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51. 发明授权

US5015637A Pyrido[3,4-b]pyrrolo[1,2-e][1,4,5]oxadiazepines 失效
标题翻译：吡啶并[3,4-b]吡咯并[1,2-e] [1,4,5]恶二氮杂
公开(公告)号：US5015637A
公开(公告)日：1991-05-14
申请号：US529082
申请日：1990-05-25
申请人： Richard C. Effland , Larry Davis
发明人： Richard C. Effland , Larry Davis
IPC分类号： A61K31/55 , A61K31/553 , A61P25/04 , C07D498/14
CPC分类号： C07D498/14
摘要： There are disclosed various compounds of the formula below, ##STR1## where X is hydrogen, halogen or loweralkyl;Y is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl;R.sub.1 is hydrogen, loweralkyl, aryl, arylloweralkyl, diloweralkylaminoloweralkyl or ##STR2## R.sub.3 being hydrogen, loweralkyl or arylloweralkyl; and R.sub.2 is hydrogen, loweralkyl or arylloweralkyl;which compounds are useful as analgesic agents.

52. 发明授权

US4918069A Spiro[(piperidine- pyrrolidine- or hexahydroazepinyl substituted) pyrrolo[2,][1,4]benzoxazepines] 失效
标题翻译：螺[（哌啶 - 吡咯烷 - 或六氢氮杂吖啶基）吡咯并[2,1-c] [1,4]苯并氧氮杂]
公开(公告)号：US4918069A
公开(公告)日：1990-04-17
申请号：US290343
申请日：1988-12-29
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples
IPC分类号： C07D401/04 , C07D401/14 , C07D498/20
CPC分类号： C07D401/04 , C07D401/14
摘要： This invention relates to spiro-[(piperidine-, pyrrolidine-, or -hexahydroazepinyl substituted) pyrrolo[2,1-c][1,4]-benzoxazepines] having the following formula ##STR1## wherein R is hydrogen, lower alkyl, arylloweralkyl, acyl, lower alkenyl, lower alkynyl, and loweralkylbenzisoxazole; X is hydrogen, halogen, loweralkoxy, and trifluoromethyl; Y is hydrogen; 2' or 3' acyl, formyl, carbinol of the formula ##STR2## where R.sub.1 and R.sub.2 are the same or different and are independently hydrogen, loweralkyl, arylloweralkyl, aryl, loweralkenyl, lower alkynyl and lower alkylbenzisoxazole; loweralkyl, loweralkenyl and halogen; and n is an integer of 1 to 3. The compounds of this invention display utility as analgesic and antihypertensive agents.
摘要翻译：本发明涉及具有下列结构式的螺[ - （哌啶 - ，吡咯烷 - 或六氢氮杂环己烷基取代的）吡咯并[2,1-c] [1,4] - 苯并恶唑]，其中R是氢，低级烷基，芳基低级烷基，酰基，低级烯基，低级炔基和低级烷基苯并异恶唑; X是氢，卤素，低级烷氧基和三氟甲基; Y是氢; 其中R 1和R 2相同或不同并且独立地是氢，低级烷基，芳基低级烷基，芳基，低级烯基，低级炔基和低级烷基苯并异恶唑;式2'或3'酰基，甲酰基甲醇，低级烷基，低级烯基和卤素; 并且n为1至3的整数。本发明化合物显示出作为镇痛和抗高血压药物的用途。

53. 发明授权

US4914204A 4-Pentafluorophenoxypiperidines 失效
标题翻译： 4-五氟苯氧基哌啶
公开(公告)号：US4914204A
公开(公告)日：1990-04-03
申请号：US167941
申请日：1988-03-14
申请人： Grover C. Helsley , Larry Davis , Gordon E. Olsen
发明人： Grover C. Helsley , Larry Davis , Gordon E. Olsen
IPC分类号： C07D211/52 , A61K31/445 , A61K31/4465 , A61K31/451 , A61P25/04 , A61P25/24 , A61P25/26 , C07D211/46 , C07D403/06 , C07D413/06 , C07F9/59
CPC分类号： C07D403/06 , C07D211/46 , C07D413/06 , C07F9/591
摘要： 4-Pentafluorophenoxypiperidines and methods for alleviating pain and treating depression, convulsions, and hypertension utilizing compounds or compositions thereof are disclosed.

