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51. 发明申请

WO2002058465A3 PERFUSION LEAD 审中-公开
公开(公告)号：WO2002058465A3
公开(公告)日：2002-08-01
申请号：PCT/US2001/049226
申请日：2001-12-19
申请人： MEDTRONIC, INC.
发明人： CLEMENS, William, J. , HESS, Douglas, N. , SOMMERS, John, L. , SOYKAN, Orhan
IPC分类号： A61N1/05
摘要： A medical electrical lead (10) including an inflatable member (12) at a distal tip section, and a system of use, are disclosed. The inflation member is adapted to engage the walls of a cardiac vein or coronary artery to occlude the vessel. According to one aspect of the invention, the inflation member is formed of a bio-absorbable material. In another embodiment, the inflation member is a micro-porous material. The lead of the current invention may include a port located distal to the inflation member is in the inflated state. This allows a fluoroscopic image of a patient's vascular system to be obtained while the lead is in place within a vessel. A perfusion lumen may be provided to allow a partial flow of blood to continue around the inflation member (18) when the inflation member is occluding a vessel. In one embodiment, lead is provided with a lumen for receiving a stiffening menber such as a stylet (64) to aid in lead is placement. According to one method of using the current invention, inflation member may be inflated after the lead is placed at a desired implant site to provide a temporary fixation mechanism during withdrawal of the stiffening member and/or a guide catheter or sheath used to place the lead at the implant site. This temporary fixation mechanism may also be employed to retain a desired lead location while thresholds are obtains. The inflation member may be retained in an inflated state for a longer predetermined period of time until tissue in-growth begins to occur around the lead.

52. 发明公开

EP2701792A1 DETECTING FOOD INTAKE BASED ON IMPEDANCE 审中-公开
标题翻译：基于阻抗营养检测中
公开(公告)号：EP2701792A1
公开(公告)日：2014-03-05
申请号：EP12719190.6
申请日：2012-04-24
申请人： Medtronic Inc.
发明人： STARKEBAUM, Warren L. , SOYKAN, Orhan , BLOOMBERG, Daniel
IPC分类号： A61N1/36 , A61B5/053 , A61B5/04
CPC分类号： A61N1/36007 , A23L33/30 , A61B5/04 , A61B5/053 , A61B5/0538 , A61B5/42 , A61B5/4238 , A61B5/4836 , A61B5/4839 , A61B5/686 , A61B5/6871 , A61B5/688 , A61B5/6882 , A61B5/6883 , A61B2562/0209 , A61B2562/043 , A61F5/0026
摘要： In some examples, the disclosure relates to a systems, devices, and techniques for monitoring the occurrence of food intake by a patient. In one example, the disclosure relates to a method including determining a phase of tissue impedance at one or more gastrointestinal tract locations of a patient via a medical device, and determining the occurrence of food intake by the patient based on the determined phase of the tissue impedance. In some examples, a medical device may control the delivery of therapy to a patient based on the determination of food intake based on the phase to the tissue impedance.

53. 发明公开

EP2480283A1 WAVEFORMS FOR ELECTRICAL STIMULATION THERAPY 审中-公开
标题翻译：曲线地图电刺激疗法
公开(公告)号：EP2480283A1
公开(公告)日：2012-08-01
申请号：EP10757921.1
申请日：2010-09-21
申请人： Medtronic, Inc.
发明人： STARKEBAUM, Warren, L. , MAUDE-GRIFFIN, Roland, C. , FIRESTONE, Elizabeth, D. , SCHU, Carl, A. , SOYKAN, Orhan
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/36085 , A61N1/36171 , A61N1/36175
摘要： In some examples, the disclosure relates to a systems, devices, and techniques for delivering electrical stimulation therapy to a patient. In one example, the disclosure relates to a method including delivering a series of pulses with alternating pulse polarities to a gastrointestinal tract of a patient. The series of pulses includes at least a first pulse of a first polarity, a second pulse of a second polarity, and a third pulse of the first polarity, where the first, second and third pulses are delivered in direct succession and in that order. The first and second pulses are separated by a first time delay and the second and third pulses are separated by a second time delay. In some examples, each of the first and second time delays depend on the frequency that the series of pulses are delivered.

