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51. 发明申请

WO2003022352A1 ELECTRONIC LEAD FOR A MEDICAL IMPLANT DEVICE, METHOD OF MAKING SAME, AND METHOD AND APPARATUS FOR INSERTING SAME 审中-公开
标题翻译：用于医疗植入装置的电子引线，其制造方法和用于插入其的方法和装置
公开(公告)号：WO2003022352A1
公开(公告)日：2003-03-20
申请号：PCT/US2002/028014
申请日：2002-09-04
申请人： MEDTRONIC MINIMED, INC.
发明人： GIBSON, Scott, R. , SHAH, Rajiv , CHERNOFF, Edward , BYERS, Charles
IPC分类号： A61N1/05
CPC分类号： A61N1/3752 , A61N1/05 , Y10S439/909
摘要： An implantable coaxial lead includes a cable with male and female connectors. The cable includes inner and outer helical coils separated by an inner insulator tube, with an outer insulator tube surrounding the outer helical coil. The male connector includes an outer conductive cylinder, a conductive pin and an insulator molded in between. For increased strength, a braided cylinder, infused with rubber, is included at the juncture of the male connector and the cable. The female connector includes a cylinder formed by two conducting body elements (400, 402) and an intervening insulating body element (401). The female connector includes respective conductive tension elements (408, 416) configured to engage the male connector. A first seal (412) is provided between the conductive tension members for electrical isolation and tactile feedback. An insertion tool includes a cylinder with a hollow bore and detachable head, and a rod for pulling the lead through the cylinder.
摘要翻译：可植入同轴引线包括具有阳和阴连接器的电缆。电缆包括由内绝缘管隔开的内螺旋线圈和外螺旋线圈，外绝缘管围绕外螺旋线圈。阳连接器包括外导电圆筒，导电针和模制在其间的绝缘体。为了增加强度，在公连接器和电缆的接合处包括注入橡胶的编织圆筒。阴连接器包括由两个导电体元件（400,402）和中间绝缘体元件（401）形成的圆筒。阴连接器包括配置成接合阳连接器的各自的导电张力元件（408,416）。在导电张力构件之间提供第一密封件（412），用于电隔离和触觉反馈。插入工具包括具有中空孔和可拆卸头的圆柱体，以及用于将引线拉过圆筒的杆。

52. 发明申请

WO2017116505A1 RETROSPECTIVE SENSOR CALIBRATION METHODS 审中-公开
标题翻译：回顾性传感器校准方法
公开(公告)号：WO2017116505A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/043599
申请日：2016-07-22
申请人： MEDTRONIC MINIMED, INC.
发明人： NOGUEIRA, Keith , ENGEL, Taly G. , GROSMAN, Benyamin , LI, Xiaolong , LIANG, Bradley C. , SHAH, Rajiv , LIU, Mike C. , TSAI, Andy Y. , VARSAVSKY, Andrea , NISHIDA, Jeffrey
IPC分类号： A61B5/145 , A61B5/1495 , A61B5/053
CPC分类号： G06F19/3412 , A61B5/14532 , A61B5/14735 , A61B5/1495 , A61B5/6849 , G06F19/00 , G06N3/126 , G06N99/005 , G16H40/40
摘要： A method for retrospective calibration of a glucose sensor uses stored values of measured working electrode current (Isig) to calculate a final sensor glucose (SG) value retrospectively. The Isig values may be preprocessed, discrete wavelet decomposition applied. At least one machine learning model, such as, e.g., Genetic Programing (GP) and Regression Decision Tree (DT), may be used to calculate SG values based on the Isig values and the discrete wavelet decomposition. Other inputs may include, e.g., counter electrode voltage (Vcntr) and Electrochemical Impedance Spectroscopy (EIS) data. A plurality of machine learning models may be used to generate respective SG values, which are then fused to generate a fused SG. Fused SG values may be filtered to smooth the data, and blanked if necessary.
摘要翻译：回顾性校准葡萄糖传感器的方法使用测量的工作电极电流（Isig）的存储值来回顾性地计算最终的传感器葡萄糖（SG）值。可以对Isig值进行预处理，应用离散小波分解。基于Isig值和离散小波分解，可以使用至少一个机器学习模型，例如遗传编程（GP）和回归决策树（DT）来计算SG值。其他输入可以包括例如对电极电压（V cntr）和电化学阻抗谱（EIS）数据。多个机器学习模型可以用于生成相应的SG值，然后将其融合以生成融合的SG。可以过滤融合的SG值以平滑数据，并在必要时消隐。

