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51. 发明专利

FR2463807A1 Biological molecule fixation on magnetic vinyl-aromatic polymers - adsorbed proteins e.g. bacteria, viruses, cells, antigens, antibodies are used in sepn. processes and determinations 未知
公开(公告)号：FR2463807A1
公开(公告)日：1981-02-27
申请号：FR7921343
申请日：1979-08-24
申请人： PASTEUR INSTITUT
发明人： AVRAMEAS STRATIS , GUESDON JEAN-LUC
IPC分类号： A61K39/02 , A61K47/48 , C08F2/44 , C08F292/00 , C12N1/04 , C12N7/02 , C12N11/08 , G01N33/543 , C08F12/06 , C12Q1/00 , G01N33/48
摘要： Process for the fixation of biological molecules on magnetic supports by contacting a soln. contg. the biological molecules to be fixed with a magnetic support based on vinylaromatic polymer particles. When the molecules have been adsorbed, the support is sepd. from the soln. Pref. the vinylaromatic polymers are obtd. by suspension polymerisation of the vinylaromatic cpd. alone or in mixt. with a copolymerisable monomer in the presence of an initiator, a suspension agent and a magnetic charge e.g. ferrite or magnetite particles. The magnetic charge is dispersed in a soln. of the homo- or copolymer or the monomer(s) and the obtd. dispersion is suspended in water and the monomer(s) polymerised. The obtd. biological support is used in immunoenzymatic, radioimmunological or fluorimetry determinations or in determination using other markers. The process may also be used to separate biological substances, e.g. proteins such as bacteria, viruses, cells, antigens and antibodies. Examples of biological molecules fixed to the polymers are DNA, bovine serum albumin, rabbit Ig, Herpes antigen and Candida albicans antigen which may be used to detect the antigens.

52. 发明专利

CA2852463C MUTATION WITHIN THE CONNEXIN 26 GENE RESPONSIBLE FOR PRELINGUAL NON-SYNDROMIC DEAFNESS AND METHOD OF DETECTION 未知
公开(公告)号：CA2852463C
公开(公告)日：2017-08-29
申请号：CA2852463
申请日：1998-08-14
申请人： PASTEUR INSTITUT
发明人： PETIT CHRISTINE , DENOYELLE-GRYSON FRANCOISE , WEIL DOMINIQUE , MARLIN-DUVERNOIS SANDRINE , GUESDON JEAN-LUC
IPC分类号： C12Q1/68 , G01N33/53 , C12N15/09 , C12Q1/6883 , C12Q1/6886 , G01N33/566 , G06F19/20 , G06F19/22
摘要： A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated purified polynucleotide presents a mutation responsible for prelingual non-syndromic deafness selected from the group consisting of a specific deletion of at least one nucleotide.

53. 发明专利

DK0636187T3 未知
公开(公告)号：DK0636187T3
公开(公告)日：2000-12-18
申请号：DK94905767
申请日：1994-01-31
申请人： PASTEUR INSTITUT
发明人： GUESDON JEAN-LUC , STONNET VERONIQUE
IPC分类号： C12N15/09 , C07H21/04 , C12Q1/68 , C12Q1/689 , C07H21/00 , C12N15/63
摘要： PCT No. PCT/FR94/00122 Sec. 371 Date Sep. 29, 1994 Sec. 102(e) Date Sep. 29, 1994 PCT Filed Jan. 31, 1994 PCT Pub. No. WO94/17205 PCT Pub. Date Aug. 4, 1994The subject of the present invention is thus a nucleotide sequence which hybridizes specifically with a Campylobacter jejuni genomic nucleic acid sequence chosen from the nucleotide sequence SEQ ID No. 1, the nucleotide sequence SEQ ID No. 2 the sequences complementary to the latter, as well as the sequences differing therefrom by nutation, insertion, deletion or substitution of one or more bases, and which does not or virtually does not hybridize with nucleic acids from other Campylobacter species. Fragments of this sequence can be used as specific primers for the amplification of sequences specific for Campylobacter jejuni and as nucleic probes specific for Campylobacter jejuni nucleic sequences. The subject of the invention is also a method of detecting the presence of Campylobacter jejuni stains in a biological sample, as well a kit for carrying out the method.