54. 发明公开

EP2079517A2 ELECTRONIC AND BIOLOGICAL PACEMAKER SYSTEMS 审中-公开
标题翻译：电子及生物PACER系统
公开(公告)号：EP2079517A2
公开(公告)日：2009-07-22
申请号：EP07871203.1
申请日：2007-10-22
申请人： MEDTRONIC, INC.
发明人： SIGG, Daniel C. , LASKE, Timothy G. , SHARMA, Vinrod , SOYKAN, Orhan
IPC分类号： A61N1/362 , A61K48/00 , C12N5/06
CPC分类号： A61N1/362 , A61N1/3627
摘要： Heart pacing systems include at least one electronic or biological pacemaker as a primary pacemaker, and at least one electronic or biological pacemaker as a backup pacemaker. When implanted, the primary pacemaker(s) produce primary pacing stimuli that modulate cardiac function. The backup pacemaker(s) provide backup pacing stimuli when the electronic pacemaker is unable to modulate cardiac function at the predetermined pacing rate. The heart pacing systems are implemented by implantation in regions where they can provide pacing stimuli to cardiac tissue.

55. 发明授权

EP1496988B1 VASCULAR ELECTRODE SYSTEM FOR ELECTRICAL STIMULATION FOR THROMBOLYTIC THERAPY 有权
标题翻译： VESSEL电极系统欲了解溶栓治疗电刺激
公开(公告)号：EP1496988B1
公开(公告)日：2009-07-01
申请号：EP03721694.2
申请日：2003-04-16
申请人： MEDTRONIC, INC.
发明人： SOYKAN, Orhan , DENO, Curtis, D. , TRESCONY, Paul, V. , DONOVAN, Maura, G. , WILLIAMS, Terrell, M. , ROBINSON, Timothy, H.
IPC分类号： A61N1/32
CPC分类号： A61N1/326
摘要： This invention is an electrical stimulation apparatus for delivering an electrical field or electrical current over a predetermined period of time to a vascular tissue (150) in order to stimulate a cell initiated thrombolytic peptide response in cells within the vascular tissue. The electrical stimulation apparatus includes an electrical field or electrical current generating unit including a power support , a control mechanism interconnected with the power supply , and a plurality of electrodes designed to generate an electrical field or electrical current proximal to, or within to the vascular tissue. The amplitude of the electrical field or electrical current delivered to or generated proximal to, or within the vascular tissue, and the duration of the period of delivery are sufficient to stimulate production of thrombolytic peptides in the vascular tissue. The control mechanism preferably includes a computer processing unit in electronic communication with the power supply, the computer being programmed to cause the electrical stimulation apparatus to deliver a predetermined amount of electricalcurrent or voltage over a predetermined period of delivery to the plurality of electrodes such that the plurality of electrodes are in contact or proximity with the vascular tissue.

56. 发明公开

EP1833413A1 CELLULAR AND GENETIC INTERVENTION TO TREAT VENTRICULAR TACHYCARDIA 审中-公开
标题翻译：细胞与遗传干预治疗室性心动过速
公开(公告)号：EP1833413A1
公开(公告)日：2007-09-19
申请号：EP05818255.1
申请日：2005-10-13
申请人： MEDTRONIC, INC.
发明人： SHARMA, Vinrod , SOYKAN, Orhan , DONOVAN, Maura, G. , OLSON, Walter, H.
IPC分类号： A61F2/00 , A61B5/0464
CPC分类号： A61L27/3873 , A61K9/0024 , A61K38/00 , A61K48/005 , A61L27/227 , A61L27/3834 , C07K14/705

57. 发明公开

EP1774040A2 GENETIC DIAGNOSTIC METHOD FOR SCD RISK STRATIFICATION 审中-公开
标题翻译：基因诊断程序用于评估心脏猝死的危险
公开(公告)号：EP1774040A2
公开(公告)日：2007-04-18
申请号：EP05799823.9
申请日：2005-06-22
申请人： MEDTRONIC, INC.
发明人： SOYKAN, Orhan , CROSS, Daisy, P.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/16 , G06F19/00 , G06F19/18 , G16H50/70
摘要： A self-improving classification system classifies specimens based on class identifiers. The system stores specimen profiles in a database that is updated with additional specimen profiles and with follow-up data that corrects classification of specimens that were initially incorrectly classified. Algorithms use the updated database to discover new class identifiers, modify thresholds of known class identifiers, and drop unnecessary class identifiers to improve classification of specimens.

