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51. 发明申请

US20060040999A1 CETP inhibitors 有权
标题翻译： CETP抑制剂
公开(公告)号：US20060040999A1
公开(公告)日：2006-02-23
申请号：US11173295
申请日：2005-07-01
申请人： Amjad Ali , Joann Napolitano , Qiaolin Deng , Zhijian Lu , Peter Sinclair , Gayle Taylor , Christopher Thompson , Nazia Quraishi , Cameron Smith , Julianne Hunt , Adrian Dowst , Yi-Heng Chen , Hong Li
发明人： Amjad Ali , Joann Napolitano , Qiaolin Deng , Zhijian Lu , Peter Sinclair , Gayle Taylor , Christopher Thompson , Nazia Quraishi , Cameron Smith , Julianne Hunt , Adrian Dowst , Yi-Heng Chen , Hong Li
IPC分类号： A61K31/421 , C07D263/16
CPC分类号： C07F7/10 , A61K31/4015 , A61K31/4166 , A61K31/4168 , A61K31/421 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D207/26 , C07D207/27 , C07D233/32 , C07D233/38 , C07D233/50 , C07D233/52 , C07D263/04 , C07D263/20 , C07D263/22 , C07D263/24 , C07D263/26 , C07D285/06 , C07D285/10 , C07D401/04 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D417/10
摘要： Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: In the compounds of Formula I, B or R2 is a phenyl group which has an ortho aryl, heterocyclic, benzoheterocyclic or benzocycloalkyl substituent, and one other position on the 5-membered ring has an aromatic, heterocyclic, cycloalkyl, benzoheterocyclic or benzocycloalkyl substituent connected directly to the ring or attached to the ring through a —CH2—.
摘要翻译：具有式I结构的化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于升高HDL-胆固醇，降低LDL-胆固醇，以及用于治疗或预防动脉粥样硬化。在式I化合物中，B或 R 2是具有邻芳基，杂环，苯并杂环或苯并环烷基取代基的苯基，并且在5元环上的另一个位置具有直接连接的芳族，杂环，环烷基，苯并杂环或苯并环烷基取代基通过-CH 2 - 2连接到环上或连接到环上。

52. 发明申请

US20050199248A1 Apparatus and methods for treating sleep apnea 有权
标题翻译：用于治疗睡眠呼吸暂停的装置和方法
公开(公告)号：US20050199248A1
公开(公告)日：2005-09-15
申请号：US11126649
申请日：2005-05-10
申请人： D. Pflueger , Christopher Thompson
发明人： D. Pflueger , Christopher Thompson
IPC分类号： A61F2/00 , A61F2/20 , A61F2/82 , A61F5/56 , A62B7/00 , A61M16/00
CPC分类号： A61F2/203 , A61F2/20 , A61F2/82 , A61F5/566 , A61F2210/0014 , Y10S602/902 , Y10S623/902
摘要： An apparatus and method for treating sleep apnea and/or snoring is provided. The apparatus includes an appliance sized and structured to be placed in the pharyngeal region of a human or animal and being effective in treating sleep apnea and/or snoring, for example in maintaining openness of an oropharyngeal region of a human or animal during natural sleep, advantageously while not interfering with normal functioning of the epiglottis. Preferably, the appliance is non-circumferential in form and includes rounded, spaced apart end portions.
摘要翻译：提供了一种治疗睡眠呼吸暂停和/或打鼾的装置和方法。该装置包括尺寸和构造为放置在人或动物的咽部区域中并且有效治疗睡眠呼吸暂停和/或打鼾的装置，例如在自然睡眠期间保持人或动物的口咽部区域的开放性，有利地同时不妨碍会厌的正常功能。优选地，该器具是非圆周形的并且包括圆形的间隔开的端部。

