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51. 发明授权

US3939049A Process for radiation grafting hydrogels onto organic polymeric substrates 失效
标题翻译：将水凝胶辐射接枝到有机聚合物基材上的方法
公开(公告)号：US3939049A
公开(公告)日：1976-02-17
申请号：US459734
申请日：1974-04-10
申请人： Buddy D. Ratner , Allan S. Hoffman
发明人： Buddy D. Ratner , Allan S. Hoffman
IPC分类号： C08F291/00 , C08F2/46 , C08F2/54 , C08F291/18 , C08L43/04 , C08L83/10
CPC分类号： C08F291/18
摘要： An improved process for radiation grafting of hydrogels onto organic polymeric substrates is provided comprising the steps of incorporating an effective amount of cupric or ferric ions in an aqueous graft solution consisting of N-vinyl-2 - pyrrolidone or mixture of N-vinyl-2 - pyrrolidone and other monomers, e.g., 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate, propylene glycol acrylate, acrylamide, methacrylic acid and methacrylamide, immersing an organic polymeric substrate in the aqueous graft solution and thereafter subjecting the contacted substrate with ionizing radiation.
摘要翻译：提供了一种用于将水凝胶辐射接枝到有机聚合物基底上的改进方法，其包括以下步骤：将有效量的铜或铁离子掺入由N-乙烯基-2-吡咯烷酮或N-乙烯基-2-吡咯烷酮的混合物组成的接枝水溶液中，吡咯烷酮和其它单体，例如甲基丙烯酸2-羟基乙酯，丙烯酸2-羟乙酯，丙二醇丙烯酸酯，丙烯酰胺，甲基丙烯酸和甲基丙烯酰胺，将有机聚合物基材浸入含水接枝溶液中，然后用电离辐射对接触的基材进行处理。

52. 发明申请

US20110288238A1 ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS 有权
标题翻译：使用薄膜破坏剂加强运输
公开(公告)号：US20110288238A1
公开(公告)日：2011-11-24
申请号：US13182756
申请日：2011-07-14
申请人： Allan S. Hoffman , Patrick Stayton , Oliver W. Press , Niren Murthy , Chantal Lackey Reed , Lawrence A. Crum , Pierre D. Mourad , Tyrone M. Porter , David Tirrell
发明人： Allan S. Hoffman , Patrick Stayton , Oliver W. Press , Niren Murthy , Chantal Lackey Reed , Lawrence A. Crum , Pierre D. Mourad , Tyrone M. Porter , David Tirrell
IPC分类号： C08F220/06 , C08F265/02 , C08F299/00
CPC分类号： A61K47/481 , A61K41/0028 , A61K41/0047 , A61K47/48376 , A61K47/6801
摘要： Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophoresis can also be used with the disrupting agents.
摘要翻译：描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声波，温度或其组合都有反应。这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。待递送的药剂可以是治疗和/或诊断剂。增强递送的治疗如超声波，离子分离和/或电泳也可与破坏剂一起使用。

53. 发明授权

US6165509A Pegylated drug complexed with bioadhesive polymer suitable for drug delivery and methods relating thereto 失效
标题翻译：与适用于药物递送的生物粘附聚合物复合的聚乙二醇化药物和与其相关的方法
公开(公告)号：US6165509A
公开(公告)日：2000-12-26
申请号：US145062
申请日：1998-09-01
申请人： Allan S. Hoffman , Yoshiki Hayashi
发明人： Allan S. Hoffman , Yoshiki Hayashi
IPC分类号： A61K9/00 , A61K47/34 , A61K47/32
CPC分类号： A61K9/006
摘要： PEGylated drugs complexed with bioadhesive polymers, wherein the PEGylated drugs comprise a polyethylene glycol covalently bonded to the drugs are disclosed. The PEGylated drug/bioadhesive polyner complex and compositions thereof may be topically administered to body fluids or mucosal tissues. Methods of administering the PEGylated drug/bioadhesive polymer complex and compositions thereof to an animal are also disclosed.
摘要翻译：与生物粘附聚合物复合的聚乙二醇化药物，其中聚乙二醇化药物包含与药物共价结合的聚乙二醇。 PEG化的药物/生物粘附剂多聚体复合物及其组合物可以局部施用于体液或粘膜组织。还公开了将PEG化的药物/生物粘附性聚合物复合物及其组合物施用于动物的方法。

54. 发明授权

US5055316A Tight binding of proteins to surfaces 失效
标题翻译：蛋白质与表面的紧密结合
公开(公告)号：US5055316A
公开(公告)日：1991-10-08
申请号：US183794
申请日：1988-04-20
申请人： Allan S. Hoffman , Thomas A. Horbett , Janice Bohnert , Bradford C. Fowler , David Kiaei
发明人： Allan S. Hoffman , Thomas A. Horbett , Janice Bohnert , Bradford C. Fowler , David Kiaei
IPC分类号： C07K17/08 , G01N33/543 , G01N33/545
CPC分类号： G01N33/545 , C07K17/08 , G01N33/543 , Y10S530/815
摘要： There is disclosed a method for producing extremely tight binding of proteins to surfaces and to a protein surface wherein the protein is tightly bound to the surface.
摘要翻译：公开了一种用于产生蛋白质与表面和蛋白质表面非常紧密结合的方法，其中蛋白质与表面紧密结合。