54. 发明授权

US4861889A 3-(2,3,4,5,6-pentafluorophenoxy)-8-azabicyclo[3.2.1]octanes 失效
标题翻译： 3-（2,3,4,5,6-五氟苯氧基）-8-氮杂双环[3.2.1]辛烷
公开(公告)号：US4861889A
公开(公告)日：1989-08-29
申请号：US167942
申请日：1988-03-14
申请人： Grover C. Helsley , Larry Davis , Gordon E. Olsen
发明人： Grover C. Helsley , Larry Davis , Gordon E. Olsen
IPC分类号： A61K31/46 , A61K31/495 , A61P9/12 , A61P25/04 , A61P25/08 , A61P25/24 , A61P25/26 , C07D451/06
CPC分类号： C07D451/06
摘要： 3-(2,3,4,5,6-pentafluorophenoxy)-8-azabicyclo[3.2.1]octanes and methods for treating depression, convulsions, pain, and hypertension utilizing compounds or compositions thereof are disclosed.

55. 发明授权

US4045448A Pyrrolo[2,1-c][1,4]benzoxazepine and benzoxazocine derivatives 失效
标题翻译：吡咯并[{2,1-c {9 {8 1,4 {9苯并氧杂吖庚因和苯并吖嗪类衍生物
公开(公告)号：US4045448A
公开(公告)日：1977-08-30
申请号：US661533
申请日：1976-02-26
申请人： Richard C. Effland , Larry Davis , Wolfgang Schaub
发明人： Richard C. Effland , Larry Davis , Wolfgang Schaub
IPC分类号： A61K31/55 , A61P25/04 , A61P25/20 , C07D207/32 , C07D207/325 , C07D498/04
CPC分类号： C07D207/325 , Y10S514/937 , Y10S514/96
摘要： Novel pyrrolobenzoxazalkanes, physiologically tolerable acid addition salts thereof and a method of preparing same are described. Compounds of the present invention are useful as analgesic, tranquilizing and anticonvulsant agents.
摘要翻译：描述了新的吡咯并苯并恶唑烷，其生理上可耐受的酸加成盐及其制备方法。本发明的化合物可用作镇痛，镇静剂和抗惊厥剂。

56. 发明申请

US20070142435A1 [4-(5-Aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase 审中-公开
标题翻译： [4-（5-氨基甲基-2-氟 - 苯基） - 哌啶-1-基] - （4-溴-3-甲基-5-丙氧基 - 噻吩-2-基） - 甲酮盐酸盐作为肥大细胞的抑制剂类胰蛋白酶
公开(公告)号：US20070142435A1
公开(公告)日：2007-06-21
申请号：US11520998
申请日：2006-09-14
申请人： Zhongli Gao , Larry Davis , Julian Levell , Mark Czekaj , Adam Sledeski
发明人： Zhongli Gao , Larry Davis , Julian Levell , Mark Czekaj , Adam Sledeski
IPC分类号： A61K31/453 , C07D409/02
CPC分类号： C07D409/06
摘要： The present invention extends to the compound of formula I: or a prodrug, pharmaceutically acceptable salt, or solvate of said compound. Furthermore, the present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier. Furthermore, the present invention is directed to the use of a compound of formula I as an inhibitor of tryptase, comprising introducing the compound into a composition comprising tryptase. In addition, the present invention is directed to the use of a compound of formula I for treating a patient suffering from, or subject to, a physiological condition in need of amelioration of an inhibitor of tryptase comprising administering to the patient a therapeutically effective amount of the compound of claim 1 The present invention is directed also to the preparation of a compound of formula I.
摘要翻译：本发明延伸到式I化合物：或所述化合物的前药，药学上可接受的盐或溶剂合物。此外，本发明涉及包含药学有效量的式I化合物和药学上可接受的载体的药物组合物。此外，本发明涉及式I化合物作为类胰蛋白酶抑制剂的用途，其包括将化合物引入包含类胰蛋白酶的组合物中。此外，本发明涉及式I化合物用于治疗患有或受制于需要改善类胰蛋白酶抑制剂的生理条件的患者，包括向患者施用治疗有效量的权利要求1的化合物本发明还涉及式I化合物的制备。