53. 发明申请

US20050075483A1 Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same 失效
标题翻译：糖肽抗生素，糖肽抗生素组合文库及其生产方法
公开(公告)号：US20050075483A1
公开(公告)日：2005-04-07
申请号：US10676391
申请日：2003-10-01
申请人： Daniel Kahne , Robert Kerns , Seketsu Fukuzawa , Min Ge , Christopher Thompson
发明人： Daniel Kahne , Robert Kerns , Seketsu Fukuzawa , Min Ge , Christopher Thompson
IPC分类号： A61K38/00 , A61K38/14 , A61K38/16 , A61P31/04 , C07K1/00 , C07K1/04 , C07K7/50 , C07K9/00 , C07K14/00 , C07K17/00
CPC分类号： C07K1/047 , A61K38/00 , C07K9/008 , Y10S930/19
摘要： A glycopeptide of the formula A1-A2-A3-A4-A5-A6-A7, in which each dash represents a covalent bond; wherein A1 comprises a modified or unmodified α-amino acid residue, alkyl, aryl, aralkyl, alkanoyl, aroyl, aralkanoyl, heterocyclic, heterocyclic-carbonyl, heterocyclic-alkyl, heterocyclic-alkyl-carbonyl, alkylsulfonyl, arylsulfonyl, guanidinyl, carbamoyl, or xanthyl; wherein each of A2 to A7 comprises a modified or unmodified α-amino acid residue, whereby (i) A1 is linked to an amino group on A2, (ii) each of A2, A4 and A6 bears an aromatic side chain, which aromatic side chains are cross-linked together by two or more covalent bonds, and (iii) A7 bears a terminal carboxyl, ester, amide, or N-substituted amide group; and wherein one or more of A1 to A7 is linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues, at least one of the sugar residues bearing one or more substituents of the formula YXR, N+(R1)═CR2R3, N═PR1R2R3, N+R1R2R3 or P+R1R2R3 in which Y is a single bond, O, NR1 or S; X is O, NR1, S, SO2, C(O)O, C(O)S, C(S)O, C(S)S, C(NR1)O, C(O)NR1, or halo (in which case Y and R are absent). A chemical library comprising a plurality of the glycopeptides of the invention. A method for preparing a glycopeptide by glycosylation of an aglycone derived from a glycopeptide antibiotic. A method for preparing a glycopeptide by preparing a pseudoaglycone from a glycopeptide antibiotic and glycosylating the pseudoaglycone.
摘要翻译：式A1-A2-A3-A4-A5-A6-A7的糖肽，其中每个短划线代表共价键; 其中A1包含经修饰或未修饰的α-氨基酸残基，烷基，芳基，芳烷基，烷酰基，芳酰基，芳烷酰基，杂环，杂环羰基，杂环烷基，杂环 - 烷基 - 羰基，烷基磺酰基，芳基磺酰基，胍基，氨基甲酰基或呫吨其中A2至A7各自包含经修饰或未修饰的α-氨基酸残基，由此（i）A1与A2上的氨基连接，（ii）每个A2，A4和A6均带有芳香侧链，该芳族侧链通过两个或更多个共价键交联在一起，和（iii）A7具有末端羧基，酯，酰胺或N-取代的酰胺基; 并且其中A1至A7中的一个或多个通过糖苷键连接至每个具有一个或多个糖残基的一个或多个糖苷基，至少一个含有一个或多个式YXR，N + （R1）= CR2R3，N = PR1R2R3，N + R1R2R3或P + R1R2R3，其中Y为单键，O，NR1或S; X是O，NR1，S，SO2，C（O）O，C（O）S，C（S）O，C（S）S，C（NR1）O，C（O）NR1或卤素哪种情况下Y和R不存在）。包含本发明多种糖肽的化学文库。通过糖衍生自糖肽抗生素的糖苷配基制备糖肽的方法。一种通过从糖肽抗生素制备假糖苷配基并糖基化假糖苷配基来制备糖肽的方法。

