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51. 发明申请

US20050261508A1 Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds 审中-公开
标题翻译：可用作钠/质子交换剂（NHE）抑制剂的氨基甾醇化合物，使用这种抑制剂的药物方法和组合物，以及评价化合物的NHE抑制功效的方法
公开(公告)号：US20050261508A1
公开(公告)日：2005-11-24
申请号：US11046906
申请日：2005-02-01
申请人： Michael Zasloff , Ann Shinnar , William Kinney , Steven Jones
发明人： Michael Zasloff , Ann Shinnar , William Kinney , Steven Jones
IPC分类号： A61K31/56 , C07J9/00 , C07J41/00 , G01N33/50
CPC分类号： G01N33/5011 , A61K31/56 , C07J9/00 , C07J41/0005 , G01N33/5008 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/5064 , G01N33/5088 , G01N33/5091 , G01N2500/00
摘要： Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
摘要翻译：描述了可用作钠/质子交换器（NHE）的抑制剂的氨基甾醇化合物。还包括使用这种氨基甾醇化合物的方法，包括使用作为NHE光谱抑制剂的化合物的那些以及仅使用一种特异性NHE抑制剂的化合物。还公开了有利的筛选技术和用于评价化合物治疗活性的测定法。

52. 发明授权

US06962909B2 Treatment of neovascularization disorders with squalimine 失效
标题翻译：用squalimine治疗新生血管形成障碍
公开(公告)号：US06962909B2
公开(公告)日：2005-11-08
申请号：US09985417
申请日：2001-11-02
申请人： Michael Zasloff , Ann Shinnar , William Kinney , Steven Jones
发明人： Michael Zasloff , Ann Shinnar , William Kinney , Steven Jones
IPC分类号： A61K31/56 , C07J9/00 , C07J41/00 , G01N33/50 , C07C305/12
CPC分类号： G01N33/5011 , A61K31/56 , C07J9/00 , C07J41/0005 , G01N33/5008 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/5064 , G01N33/5088 , G01N33/5091 , G01N2500/00
摘要： Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
摘要翻译：描述了可用作钠/质子交换器（NHE）的抑制剂的氨基甾醇化合物。还包括使用这种氨基甾醇化合物的方法，包括使用作为NHE光谱抑制剂的化合物的那些以及仅使用一种特异性NHE抑制剂的化合物。还公开了有利的筛选技术和用于评价化合物治疗活性的测定法。

53. 发明申请

US20050180969A1 Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency 有权
标题翻译：用于治疗肿瘤性疾病或免疫缺陷的人源免疫调节单克隆抗体
公开(公告)号：US20050180969A1
公开(公告)日：2005-08-18
申请号：US10994091
申请日：2004-11-19
申请人： Britta Hardy , Steven Jones , Leah Klapper
发明人： Britta Hardy , Steven Jones , Leah Klapper
IPC分类号： A61K39/395 , C07K16/28 , C07K16/44 , C12N20060101
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/73
摘要： The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation of peripheral blood lymphocytes, and is capable of eliciting an anti-tumor effect upon administration to subjects suffering from cancer.
摘要翻译：本发明提供具有免疫刺激作用的人源化单克隆抗体。该抗体特异性结合B类淋巴母细胞，诱导外周血淋巴细胞的增殖和活化，并且能够在给予患有癌症的受试者时引发抗肿瘤作用。

54. 发明申请

US20050152763A1 Blind rivet and method to make same 审中-公开
标题翻译：盲铆钉和方法制作相同
公开(公告)号：US20050152763A1
公开(公告)日：2005-07-14
申请号：US10511071
申请日：2003-04-09
申请人： Steven Jones
发明人： Steven Jones
IPC分类号： B21K1/60 , B23D21/02 , F16B19/10 , F16B13/04
CPC分类号： F16B19/1054 , B21K1/60 , B23D21/02
摘要： The invention is directed to a peel-type blind rivet assembly (110) for setting in relatively soft material and comprising an elongate tubular body (102) having a shank (106) with an enlarged head (108). A free end (114) of the shank, remote from the head (108), has an expandable portion formed by a plurality of slots (112) extending partway along the shank from this remote end (114). A mandrel (104) has a stem, and a mandrel head (126) with a maximum external diameter greater than the internal diameter of the body (102), wherein at least one of the plurality of slots (112) increases in width as it extends from an outer surface of the shank towards an inner surface of the shank. There is also provided a punch (280) for forming the tapered slots (112) in the rivet body, comprising an elongate solid body having a polygonal cross section wherein at least one convergence zone formed on an end face of the punch by the tapering convergence of two adjacent side walls forms a slot cutting element (285).
摘要翻译：本发明涉及一种剥离型盲铆钉组件（110），用于设置相对柔软的材料并且包括具有带扩大头部（108）的柄（106）的细长管状体（102）。远离头部（108）的柄部的自由端（114）具有由多个从该远端（114）的柄部延伸的多个狭槽（112）形成的可扩张部分。心轴（104）具有杆和具有大于主体（102）的内径的最大外径的心轴头（126），其中多个狭槽（112）中的至少一个宽度随着其宽度而增加从柄的外表面朝向柄的内表面延伸。还提供了一种用于在铆钉体中形成锥形狭槽（112）的冲头（280），其包括具有多边形横截面的细长固体，其中通过渐缩收敛形成在冲头的端面上的至少一个会聚区两个相邻的侧壁形成槽切割元件（285）。