53. 发明申请

WO2008069931A1 ANALYTE SENSING APPARATUS FOR HOSPITAL USE 审中-公开
标题翻译：分析用于医院使用的感觉装置
公开(公告)号：WO2008069931A1
公开(公告)日：2008-06-12
申请号：PCT/US2007/024441
申请日：2007-11-27
申请人： MEDTRONIC MINIMED, INC.
发明人： MASTROTOTARO, John, J. , SHAH, Rajiv , RAY, Partha , LONG, Kenny, J. , HAYES, Andrew, C. , PATEL, Nandita , TALBOT, Cary, D. , REGHABI, Bahar
IPC分类号： A61B5/00
CPC分类号： A61M5/14244 , A61B5/01 , A61B5/031 , A61B5/14532 , A61B5/1495 , A61B5/412 , A61B5/413 , A61B2562/0295 , A61M2005/1405 , A61M2205/18 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/587 , A61M2230/201 , G06F19/00 , G06F19/3418 , G06Q50/22 , G16H40/20
摘要： A system is provided for monitoring blood glucose data of a patient. The system includes a sensing device and hospital monitor. The sensing device includes a sensor and sensor electronics and is adapted to transmit information to the hospital monitor while continuing to sense blood glucose data. The communication between the sensing device and the hospital monitor may be wireless. The sensor electronics may include a sensor power supply, a voltage regulator, and optionally a memory and processor.
摘要翻译：提供一种用于监测患者血糖数据的系统。该系统包括感测装置和医院监护仪。感测装置包括传感器和传感器电子装置，并且适用于在继续感测血糖数据的同时向医院监护仪发送信息。感测装置和医院监视器之间的通信可以是无线的。传感器电子器件可以包括传感器电源，电压调节器以及可选地的存储器和处理器。

54. 发明申请

WO2007079015A3 METHOD OF AND SYSTEM FOR STABILIZATION OF SENSORS 审中-公开
公开(公告)号：WO2007079015A3
公开(公告)日：2007-07-12
申请号：PCT/US2006/048950
申请日：2006-12-21
申请人： MEDTRONIC MINIMED, INC.
发明人： SHAH, Rajiv , REGHABI, Bahar , HENKE, James, L. , MORGAN, Wayne, A. , SOUNDARARAJAN, Gopikrishnan , CHOY, David, Y. , SCHULTZ, Peter , HOSS, Udo
IPC分类号： A61B5/00
摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The.stabiltzation circuitry cases a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic - cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulator voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

55. 发明申请

WO2004036183A2 ANALYTE SENSORS AND METHODS FOR MAKING THEM 审中-公开
标题翻译：分析传感器及其制造方法
公开(公告)号：WO2004036183A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/033065
申请日：2003-10-17
申请人： MEDTRONIC MINIMED, INC.
发明人： HOLKER, James, D. , MASTROTOTARO, John, J. , NORONHA, Glenn , SHAH, Rajiv , ZHANG, Yanan , HOSS, Udo , BRANCH, Kevin, D.
IPC分类号： G01N
CPC分类号： A61B5/1486 , C12Q1/006 , G01N27/307
摘要： Embodiments of the invention provide analyte sensors having stabilized coating compositions and methods for making such sensors. Illustrative embodiments include electrochemical glucose sensors having stabilized glucose oxidase coatings that are generated for example, via spin coating processes.
摘要翻译：本发明的实施例提供了具有稳定的涂层组合物的分析物传感器以及用于制造这种传感器的方法。说明性实施例包括具有稳定的葡萄糖氧化酶涂层的电化学葡萄糖传感器，所述葡萄糖氧化酶涂层例如经由旋涂工艺而产生。

56. 发明申请

WO2004029994A2 MULTILAYER SUBSTRATE 审中-公开
标题翻译：多层基板
公开(公告)号：WO2004029994A2
公开(公告)日：2004-04-08
申请号：PCT/US2003/029224
申请日：2003-09-15
申请人： MEDTRONIC MINIMED, INC.
发明人： SHAH, Rajiv , PENDO, Shaun , BABIRICKI, Edward, B.
IPC分类号： H01F
CPC分类号： H01L21/4857 , H01L2924/0002 , H05K1/092 , H05K3/4061 , H05K3/4647 , H05K3/4667 , H05K3/467 , H05K2201/0179 , H05K2203/0278 , H01L2924/00
摘要： A multilayer substrate device formed from a base substrate and alternating metalization layers and dielectric layers. Each layer is formed without firing. Vias may extend through one of the dielectric layers such that two metalization layers surrounding the dielectric layers make contact with each other. The vias may be formed by placing pillars ontop of a metalization layer, forming a dielectric layer on top of the metalization layer and surrounding the pillars, and removing the pillars. Dielectric layers may be followed by other dielectric layers and metalization layers may be followed by other metalization layers. Vias in the substrate may be filled by forming an assembly around the substrate, the assembly including printing sheets containing a conductive ink and pressure plates for applying pressure. A vacuum may be applied to remove air in the ink. Pressure may then be applied to the printing sheets through the pressure plates. The conductive ink in the printing sheets is pushed through the vias when pressure isapplied by the pressure plates.
摘要翻译：由基底基板和交替的金属化层和电介质层形成的多层衬底器件。每层形成而不烧制。通孔可以延伸穿过介电层之一，使得围绕电介质层的两个金属化层彼此接触。通孔可以通过将金属化层顶部放置柱子，在金属化层的顶部上形成电介质层并围绕柱子形成，并且去除支柱。电介质层之后可以是其它电介质层，金属化层之后可以是其它金属化层。可以通过在基板周围形成组件来填充基板中的通孔，该组件包括含有导电油墨的印刷纸和用于施加压力的压力板。可以施加真空以除去油墨中的空气。然后可以通过压力板将压力施加到印刷纸上。当压力被压力板施加时，打印纸中的导电油墨被推过通孔。

