Paul Harris
发明人： Scott Wofford , Dale L. Phillips, Jr. , Paul Harris
IPC分类号： A61N1/18
CPC分类号： A61N1/36014 , A61N1/326 , A61N1/36003
摘要： The current invention provides novel methods for treating victims of cerebrovascular diseases such as stroke. The methods of the current invention rehabilitate weakened and atrophied muscles by applying electrical stimulation to the muscles. Preferably, the electric current cycles between on and off thereby at 10 second intervals thereby stimulating the muscle for 10 seconds and allowing the muscle to relax for 10 seconds. Treatment periods are preferably 15 minutes per day, five days per week. In general, treatments are performed over a 3 to 12 month period. Patients treated according to the disclosed methodology experience significant improvements in their overall quality of life.
摘要翻译：本发明提供了治疗脑血管疾病如中风的受害者的新方法。本发明的方法通过对肌肉进行电刺激来恢复弱化和萎缩的肌肉。优选地，电流在10秒间隔开启和关闭之间循环，由此刺激肌肉10秒，并允许肌肉放松10秒。治疗期优选为每天15分钟，每周5天。一般来说，治疗在3至12个月的时间内进行。根据公开的方法治疗的患者在整体生活质量方面经历显着改善。

55. 发明申请

US20060217295A1 Neuroprotective macrocyclic compounds and methods for their use 有权
公开(公告)号：US20060217295A1
公开(公告)日：2006-09-28
申请号：US10549951
申请日：2004-03-16
申请人： Paul Harris , Margaret Brimble
发明人： Paul Harris , Margaret Brimble
IPC分类号： C07K5/12 , C07D487/04 , A61K38/12
CPC分类号： C07D487/04 , C07D471/04 , C07K5/06139 , C07K5/0821
摘要： Embodiments of this invention provide novel peptidomimetics that contain a macrocycle. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterised by neuronal degeneration and/or death. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.

56. 发明申请

US20050210548A1 Polypeptides having xylanase activity and polynucleotides encoding same 有权
标题翻译：具有木聚糖酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：US20050210548A1
公开(公告)日：2005-09-22
申请号：US11054191
申请日：2005-02-09
申请人： Debbie Yaver , Paul Harris , Suzanne Otani , Janine Lin , Haiyan Ge
发明人： Debbie Yaver , Paul Harris , Suzanne Otani , Janine Lin , Haiyan Ge
IPC分类号： A01H1/00 , C07H21/04 , C12N5/04 , C12N9/24 , C12N15/87 , C12Q1/68
CPC分类号： C12N9/2482 , C12N9/248 , C12Y302/01008
摘要： The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有木聚糖酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

57. 发明申请

US20050173315A1 Tangential flow filtration devices and methods for leukocyte enrichment 有权
标题翻译：切向流过滤装置和白细胞富集方法
公开(公告)号：US20050173315A1
公开(公告)日：2005-08-11
申请号：US10517871
申请日：2003-06-19
申请人： Marnix Bosch , Paul Harris , Steven Monahan , Allen Turner , Alton Boynton , Patricia Lodge
发明人： Marnix Bosch , Paul Harris , Steven Monahan , Allen Turner , Alton Boynton , Patricia Lodge
IPC分类号： C12M1/26 , A61M1/34 , A61M1/36 , A61M1/38 , B01D61/00 , B01D61/14 , B01D61/16 , B01D61/18 , B01D61/22 , C12M3/00 , C12N5/06
CPC分类号： A61M1/3496 , A61M1/3633 , A61M1/38 , A61M2202/0439 , B01D61/147 , B01D61/16 , B01D61/18 , B01D61/22 , B01D2315/10 , Y10T436/255
摘要： The present invention provides tangential flow filtration devices and methods for enriching a heterogeneous mixture of blood constituents for leukocytes by removal of non-leukocyte blood constituents. In one particular embodiment the device can provide a composition enriched in monocytes. One embodiment includes a remover unit (1) having a crossflow chamber (3) separated by a microporous filter (5) from a filtrate chamber (4), the remover unit (1) also having a tangential flow inlet (6), a fluid outlet (7) for a fluid enriched in leukocytes and a filtrate outlet (8).
摘要翻译：本发明提供切向流过滤装置和通过去除非白细胞血液成分来富集白细胞的血液成分的非均相混合物的方法。在一个具体实施方案中，该装置可以提供富含单核细胞的组合物。一个实施例包括具有从滤液室（4）与微孔过滤器（5）分离的交叉流室（3）的去除单元（1），所述去除单元（1）还具有切向流入口（6），流体出口（7），用于富含白细胞的液体和滤液出口（8）。