54. 发明授权

US06873430B2 Knowledge management system and method 有权
标题翻译：知识管理系统与方法
公开(公告)号：US06873430B2
公开(公告)日：2005-03-29
申请号：US09746913
申请日：2000-12-22
申请人： Antonietta Grasso , Jean-Luc Meunier , Christopher Thompson
发明人： Antonietta Grasso , Jean-Luc Meunier , Christopher Thompson
IPC分类号： G06F17/30 , G06K15/00 , G06K9/64
CPC分类号： G06F17/30011
摘要： A knowledge management system according to the invention uses print cover sheets to connect users to knowledge relevant both to the user and the communities to which they belong by making use of the declaration of relevance implicit in the print process. The cover sheet becomes an input, output and surrogate document mechanism enabling access to both document repositories and associated knowledge management services, such as for example, document related services and a recommender service.
摘要翻译：根据本发明的知识管理系统使用打印封面来通过利用印刷过程中隐含的相关声明来将用户连接到与用户及其所属社区相关的知识。封面成为输入，输出和代理文档机制，能够访问文档存储库和相关知识管理服务，例如文档相关服务和推荐器服务。

55. 发明授权

US09580461B2 Method for purifying active polypeptides or immunoconjugates 有权
标题翻译：纯化活性多肽或免疫缀合物的方法
公开(公告)号：US09580461B2
公开(公告)日：2017-02-28
申请号：US13813083
申请日：2011-07-27
申请人： Thomas Linke , William K. Wang , Ambarish Shah , Hasige Sathish , Alan Hunter , Christopher Thompson
发明人： Thomas Linke , William K. Wang , Ambarish Shah , Hasige Sathish , Alan Hunter , Christopher Thompson
IPC分类号： A61K49/00 , A61K39/395 , A61K39/00 , C07K1/18 , B01D15/16 , B01D15/36 , B01J41/14 , B01J41/20 , C07K17/02 , A61K47/48 , C07K16/28
CPC分类号： C07K16/2851 , A61K39/3955 , A61K47/02 , A61K47/6829 , A61K47/6849 , A61K2039/505 , B01D15/166 , B01D15/363 , B01J41/14 , B01J41/20 , C07K1/18 , C07K16/2803 , C07K17/02 , C07K2317/56 , C07K2317/94 , C07K2319/35 , C07K2319/55
摘要： The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.
摘要翻译：本发明提供了通过使用阴离子交换层析纯化含有活性多肽或免疫偶联物及其酸性变体例如脱酰胺化变体的溶液来分离活性多肽或免疫缀合物的方法。

56. 发明申请

US20140182264A1 AIRCRAFT ENGINE SYSTEMS AND METHODS FOR OPERATING SAME 审中-公开
标题翻译：飞机发动机系统及其操作方法
公开(公告)号：US20140182264A1
公开(公告)日：2014-07-03
申请号：US13876863
申请日：2011-09-30
申请人： Robert Harold Weisgerber , Kurt David Murrow , Michael Jay Epstein , Nicholas Dinsmore , Samuel Jacob Martin , Randy M. Vondrell , Christopher Thompson , Craig Gonyou
发明人： Robert Harold Weisgerber , Kurt David Murrow , Michael Jay Epstein , Nicholas Dinsmore , Samuel Jacob Martin , Randy M. Vondrell , Christopher Thompson , Craig Gonyou
IPC分类号： F02C7/22
CPC分类号： F02C7/22 , B64D37/30 , F01D11/24 , F01D25/18 , F02C7/143 , F02C7/16 , F02C7/224 , H05K7/20218 , Y02T50/44 , Y02T50/672 , Y02T50/675
摘要： A gas turbine propulsion system includes a system which utilizes a cryogenic liquid fuel for a non-combustion function.
摘要翻译：燃气轮机推进系统包括利用低温液体燃料用于非燃烧功能的系统。

57. 发明授权

US08482163B2 Inverter cooler 有权
标题翻译：逆变器冷却器
公开(公告)号：US08482163B2
公开(公告)日：2013-07-09
申请号：US12722027
申请日：2010-03-11
申请人： Michael A. Belikoff , Thomas Kuster , Christopher Thompson
发明人： Michael A. Belikoff , Thomas Kuster , Christopher Thompson
IPC分类号： G05F3/06
CPC分类号： H05K7/20945
摘要： A DC to AC inverter used in a solar cell power system can include an improved structure for cooling itself and increasing power output.
摘要翻译：在太阳能电池电力系统中使用的直流到交流逆变器可以包括用于自身冷却和增加功率输出的改进的结构。

