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51. 发明专利

CA2730610A1 BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS GPCR MODULATORS 未知
公开(公告)号：CA2730610A1
公开(公告)日：2010-01-21
申请号：CA2730610
申请日：2009-07-15
申请人： SCHERING CORP
发明人： NEELAMKAVIL SANTHOSH FRANCIS , BOYLE CRAIG D , HARRIS JOEL M , STAMFORD ANDREW W , HAO JINSONG , NEUSTADT BERNARDT R , CHACKALAMANNIL SAMUEL , XIA YAN , GREENLEE WILLIAM J
IPC分类号： C07D473/30 , A61K31/519 , A61K31/52 , A61P3/00 , A61P9/00 , C07D473/34 , C07D487/04
摘要： The present invention relates to Bicyclic Heterocycle Derivatives of Formula (I), compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a diabetic complication, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G protein-coupled receptor (GPCR) in a patient.

52. 发明专利

AU2009270983A1 Bicyclic heterocycle derivatives and their use as GPCR modulators 未知
公开(公告)号：AU2009270983A1
公开(公告)日：2010-01-21
申请号：AU2009270983
申请日：2009-07-15
申请人： SCHERING CORP
发明人： GREENLEE WILLIAM J , HARRIS JOEL M , NEELAMKAVIL SANTHOSH FRANCIS , XIA YAN , CHACKALAMANNIL SAMUEL , BOYLE CRAIG D , NEUSTADT BERNARDT R , HAO JINSONG , STAMFORD ANDREW W
IPC分类号： C07D473/30 , A61K31/519 , A61K31/52 , A61P3/00 , A61P9/00 , C07D473/34 , C07D487/04
摘要： The present invention relates to Bicyclic Heterocycle Derivatives of Formula (I), compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a diabetic complication, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G protein-coupled receptor (GPCR) in a patient.

53. 发明专利

PT1319003E INIBIDORES DE FOSFODIESTERASE V DE XANTINA 未知
公开(公告)号：PT1319003E
公开(公告)日：2009-07-23
申请号：PT01971092
申请日：2001-09-17
申请人： SCHERING CORP
发明人： STAMFORD ANDREW W , BOYLE CRAIG D , CHACKALAMANNIL SAMUEL , WANG YUGUANG
IPC分类号： C07D473/04 , A61K31/522 , A61K45/00 , A61P1/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/00 , A61P13/12 , A61P15/00 , A61P27/06 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D473/02 , C07D473/06 , C07D473/08 , C07F7/18

54. 发明专利

DE60138955D1 XANTHIN-PHOSPHODIESTERAS-V-INHIBITOREN 未知
公开(公告)号：DE60138955D1
公开(公告)日：2009-07-23
申请号：DE60138955
申请日：2001-09-17
申请人： SCHERING CORP
发明人： CHACKALAMANNIL SAMUEL , WANG YUGUANG , BOYLE CRAIG D , STAMFORD ANDREW W
IPC分类号： C07D473/04 , A61K31/522 , A61K45/00 , A61P1/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/00 , A61P13/12 , A61P15/00 , A61P27/06 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D473/02 , C07D473/06 , C07D473/08 , C07F7/18
摘要： A xanthine phosphodiesterase V inhibitor having the formula (I), with the variables defined herein, which is especially useful for treating male (erectile) and female sexual dysfunction and other physiological disorders: For example, a representative compound of the invention is:

55. 发明专利

MX2009003761A DERIVADOS BICICLICOS Y TRICICLICOS COMO ANTAGONISTAS DEL RECEPTOR DE TROMBINA. 未知
公开(公告)号：MX2009003761A
公开(公告)日：2009-06-30
申请号：MX2009003761
申请日：2007-10-02
申请人： SCHERING CORP
发明人： XIA YAN , CHACKALAMANNIL SAMUEL , CHELLIAH MARIAPPAN V , WANG YUGUGUANG
IPC分类号： C07D401/06 , C07D417/06
摘要： Los tricíclicos heterocíclicos-sustituidos de la fórmula (I): (ver fórmula (I)) o una sal o solvato farmacéuticamente aceptable de dicho compuesto, isómero o mezcla racémica, en donde representa un enlace doble opcional, la línea punteada es opcionalmente un enlace o no es un enlace, dando como resultado un enlace doble o un enlace sencillo, según lo permita el requerimiento de valencia y en donde E, A, G, M Het, B, X, R3, R10, R11, R32 y R33 son como se definen en la presente y los sustituyentes restantes son como se definen en la especificación, así como composiciones farmacéuticas que los contienen y un método para el tratamiento de enfermedades asociadas con trombosis, aterosclerosis, restenosis, hipertensión, angina de pecho, arritmia, paro cardíaco, cáncer, con la administración de dichos compuestos; también se reclama la terapia de combinación con otros agentes cardiovasculares.

