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51. 发明公开

EP2081901A1 NOVEL 2-AMINO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译： NEW 2-氨基吡啶衍生物及其作为钾通道调节剂的使用
公开(公告)号：EP2081901A1
公开(公告)日：2009-07-29
申请号：EP07817894.4
申请日：2007-11-13
申请人： NeuroSearch A/S
发明人： SØRENSEN, Ulrik Svane , ERIKSEN, Brigitte L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D213/74 , A61K31/4402 , A61P25/00 , A61P25/28
CPC分类号： C07D213/74
摘要： This invention relates to novel 2-amino-pyridine derivative useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

52. 发明公开

EP2043641A2 COMBINATIONS OF MONOAMINE REUPTAKE INHIBITORS AND POTASSIUM CHANNEL ACTIVATORS 审中-公开
标题翻译：组合MONO AMIN回收抑制剂和钾通道激活剂
公开(公告)号：EP2043641A2
公开(公告)日：2009-04-08
申请号：EP07786977.4
申请日：2007-07-02
申请人： NeuroSearch A/S
发明人： SØRENSEN, Ulrik Svane , ERIKSEN, Birgitte L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina Holm , CHRISTOPHERSEN, Palle , REDROBE, John Paul
IPC分类号： A61K31/445 , A61K31/495 , A61K45/06 , A61P1/00 , A61P25/00 , A61P25/16 , A61P25/30 , A61P43/00
CPC分类号： A61K45/06 , A61K31/445 , A61K31/495 , A61K2300/00
摘要： This invention provides pharmaceutical compositions comprising therapeutically effective amounts of a monoamine reuptake inhibitor and an SK inhibitor. In another aspect the invention provides novel benzoimidazole derivatives for use according to the invention.

53. 发明授权

EP0853615B1 PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS 失效
标题翻译： PIPERINDINVERBINDUNGEN ALS CALCUM-KANAL-BLOCKER
公开(公告)号：EP0853615B1
公开(公告)日：2003-12-10
申请号：EP96932528.1
申请日：1996-09-13
申请人： NEUROSEARCH A/S
发明人： AXELSSON, Oskar , PETERS, Dan , OSTERGAARD NIELSEN, Elsebet , CHRISTOPHERSEN, Palle
IPC分类号： C07D211/42 , C07D471/10
CPC分类号： C07D491/10 , C07D211/42
摘要： The present invention discloses compounds of formula (I) any of its enantiomers or any mixture thereof, or a pharmaceutically-acceptable addition salt thereof, wherein X is O, S, or NR3, wherein R3 is hydrogen, alkyl, or aryl which may be substituted one or more times with substituents selected from the group consisting of alkyl, alkoxy, halogen, amino, nitro, cyano, trifluoromethyl, aryl, arylalkyl, aryloxy and arylalkyloxy; m is 0, 1, or 2; n is 0, 1, or 2; R is cycloalkyl, cycloalkylalkyl, (aryl)¿p?-alkyl, (aryl)p-alkenyl, or (aryl)p-alkynyl, wherein the aryl group may be substituted one or more times with substituents selected from the group consisting of alkyl, alkoxy, halogen, amino, nitro, cyano and trifluoromethyl, and p is 0, or 1; one of R?1 and R2¿ is -O-Z, or -S-Z, wherein Z is hydrogen; alkyl; alkenyl; alkynyl; cycloalkyl; cycloalkylalkyl; arylalkyl, arylalkenyl, arylalkynyl, or aryl-CO-, wherein the aryl groups may be substituted one or more times with substituents selected from the group consisting of alkyl, alkoxy, halogen, amino, nitro, cyano and trifluoromethyl; or Z is -(CH¿2?)o-CO-R?2¿, -(CH¿2?)o-COOR?2¿, -(CH¿2?)o-CONR?2R3¿, or -(CH¿2?)o-Het, wherein o is 0, 1, 2, 3, 4, or 5 and R?2 and R3¿ each independently are hydrogen, or alkyl, and Het is a five- or six-membered monocyclic heterocyclic ring; or Z is -(CH¿2)o-WR?4, or (II), wherein o is 0, 1, 2, 3, 4, or 5, W and W' each independently are O, or S, and R?4 and R5¿ each independently are hydrogen, or alkyl, or wherein R?4 and R5¿ together is -(CH¿2?)q-, wherein q is 2, or 3; and the other of R?1 and R2¿ is hydrogen, alkoxy, or alkoxyalkoxy; or R?1 and R2¿ together form a chain -W-(CH¿2?)q-W'-, wherein W and W' each independently are O, or S and q is 2, or 3; Ar is aryl which may be subsittuted one or more times with substituents selected from the group consisting of alkyl, alkoxy, halogen, amino, nitro, cyano, trifluoromethyl, aryl, arylalkyl, aryloxy, and arylalkyloxy. The compounds are useful as pharmaceuticals, for example, in the treatment of ischemia, anoxia, migraine and psychosis.

