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51. 发明授权

US07566557B2 Gene variants coding for proteins from the metabolic pathway of fine chemicals 有权
标题翻译：编码精细化学物质代谢途径蛋白质的基因变体
公开(公告)号：US07566557B2
公开(公告)日：2009-07-28
申请号：US10583404
申请日：2004-12-16
申请人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Haefner , Uwe Ruffer , Claudia Isabella Graef , Gregor Haberhauer
发明人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Haefner , Uwe Ruffer , Claudia Isabella Graef , Gregor Haberhauer
IPC分类号： C12N9/10 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C07K14/34
摘要： The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing genetically modified organisms, and to genetically modified organisms themselves.
摘要翻译：本发明涉及精细化学品的代谢途径的突变核酸和蛋白质，制备经遗传修饰的生物体生物体的方法，通过培养经遗传修饰的生物体来制备精细化学品的方法以及转基因生物本身。

52. 发明授权

US07192749B2 Use of the repressor glxR for the synthesis of lysine in Corynebacterium glutamicum 有权
标题翻译：在谷氨酸棒杆菌中使用阻遏物glxR用于合成赖氨酸
公开(公告)号：US07192749B2
公开(公告)日：2007-03-20
申请号：US10514076
申请日：2003-05-13
申请人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Häfner , Heung-Shick Lee
发明人： Corinna Klopprogge , Oskar Zelder , Burkhard Kröger , Hartwig Schröder , Stefan Häfner , Heung-Shick Lee
IPC分类号： C12P13/08 , C12P21/06 , C12N1/21 , C12N15/17 , C12N9/10 , C07H21/02 , C12H21/04
CPC分类号： C07K14/34
摘要： Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.
摘要翻译：具有SEQ ID NO：1的序列的分离的多肽序列或其突变蛋白具有结合cAMP的能力并抑制谷氨酸棒杆菌的aceB基因的表达，并且可以通过插入，缺失或替代从SEQ ID NO：1获得高达20％的氨基酸。

53. 发明申请

US20100003727A1 Coryneform Bacteria with Formate-THF-Synthetase and/or Glycine Cleavage Activity 审中-公开
标题翻译：具有甲酸-THF合成酶和/或甘氨酸裂解活性的棒状杆菌细菌
公开(公告)号：US20100003727A1
公开(公告)日：2010-01-07
申请号：US12519909
申请日：2008-02-14
申请人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , Thomas A. Patterson , R. Rogers Yocum , Janice G. Pero
发明人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , Thomas A. Patterson , R. Rogers Yocum , Janice G. Pero
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12P13/12 , C12N15/52
摘要： The present invention relates to microorganisms, in particular C. glutamicum in which the formation of N5,N10-methylene-THF is increased.The present invention also relates to the use of such microorganisms for producing methionine.
摘要翻译：本发明涉及增加N5，N10-亚甲基-THF的形成的微生物，特别是谷氨酸棒杆菌。本发明还涉及这种微生物用于产生甲硫氨酸的用途。

54. 发明申请

US20090246836A1 Pgro expression units 审中-公开
标题翻译： Pgro表达单位
公开(公告)号：US20090246836A1
公开(公告)日：2009-10-01
申请号：US10582822
申请日：2004-12-15
申请人： Burkhard Kröger , Oskar Zelder , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner
发明人： Burkhard Kröger , Oskar Zelder , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner
IPC分类号： C12P13/12 , C12P1/00 , C12P13/08 , C12N15/74 , C12N1/00 , C12N15/63 , C07H21/04
CPC分类号： C12P13/08 , C07K14/34 , C12N15/77
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译：本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。

55. 发明授权

US07485444B2 Methods for producing sulphurous fine chemicals by fermentation using metH-coding cornyeform bacteria 有权
标题翻译：使用metH编码玉米角质细菌通过发酵生产硫化精细化学品的方法
公开(公告)号：US07485444B2
公开(公告)日：2009-02-03
申请号：US10511302
申请日：2003-04-16
申请人： Burkhard Kröger , Oskar Zelder , Corinna Klopprogge , Hartwig Schröder , Stefan Häfner
发明人： Burkhard Kröger , Oskar Zelder , Corinna Klopprogge , Hartwig Schröder , Stefan Häfner
IPC分类号： C12P13/12 , C12N15/09 , C12N15/77
CPC分类号： C12N9/1007 , C12P13/12
摘要： The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.
摘要翻译：本发明涉及通过使用表达编码甲硫氨酸合成酶（metH）基因的核苷酸序列的细菌来发酵生产含硫精细化学品，特别是L-甲硫氨酸的方法。

56. 发明授权

US07323559B2 Genes encoding genetic stability, gene expression and folding proteins 有权
公开(公告)号：US07323559B2
公开(公告)日：2008-01-29
申请号：US11591868
申请日：2006-11-02
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
IPC分类号： C07H21/04 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C12N9/00 , C07K14/34 , C12N9/0006 , C12P13/08
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

