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51. 发明授权

US07766860B2 Catheter systems having flow restrictors 有权
标题翻译：具有流量限制器的导管系统
公开(公告)号：US07766860B2
公开(公告)日：2010-08-03
申请号：US11112077
申请日：2005-04-22
申请人： James M. Olsen , Mary M. Morris , Michael Hegland , Justin A. Blanco
发明人： James M. Olsen , Mary M. Morris , Michael Hegland , Justin A. Blanco
IPC分类号： A61M1/00
CPC分类号： A61M25/0021 , A61M5/14276 , A61M5/16813 , A61M25/00 , A61M25/0029 , A61M25/003 , A61M25/0043 , A61M25/0068 , A61M25/0071 , A61M25/0075 , A61M27/006 , A61M2025/0073 , A61M2039/1005 , A61M2205/15 , A61M2206/16
摘要： Catheter systems including one or more flow restrictors are disclosed. The catheter systems may include two or more delivery branches. The delivery branches may be connected to a supply catheter section using a branching catheter connector that may include one or more flow restrictors. The flow restrictors may include a restrictor body located within a lumen with a channel located between the restrictor body and interior surface of the lumen, the channel restricting flow through the lumen past the flow restrictor. The channel may be defined by a groove formed in the restrictor body and/or the interior surface of the lumen. Methods of providing pressure relief by flowing fluid past a flow restrictor are also disclosed.
摘要翻译：公开了包括一个或多个流量限制器的导管系统。导管系统可以包括两个或更多个输送分支。输送分支可以使用可包括一个或多个限流器的分支导管连接器连接到供应导管部分。限流器可以包括位于管腔内的节流体，通道位于限流器主体和内腔内表面之间，通道限制流经管腔的流经限流器。通道可以由形成在限流器主体中的凹槽和/或内腔的内表面限定。还公开了通过使流体流过限流器来提供压力释放的方法。

52. 发明授权

US06685452B2 Implantable drug delivery pump with desiccant humidity protection 失效
标题翻译：具有干燥剂湿度保护的植入式药物输送泵
公开(公告)号：US06685452B2
公开(公告)日：2004-02-03
申请号：US09925598
申请日：2001-08-09
申请人： Chris C. Christiansen , James M. Olsen
发明人： Chris C. Christiansen , James M. Olsen
IPC分类号： F04B3900
CPC分类号： A61M5/14276
摘要： A human body implantable drug delivery pump has a housing including at least a first shield and a second shield. The housing defines an interior within the shields. The pump further includes a fluid reservoir within the housing, a fluid conduit also within the housing from the reservoir, an outlet from the fluid conduit to the exterior of the housing, and a pump member in the housing adapted to move fluid through the fluid conduit to the outlet. The fluid in the reservoir and fluid conduit is isolated from the pump interior. The pump further has a desiccant in the pump interior, the desiccant absorbent of moisture in the pump interior, and preferably absorbent of substantially all the moisture in the pump interior. The desiccant also preferably has a moisture absorbent property dependent on temperature, being lessened at higher temperatures, the desiccant being pre-baked to improve its moisture absorbent property before being placed in the pump.
摘要翻译：人体可植入药物输送泵具有至少包括第一屏蔽和第二屏蔽的壳体。壳体限定了屏蔽内的内部。所述泵还包括在所述壳体内的流体贮存器，还存在从所述容器的壳体内的流体导管，从所述流体导管到所述壳体的外部的出口以及所述壳体中的泵构件，其适于将流体移动通过所述流体导管到出口。储存器和流体导管中的流体与泵内部隔离。泵还在泵内部具有干燥剂，泵内部的湿气的干燥剂吸收剂，并且优选地在泵内部基本上吸收所有的水分。干燥剂还优选具有取决于温度的吸湿性，在较高温度下减弱，干燥剂被预烘烤以在放入泵之前改善其吸湿性能。