54. 发明授权

EP0977741B1 SUBSTITUTED PHENYL DERIVATIVES, THEIR PREPARATION AND USE 失效
标题翻译：取代的苯基衍生物，生产和使用
公开(公告)号：EP0977741B1
公开(公告)日：2003-09-03
申请号：EP98914851.5
申请日：1998-04-21
申请人： NEUROSEARCH A/S
发明人： CHRISTOPHERSEN, Palle , PEDERSEN, Ove
IPC分类号： C07D257/04 , C07D249/12 , C07D271/10 , C07D401/10 , C07D405/10 , C07D409/10 , A61K31/41
CPC分类号： C07C275/42 , C07C233/55 , C07C271/58 , C07C275/40 , C07C309/51 , C07C311/08 , C07C311/21 , C07C311/47 , C07C311/60 , C07C335/22

55. 发明公开

EP2114916A2 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：吡啶基吡唑衍生物及其作为钾通道调节剂
公开(公告)号：EP2114916A2
公开(公告)日：2009-11-11
申请号：EP08708543.7
申请日：2008-02-01
申请人： NeuroSearch A/S
发明人： ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D401/04 , C07D405/14 , A61K31/4439 , A61P11/00
CPC分类号： C07D401/04 , C07D405/14
摘要： This invention relates to novel pyridinyl-pyrazole derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

56. 发明公开

EP2094655A1 NOVEL BIPHENYL THIO-UREA DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：作为钾通道调节剂适合...新的联苯基硫脲
公开(公告)号：EP2094655A1
公开(公告)日：2009-09-02
申请号：EP07857650.1
申请日：2007-12-17
申请人： NeuroSearch A/S
发明人： NARDI, Antonio , DEMNITZ, Joachim , GRUNNET, Morten , CHRISTOPHERSEN, Palle , JONES, David Spencer , NIELSEN, Elsebet Østergaard , STRØBÆK, Dorte , MADSEN, Lars Siim
IPC分类号： C07C335/18 , C07D257/04 , A61K31/17 , A61P15/12
CPC分类号： C07D257/04 , A61K31/17 , A61K31/41 , A61K31/496 , A61K31/5025 , A61K31/53 , C07C335/18
摘要： The invention relates to novel biphenyl thio-urea derivatives of Formula (I), wherein A represents hydroxy or tetrazolyl; R1 represents halo, hydroxy or phenyl, which phenyl may optionally be substituted with halo; and R2 and R3, independent of each other, represent halo, trifluoromethyl, nitro and/or phenyl, that are found to be potent modulators of ion channels and, as such, they are valuable candidates for the treatment of disease or disorders as diverse as those which are responsive to modulation of ion channels.

57. 发明授权

EP1663192B1 hERG1 CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS 有权
标题翻译： HERG1 CHANNEL首战治疗心律失常
公开(公告)号：EP1663192B1
公开(公告)日：2008-12-03
申请号：EP04766708.4
申请日：2004-09-06
申请人： NeuroSearch A/S
发明人： OLESEN, Soeren, Peter , GRUNNET, Morten , CHRISTOPHERSEN, Palle , STROBAEK, Dorte , DEMNITZ, Joachim , HANSEN, Rie, S.
IPC分类号： A61K31/17 , A61K31/41 , A61K31/00 , A61P9/06 , A61P9/10
CPC分类号： A61K31/00 , A61K31/17 , A61K31/41
摘要： This invention relates to the use of ERG channel openers for the treatment of cardiac arrhythmias, and to the use of specific compounds for such treatment. In a separate aspect the invention provides novel compounds useful as ERG channel openers.

58. 发明公开

EP1940804A2 NOVEL PYRIMIDINE-2,4-DIAMINE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 审中-公开
标题翻译： NEW嘧啶-2,4-二胺化合物和它们作为调制器，具有低的电导率钙激活钾通道
公开(公告)号：EP1940804A2
公开(公告)日：2008-07-09
申请号：EP06807251.1
申请日：2006-10-13
申请人： NeuroSearch A/S
发明人： SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D239/48 , A61K31/505 , A61P25/28
CPC分类号： C07D239/48
摘要： This invention relates to novel pyrimidine-2,4-diamine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

59. 发明公开

EP1838306A1 NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 有权
标题翻译： NEW 2-氨基 - 苯并咪唑衍生物和它们作为调制器，具有低的电导率钙激活钾通道
公开(公告)号：EP1838306A1
公开(公告)日：2007-10-03
申请号：EP06701206.2
申请日：2006-01-10
申请人： NEUROSEARCH A/S
发明人： SØRENSEN, Ulrik, Svane , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , NIELSEN, Karin, Sandager , CHRISTOPHERSEN, Palle
IPC分类号： A61K31/4184 , C07D235/30 , A61P25/00
CPC分类号： C07D235/30
摘要： This invention relates to novel 2-amino benzimidazole derivatives of formula (I1) and (Ib) useful as modulators of small-conductance calcium-activated potassium channels (SK channels) . In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

60. 发明授权

EP0906273B1 PHENYL DERIVATIVES CONTAINING AN ACIDIC GROUP, THEIR PREPARATION AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS 失效
标题翻译： IHRE HERTELLUNG IN IHRE VERWENDUNG ALS CHLORIDKANALBLOCKER，SAE GRUPPEN ENTHALTENDE PHENYLDERIVATE
公开(公告)号：EP0906273B1
公开(公告)日：2002-10-16
申请号：EP97924019.9
申请日：1997-05-26
申请人： NEUROSEARCH A/S
发明人： CHRISTOPHERSEN, Palle , PEDERSEN, Ove
IPC分类号： C07C275/42 , C07C311/39 , C07C311/51 , C07C335/22 , C07C275/40 , C07C311/08 , C07C311/60 , C07C271/58 , A61K31/19 , A61K31/17 , A61K31/18
CPC分类号： C07C311/47 , A61K31/155 , A61K31/17 , C07C233/55 , C07C271/58 , C07C275/40 , C07C275/42 , C07C309/51 , C07C311/08 , C07C311/21 , C07C311/60 , C07C335/22

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