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51. 发明授权

US4770569A Boring device 失效
标题翻译：镗孔装置
公开(公告)号：US4770569A
公开(公告)日：1988-09-13
申请号：US82339
申请日：1987-08-06
申请人： Yasumasa Ooki , Osamu Asano , Toshio Mikiya
发明人： Yasumasa Ooki , Osamu Asano , Toshio Mikiya
IPC分类号： B23B47/34
CPC分类号： B23B47/34 , Y10T408/23 , Y10T74/18024
摘要： A boring device has a spindle moving mechanism which retards a tool spindle when the spindle rotates through a predetermined angle. The mechanism has coaxial first and second thrust rings. Thrust balls are disposed between the thrust rings in rolling contact therewith. A retaining element holds the thrust balls such that they keep constant circumferential spaces therebetween. The first thrust ring is fixed to the tool spindle and has recesses in the surface facing the second thrust ring. The second thrust ring is fixed to the casing of the boring device. As the first thrust ring is rotated by the tool spindle, the thrust balls are fitted in the respective recesses, whereby the tool retards by the amount equal to the depth of the recesses. Then, cutting edges of a cutter is separated from the face of a workpiece which is being cut, and a continuous chip is broken into pieces having a predetermined length and is removed from a hole being formed.
摘要翻译：镗孔装置具有主轴移动机构，当主轴旋转预定角度时，主轴移动机构延迟工具主轴。该机构具有同轴的第一和第二推力环。推力球设置在与其滚动接触的推力环之间。保持元件保持推力球，使得它们之间保持恒定的周向空间。第一推力环固定在工具主轴上并且在面向第二推力环的表面中具有凹槽。第二止推环固定在钻孔装置的外壳上。当第一推力环由工具主轴旋转时，推力球装配在相应的凹部中，由此工具延迟等于凹槽深度的量。然后，切割器的切割刃与被切割的工件的表面分离，并且将连续的切屑分解成具有预定长度的片，并从形成的孔中移除。

52. 发明授权

US07939540B2 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives 有权
标题翻译： 4-（3-苯甲酰氨基苯基）-6,7-二甲氧基-2-甲基氨基喹唑啉衍生物
公开(公告)号：US07939540B2
公开(公告)日：2011-05-10
申请号：US11707904
申请日：2007-02-20
申请人： Kazuki Miyazaki , Kazutomi Kusano , Yasutaka Takase , Osamu Asano , Manabu Shirato , Hisashi Wakita , Naoto Ishii , Takao Saeki , Tomoko Saeki, legal representative , Mai Saeki, legal representative
发明人： Kazuki Miyazaki , Kazutomi Kusano , Yasutaka Takase , Osamu Asano , Manabu Shirato , Hisashi Wakita , Naoto Ishii , Takao Saeki
IPC分类号： C07D239/84 , A61K31/517 , A61P17/04
CPC分类号： C07D239/84
摘要： A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.
摘要翻译：由下式（I）表示的化合物，其盐或其水合物可以有效地缓解由特应性疾病等引起的瘙痒：其中R表示羟基，任选被C 1-6烷氧基取代的C 1-6烷氧基或任选的氨基被C 1-6烷基取代。

53. 发明申请

US20090270433A1 2,3-DIHYDRO-IMINOISOINDOLE DERIVATIVES 失效
标题翻译： 2,3-二氢 - 咪唑啉衍生物
公开(公告)号：US20090270433A1
公开(公告)日：2009-10-29
申请号：US12234116
申请日：2008-09-19
申请人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimlyo Tabata
发明人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimlyo Tabata
IPC分类号： A61K31/506 , C07D413/14 , C07D405/14 , A61K31/427
CPC分类号： C07D417/14 , C07D209/44 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.]
摘要翻译：由以下通式（1）表示的化合物或其盐具有丝氨酸蛋白酶抑制活性，对凝血因子VIIa特别优异的抑制活性。该化合物或其盐可用作与血栓形成相关的疾病的治疗和/或预防剂。 [其中R 1表示氢，R 2表示任选取代的苯基等，R 3表示任选取代的C 6-10芳基等]