53. 发明授权

US06228050B1 Overfill protection systems for implantable drug delivery devices 有权
标题翻译：用于可植入药物输送装置的溢出保护系统
公开(公告)号：US06228050B1
公开(公告)日：2001-05-08
申请号：US09303006
申请日：1999-04-30
申请人： James M. Olsen , Reginald D. Robinson , Chris Christiansen , Paul Kratoska
发明人： James M. Olsen , Reginald D. Robinson , Chris Christiansen , Paul Kratoska
IPC分类号： A61M1100
CPC分类号： A61M5/14276 , A61M39/22 , A61M2209/045
摘要： The displacement of refill valves in an implantable drug delivery device is reduced to permit the housings of a drug delivery device to remain compact in size while permitting reservoirs of increased depth to be used. In a preferred embodiment, a collapsible link is provided as a telescoping member incorporating a coil spring. As the valve is pulled into contact with its seat, a detectable pressure increase is sensed in the refill device. In accordance with the invention, as the drug supply contained in the reservoir depletes, the reservoir surface moves towards a collapsed position, compressing the coil spring and eventually contacting the valve stem, thereby lifting the valve from its seat. By virtue of telescoping link, the valve stem length and therefore the valve travel may be reduced as compared to prior art devices, thus eliminating the need for increased housing depth when deeper reservoirs are used. The collapsible link may be comprised of a second spring combined with a telescoping link. The second spring is situated on a side of the valve opposite the telescoping link, thereby providing a downward force on the valve and valve stem. As an other alternative, the invention provides a lever arm for actuating the refill valve. A pivot for the lever arm is situated near the refill valve and a distal end of the lever arm maintained in contact with the reservoir surface using a spring bias. An intermediate portion of the lever arm engages the valve stem. Thus, as the reservoir surface moves towards the collapsed position, the displacement of the valve is a fraction of the displacement of the distal end of the lever arm.
摘要翻译：可植入药物输送装置中的再填充阀的位移被减少以允许药物输送装置的壳体保持紧凑的尺寸，同时允许使用增加深度的储存器。在优选实施例中，可折叠连杆被提供为包括螺旋弹簧的伸缩构件。当阀被拉动与其座位接触时，在再填充装置中感测到可检测的压力增加。根据本发明，随着储存器中所含的药物供给消耗，贮存器表面向收缩位置运动，压缩螺旋弹簧并最终接触阀杆，从而将阀从其座上提起。通过伸缩连杆，与现有技术的装置相比，阀杆长度和阀行程可以减小，从而在使用更深的储存器时消除了增加壳体深度的需要。可折叠连杆可以由与伸缩连杆组合的第二弹簧构成。第二弹簧位于与伸缩连杆相对的阀的一侧，从而在阀和阀杆上提供向下的力。作为另一种替代方案，本发明提供一种用于致动再填充阀的杠杆臂。用于杠杆臂的枢轴位于补充阀附近，并且杠杆臂的远端使用弹簧偏压保持与储存器表面接触。杠杆臂的中间部分与阀杆接合。因此，当储存器表面朝向折叠位置移动时，阀的位移是杠杆臂的远端的位移的一部分。

54. 发明授权

US5647854A Base plate for a drug pump 失效
标题翻译：用于药泵的基板
公开(公告)号：US5647854A
公开(公告)日：1997-07-15
申请号：US618574
申请日：1996-03-20
申请人： James M. Olsen , Jay Gregory Johnson
发明人： James M. Olsen , Jay Gregory Johnson
IPC分类号： A61M5/00 , A61J1/14 , A61M5/142 , A61M5/145 , A61M5/172 , F04B43/12 , F04B49/06 , F04B51/00 , A61M5/32
CPC分类号： F04B51/00 , A61M5/142 , A61M5/172 , F04B49/065 , A61M2205/12 , A61M2205/14 , A61M2205/3306 , A61M2205/6018 , A61M2205/6036 , A61M2205/6063 , A61M5/14228 , F04B2207/041 , F04B2207/042 , F04B2207/043 , Y10S128/12 , Y10S128/13 , Y10S128/26
摘要： The present invention concerns a pump provided with a control module and an attachable fluid reservoir cassette. The control module includes a pumping mechanism for pumping fluid from the fluid reservoir to the patient. The cassette is provided with appropriate indicia to identify differences between a plurality of cassettes. The control module further includes cassette indicia identification structure for identifying indicia on the cassette. One type of cassette identification system includes a projection extending from the cassette and structure associated with the control module which engages the projection. Another type of cassette identification system includes a light reflecting system which utilizes light from the control module and reflected off the cassette. Still other types of cassette identification systems utilize other non-contact switches or sensors to sense indicia on the cassette to identify the cassette from a plurality of cassettes.
摘要翻译：本发明涉及一种设置有控制模块和可附接液体储存盒的泵。控制模块包括用于将流体从流体储存器泵送到患者的泵送机构。为盒提供适当的标记以识别多个盒之间的差异。控制模块还包括用于识别盒上的标记的盒式标记识别结构。一种类型的盒式磁带识别系统包括从盒子延伸的突起和与控制模块相关联的与突起接合的结构。另一种类型的盒式磁带识别系统包括光反射系统，其利用来自控制模块的光并从盒子反射出来。其他类型的盒式磁带识别系统利用其他非接触开关或传感器来感测盒上的标记以从多个盒中识别盒。