57. 发明授权

US07141663B2 Genes coding for metabolic pathway proteins 有权
标题翻译：编码代谢途径蛋白的基因
公开(公告)号：US07141663B2
公开(公告)日：2006-11-28
申请号：US10494675
申请日：2002-10-31
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
IPC分类号： C07H21/04 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C12N15/77 , C12N15/52 , C12P13/08
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
摘要翻译：本发明涉及新颖的核酸分子，其用于构建遗传改良的微生物的用途，以及借助所述遗传改良的微生物制备精细化学品，特别是氨基酸的方法。

58. 发明授权

US08771998B2 Process for the production of gamma-aminobutyric acid 失效
标题翻译：生产γ-氨基丁酸的方法
公开(公告)号：US08771998B2
公开(公告)日：2014-07-08
申请号：US12918241
申请日：2009-02-20
申请人： Oskar Zelder , Weol Kyu Jeong , Corinna Klopprogge , Andrea Herold , Hartwig Schröder
发明人： Oskar Zelder , Weol Kyu Jeong , Corinna Klopprogge , Andrea Herold , Hartwig Schröder
IPC分类号： C12P13/00 , C12N9/88 , C12N1/20 , C12N15/00 , C12P19/34 , C08G69/08 , C07H21/04 , C07K1/00
CPC分类号： C12P13/005 , C12N9/88 , C12P13/02
摘要： The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant microorganism expressing an enzyme having a glutamate decarboxylase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as to a method for preparing polyamides making use of GABA as obtained fermentative production.
摘要翻译：本发明涉及通过培养表达具有谷氨酸脱羧酶活性的酶的重组微生物来发酵γ-氨基丁酸（GABA）的新方法。本发明还涉及适用于制备这种宿主的相应的重组宿主，重组载体，表达盒和核酸以及使用GABA制备聚酰胺作为获得的发酵生产的方法。

59. 发明授权

US08741623B2 Process for the production of cadaverine 有权
标题翻译：生产尸体素的方法
公开(公告)号：US08741623B2
公开(公告)日：2014-06-03
申请号：US12295348
申请日：2007-03-23
申请人： Oskar Zelder , Weol Kyu Jeong , Corinna Klopprogge , Andrea Herold , Hartwig Schröder
发明人： Oskar Zelder , Weol Kyu Jeong , Corinna Klopprogge , Andrea Herold , Hartwig Schröder
IPC分类号： C12N1/20 , C12N15/74 , C12N15/77 , A01N63/00 , C07H21/04
CPC分类号： C12P13/02 , C12N9/88 , C12P13/001
摘要： Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.
摘要翻译：通过构建具有失调的赖氨酸脱羧酶基因的重组微生物和选自由天冬氨酸激酶，天冬氨酸二甲醛脱氢酶，二氢吡啶二羧酸合成酶，二氢吡啶二羧酸还原酶，四氢吡啶二羧酸盐琥珀酰基酶，琥珀酰 - 氨基酮基庚酸酯转氨酶，琥珀酰 - 二氨基 - 庚二酸二琥珀酰酶，二氨基庚二酸差向异构酶，二氨基庚二酸脱氢酶，精氨酰-tRNA合成酶，二氨基庚二酸脱羧酶，丙酮酸羧化酶，磷酸烯醇丙酮酸羧化酶，葡萄糖-6-磷酸脱氢酶，转酮酶，转醛醇酶，6-磷酸葡萄糖醛酸酶，果糖1， 6-二磷酸酶，高丝氨酸脱氢酶，磷酸烯醇丙酮酸羧激酶，琥珀酰辅酶A合成酶，甲基丙二酰-CoA变位酶，条件是如果天冬氨酸激酶被释放为基因（i）至少第二个基因（i），除了天冬氨酸激酶外必须解除调节，并培养所述微生物。

60. 发明申请

US20120295315A1 Nucleic acid encoding a cobalamin-dependent methionine synthase polypeptide 审中-公开
标题翻译：编码钴胺素依赖性甲硫氨酸合成酶多肽的核酸
公开(公告)号：US20120295315A1
公开(公告)日：2012-11-22
申请号：US13524184
申请日：2012-06-15
申请人： Oskar Zelder , Wolfgang Grabarse , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Anja Knietsch , Andrea Herold
发明人： Oskar Zelder , Wolfgang Grabarse , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Anja Knietsch , Andrea Herold
IPC分类号： C12N15/54 , C12N1/21 , C12P13/12 , C12N15/63
CPC分类号： C12N9/0091 , C12P13/12
摘要： The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of such nucleotide sequences.
摘要翻译：本发明涉及编码酶促活性钴胺素 - 甲硫氨酸合成酶的核糖核酸序列及其功能片段，其与相应的野生型酶相比被修饰，使得所述酶显示产品抑制蛋氨酸的产物减少。本发明还涉及由该核苷酸序列编码的多肽和包含该核苷酸序列的宿主细胞。此外，本发明涉及通过利用这种核苷酸序列在宿主生物体中产生甲硫氨酸的方法。

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