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51. 发明专利

PL327602A1 METHOD OF MAKING THERAPEUTICAL PLASTERS FOR TRANSDERMAL DRUG APPLICATION 未知
公开(公告)号：PL327602A1
公开(公告)日：1998-12-21
申请号：PL32760296
申请日：1996-12-04
申请人： LOHMANN THERAPIE SYST LTS
发明人： ASMUSSEN BODO , HILLE THOMAS , SCHUMANN KLAUS , STEINBORN PETER
IPC分类号： A61F13/02 , A61K9/70
摘要： PCT No. PCT/EP96/05410 Sec. 371 Date Oct. 30, 1998 Sec. 102(e) Date Oct. 30, 1998 PCT Filed Dec. 4, 1996 PCT Pub. No. WO97/22315 PCT Pub. Date Jun. 26, 1997A process for the continuous production of transdermal therapeutic patches, wherein a laminate of an auxiliary layer (3) siliconized at least on one side, an active substance-containing, pressure-sensitive adhesive layer (4), and a supporting layer (9) is prepared as a strip-shaped web (1) first, and the active substance-containing sections (4') obtained by punching said layers (3) and (4) across the web direction are intermittently transferred onto a second web (2), the punching procedure taking place in the rest phase between the cycles and the transfer procedure onto the second web (2) being carried out preferably at equal distances by means of a transfer device (11, 12), is characterized by the fact that the supporting layer (9) is stripped from the active substance-containing sections (4') during the transfer first, and that then the sections (3') of the auxiliary layer are removed with the aid of a process layer (5) which has been rendered pressure-sensitive adhesive.

52. 发明专利

MX9804996A METODO PARA PRODUCIR PARCHES TRANSDERMICOS. 未知
公开(公告)号：MX9804996A
公开(公告)日：1998-09-30
申请号：MX9804996
申请日：1998-06-19
申请人： LOHMANN THERAPIE SYST LTS
发明人： ASMUSSEN BODO , HILLE THOMAS , SCHUMANN KLAUS , STEINBORN PETER
IPC分类号： A61F13/02 , A61K9/70
摘要： La invencion se refiere a un método para la produccion continua de parches transdérmicos. En dicho método, un laminado que comprende una capa auxiliar (3), la cual está siliconizada por un lado, una capa autoadhesiva (4) que contiene la sustancia activa, y una capa portadora (9) está provista en la forma de una banda con forma de vía (1). Las secciones (4') conteniendo la sustancia activa y se obtiene punzonando las capas (3) y (4) en ángulos rectos a la direccion de la banda, son transferidas en etapas a una segunda banda (2). Existe un punzonado durante la etapa de reposo entre las etapas y la transferencia hacia la segunda banda (2) se realiza preferiblemente a distancias iguales utilizando medios de transferencia (11,12). La invencion se caracteriza porque durante la transferencia, la capa portadora (9) es inicialmente removida de las secciones (4') que contienen la sustancia activa y subsecuentemente las secciones (3') de la capa auxiliar son removidas utilizando una capa de proceso autoadhesiva (5).

53. 发明专利

AU687011B2 Transfer process for making transdermal therapeutic systems 未知
公开(公告)号：AU687011B2
公开(公告)日：1998-02-19
申请号：AU4817293
申请日：1993-09-15
申请人： LOHMANN THERAPIE SYST LTS
发明人： HILLE THOMAS , DEURER LOTHAR , STEINBORN PETER , GRADER LUDWIG , ANHAUSER DIETER
IPC分类号： B65C1/02 , A61F13/00 , A61F13/02 , A61K9/70 , A61L15/44 , A61L15/58 , A61M37/00 , B32B37/22
摘要： PCT No. PCT/EP93/02495 Sec. 371 Date May 9, 1995 Sec. 102(e) Date May 9, 1995 PCT Filed Sep. 15, 1993 PCT Pub. No. WO94/07449 PCT Pub. Date Apr. 14, 1994The invention provides a process for the production of transdermal therapeutic systems. A layer containing active substance is initially present as a tape or web in the form of a laminate, with a carrier layer and, possibly, further auxiliary layers and/or protective layers or the like. The active substance is then transferred from this layer, either by itself or in combination with at least one further layer, in sections, to the center of a second, wider web. The process is characterized by the fact that the tape or web (1) and the second web (2) are moved forward by steps, with different phases of motion and inoperative phases and/or different step lengths and/or differing speeds and that in the same appliance, during each inoperative or stationary phase of the webs (1, 2) the subdivision of the layer containing active substance and, as the case may be, of one or more further layers, with the exception of the carrier layer, takes place in phases and in the same forward direction, at right angles to the direction of web, into sections (7, 8) containing active substance of a size suitable for the user, and their transfer to the second web, the carrier sheet (9) being removed, in preferably equal intervals, using a transfer device which can be moved backwards and forwards in the direction of the web.