55. 发明授权

US08849417B2 Lead electrode for use in an MRI-safe implantable medical device 有权
标题翻译：用于MRI安全可植入医疗器械的引线电极
公开(公告)号：US08849417B2
公开(公告)日：2014-09-30
申请号：US12954585
申请日：2010-11-24
申请人： James M. Olsen , Gregory A. Hrdlicka , Carl D. Wahlstrand , Thomas Barry Hoegh
发明人： James M. Olsen , Gregory A. Hrdlicka , Carl D. Wahlstrand , Thomas Barry Hoegh
IPC分类号： A61N1/05 , A61N1/08
CPC分类号： A61N1/08 , A61N1/0529 , A61N1/0534 , A61N1/0551 , A61N1/0553 , A61N1/086 , A61N1/3605 , A61N1/36142
摘要： A medical lead is configured to be implanted into a patient's body and comprises a lead body, and an electrode coupled to the lead body. The electrode comprises a first section configured to contact the patient's body, and a second section capacitively coupled to the first section and configured to be electrically coupled to the patient's body.
摘要翻译：医疗用引线被配置为植入患者体内并且包括引线体和连接到引线体的电极。电极包括构造成接触患者身体的第一部分和电容耦合到第一部分并被配置为电耦合到患者身体的第二部分。

56. 发明授权

US07831311B2 Reduced axial stiffness implantable medical lead 有权
标题翻译：降低轴向刚度可植入医用铅
公开(公告)号：US07831311B2
公开(公告)日：2010-11-09
申请号：US11119416
申请日：2005-04-29
申请人： Thomas E. Cross, Jr. , James M. Olsen , Stephen L. Bolea
发明人： Thomas E. Cross, Jr. , James M. Olsen , Stephen L. Bolea
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： An implantable lead has a lead body construction designed to accommodate loading forces exerted on the lead body during patient movement. The lead body is sufficiently stretchable to resist forces that could otherwise cause lead failure, axial migration of the electrodes, anchor damage, or tissue damage. The lead body may include a variety of features that reduce the axial stiffness of the lead without significantly impacting the operation and structural integrity of lead components, such as electrodes, conductors and insulators.
摘要翻译：可植入引线具有引线本体结构，其设计用于在患者移动期间适应施加在引线本体上的负载力。引线体具有足够的拉伸能力以抵抗否则会导致引线故障，电极的轴向迁移，锚固损坏或组织损伤的力。引线体可以包括减少引线的轴向刚度的各种特征，而不会显着地影响诸如电极，导体和绝缘体的引线部件的操作和结构完整性。

57. 发明授权

US07519432B2 Implantable medical lead with helical reinforcement 有权
标题翻译：可植入医用铅带螺旋加固
公开(公告)号：US07519432B2
公开(公告)日：2009-04-14
申请号：US11119389
申请日：2005-04-29
申请人： Stephen L. Bolea , Thomas C. Bischoff , Thomas E. Cross, Jr. , James M. Olsen
发明人： Stephen L. Bolea , Thomas C. Bischoff , Thomas E. Cross, Jr. , James M. Olsen
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： An implantable lead has a lead body construction designed to accommodate loading forces exerted on the lead body during patient movement. The lead body may be sufficiently stretchable to resist forces that could otherwise cause lead failure, axial migration of the electrodes, anchor damage, or tissue damage. Increasing stretchability of a lead body can also increase the vulnerability of the lead body to flex fatigue, buckling fatigue, kinking, and crush. Therefore, the lead described herein includes a reinforcement to create a lead body that is resistant to flex fatigue, buckling fatigue, kinking and crush.
摘要翻译：可植入引线具有引线本体结构，其设计用于在患者移动期间适应施加在引线本体上的负载力。引线体可以是足够的可拉伸的以抵抗否则会导致引线故障，电极的轴向迁移，锚固损伤或组织损伤的力。引线体的增加拉伸性也可以增加引线体疲劳疲劳，弯曲疲劳，扭结和挤压的脆弱性。因此，本文所述的导线包括增强以产生耐挠曲疲劳，弯曲疲劳，扭结和挤压的引线体。