55. 发明申请

US20050152762A1 Blind rivet 审中-公开
标题翻译：盲铆钉
公开(公告)号：US20050152762A1
公开(公告)日：2005-07-14
申请号：US10511070
申请日：2003-04-09
申请人： Steven Jones
发明人： Steven Jones
IPC分类号： F16B19/10 , F16B13/04
CPC分类号： F16B19/1054
摘要： The invention is directed to a peel-type blind rivet assembly (110) for setting in relatively soft material (152) and comprising an elongate tubular body (102) having a shank (106) with a enlarged head (108). A free end (114) of the shank, remote from the head (108), has an expandable portion formed by a plurality of slots (112) extending partway along the shank from this remote end (114). A mandrel (104) has a stem, and a mandrel head (126) with a maximum external diameter greater than the internal diameter of the body (102) such that the mandrel head (126) forms a shoulder (128) between the mandrel stem and an outer surface of the mandrel head, which shoulder (128) extends substantially perpendicular to the axis of the rivet body (102).
摘要翻译：本发明涉及一种用于设置在相对较软的材料（152）中的剥离型盲铆钉组件（110），并且包括具有带有扩大头部（108）的柄（106）的细长管状体（102）。远离头部（108）的柄部的自由端（114）具有由多个从该远端（114）的柄部延伸的多个狭槽（112）形成的可扩张部分。心轴（104）具有柄部和心轴头部（126），其具有大于主体（102）的内径的最大外径，使得心轴头部（126）在心轴杆（122）之间形成肩部（128）以及所述心轴头的外表面，所述肩部（128）基本上垂直于所述铆钉体（102）的轴线延伸。

56. 发明申请

US20050137305A1 Low visibility laser marking additive 失效
标题翻译：低可见度激光打标添加剂
公开(公告)号：US20050137305A1
公开(公告)日：2005-06-23
申请号：US10976777
申请日：2004-11-01
申请人： James Carroll , Steven Jones
发明人： James Carroll , Steven Jones
IPC分类号： B41M5/26 , C01G19/00 , C01G30/00 , C08K3/22
CPC分类号： C01G30/00 , B41M5/267 , C01G19/00 , Y10S977/951
摘要： Laser marking of plastic material is achieved by incorporating into the plastic a laser marking particulate additive having a particle size of less than 100 nm. A mixed oxide particle of tin and antimony having a particle size of 10-70 nm is useful as a laser marking additive when using a YAG laser. A metallic powder can further be added to improve marking contrast.
摘要翻译：通过将具有小于100nm的粒度的激光标记颗粒添加剂掺入到塑料中来实现塑料材料的激光标记。当使用YAG激光器时，粒径为10-70nm的锡和锑的混合氧化物颗粒可用作激光标记添加剂。可以进一步添加金属粉末以改善标记对比度。