55. 发明授权

US5034428A Immobilized biomolecules and method of making same 失效
标题翻译：固定生物分子及其制备方法
公开(公告)号：US5034428A
公开(公告)日：1991-07-23
申请号：US348049
申请日：1989-05-04
申请人： Allan S. Hoffman , Liang C. Dong
发明人： Allan S. Hoffman , Liang C. Dong
IPC分类号： C12N11/02 , G01N33/543 , G01N33/545
CPC分类号： G01N33/54393 , C12N11/02 , G01N33/545 , G01N2650/00
摘要： A method of biomolecule immobilization is described in which the biomolecule itself or, alternatively, a monomer-conjugated biomolecule, is grafted with free monomer onto a hydrophilic, solid-phase, polymeric substrate which has been pre-irradiated with ionizing radiation. The pre-irradiation step is carried out, preferably at -78.degree. C. in air, while the grafting step is carried out at 0.degree. C. in a substantially oxygen-free atmosphere. The technique is applicable to immobilization of a wide variety of biomolecules, such as enzymes, catalysts, hormones, lectins, drugs, vitamins, antibodies, antigens, nucleic acids, DNA and RNA segments, pesticides, dyes and fertilizers. The products may be used for therapeutic or diagnostic applications or bioseparations.
摘要翻译：描述了一种生物分子固定方法，其中将生物分子本身或可选地，单体共轭的生物分子用游离单体接枝到已经用电离辐射预照射的亲水性固相聚合物基质上。在空气中进行预辐射步骤，优选在-78℃下进行，而接枝步骤在基本上无氧的气氛中在0℃下进行。该技术适用于各种各样的生物分子如酶，催化剂，激素，凝集素，药物，维生素，抗体，抗原，核酸，DNA和RNA片段，农药，染料和化肥的固定。该产品可用于治疗或诊断应用或生物分离。

56. 发明授权

US4912032A Methods for selectively reacting ligands immobilized within a temperature-sensitive polymer gel 失效
标题翻译：选择性地使固定在温度敏感的聚合物凝胶中的配体反应的方法
公开(公告)号：US4912032A
公开(公告)日：1990-03-27
申请号：US948377
申请日：1986-12-31
申请人： Allan S. Hoffman , Nobuo Monji
发明人： Allan S. Hoffman , Nobuo Monji
IPC分类号： A61K9/20 , B01D15/00 , C02F9/00
CPC分类号： C02F9/005 , A61K9/2027 , B01D15/00 , B01D15/34 , B01D15/3804 , B01D15/3876 , Y10S436/824
摘要： Methods for delivering substances into, removing substances from, or reacting substances with a selected environment utilizing polymer gels or coatings characterized by a critical solution temperature (CST) are disclosed. The CST as well as the pore structure, pore size, pore distribution, and absorbing capacity of the gel may be selectively controlled. The substances may be physically or chemically immobilized within the polymer gels. In addition, a method for altering the surface wettability of CST polymers is also disclosed.
摘要翻译：公开了使用聚合物凝胶或以临界溶解温度（CST）为特征的涂层将物质输送，从物质中除去或与物质反应的方法。可以选择性地控制CST以及凝胶的孔结构，孔径，孔分布和吸收能力。物质可以在聚合物凝胶内物理或化学固定。此外，还公开了改变CST聚合物的表面润湿性的方法。

57. 发明授权

US4843010A Polymerization-induced separation immunoassays 失效
标题翻译：聚合诱导分离免疫测定
公开(公告)号：US4843010A
公开(公告)日：1989-06-27
申请号：US574558
申请日：1984-01-27
申请人： Robert C. Nowinski , Allan S. Hoffman
发明人： Robert C. Nowinski , Allan S. Hoffman
IPC分类号： C08F290/14 , G01N33/545
CPC分类号： G01N33/545 , C08F290/14 , G01N2650/00 , Y10S525/904
摘要： Immunoassay methods and compositions are disclosed for the detection of analytes in fluid samples. The disclosure provides conjugates of analytes or reactants with polymerizable organic monomers. Specific binding reactions between reactants are detected by means of resporter/reactant conjugates. Free and specifically-bound reporter/reactant conjugates are separated by a polymerization reaction which renders the polymerized monomers insolule.
摘要翻译：公开了用于检测流体样品中分析物的免疫测定方法和组合物。本公开提供分析物或反应物与可聚合有机单体的缀合物。反应物之间的特异性结合反应可以通过还原剂/反应物共轭物进行检测。游离和特异结合的报告物/反应物共轭物通过聚合反应分离，使聚合的单体不规则。