54. 发明专利

ES2125577T3 未知
公开(公告)号：ES2125577T3
公开(公告)日：1999-03-01
申请号：ES95402537
申请日：1995-11-13
申请人： PASTEUR INSTITUT
发明人： STONNET VERONIQUE , GUESDON JEAN-LUC
IPC分类号： C12N15/09 , C12Q1/04 , C12Q1/68 , C12Q1/689
摘要： A new nucleic acid sequence (I) hybridises specifically with genomic nucleic acid of Campylobacter coli strains but not (under normal conditions) with other Campylobacter species or with bacteria of other genera, and has the 604 bp sequence given in the specification (or its complement or a sequence differing by mutation, insertion, deletion or substitution of one or more bases).

55. 发明专利

CA2852463A1 MUTATION WITHIN THE CONNEXIN 26 GENE RESPONSIBLE FOR PRELINGUAL NON-SYNDROMIC DEAFNESS AND METHOD OF DETECTION 未知
公开(公告)号：CA2852463A1
公开(公告)日：1999-02-25
申请号：CA2852463
申请日：1998-08-14
申请人： PASTEUR INSTITUT
发明人： PETIT CHRISTINE , DENOYELLE-GRYSON FRANCOISE , WEIL DOMINIQUE , MARLIN-DUVERNOIS SANDRINE , GUESDON JEAN-LUC
IPC分类号： C12Q1/68 , G01N33/53 , C12N15/09 , C12Q1/6883 , C12Q1/6886 , G01N33/566 , G06F19/20 , G06F19/22
摘要： A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated purified polynucleotide presents a mutation responsible for prelingual non-syndromic deafness selected from the group consisting of a specific deletion of at least one nucleotide.

56. 发明专利

AT172250T 未知
公开(公告)号：AT172250T
公开(公告)日：1998-10-15
申请号：AT95402537
申请日：1995-11-13
申请人： PASTEUR INSTITUT
发明人： STONNET VERONIQUE , GUESDON JEAN-LUC
IPC分类号： C12N15/09 , C12Q1/04 , C12Q1/68 , C12Q1/689
摘要： A new nucleic acid sequence (I) hybridises specifically with genomic nucleic acid of Campylobacter coli strains but not (under normal conditions) with other Campylobacter species or with bacteria of other genera, and has the 604 bp sequence given in the specification (or its complement or a sequence differing by mutation, insertion, deletion or substitution of one or more bases).

57. 发明专利

GR3021781T3 Specific detection of mycobacterium tuberculosis 未知
公开(公告)号：GR3021781T3
公开(公告)日：1997-02-28
申请号：GR960403179
申请日：1996-11-27
申请人： PASTEUR INSTITUT
发明人： GUESDON JEAN-LUC , THIERRY DOMINIQUE
IPC分类号： C12N15/09 , C12Q1/68 , C12Q1/689 , C07H21/04 , C12P19/34

58. 发明专利

DE69026716T2 未知
公开(公告)号：DE69026716T2
公开(公告)日：1996-11-14
申请号：DE69026716
申请日：1990-09-06
申请人： PASTEUR INSTITUT
发明人： GUESDON JEAN-LUC , THIERRY DOMINIQUE , ULLMANN AGNES , GICQUEL BRIGITTE , BRISSON-NOEL ANNE
IPC分类号： C07H21/04 , C07K14/35 , C12N15/09 , C12N15/11 , C12N15/31 , C12Q1/68 , C12R1/32
摘要： Fragments of nucleic acids derived from an appropriate mycobacteria genome, particularly Mycobacterium tuberculosis, their applications in the diagnosis of mycobacteria infections, as well as plasmides containing said fragments. The nucleotidic sequence is comprised of a nucleotidic sequence repeated in the genome of a mycobacterium and specific of the bacillus of tuberculosis and is characterized by a strong hybridation with M. tuberculosis.

59. 发明专利

ES2088660T3 未知
公开(公告)号：ES2088660T3
公开(公告)日：1996-08-16
申请号：ES93900219
申请日：1992-10-30
申请人： PASTEUR INSTITUT
发明人： GUESDON JEAN-LUC , THIERRY DOMINIQUE , VINCENT VERONIQUE
IPC分类号： C07K14/35 , C12Q1/68 , C12Q1/689

60. 发明专利

AU4179696A Nucleotide sequences specifically hybridising with a genomic nucleic sequence of campylobacter fetus 未知
公开(公告)号：AU4179696A
公开(公告)日：1996-06-06
申请号：AU4179696
申请日：1995-11-10
申请人： PASTEUR INSTITUT
发明人： GUESDON JEAN-LUC , GAUTIER ISABELLE
IPC分类号： C12Q1/68 , C12Q1/689

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