57. 发明申请

US20070131864A1 SYSTEM AND METHOD FOR DETECTING AND REMEDIATING CONTAMINATION 有权
标题翻译：用于检测和补救污染的系统和方法
公开(公告)号：US20070131864A1
公开(公告)日：2007-06-14
申请号：US11548559
申请日：2006-10-11
申请人： Mark Ellis , Son Le , Larry Davis
发明人： Mark Ellis , Son Le , Larry Davis
IPC分类号： G01J5/02
CPC分类号： G01N21/05 , G01N21/3504 , G01N21/6428 , G01N21/783
摘要： A system for detecting and remediating a discharge of fuel from a fuel source facility is disclosed. The system can comprise a contamination detection subsystem configured to detect a discharge of fuel from the fuel source facility and a remediation subsystem configured to remediate contamination due to the discharge of fuel. A controller can automatically activate the remediation subsystem upon detection of a discharge by the contamination detection subsystem. The controller can automatically send a notification that a contamination has been detected and the remediation system has been activated. Alternatively or in addition, the controller can automatically send a notification that a contamination has been detected and the remediation system has been activated.
摘要翻译：公开了一种用于从燃料源设备检测和补救燃料排放的系统。该系统可以包括被配置为检测来自燃料源设备的燃料排放物的污染检测子系统和被配置为修复由于燃料排放引起的污染物的修复子系统。检测到污染检测子系统的放电时，控制器可以自动激活补救子系统。控制器可以自动发送已经检测到污染的通知，并且修复系统已被激活。或者或另外，控制器可以自动发送已经检测到污染并且补救系统已被激活的通知。

58. 发明授权

US06323195B1 Galanthamine derivatives as acetylcholinesterase inhibitors 失效
标题翻译： Galanthamine衍生物作为乙酰胆碱酯酶抑制剂
公开(公告)号：US06323195B1
公开(公告)日：2001-11-27
申请号：US08137440
申请日：1993-10-15
申请人： Raymond W. Kosley, Jr. , Larry Davis , Veronica Taberna
发明人： Raymond W. Kosley, Jr. , Larry Davis , Veronica Taberna
IPC分类号： C07D49106
CPC分类号： C07D491/10 , C07D491/06
摘要： This application relates to compounds of the formula wherein R1 is hydrogen, (C1-C12alkylcarbonyl, (C1-C12)alkoxycarbonyl, mono(C1-C12)alkylaminocarbonyl, or di(C1-C12)alkylaminocarbonyl; R2 is hydrogen, (C3-C12)alkenylcarbonyloxy, (C3-C12)cycloalkylcarbonyloxy, (C3-C12)cycloalkyl(C1-C12)alkylcarbonyloxy, oxygen containing heterocycloxy, oxygen containing heterocyclylcarbonyloxy, sulfur containing heterocyclyloxy, sulfur containing heterocyclylcarbonyloxy, nitrogen containing hetercyclyloxy, nitrogen containing heterocyclylcarbonyloxy, haloalkylsulfonyloxy, (C1-C6)alkylsilyloxy; R3 is hydrogen, halo or (C1-C4)alkyl; R4 is hydrogen or (C1-C6)alkyl; with the proviso that R1 and R2 are not both hydrogen when R3 and R4 are hydrogen; all geometric, and optical stereoisomers thereof, or a pharmaceutically acceptable addition salt thereof; which compounds are useful for the treatment of memory dysfunction characterized by decreased cholinergic function, pharmaceutical compositions containing the compounds and methods for making and using the compounds.
摘要翻译：本申请涉及式（Ⅳ）的化合物是氢，（C1-C12烷基羰基，（C1-C12）烷氧基羰基，单（C1-C12）烷基氨基羰基或二（C1-C12）烷基氨基羰基; R2是氢，（C3-C12）烯基羰氧基，（C 3 -C 12）环烷基羰基氧基，（C 3 -C 12）环烷基（C 1 -C 12）烷基羰基氧基，含氧杂环氧基，含氧杂环基羰基氧基，含硫杂环基氧基，含硫杂环基羰基氧基，含氮杂环氧基，含氮杂环基羰基氧基，卤代烷基磺酰氧基，（C1- C6）烷基甲硅烷氧基; R3是氢，卤素或（C1-C4）烷基; R4是氢或（C1-C6）烷基;条件是当R3和R4是氢时，R1和R2不都是氢; 其光学立体异构体或其药学上可接受的加成盐;这些化合物可用于治疗以胆碱能功能降低为特征的记忆功能障碍，含有该组合物的药物组合物制备和使用该化合物的方法和方法。