57. 发明授权

US06309703B1 Carbon and ceramic matrix composites fabricated by a rapid low-cost process incorporating in-situ polymerization of wetting monomers 失效
标题翻译：通过包含润湿单体的原位聚合的快速低成本工艺制造的碳和陶瓷基体复合材料
公开(公告)号：US06309703B1
公开(公告)日：2001-10-30
申请号：US09100774
申请日：1998-06-08
申请人： Phillip G. Wapner , Wesley P. Hoffman , Steven Jones
发明人： Phillip G. Wapner , Wesley P. Hoffman , Steven Jones
IPC分类号： B05D300
CPC分类号： C04B35/83 , Y10S428/907 , Y10T428/24074 , Y10T428/24669 , Y10T428/249928 , Y10T428/24993 , Y10T428/30
摘要： This invention is a rapid low-cost technique for manufacturing thick high-performance carbon and ceramic composites in the form of uniformly densified near-net shaped structures. This is accomplished by impregnating composite preforms with low-viscosity wetting monomers which undergo polymerization followed by pyrolysis reactions in the preform ultimately creating ceramic and/or carbon matrices. Since the monomers possess low-molecular-weight they have low viscosities. Thus, if they wet the fiber and partially-densified preform they can easily impregnate even the smallest pores. Once inside the preforms, polymerization of the monomers is then initiated, resulting in a liquid matrix-precursor of the high molecular weight needed to produce a superior matrix (upon pyrolysis) with high efficiency.
摘要翻译：本发明是用于制造均匀致密的近网状结构形式的厚的高性能碳和陶瓷复合材料的快速低成本技术。这是通过用低粘度润湿单体浸渍复合预成型件来实现的，所述单体在预成型件中进行聚合，随后进行热解反应，最终形成陶瓷和/或碳基体。由于单体具有低分子量，因此它们具有低粘度。因此，如果它们润湿纤维和部分致密化的预成型件，它们可以容易地浸渍甚至最小的孔。一旦进入预制件，然后开始单体的聚合，产生高效分离产生高分子量（在热解时）所需的高分子量的液体基质前体。

58. 发明授权

US5847172A Certain aminosterol compounds and pharmaceutical compositions including these compounds 失效
公开(公告)号：US5847172A
公开(公告)日：1998-12-08
申请号：US487443
申请日：1995-06-07
申请人： Michael Zasloff , Ann Shinnar , William Kinney , Steven Jones
发明人： Michael Zasloff , Ann Shinnar , William Kinney , Steven Jones
IPC分类号： A61K31/56 , C07J9/00 , C07J41/00 , G01N33/50
CPC分类号： G01N33/5011 , A61K31/56 , C07J41/0005 , C07J9/00 , G01N33/5008 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/5064 , G01N33/5088 , G01N33/5091 , G01N2500/00
摘要： Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

59. 发明授权

US11034841B2 Carbon black in effect pigments 有权
公开(公告)号：US11034841B2
公开(公告)日：2021-06-15
申请号：US14579032
申请日：2014-12-22
申请人： Lizzabeth Ponce , Geoffrey Johnson , Louis R. Cerce , Steven Jones , Curtis Zimmermann
发明人： Lizzabeth Ponce , Geoffrey Johnson , Louis R. Cerce , Steven Jones , Curtis Zimmermann
IPC分类号： C09C1/00 , A61Q19/00 , B05D1/18 , A61K8/02 , A61Q1/06 , A61Q1/10 , A61Q1/08 , A61Q3/02 , A61Q1/12 , A61K8/19
摘要： The present application is directed to combination effect pigments comprising an effect pigment and carbon black, wherein the carbon black is adherently deposited on the effect pigment interposed within the substrate and at least one subsequent layer of the effect pigment. This structure of the combination effect pigment results in advantageous non-staining properties of the pigment and maximizes color effects of the carbon black.

60. 发明申请

US20160145437A1 Carbon Black in Effect Pigments 审中-公开
标题翻译：碳黑效果颜料
公开(公告)号：US20160145437A1
公开(公告)日：2016-05-26
申请号：US14579032
申请日：2014-12-22
申请人： Lizzabeth Ponce , Geoffrey Johnson , Louis R. Cerce , Steven Jones , Curtis J. Zimmermann
发明人： Lizzabeth Ponce , Geoffrey Johnson , Louis R. Cerce , Steven Jones , Curtis J. Zimmermann
IPC分类号： C09C1/00 , A61Q1/06 , A61Q1/12 , A61Q1/08 , A61Q3/02 , A61K8/02 , A61Q1/10
CPC分类号： C09C1/0015 , A61K8/0266 , A61K8/19 , A61K2800/412 , A61K2800/436 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q3/02 , C01P2004/20 , C09C1/0024 , C09C1/0045 , C09C1/0075 , C09C2200/102 , C09C2220/10 , C09C2220/106
摘要： The present application is directed to combination effect pigments comprising an effect pigment and carbon black, wherein the carbon black is adherently deposited on the effect pigment interposed within the substrate and at least one subsequent layer of the effect pigment. This structure of the combination effect pigment results in advantageous non-staining properties of the pigment and maximizes color effects of the carbon black.
摘要翻译：本申请涉及包含效果颜料和炭黑的组合效果颜料，其中炭黑粘附沉积在插入基材内的效果颜料和影响颜料的至少一个后续层上。这种组合效果颜料的结构导致颜料的有利的非染色性能并且使炭黑的颜色效应最大化。

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