54. 发明专利

DE59207727D1 未知
公开(公告)号：DE59207727D1
公开(公告)日：1997-01-30
申请号：DE59207727
申请日：1992-03-09
申请人： LOHMANN THERAPIE SYST LTS
发明人： ANHAEUSER DIETER , DEURER LOTHAR , HILLE THOMAS , STEINBORN PETER
IPC分类号： A61M37/00 , A61K9/70 , A61L15/44 , A61M35/00
摘要： A process for continuously manufacturing transdermal therapeutic patches having a backing layer, a pressure-sensitive adhesive drug reservoir layer, and a removable protective layer, whereby loss of active substances during fabrication of the patches is minimized, said process being characterized in that, in a tape-like laminate having a pressure-sensitive adhesive backing layer (1) and a removable protective layer (3), single quadrangular pressure-sensitive adhesive drug reservoir sections (2) are inserted one after the other in the longitudinal direction between the layers (2,3); the clearance between said drug reservoir sections remains constant in the longitudinal direction; their width is calculated such that the backing layer (1) and the removable protective layer (3) project beyond both sides of said sections; the pressure-sensitive adhesive backing layer (1) is first cut by punching in such a way that the punching line (1a) surrounds the individual drug reservoir sections (2) at an evident distance from their outer dimensions; the the resulting lattice-type refuse of the drug-free pressure-sensitive adhesive backing layer (1) is removed; and subsequently the protective layer (3) is cut in the resultant spaces between the drug reservoir sections (2).

55. 发明专利

AT146365T 未知
公开(公告)号：AT146365T
公开(公告)日：1997-01-15
申请号：AT92905728
申请日：1992-03-09
申请人： LOHMANN THERAPIE SYST LTS
发明人： ANHAEUSER DIETER , DEURER LOTHAR , HILLE THOMAS , STEINBORN PETER
IPC分类号： A61M37/00 , A61K9/70 , A61L15/44 , A61M35/00
摘要： A process for continuously manufacturing transdermal therapeutic patches having a backing layer, a pressure-sensitive adhesive drug reservoir layer, and a removable protective layer, whereby loss of active substances during fabrication of the patches is minimized, said process being characterized in that, in a tape-like laminate having a pressure-sensitive adhesive backing layer (1) and a removable protective layer (3), single quadrangular pressure-sensitive adhesive drug reservoir sections (2) are inserted one after the other in the longitudinal direction between the layers (2,3); the clearance between said drug reservoir sections remains constant in the longitudinal direction; their width is calculated such that the backing layer (1) and the removable protective layer (3) project beyond both sides of said sections; the pressure-sensitive adhesive backing layer (1) is first cut by punching in such a way that the punching line (1a) surrounds the individual drug reservoir sections (2) at an evident distance from their outer dimensions; the the resulting lattice-type refuse of the drug-free pressure-sensitive adhesive backing layer (1) is removed; and subsequently the protective layer (3) is cut in the resultant spaces between the drug reservoir sections (2).

56. 发明专利

CZ281267B6 PROCESS FOR CONTINUOUS PRODUCTION OF TRANSDERNAL THERAPEUTIC PLASTERS 未知
公开(公告)号：CZ281267B6
公开(公告)日：1996-07-17
申请号：CS193293
申请日：1992-03-09
申请人： LOHMANN THERAPIE SYST LTS
发明人： ANHAUSER DIETER , DEURER LOTHAR , HILLE THOMAS , STEINBORN PETER
IPC分类号： A61M37/00 , A61K9/70 , A61L15/44 , A61M35/00 , A61F13/02
摘要： A process for continuously manufacturing transdermal therapeutic patches having a backing layer, a pressure-sensitive adhesive drug reservoir layer, and a removable protective layer, whereby loss of active substances during fabrication of the patches is minimized, said process being characterized in that, in a tape-like laminate having a pressure-sensitive adhesive backing layer (1) and a removable protective layer (3), single quadrangular pressure-sensitive adhesive drug reservoir sections (2) are inserted one after the other in the longitudinal direction between the layers (2,3); the clearance between said drug reservoir sections remains constant in the longitudinal direction; their width is calculated such that the backing layer (1) and the removable protective layer (3) project beyond both sides of said sections; the pressure-sensitive adhesive backing layer (1) is first cut by punching in such a way that the punching line (1a) surrounds the individual drug reservoir sections (2) at an evident distance from their outer dimensions; the the resulting lattice-type refuse of the drug-free pressure-sensitive adhesive backing layer (1) is removed; and subsequently the protective layer (3) is cut in the resultant spaces between the drug reservoir sections (2).