58. 发明授权

US06881791B2 Poly-electrolyte free block copolymers and their use in crosslinking coatings applications 失效
标题翻译：多电解质自由基嵌段共聚物及其在交联涂料中的应用
公开(公告)号：US06881791B2
公开(公告)日：2005-04-19
申请号：US10455066
申请日：2003-06-05
申请人： Swaminathan Ramesh , Paul Harris , Wolfgang Bremser , Walter H. Ohrbom
发明人： Swaminathan Ramesh , Paul Harris , Wolfgang Bremser , Walter H. Ohrbom
IPC分类号： C08F8/00 , C08F8/30 , C08F212/32 , C08F293/00 , C08K5/17 , C08L53/00 , C09D151/00 , C09D153/00 , C08J3/26
CPC分类号： C08F212/32 , C08F8/30 , C08F293/005 , C08F2810/20 , C08K5/17 , C08L53/00 , C09D151/003 , C09D153/00 , C08L2666/02
摘要： A curable, water-based coating composition comprising a reaction product of: a copolymer comprising a free-radical polymerization product of: a first block comprising a reaction product of: a plurality of ethylenically unsaturated monomers, and a vinyl aromatic hydrocarbon monomer, wherein at least one monomer of the plurality of ethylenically unsaturated monomers includes a functional group that can react with a water-dispersible cross-linking agent, and at least one monomer of the plurality of ethylenically unsaturated monomers is present in an amount such that it can render the copolymer water dispersible, and a second block comprising a reaction product of at least one ethylenically unsaturated monomer, wherein at least a portion of which are non-functional, and a water-dispersible cross-linking agent, wherein the water-based copolymer is free of salt structures.
摘要翻译：一种可固化的水性涂料组合物，其包含以下反应产物的反应产物：包含自由基聚合产物的共聚物，该自由基聚合产物包含：包含多个烯属不饱和单体和乙烯基芳族烃单体的反应产物的第一嵌段，其中在多个烯属不饱和单体中的至少一个单体包括可与水分散性交联剂反应的官能团，并且多个烯键式不饱和单体中的至少一种单体的存在量可以使得共聚物水分散体，和包含至少一种烯属不饱和单体的反应产物的第二嵌段，其中至少一部分是非官能的，和水分散性交联剂，其中所述水基共聚物是游离的的盐结构。

59. 发明申请

US20050073203A1 Stage for a workpiece 审中-公开
标题翻译：工件的阶段
公开(公告)号：US20050073203A1
公开(公告)日：2005-04-07
申请号：US10953884
申请日：2004-09-29
申请人： Paul Harris
发明人： Paul Harris
IPC分类号： B23Q1/01 , B23Q1/58 , B23Q1/62 , B23Q11/00 , H01L21/027 , H02K1/00
CPC分类号： B23Q1/58 , B23Q11/0003
摘要： A stage (10) for a workpiece comprises an upper member (13) for carrying a workpiece holder (15), a lower member (12) and two guide assemblies (16) mounting the upper member (13) on the lower member (12) to be rectilinearly displaceable relative thereto. The lower member (12) is in turn preferably similarly mounted on a fixed base plate (11) by further such guide assemblies (16), the two members (12, 13) being respectively displaceable in an X direction and a Y direction. At least one of the members (12 or 13), but preferably both members and also the base plate (11), is made of a machinable lightweight composite, for example aluminium alloy and silicon carbide, having a coefficient of thermal expansion not exceeding that of the principal material of the guide assemblies by more than substantially 50%, preferably by no more than 30 to 35%.
摘要翻译：用于工件的台架（10）包括用于承载工件保持器（15）的上部构件（13），下部构件（12）和将上部构件（13）安装在下部构件（12）上的两个引导组件（16））相对于其可直线地移位。另外，通过另外的这种引导组件（16），下部构件（12）优选地类似地安装在固定的基板（11）上，两个构件（12,13）可分别在X方向和Y方向上移动。构件（12或13）中的至少一个，但优选两个构件以及基板（11）由可加工的轻质复合材料制成，例如铝合金和碳化硅，其热膨胀系数不超过的引导组件的主要材料超过基本上50％，优选不超过30至35％。

60. 发明授权

US5112252A Intrinsically safe electrical connector 失效
标题翻译：本安电气连接器
公开(公告)号：US5112252A
公开(公告)日：1992-05-12
申请号：US698340
申请日：1991-05-07
申请人： Paul Harris
发明人： Paul Harris
IPC分类号： H01R13/533 , H01R13/627 , H01R13/648
CPC分类号： H01R13/627 , H01R13/648
摘要： A two part electrical connector, one part 10 of which comprises one or more electrical contacts 12 mounted in a connector shell 14 of insulating material. Around the contact or contacts 12 and connector shell 44 is a conductive casing 16 shaped to cooperate with a similar casing on the other part of the connector. The conductive casing 16 is electrically connected to the wire braiding 26 of the cable 22 via a metallic sleeve plate 24, to ensure continuity of the earth shielding across the connector. A non-conductive outer body 36 covers at least a part of the conductive casing b 16. Non-conductive material is also used for the clamp nut 40 which tightens the braiding clamp 30 and the connecting nut 44 which locks the two parts of the connector together. The resulting connector has earth shielding but no external conductive surfaces capable of being charged to high voltage potential should internal shorting occur.
摘要翻译：两部分电连接器，其一部分10包括安装在绝缘材料的连接器壳体14中的一个或多个电触点12。触点12和连接器外壳44周围是导电壳体16，导电壳体16成形为与连接器的另一部分上的类似外壳配合。导电壳体16经由金属套筒板24电连接到电缆22的导线编织层26，以确保穿过连接器的接地屏蔽的连续性。不导电的外部主体36覆盖导电壳体b16的至少一部分。非导电材料也用于夹紧螺母40，夹紧螺母40使编织夹30和连接螺母44紧固，该连接螺母44锁定连接器的两个部分一起。所产生的连接器具有接地屏蔽，但没有外部导电表面能够充电到高电压电位，如果发生内部短路。

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