57. 发明申请

WO2003036255A2 METHOD FOR FORMULATING A GLUCOSE OXIDASE ENZYME WITH A DESIRED PROPERTY OR PROPERTIES AND A GLUCOSE OXIDASE ENZYME WITH THE DESIRED PROPERTY 审中-公开
标题翻译：制备具有期望特性或性质的葡萄糖氧化酶的方法以及具有所需特性的葡萄糖氧化酶酶
公开(公告)号：WO2003036255A2
公开(公告)日：2003-05-01
申请号：PCT/US2002/030849
申请日：2002-09-27
申请人： MEDTRONIC MINIMED, INC.
发明人： SHAH, Rajiv , REGHABI, Bahar
IPC分类号： G01N
CPC分类号： C12N9/0006
摘要： A method for formulating a glucose oxidase enzyme with peroxide resistant properties and a glucose oxidase enzyme formulated by the method. The enzyme formulation method results in a glucose oxidase enzyme with improve resistance to peroxide, and therefore, with improved resistance to oxidative inactivation. The method employs directed evolution techniques to evolve glucose oxidase to achieve the desirable properties. A peroxide resistant glucose oxidase may improve the longevity of, for example, glucose biosensors in which a peroxide resistant glucose oxidase may be placed.
摘要翻译：用于配制具有过氧化物抗性的葡萄糖氧化酶和通过该方法配制的葡萄糖氧化酶的方法。酶制剂方法产生对过氧化物具有改善的抗性的葡萄糖氧化酶，并且因此具有改善的对氧化失活的抗性。该方法采用定向进化技术来发展葡萄糖氧化酶以实现所需的性质。过氧化物抗性葡萄糖氧化酶可以改善例如其中可以放置过氧化物抗性葡萄糖氧化酶的葡萄糖生物传感器的寿命。

58. 发明申请

WO2015069692A3 ENZYME MATRICES FOR USE WITH ETHYLENE OXIDE STERILIZATION 审中-公开
公开(公告)号：WO2015069692A3
公开(公告)日：2015-05-14
申请号：PCT/US2014/064015
申请日：2014-11-05
申请人： MEDTRONIC MINIMED, INC.
发明人： SHAH, Rajiv , YANG, Qingling , MUCIC, Robert C. , WANG, Jenn-Hann Larry , PEREZ, Mercedes M. , HUANG, Ting
IPC分类号： C12Q1/00 , A61L2/20
摘要： The invention pertains to analyte sensors designed to include layered compositions that provide these sensors with enhanced functional and/or material properties including, for example, resistance to damage caused by ethylene oxide during sterilization processes. Embodiments of the invention include polyvinyl alcohol N-methyl-4(4'-formylstyryl)pyridinium (SbQ) polymer materials and methods for employing such materials during the ethylene oxide sterilization of glucose sensors.

59. 发明申请

WO2013184416A3 APPLICATION OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY IN SENSOR SYSTEMS, DEVICES, AND RELATED METHODS 审中-公开
公开(公告)号：WO2013184416A3
公开(公告)日：2013-12-12
申请号：PCT/US2013/042680
申请日：2013-05-24
申请人： MEDTRONIC MINIMED, INC.
发明人： YANG, Ning , GAUTHAM, Raghavendhar , LIANG, Bradley C. , SHAH, Rajiv , SZYMAN, Catherine M. , MILLER, Michael E. , WANG, Jenn-Hann Larry , LI, Yiwen , MORGAN, Wayne A. , CHEN, Paris , MUCIC, Robert C. , DE BARROS, Genival D. , CALLIRGOS, Carlos A. , SIRIGIRI, Manjunath , BRINSON, Joseph Paul
IPC分类号： A61B5/145 , A61B5/1486 , A61B5/1495 , A61B5/00
摘要： A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the ElS-based diagnostics, fusion algorithms, and other processes based on measurement of ElS-based parameters.

60. 发明申请

WO2004030514A2 METHOD AND APPARATUS FOR ENHANCING THE INTEGRITY OF AN IMPLANTABLE SENSOR DEVICE 审中-公开
标题翻译：用于增强可植入传感器装置的完整性的方法和装置
公开(公告)号：WO2004030514A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/028854
申请日：2003-09-15
申请人： MEDTRONIC MINIMED, INC.
发明人： SHAH, Rajiv , ZHANG, Yanan , GOTTLIEB, Rebecca , REGHABI, Bahar , MILLER, Michael, E.
IPC分类号： A61B
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/686 , A61B2562/02 , G01N33/5438 , Y10T29/49002 , Y10T29/49007 , Y10T29/49128 , Y10T29/49155
摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
摘要翻译：一种用于增强可植入传感器的完整性的方法和装置。形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。涂层可沉积在传感器引线的表面上，提供加强和润滑。

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