57. 发明专利

CA2184633A1 DEVICE FOR TRANSFERRING SECTIONS WHICH ARE SELF-ADHESIVE ON ONE SIDE FROM A FIRST MOVING WEB ONTO A SECOND MOVING WEB 未知
公开(公告)号：CA2184633A1
公开(公告)日：1995-09-08
申请号：CA2184633
申请日：1995-02-24
申请人： LOHMANN THERAPIE SYST LTS
发明人： DEURER LOTHAR , GRADER LUDWIG , HILLE THOMAS , STEINBORN PETER
IPC分类号： B65C9/18 , B31D1/02 , B65C9/00
摘要： A device for the transfer of sections (10) that are self-adhesive on one side from a moving first web (20) onto a moving second web (21), portions (11) to be discarded remaining undetached on the first web (20), comprising a dispenser edge (1) that is associated to and extends across the direction of the first web (20) and around which the web (20) is led with reversal of its direction to release the sections (10) is characterized by the fact that the dispenser edge (1) has a shape in the region of portions (11) that are not to be detached which is different from that in the region of portions (10) that are to be released.

58. 发明专利

NO951137A 未知
公开(公告)号：NO951137A
公开(公告)日：1995-03-24
申请号：NO951137
申请日：1995-03-24
申请人： LOHMANN THERAPIE SYST LTS
发明人： HILLE THOMAS , DEURER LOTHAR , STEINBORN PETER , GRADER LUDWIG , ANHAUSER DIETER
IPC分类号： B65C1/02 , A61F13/00 , A61F13/02 , A61K9/70 , A61L15/44 , A61L15/58 , A61M37/00 , B32B37/22
CPC分类号： B32B37/22 , A61F2013/0296 , A61K9/7061 , B32B38/1825 , B32B2309/14 , Y10T156/1062 , Y10T156/1093 , Y10T156/1335

59. 发明专利

FI951419A 未知
公开(公告)号：FI951419A
公开(公告)日：1995-03-24
申请号：FI951419
申请日：1995-03-24
申请人： LOHMANN THERAPIE SYST LTS
发明人： HILLE THOMAS , DEURER LOTHAR , STEINBORN PETER , GRADER LUDWIG , ANHAEUSER DIETER
IPC分类号： A61F13/00 , A61F13/02 , B65C1/02 , A61K9/70 , A61L15/44 , A61L15/58 , A61M37/00 , B32B37/22 , A61F , A61J
摘要： PCT No. PCT/EP93/02495 Sec. 371 Date May 9, 1995 Sec. 102(e) Date May 9, 1995 PCT Filed Sep. 15, 1993 PCT Pub. No. WO94/07449 PCT Pub. Date Apr. 14, 1994The invention provides a process for the production of transdermal therapeutic systems. A layer containing active substance is initially present as a tape or web in the form of a laminate, with a carrier layer and, possibly, further auxiliary layers and/or protective layers or the like. The active substance is then transferred from this layer, either by itself or in combination with at least one further layer, in sections, to the center of a second, wider web. The process is characterized by the fact that the tape or web (1) and the second web (2) are moved forward by steps, with different phases of motion and inoperative phases and/or different step lengths and/or differing speeds and that in the same appliance, during each inoperative or stationary phase of the webs (1, 2) the subdivision of the layer containing active substance and, as the case may be, of one or more further layers, with the exception of the carrier layer, takes place in phases and in the same forward direction, at right angles to the direction of web, into sections (7, 8) containing active substance of a size suitable for the user, and their transfer to the second web, the carrier sheet (9) being removed, in preferably equal intervals, using a transfer device which can be moved backwards and forwards in the direction of the web.

60. 发明专利

HRP930668A2 TRANSDERMAL THERAPEUTIC ADHESIVE PLASTER 未知
公开(公告)号：HRP930668A2
公开(公告)日：1994-10-31
申请号：HRP930668
申请日：1993-04-01
申请人： LOHMANN THERAPIE SYST LTS
发明人： ANHAUSER DIETER , DEURER LOTHAR , HILLE THOMAS , STEINBORN PETER
IPC分类号： A61K9/70 , A61L15/44 , A61M37/00 , A61M35/00
摘要： A process for continuously manufacturing transdermal therapeutic patches having a backing layer, a pressure-sensitive adhesive drug reservoir layer, and a removable protective layer, whereby loss of active substances during fabrication of the patches is minimized, said process being characterized in that, in a tape-like laminate having a pressure-sensitive adhesive backing layer (1) and a removable protective layer (3), single quadrangular pressure-sensitive adhesive drug reservoir sections (2) are inserted one after the other in the longitudinal direction between the layers (2,3); the clearance between said drug reservoir sections remains constant in the longitudinal direction; their width is calculated such that the backing layer (1) and the removable protective layer (3) project beyond both sides of said sections; the pressure-sensitive adhesive backing layer (1) is first cut by punching in such a way that the punching line (1a) surrounds the individual drug reservoir sections (2) at an evident distance from their outer dimensions; the the resulting lattice-type refuse of the drug-free pressure-sensitive adhesive backing layer (1) is removed; and subsequently the protective layer (3) is cut in the resultant spaces between the drug reservoir sections (2).

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