54. 发明申请

US20070299094A1 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives 有权
标题翻译： 4-（3-苯甲酰氨基苯基）-6,7-二甲氧基-2-甲基氨基喹唑啉衍生物
公开(公告)号：US20070299094A1
公开(公告)日：2007-12-27
申请号：US11707904
申请日：2007-02-20
申请人： Kazuki Miyazaki , Kazutomi Kusano , Yasutaka Takase , Osamu Asano , Manabu Shirato , Hisashi Wakita , Naoto Ishii , Takao Saeki , Tomoko Saeki , Mai Saeki
发明人： Kazuki Miyazaki , Kazutomi Kusano , Yasutaka Takase , Osamu Asano , Manabu Shirato , Hisashi Wakita , Naoto Ishii , Takao Saeki , Tomoko Saeki , Mai Saeki
IPC分类号： A61K31/517 , A61P17/00 , C07D239/72
CPC分类号： C07D239/84
摘要： A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.
摘要翻译：由下式（I）表示的化合物，其盐或其水合物可以有效地缓解由特应性疾病等引起的瘙痒：其中R表示羟基，C 1-6烷氧基，其任选被 C 1-6烷氧基或任选被C 1-6烷基取代的氨基。

55. 发明授权

US07189717B2 Medicinal compositions promoting bowel movement 失效
标题翻译：促进排便的药物成分
公开(公告)号：US07189717B2
公开(公告)日：2007-03-13
申请号：US10257091
申请日：2001-04-26
申请人： Masahiro Yasuda , Hitoshi Harada , Shuhei Miyazawa , Seiichi Kobayashi , Kokichi Harada , Takayuki Hida , Hisashi Shibata , Nobuyuki Yasuda , Osamu Asano , Yoshihiko Kotake
发明人： Masahiro Yasuda , Hitoshi Harada , Shuhei Miyazawa , Seiichi Kobayashi , Kokichi Harada , Takayuki Hida , Hisashi Shibata , Nobuyuki Yasuda , Osamu Asano , Yoshihiko Kotake
IPC分类号： A61K31/506
CPC分类号： A61K31/506 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/7076 , H04B10/112
摘要： The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2 receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.
摘要翻译：本发明提供一种具有温和但强烈的排便促进作用而不引起腹泻的药物。也就是说，它提供了包含具有腺苷A 2受体拮抗作用的化合物，优选腺苷A 2b受体拮抗剂或其盐的排便促进剂。

56. 发明授权

US06916837B2 Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them 失效
标题翻译：脒衍生物和含有它们的抗凝血剂和血栓形成治疗剂
公开(公告)号：US06916837B2
公开(公告)日：2005-07-12
申请号：US10294198
申请日：2002-11-14
申请人： Takashi Satoh , Yasushi Okamoto , Osamu Asano , Nobuhisa Watanabe , Tadashi Nagakura , Takao Saeki , Atsushi Inoue , Masahiro Sakurai
发明人： Takashi Satoh , Yasushi Okamoto , Osamu Asano , Nobuhisa Watanabe , Tadashi Nagakura , Takao Saeki , Atsushi Inoue , Masahiro Sakurai
IPC分类号： A61K31/192 , A61K31/194 , A61K31/36 , A61K31/381 , A61K31/4164 , A61K31/472 , A61K31/606 , A61P7/02 , A61P43/00 , C07C257/18 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/46 , C07C317/14 , C07C317/32 , C07D217/06 , C07D217/22 , C07D233/84 , C07D317/68 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/40 , C07D333/62 , C40B40/04 , A61K31/415 , A61K31/21 , A61K31/24 , A61K31/38
CPC分类号： C07D333/62 , C07C257/18 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/46 , C07C317/14 , C07D217/22 , C07D233/84 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/40
摘要： Amidino derivatives represented by the following general formula (I): {where X is a group represented by R1SO2NR2— (wherein R1 represents optionally substituted C6-14 aryl, etc. and R2 represents hydrogen atom, etc.), etc., Ar1 represents 2,6-naphthylene, etc., R3 represents hydrogen atom, etc. and Y represents carboxyphenyl, etc.} and their pharmacologically acceptable salts or solvates.
摘要翻译：由以下通式（I）表示的脒基衍生物：其中X是由R 1表示的基团SO 2 - （其中 R 1表示任选取代的C 6-14芳基等，R 2表示氢原子等）等，Ar 1， SUP> 1表示2,6-亚萘基等，R 3表示氢原子等，Y表示羧基苯基等}及其药理学上可接受的盐或溶剂化物。

