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    • 51. 发明授权
    • Noninvasive vascular therapy
    • 无创血管治疗
    • US07767208B2
    • 2010-08-03
    • US09905777
    • 2001-07-13
    • James Chen
    • James Chen
    • A61K39/395A61K9/127A61N5/06
    • A61N5/062A61B18/1815A61B2090/378A61K41/0057A61K41/0071A61N5/0601A61N2005/0602A61N2005/0604A61N2005/0609A61N2005/0651A61N2005/0659
    • The present invention is drawn to methods and compounds for transcutaneous photodynamic therapy (“PDT”) of a target tissue or compositions in a mammalian subject, which includes administering to the subject a therapeutically effective amount of a photosensitizing agent or a photosensitizing agent delivery system or prodrug, where the photosensitizing agent or photosensitizing agent delivery system or prodrug selectively binds to the target tissue; and irradiating at least a portion of the subject with light at a wavelength absorbed by the photosensitizing agent or if prodrug, by a prodrug product thereof, where the light is provided by a light source, and where the irradiation is at low fluence rate that results in the activation of the photosensitizing agent or prodrug product. These methods of transcutaneous PDT are useful in the treatment of specifically selected target tissues, such as: vascular endothelial tissue; abnormal vascular wall of tumors; tumors of the head and neck; tumors of the gastrointestinal tract; tumors of the liver; tumors of the esophopharyngeal; tumors of the lung; lymphoid tissue; lesions in the vascular system; bone marrow and tissue related to autoimmune disease.
    • 本发明涉及用于哺乳动物受试者的靶组织或组合物的经皮光动力治疗(“PDT”)的方法和化合物,其包括向受试者施用治疗有效量的光敏剂或光敏剂递送系统或 前药,其中光敏剂或光敏剂递送系统或前药选择性地结合靶组织; 并用受光敏剂吸收的波长的光照射受试者的至少一部分,或者如果其前体药物通过光源提供光的前药,并且其中照射是低的注射率,则结果 在光敏剂或前药产物的活化中。 经皮PDT的这些方法可用于特异性选择的靶组织的治疗,例如:血管内皮组织; 肿瘤异常血管壁; 头颈部肿瘤; 胃肠道肿瘤; 肝肿瘤; 咽喉肿瘤; 肺肿瘤; 淋巴组织; 血管系统病变; 骨髓和组织与自身免疫性疾病有关。
    • 60. 发明申请
    • Method for performing dynamic simulations within virtualized environment
    • 在虚拟环境中执行动态模拟的方法
    • US20070078641A1
    • 2007-04-05
    • US11241696
    • 2005-09-30
    • Judith BankJames ChenSteven FroehlichKarl HupplerElisabeth Stahl
    • Judith BankJames ChenSteven FroehlichKarl HupplerElisabeth Stahl
    • G06F9/45
    • G06F11/3495G06F11/3428G06F11/3457
    • A method and apparatus for and article of manufacture for simulating workloads experienced by multiple partitions in a virtualized system are provided. A master workload driver initiates, coordinates and regulates one or more workload drivers that execute one or more workload simulation tasks in a logical partition. Further, each workload driver may be configured to report a measure of performance regarding the workload to the master control driver where results of many workload drivers may be correlated and analyzed. A configuration file specifies the characteristics of each simulation. Further, the rate and nature of workloads may be adjusted dynamically during a given simulation to model the performance under different real-world scenarios of different computational loads that may be experienced by the virtualized system.
    • 提供了一种用于模拟虚拟化系统中的多个分区所经历的工作负载的方法和装置以及制造物品。 主工作负载驱动程序启动,协调和调节在逻辑分区中执行一个或多个工作负载模拟任务的一个或多个工作负载驱动程序。 此外,每个工作负载驱动程序可以被配置为向主控制驱动器报告关于工作负载的性能的度量,其中可以关联和分析许多工作负载驱动程序的结果。 配置文件指定每个模拟的特征。 此外,可以在给定的仿真期间动态地调整工作负载的速率和性质,以对虚拟化系统可能经历的不同计算负载的不同现实世界情景下的性能进行建模。