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    • 54. 发明公开
    • VERFAHREN ZUR HERSTELLUNG VON NAPHTHALINDERIVATEN
    • EP1581469A1
    • 2005-10-05
    • EP03769471.8
    • 2003-10-30
    • Merck Patent GmbH
    • POETSCH, EikeBINDER, WernerKIRSCH, PeerTAUGERBECK, Andreas
    • C07C41/03C07C43/225C07C51/15C07D339/08
    • C07D339/08C07C41/01C07C41/06C07C43/225C07C51/15C07C2602/10C07C2602/28C07D339/06C07C63/04
    • The invention relates to a method for producing a compound of general formula (I): R-(A1-Z-)mB-CF2O-A2-(A3)n-R', in which R represents alkyl, in which one or more CH2 groups can be substituted, independently of one another, by O, CF2, CH=CH, CH=CF, CF=CF, with the exclusion of peroxide structures O-O and formaldehyde acetals O-CH2-O; A1 represents, independently of one another, 1,4-cyclohexylene, 2,5-1,3-dioxanylene, 1,3-cyclobutylene or (a); A2 and A3 represent 1,4-phenylene, in which independently of one another one to four hydrogen atoms can be substituted by fluorine or one or two CH groups can be substituted by N; Z represents a single bond -CH2-CH2-, -CF2-CF2-, -CH=CH-, -CF=CF-, -CH=CF- or -CF=CH-; B represents 2,6-disubstituted naphthalene, 2,6-disubstituted 5, 6, 7,8-tetrahydronaphthalene or 2,6-disubstituted trans-decaline; R' represents R, F, OCF3, OCF2H, CF3, Cl, SF5, CN, NCS, and m and n independently of one another represent 0 or 1. The method comprises the following steps: a) conversion of a compound of general formula (II): R-(A1-Z-)mBX, in which X represents halogen or =O and the other symbols are defined as cited for formula (I), into a carboxylic acid derivative with the expulsion of group X and introduction of a C1 structural element; b) reaction of the carboxylic acid derivative with a phenol of general formula (III): HO-A2(-A3)n-R', in which A2, A3, R' and n are defined as cited in formula (I), to form the compound of formula (I).
    • 本发明涉及制备通式(I)化合物的方法:其中R表示烷基,其中一个或多个(R 1) - (A 1 -Z-)mB-CF 2 O -A 2 - (A 3)n -R' CH 2基团可以相互独立地被O,CF 2,CH = CH,CH = CF,CF = CF取代,排除过氧化物结构OO和甲醛缩醛O-CH 2 -O; A1相互独立地代表1,4-亚环己基,2,5-1,3-二恶烷基,1,3-亚环丁基或(a); A2和A3代表1,4-亚苯基,其中相互独立地1-4个氢原子可以被氟取代或者一个或两个CH基团可以被N取代; Z表示单键-CH 2 -CH 2 - , - CF 2 -CF 2 - , - CH = CH - , - CF = CF - , - CH = CF-或-CF = CH- B代表2,6-二取代的萘,2,6-二取代的5,6,7,8-四氢萘或2,6-二取代的反式萘烷; R'表示R,F,OCF 3,OCF 2 H,CF 3,Cl,SF 5,CN,NCS,且m和n彼此独立地代表0或1。 (II):R-(A1-Z-)mBX,其中X代表卤素或= O且其它符号如式(I)所述定义,转化为羧酸衍生物并排出基团X并引入 C1结构元件; b)羧酸衍生物与通式(III)的苯酚的反应:其中A 2,A 3,R 1和n如式(I)中所定义的那样,HO-A 2(-A 3)n -R' 以形成式(I)的化合物。