58. 发明授权

US4829098A Immobilized biomolecules and method of making same 失效
标题翻译：固定生物分子及其制备方法
公开(公告)号：US4829098A
公开(公告)日：1989-05-09
申请号：US876247
申请日：1986-06-19
申请人： Allan S. Hoffman , Liang C. Dong
发明人： Allan S. Hoffman , Liang C. Dong
IPC分类号： C12N11/02 , G01N33/543 , G01N33/545
CPC分类号： C12N11/02 , G01N33/54393 , G01N33/545 , G01N2650/00
摘要： A method of biomolecule immobilization is described in which the biomolecule itself or, alternatively, a monomer-conjugated biomolecule, is grafted with free monomer onto a hydrophilic, solid-phase, polymeric substrate which has been pre-irradiated with ionizing radiation. The pre-irradiation step is carried out, preferably at -78.degree. C. in air, while the grafting step is carried out at 0.degree. C. in a substantially oxygen-free atmosphere. The technique is applicable to immobilization of a wide variety of biomolecules, such as enzymes, catalysts, hormones, lectins, drugs, vitamins, antibodies, antigens, nucleic acids, DNA and RNA segments, pesticides, dyes and fertilizers. The products may be used for therapeutic or diagnostic applications or bioseparations.
摘要翻译：描述了一种生物分子固定方法，其中将生物分子本身或可选地，单体共轭的生物分子用游离单体接枝到已经用电离辐射预照射的亲水性固相聚合物基质上。在空气中进行预辐射步骤，优选在-78℃下进行，而接枝步骤在基本上无氧的气氛中在0℃下进行。该技术适用于各种各样的生物分子如酶，催化剂，激素，凝集素，药物，维生素，抗体，抗原，核酸，DNA和RNA片段，农药，染料和化肥的固定。该产品可用于治疗或诊断应用或生物分离。

59. 发明授权

US4711840A Polymerization-induced separation immunoassays 失效
标题翻译：聚合诱导分离免疫测定
公开(公告)号：US4711840A
公开(公告)日：1987-12-08
申请号：US668247
申请日：1984-11-07
申请人： Robert C. Nowinski , Allan S. Hoffman
发明人： Robert C. Nowinski , Allan S. Hoffman
IPC分类号： C08F299/02 , G01N33/545 , G01N33/537 , C12Q1/68
CPC分类号： G01N33/545 , C08F299/022 , Y10S436/80 , Y10S525/904
摘要： Immunoassay methods and compositions are disclosed for the detection of one or more analytes in fluid samples. The disclosure provides conjugates of analytes or reactants with polymerizable organic monomers. Specific binding reactions between reactants are detected by means of reporter/reactant conjugates. Free and specifically-bound reporter/reactant conjugates are separated by a polymerization reaction which renders the polymerized monomers insoluble.
摘要翻译：公开了用于检测流体样品中一种或多种分析物的免疫测定方法和组合物。本公开提供分析物或反应物与可聚合有机单体的缀合物。通过报告物/反应物共轭物检测反应物之间的特异性结合反应。通过使聚合单体不溶的聚合反应分离游离和特异结合的报告物/反应物共轭物。

60. 发明授权

US4609707A Synthesis of polymers containing integral antibodies 失效
标题翻译：含有整体抗体的聚合物的合成
公开(公告)号：US4609707A
公开(公告)日：1986-09-02
申请号：US668248
申请日：1984-11-07
申请人： Robert C. Nowinski , Allan S. Hoffman
发明人： Robert C. Nowinski , Allan S. Hoffman
IPC分类号： C08F290/14 , G01N33/545 , C08L89/00 , C08H1/00
CPC分类号： C08F290/14 , G01N33/545 , G01N2650/00 , Y10S436/827 , Y10S530/817
摘要： A method is disclosed for the de novo synthesis of antibody-containing polymers and the preparation of a class of polymerizable compounds used in the synthesis of such antibody-containing polymers. Antibody-containing polymers formed from monomer/antibody conjugates and nonderivatized polymerizable compounds can be varied in formation of the polymer to provide control of (a) molecular spacing, steric accessibility and the number of antibody molecules that are integrally incorporated into the polymer backbone, and (b) the chemical and physical structure of the polymer itself, thus enabling specific tailoring of antibody-containing polymers for particular end-use application. Also disclosed is a method for the selective removal of a compound from a solution or suspension thereof using monomer/receptor conjugates where the compound has the capacity to bind to the receptor in the conjugate. The bound compound is removed by polymerization - induced separation of the monomer/receptor--compound complex from solution.
摘要翻译：公开了用于从含合成抗体的聚合物和制备用于合成这种含抗体聚合物的一类可聚合化合物的方法。由单体/抗体缀合物和非稀释的可聚合化合物形成的含抗体的聚合物可以在形成聚合物时变化，以提供（a）分子间距，空间可及性和整体并入聚合物主链中的抗体分子的数量的控制，以及（b）聚合物本身的化学和物理结构，从而能够特异性地定制含抗体的聚合物用于特定的最终应用。还公开了使用单体/受体共轭物从其溶液或悬浮液中选择性除去化合物的方法，其中化合物具有结合缀合物中受体的能力。通过聚合诱导分离单体/受体复合物从溶液中除去结合的化合物。

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