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51. 发明申请

US20080194459A1 Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides 有权
标题翻译：含有非离子氨基酸和多肽的组合物，涉及的方法和用途
公开(公告)号：US20080194459A1
公开(公告)日：2008-08-14
申请号：US11925740
申请日：2007-10-26
申请人： Zhenwei Miao , Junjie Liu , Thea Norman
发明人： Zhenwei Miao , Junjie Liu , Thea Norman
IPC分类号： A61K38/02 , C07C229/36 , C07K2/00 , C08F116/04
CPC分类号： C07K2/00 , C07C229/42 , C07K1/006
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛范围的可能的官能团，但典型地具有至少一个芳族胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个烷基化胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

52. 发明授权

US07385028B2 Derivatization of non-natural amino acids and polypeptides 有权
标题翻译：非天然氨基酸和多肽的衍生化
公开(公告)号：US07385028B2
公开(公告)日：2008-06-10
申请号：US11313956
申请日：2005-12-21
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C07K1/02 , C07K2/00 , C07K4/00 , C07C251/32 , C12P21/06
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛的可能的官能团，但典型的具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

53. 发明申请

US20080118464A1 Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides 失效
公开(公告)号：US20080118464A1
公开(公告)日：2008-05-22
申请号：US11925732
申请日：2007-10-26
申请人： Zhenwei Miao , Junjie Liu , Thea Norman
发明人： Zhenwei Miao , Junjie Liu , Thea Norman
IPC分类号： A61K38/16 , C07K7/00 , C07K14/00 , A61K38/19 , G01N33/566 , A61P43/00 , A61K38/21 , A61K39/395 , A61K38/04
CPC分类号： C07K2/00 , C07C229/42 , C07K1/006
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

54. 发明申请

US20060217289A1 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US20060217289A1
公开(公告)日：2006-09-28
申请号：US11313305
申请日：2005-12-21
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： A61K38/00 , A61K48/00 , A61K31/198
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛的可能的官能团，但典型的具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

55. 发明申请

US20050129609A1 Method for preparation of magnetic spinel ferrites from layered double hydroxide precursors 失效
标题翻译：从层状双氢氧化物前体制备磁性尖晶石铁氧体的方法
公开(公告)号：US20050129609A1
公开(公告)日：2005-06-16
申请号：US11040533
申请日：2005-01-21
申请人： Xue Duan , Feng Li , Junjie Liu
发明人： Xue Duan , Feng Li , Junjie Liu
IPC分类号： C01G49/02 , C04B35/26 , H01F10/20 , H01F41/02 , H01F41/24
CPC分类号： C04B35/2625 , C04B35/265 , C04B35/2658 , C04B35/2666 , C04B35/2683 , C04B35/6265 , C04B2235/3205 , C04B2235/3206 , C04B2235/3222 , C04B2235/3262 , C04B2235/3272 , C04B2235/3275 , C04B2235/3279 , C04B2235/3281 , H01F10/20 , H01F41/0253 , H01F41/24
摘要： The invention describes a method of preparing magnetic ferrites from layered precursors in which Fe2+ is first introduced into the layers of layered double hydroxides (LDHs) in order to prepare Me-Fe2+—Fe3+ LDHs, and then by utilizing the easily oxidized nature of Fe2+, binary or multi-component ferrite materials containing Fe3+ in a single crystalline phase can be prepared. Values of the saturation magnetization of ferrites prepared by the method are significantly increased compared with ferrites prepared by traditional methods. Because the metal elements in the layered precursor have the characteristics of a high degree of dispersion, high activity and small particle size (average particle size 40-200 nm), no milling is required before calcination, thus simplifying the production process, shortening the production period, reducing capital investment in equipment and economizing on energy costs. In addition, the method does not corrode production equipment and does not pollute the environment.
摘要翻译：本发明描述了一种从层状前体制备磁性铁氧体的方法，其中Fe 2+ 2首先被引入层状双氢氧化物（LDH）层中以制备Me-Fe 2+， / Fe 3+ LDH，然后通过利用Fe 2+的易氧化性质，含Fe 3+的二元或多组分铁素体材料，可以制备单晶相中的。通过该方法制备的铁氧体的饱和磁化强度与通过传统方法制备的铁氧体相比显着增加。由于层状前体中的金属元素具有高分散性，高活性，小粒径（平均粒径40〜200nm）的特征，因此在煅烧前不需要研磨，因此简化了制造工序，缩短了生产减少设备资金投入，节约能源成本。此外，该方法不会腐蚀生产设备，也不会污染环境。

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