57. 发明授权

US06841549B1 Condensed imidazole compounds and a therapeutic agent for diabetes mellitus 失效
标题翻译：缩合咪唑化合物和糖尿病治疗剂
公开(公告)号：US06841549B1
公开(公告)日：2005-01-11
申请号：US10018688
申请日：2000-06-30
申请人： Osamu Asano , Hitoshi Harada , Seiji Yoshikawa , Nobuhisa Watanabe , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Ohashi , Hiroe Minami , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi , Isao Tanaka , Tsutomu Kawata , Naoyuki Shimomura , Hiroshi Akamatsu , Naoki Ozeki , Toshikazu Shimizu , Kenji Hayashi , Toyokazu Haga , Shigeto Negi , Toshihiko Naito
发明人： Osamu Asano , Hitoshi Harada , Seiji Yoshikawa , Nobuhisa Watanabe , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Ohashi , Hiroe Minami , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi , Isao Tanaka , Tsutomu Kawata , Naoyuki Shimomura , Hiroshi Akamatsu , Naoki Ozeki , Toshikazu Shimizu , Kenji Hayashi , Toyokazu Haga , Shigeto Negi , Toshihiko Naito
IPC分类号： A61P3/10 , A61P43/00 , C07D471/04 , C07D473/00 , C07D473/34 , C07D473/40 , A16K31/33 , C07D239/70 , C07D471/00 , C07D487/00 , A16K31/52
CPC分类号： C07D471/04 , C07D473/00 , C07D473/34 , C07D473/40
摘要： The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action.That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I); (wherein R1 represents e.g. an amino group which may be substituted with an alkyl group; R2 represents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; R3 represents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g. an optionally substituted aryl or heteroaryl group; and Q and W are the same as or different from each other and each represents N or CH), a pharmacologically acceptable salt or hydrates thereof.
摘要翻译：本发明提供了一种基于腺苷A2受体拮抗剂作用的新型糖尿病和糖尿病并发症的预防或治疗剂。即提供了具有腺苷A2受体拮抗剂作用的新颖的缩合咪唑化合物，是有效预防或治疗糖尿病和糖尿病并发症，并由式（I）表示;（其中R 1表示例如可被烷基取代的氨基; R 2表示例如氢原子，可以被羟基取代的烷基，环烷基或烷基，烯基或炔基; R 3表示例如任选取代的烷基，烯基，炔基，芳基，杂芳基，吡啶酮基，嘧啶酮基或哌嗪酮基; Ar表示例如任选取代的芳基或杂芳基; Q和W彼此相同或不同，每个代表 N或CH），其药理学上可接受的盐或其水合物。