56. 发明专利

AT433454T 未知
公开(公告)号：AT433454T
公开(公告)日：2009-06-15
申请号：AT05854388
申请日：2005-12-19
申请人： SCHERING CORP
发明人： CLASBY MARTIN , CHACKALAMANNIL SAMUEL , NEUSTADT BERNARD , GAO XIAOBANG
IPC分类号： C07D487/04
摘要： Compounds having the structural formula I are disclosed, wherein A is alkylene, or optionally substituted arylene, cycloalkylene or heteroaryldiyl; X is —C(O)— or —S(O)2—; R1 is alkyl or cycloalkyl; R2 is hydrogen, halo or —CN; R3 is hydrogen or alkyl; R4 is hydrogen, alkyl, alkoxy, hydroxyalkyl, aminoalkyl-, cycloalkyl, heterocycloalkyl, heterocycloalkyl substituted by alkyl, optionally substituted arylalkyl or optionally substituted heteroarylalkyl; or R3 and R4, form an optionally substituted 5-7 membered ring, said ring optionally comprising an additional heteroatom ring member; R7 is alkyl, optionally substituted phenyl, optionally substituted heteroaryl, cycloalkyl, halo, morpholinyl, optionally substituted piperazinyl, or optionally substituted azacycloalkyl. Also disclosed is the use of the compounds in the treatment of Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, pharmaceutical compositions comprising them and kits comprising the components of the combinations.

58. 发明专利

HK1119681A1 7-[2-[4-(6-FLUORO-3-METHYL-1,2-BENZISOXAZOL-5-YL)-1-PIPERAZINYL]ETHYL]-2-(1-PROPYNYL)-7H-PYRAZOLO-[4,3-E]-[1,2,4]-TRIAZOLO-[1,5-C]-PYRIMIDIN-5 AMINE 未知
公开(公告)号：HK1119681A1
公开(公告)日：2009-03-13
申请号：HK08111733
申请日：2008-10-24
申请人： SCHERING CORP
发明人： BOYLE CRAIG D , CHACKALAMANNIL SAMUEL , SHAH UNMESH G , LACHOWICZ JEAN E
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101
摘要： The compound having the structural formula I or a pharmaceutically acceptable salt thereof, is disclosed, as well as its use in the treatment of central nervous system diseases, in particular Parkinson's disease, Extra Pyramidal Syndrome, restless legs syndrome and attention deficit hyperactivity disorder, pharmaceutical compositions comprising it, and combinations with other agents.

59. 发明专利

AU2005236059B2 Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists 未知
公开(公告)号：AU2005236059B2
公开(公告)日：2009-01-15
申请号：AU2005236059
申请日：2005-04-19
申请人： SCHERING CORP
发明人： BOYLE CRAIG D , NEUSTADT BERNARD R , STAMFORD ANDREW , HARRIS JOEL M , SHAH UNMESH G , CHACKALAMANNIL SAMUEL , HAO JINSONG , LIU HONG
IPC分类号： C07D487/14 , A61K31/519
摘要： Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or pyrrolyl, or cycloalkenyl R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; and Z is optionally substituted aryl or heteroaryl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.

60. 发明专利

AT413388T 未知
公开(公告)号：AT413388T
公开(公告)日：2008-11-15
申请号：AT03726436
申请日：2003-04-24
申请人： SCHERING CORP
发明人： BOYLE CRAIG , GREENLEE WILLIAM , CHACKALAMANNIL SAMUEL
IPC分类号： C07D221/20 , A61K31/4523 , A61P25/00 , C07D211/96

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