58. 发明授权

US08243446B2 Photovoltaic inverter 有权
标题翻译：光伏逆变器
公开(公告)号：US08243446B2
公开(公告)日：2012-08-14
申请号：US12722181
申请日：2010-03-11
申请人： Christopher Thompson
发明人： Christopher Thompson
IPC分类号： H05K7/20
CPC分类号： H05K7/20945 , Y10T307/62 , Y10T307/625
摘要： A DC to AC inverter used in a solar cell power system can include an improved control scheme for cooling itself and optimizing power output.
摘要翻译：在太阳能电池电力系统中使用的直流到交流逆变器可以包括用于冷却自身并优化功率输出的改进的控制方案。

59. 发明申请

US20110098161A1 Exercise Device 有权
标题翻译：运动装置
公开(公告)号：US20110098161A1
公开(公告)日：2011-04-28
申请号：US12968181
申请日：2010-12-14
申请人： Matt Balaker , Christopher Thompson
发明人： Matt Balaker , Christopher Thompson
IPC分类号： A63B21/00
CPC分类号： A63B21/156 , A63B21/00185 , A63B21/008 , A63B21/0083 , A63B21/023 , A63B21/4034 , A63B21/4035 , A63B21/4043 , A63B21/4045 , A63B22/203 , A63B23/03541 , A63B23/03575 , A63B69/182 , A63B2225/10
摘要： An exercise device comprising a frame; and a plurality of platforms for accommodating an exerciser's feet, each platform of the plurality of platforms including at least one moving member for facilitating both a divergent movement and a convergent movement. The device includes a tensioning structure for providing adjustable resistance.
摘要翻译：一种健身器具，包括一个框架; 以及用于容纳锻炼脚的多个平台，所述多个平台中的每个平台包括至少一个移动构件，以便于发散运动和收敛运动。该装置包括用于提供可调电阻的张紧结构。

60. 发明申请

US20080292466A1 Method to center locate cutter teeth on shrouded turbine blades 有权
标题翻译：将覆盖的涡轮叶片上的切割齿定位的方法
公开(公告)号：US20080292466A1
公开(公告)日：2008-11-27
申请号：US11805528
申请日：2007-05-24
申请人： Daniel Tragesser , Ian Reeves , Christopher Thompson , Todd Moran
发明人： Daniel Tragesser , Ian Reeves , Christopher Thompson , Todd Moran
IPC分类号： F01D5/12
CPC分类号： F01D5/225 , F05D2230/232 , F05D2230/238 , Y10T29/49318
摘要： The present application further describes a method for extending the operating life of a tip shrouded turbine blade that includes the steps of: 1) removing an end located cutter tooth from a seal rail of a tip shroud, the end located cutter tooth including a cutter tooth located at the end of one of the suction side and pressure side of the seal rail of the tip shroud; and 2) attaching a center located cutter tooth to the seal rail of the tip shroud, the center located cutter tooth including a cutter tooth that is located in the approximate center of the seal rail of the tip shroud. In such method, the center located cutter tooth may be attached to the seal rail such that the center located cutter tooth is inside the airfoil if it were projected radially outward from the narrowest point below a tip shroud fillet.
摘要翻译：本申请进一步描述了一种用于延长尖端覆盖的涡轮机叶片的使用寿命的方法，其包括以下步骤：1）从尖端护罩的密封轨道移除端部定位的切割齿，该端部定位的切割齿包括切割齿位于尖端护罩的密封导轨的吸力侧和压力侧之一的端部; 以及2）将中心定位的切割齿附接到尖端护罩的密封轨道，所述中心定位的切割齿包括位于尖端护罩的密封轨道的大致中心处的切割齿。在这种方法中，位于中心的切割齿可以附接到密封轨道，使得如果中心定位的切割齿从尖端护罩圆角下方的最窄点径向向外突出，则其位于翼型内部。

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