59. 发明授权

US06176004B1 Method of forming a sensor for sensing signals on conductors 失效
标题翻译：形成用于感测导体上的信号的传感器的方法
公开(公告)号：US06176004B1
公开(公告)日：2001-01-23
申请号：US09222224
申请日：1998-12-29
申请人： Robert L. Rainhart , Larry Davis , Charles M. Newton , Theodore R. Blumstein
发明人： Robert L. Rainhart , Larry Davis , Charles M. Newton , Theodore R. Blumstein
IPC分类号： H01P1100
CPC分类号： H01Q21/062 , G01R3/00 , G01R29/0878 , H01Q1/40 , H01Q9/30 , H01Q21/0087 , H01Q21/061 , H05K1/0219 , H05K1/0222 , H05K1/0306 , H05K1/115 , Y10T29/49002 , Y10T29/49016
摘要： A method of forming a sensor for sensing signals on conductors includes the step of forming a plurality of antenna element openings in a plurality of green tape ceramic sheets. Each antenna element opening includes a central opening and annular opening surrounding the central opening. The method includes the step of stacking successive green tape ceramic sheets so that central and annular openings are aligned with each other while also forming a planar sensor face that is to be placed adjacent the conductors to be sensed. The central openings and annular openings are filled with conductive paste. The stacked green tape ceramic sheets are heated to cure the green tape ceramic sheets and conductive paste. A signal processing integrated circuit is mounted on the side opposite the planar sensor face that is to be placed adjacent the conductors to be sensed. The method also includes the step of connecting the cured conductive paste filling central opening to the signal processing integrated circuit.
摘要翻译：形成用于感测导体上的信号的传感器的方法包括在多个生瓷带陶瓷片中形成多个天线元件开口的步骤。每个天线元件开口包括围绕中心开口的中心开口和环形开口。该方法包括堆叠连续的生瓷带陶瓷片的步骤，使得中心和环形开口彼此对准，同时还形成要邻近被感测导体放置的平面传感器面。中心开口和环形开口填充有导电膏。堆叠的绿色带状陶瓷片被加热以固化生胶带陶瓷片和导电膏。信号处理集成电路安装在与要被感测的导体相邻的平面传感器面相对的一侧。该方法还包括将固化的导电糊填充中心开口连接到信号处理集成电路的步骤。

60. 发明授权

US5519131A Synthesis of pyridooxazinyl-indoles 失效
标题翻译：吡啶并恶嗪基 - 吲哚的合成
公开(公告)号：US5519131A
公开(公告)日：1996-05-21
申请号：US138645
申请日：1993-10-20
申请人： Richard C. Effland , Larry Davis , Gordon E. Olsen
发明人： Richard C. Effland , Larry Davis , Gordon E. Olsen
IPC分类号： A61K31/535 , A61K31/5383 , A61K31/55 , A61P25/24 , A61P25/26 , A61P25/28 , C07D209/18 , C07D265/28 , C07D401/12 , C07D401/14 , C07D413/04 , C07D498/04
CPC分类号： C07D401/12
摘要： This application relates to a process for the preparation of indolylpyridooxazines of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification which comprises cyclizing compound of the formula ##STR2## in the presence of a strong base such as sodium hydride or potassium t-butoxide.
摘要翻译：本申请涉及一种制备式IMA的吲哚基吡啶并恶嗪的方法，其中R 1，R 2和R 3如说明书中所定义，其中包括在强碱如氢化钠存在下环化式IMAMA的化合物或叔丁醇钾。

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