58. 发明授权

EP1651310B1 MYOCARDIAL STIMULATION 有权
标题翻译：心肌起搏
公开(公告)号：EP1651310B1
公开(公告)日：2007-01-24
申请号：EP04778975.5
申请日：2004-07-22
申请人： MEDTRONIC, INC.
发明人： SOYKAN, Orhan , DONOVAN, Maura, G.
IPC分类号： A61N1/36 , A61N1/362 , A61N1/368
CPC分类号： A61L27/3839 , A61N1/3627 , A61N1/365 , A61N1/368
摘要： In general, the invention is directed to methods for electrically stimulating transplanted biological material, such as transplanted cells, to improve the performance of the heart during systole. In particular, the invention is directed to devices and techniques for stimulating biological material transplanted in a myocardium of a heart during an ejection phase of a cardiac cycle. The transplanted biological material may include cells, such as skeletal myoblasts, precursor cells, endothelial cells, differentiated or undifferentiated stem cells, undifferentiated contractile cells, fibroblasts and genetically engineered cells. In general, stimulation of the transplanted biological material during the ejection phase of the cardiac cycle, when the aortic and pulmonary valves are open, provides hemodynamic assistance to the heart.

59. 发明公开

EP1622673A1 SYSTEM FOR THE DELIVERY OF A BIOLOGIC THERAPY WITH DEVICE MONITORING AND BACK-UP 有权
标题翻译： SYSTEM FOR生物治疗监测行政和备份
公开(公告)号：EP1622673A1
公开(公告)日：2006-02-08
申请号：EP04759871.9
申请日：2004-04-15
申请人： MEDTRONIC, INC.
发明人： LASKE, Timothy, G. , SIGG, Daniel, C. , SOYKAN, Orhan
IPC分类号： A61M31/00 , A61K48/00 , A61M5/142 , A61M5/172 , A61B5/0205
CPC分类号： A61M5/14276 , A61B5/042 , A61B5/0452 , A61B5/0464 , A61B5/076 , A61B5/4839 , A61B5/6882 , A61K48/00 , A61M5/1723 , A61M2205/04 , A61M2210/122 , A61M2210/125 , A61M2230/04 , A61N1/0568 , C12N2750/14143
摘要： An implantable medical device (IMD), such as a cardiac monitor and/or pulse generator is implanted during a procedure where a biologic is introduced into a targeted area of the heart. The IMD monitors cardiac performance to determine the efficacy of the biologic. Based on the achieved efficacy, the IMD will either take no action, provide device based therapy, and/or ablate the tissue to destroy the biologic and its effects if the biologic proves unsuccessful.

60. 发明授权

EP1027014B1 IMPLANTABLE SYSTEM WITH DRUG-ELUTING CELLS FOR ON-DEMAND LOCAL DRUG DELIVERY 有权
标题翻译：药物洗脱药物局部用药细胞按照需要植入系统
公开(公告)号：EP1027014B1
公开(公告)日：2004-11-24
申请号：EP99942261.1
申请日：1999-08-23
申请人： Medtronic, Inc.
发明人： SOYKAN, Orhan , DONOVAN, Maura, G.
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/02 , A61F2/06 , A61F2/82 , A61F2250/0001 , A61F2250/0067 , A61K9/0009 , A61K9/0024 , A61K38/4866 , A61K38/49 , A61K48/00 , A61K2035/126 , A61L27/3804 , A61L27/3808 , A61L27/3843 , A61L27/54 , A61L29/005 , A61L29/16 , A61L31/005 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/22 , A61L2300/252 , A61L2300/254 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/64 , A61N1/36542 , C12N5/069
摘要： An implantable system that includes a carrier and eukaryotic cells, which produce and release a therapeutic agent, and a stimulating element for stimulating the release of the therapeutic agent. The system can also include a sensing element for monitoring a physiological condition and triggering the stimulating element to stimulate the delivery device to release the therapeutic agent. Alternatively, the patient in which the system is implanted can activate the stimulating element to release the therapeutic agent.

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