58. 发明授权

US06750232B2 2-aminopyridine compounds and use thereof as drugs 失效
标题翻译： 2-氨基吡啶化合物及其作为药物的用途
公开(公告)号：US06750232B2
公开(公告)日：2004-06-15
申请号：US10333689
申请日：2003-01-23
申请人： Hitoshi Harada , Osamu Asano , Shuhei Miyazawa , Masato Ueda , Masahiro Yasuda , Nobuyuki Yasuda
发明人： Hitoshi Harada , Osamu Asano , Shuhei Miyazawa , Masato Ueda , Masahiro Yasuda , Nobuyuki Yasuda
IPC分类号： C07D40102
CPC分类号： C07D213/80 , A61K31/4409 , A61K31/443 , A61K31/4436 , A61K31/444 , A61K31/455 , C07D213/82 , C07D213/85 , C07D405/04 , C07D405/14 , C07D409/14
摘要： A class of substituted compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (II), wherein R1 is selected from hydrido, halo, alkoxy, aryl, alkylthio, alkylamino, aralkoxy, azido and alkenyloxy; wherein R2 is selected from hydrido, cyano, hydroxyalkyl, haloalkyl, aminoalkyl, alkylaminoalkyl, alkylcarbonyloxyalkyl, aminocarbonyl and alkylcarbonylaminoalkyl; and wherein R5 and R6 are one more radicals independently selected from halo, alkylsulfonyl, aminosulfonyl, alkoxy and alkylthio; provided one of R5 and R6 is substituted with alkysulfonyl, aminosulfonyl, or haloalkylsulfonyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类取代的化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式（II）定义，其中R 1选自氢，卤素，烷氧基，芳基，烷硫基，烷基氨基，芳烷氧基，叠氮基和烯氧基; 氰基，羟基烷基，卤代烷基，氨基烷基，烷基氨基烷基，烷基羰氧基烷基，氨基羰基和烷基羰基氨基烷基;其中R 2选自氢，氰基，并且其中R 5和R 6分别独立地选自卤素，烷基磺酰基，氨基磺酰基，烷氧基和烷硫基; 其中R 5和R 6之一被烷基磺酰基，氨基磺酰基或卤代烷基磺酰基取代; 或其药学上可接受的盐。

59. 发明授权

US06472032B1 Double-glazing unit 有权
标题翻译：双层玻璃单元
公开(公告)号：US06472032B1
公开(公告)日：2002-10-29
申请号：US09529519
申请日：2000-04-13
申请人： Osamu Asano
发明人： Osamu Asano
IPC分类号： E06B324
CPC分类号： E06B3/6612 , C03C8/245 , C03C27/06 , E06B3/66304 , Y02A30/25 , Y02B80/24
摘要： A double glazing having a plurality of sheet glass (1) (2) juxtaposed in the direction of thickness with spacers (3) arranged in between, peripheries of these sheet glasses (1) (2) being sealed throughout the circumference thereof. Reinforced sheet glass is employed for at least one of the plurality of sheet glasses (1) (2), and the peripheries of the sheet glasses are sealed by a sealing material having a sealing temperature below 400° C.
摘要翻译：具有多个平板玻璃（1）（2）的双层玻璃（1）（2）沿着厚度方向并排布置在其间的间隔物（3），其周边部分密封在这些片状玻璃（1）（2）的周围。多个玻璃板（1）（2）中的至少一个被使用了钢板玻璃，并且通过密封温度低于400℃的密封材料将片状玻璃的周边密封。

60. 发明授权

US5843918A Anti-endotoxin compounds 失效
公开(公告)号：US5843918A
公开(公告)日：1998-12-01
申请号：US472820
申请日：1995-06-07
申请人： William J. Christ , Lynn D. Hawkins , Tsutomu Kawata , Daniel P. Rossignol , Seiichi Kobayashi , Osamu Asano
发明人： William J. Christ , Lynn D. Hawkins , Tsutomu Kawata , Daniel P. Rossignol , Seiichi Kobayashi , Osamu Asano
IPC分类号： A61K31/35 , A61K31/351 , A61K31/739 , A61P31/04 , A61P31/12 , C07D309/10 , C07H3/04 , C07H5/04 , C07H5/06 , C07H7/02 , C07H11/04 , C07H13/06 , C07H15/10 , A61K31/715 , A61K31/72 , A61K31/73
CPC分类号： C07H13/06 , C07H3/04 , Y10S514/885
摘要： Disclosed are lipid A analogs useful for the treatment of septic shock and LPS-mediated activation of viral infection.

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