58. 发明授权

US07174219B2 Lead electrode for use in an MRI-safe implantable medical device 有权
标题翻译：用于MRI安全可植入医疗器械的引线电极
公开(公告)号：US07174219B2
公开(公告)日：2007-02-06
申请号：US10981092
申请日：2004-11-03
申请人： Carl D. Wahlstrand , Thomas Barry Hoegh , Gregory A. Hrdlicka , Thomas E. Cross, Jr. , James M. Olsen
发明人： Carl D. Wahlstrand , Thomas Barry Hoegh , Gregory A. Hrdlicka , Thomas E. Cross, Jr. , James M. Olsen
IPC分类号： A61N1/05
CPC分类号： A61N1/0529 , A61N1/05 , A61N1/0534 , A61N1/0553 , A61N1/06 , A61N1/086 , A61N1/3718
摘要： A pulse stimulation system configured for implantation into a patient's body comprises a pulse stimulator, a conductive stimulation lead having a proximal end electrically coupled to the pulse simulator and having a distal end, and an electrode assembly coupled to the distal end of the stimulation lead. The electrode assembly comprises an electrode body having a therapy electrode thereon that is electrically coupled to the stimulation lead for delivering therapy to the patient. A floating electrode is configured to contact the patient's body tissue and has a surface area substantially larger than that of the therapy electrode. A filter is coupled between the therapy electrode and the floating electrode for diverting RF energy toward the floating electrode and away from the therapy electrode.
摘要翻译：构造成用于植入患者体内的脉冲刺激系统包括脉冲刺激器，具有电耦合到脉冲模拟器的近端的导电刺激引线，并且具有远端，以及耦合到刺激引线的远端的电极组件。电极组件包括其上具有治疗电极的电极体，其电耦合到刺激引线以将治疗递送给患者。浮动电极被配置为接触患者的身体组织，并且其表面积基本上大于治疗电极的表面积。过滤器耦合在治疗电极和浮动电极之间，用于将RF能量朝向浮动电极转移并远离治疗电极。

59. 发明授权

US07066915B2 Low profile inlet valve for a piston pump therapeutic substance delivery device 有权
公开(公告)号：US07066915B2
公开(公告)日：2006-06-27
申请号：US09953527
申请日：2001-09-14
申请人： James M. Olsen
发明人： James M. Olsen
IPC分类号： A61K9/22
CPC分类号： A61M5/14276 , A61M5/14216 , A61M39/22 , A61M39/24 , F04B17/046 , F04B53/1062
摘要： Low profile inlet valve embodiments for a piston pump therapeutic substance infusion device are disclosed that reduce dead volume, occupies little residential space, operates rapidly, and have many other improvements. The therapeutic substance infusion device has a housing, a therapeutic substance reservoir, a power source carried in the housing, electronics, a piston pump, and an inlet valve. The piston pump is configured for pumping therapeutic substance from the therapeutic substance reservoir through an infusion port at a programmed rate. The inlet valve is in fluid communication with a reservoir outlet to control the flow of therapeutic substance into the piston pump. The inlet valve has a substantially coplanar valve surface and valve spring. Many embodiments of the low profile inlet valve and its methods of operation are possible.

60. 发明授权

US6152898A Overfill protection systems for implantable drug delivery devices 有权
标题翻译：用于可植入药物输送装置的溢出保护系统
公开(公告)号：US6152898A
公开(公告)日：2000-11-28
申请号：US303034
申请日：1999-04-30
申请人： James M. Olsen
发明人： James M. Olsen
IPC分类号： A61M5/142 , A61M5/168 , A61M11/00
CPC分类号： A61M5/14276 , A61M5/1684 , A61M2209/045
摘要： A pressure-sensitive overfill protection system for a refillable drug delivery device includes a collapsible link which, in a preferred embodiment, comprises an aneroid having an internal volume of gas at a reference pressure. The collapsible link, in its expanded state, supports on inlet valve in an open position to permit the ingress of new drug fluid into a bellows reservoir. The external surface of the aneroid is exposed to the bellows pressure. When the bellows pressure exceeds the reference pressure, the aneroid collapses and permits the inlet valve to move to a closed position under a biasing force provided by a spring. Further flow of new drug fluid into the drug delivery device is thereby prevented. Moreover, the closure of the valve provides a large increase in pressure is experienced in the refill device and may therefore be sensed by a clinician. Because the overfill protection system is pressure sensitive, it may be used with different sized bellows without modification.
摘要翻译：用于可再填充药物递送装置的压敏式过充保护系统包括可折叠连杆，在可取的实施例中，该可折叠连杆包括在参考压力下具有内部体积气体的无液体。处于其膨胀状态的可折叠连杆支撑入口阀处于打开位置，以允许将新药物流入波纹管储存器。空气的外表面暴露于波纹管压力。当波纹管压力超过参考压力时，无弹性片塌陷并允许入口阀在由弹簧提供的偏压力下移动到关闭位置。从而防止了新的药物流体进入药物输送装置的进一步流动。此外，阀的关闭提供了在补充装置中经历的压力的大的增加，并且因此可能由临床医生感测到。因为过充保护系统是压敏的，所以它可以与不同大小的波纹管一起使用，无需修改。

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