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51. 发明申请

US20110207912A1 FGF-19 NUCLEIC ACIDS 审中-公开
标题翻译： FGF-19核酸
公开(公告)号：US20110207912A1
公开(公告)日：2011-08-25
申请号：US13013734
申请日：2011-01-25
申请人： David Botstein , Audrey Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Margaret Ann Roy
发明人： David Botstein , Audrey Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Margaret Ann Roy
IPC分类号： C07K14/50 , C07H21/04 , C12N15/63 , C12N1/19 , C12P21/02 , C12N5/10 , C12N1/21
CPC分类号： C07K14/50 , C07K2317/24 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention. The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis and/or autocrine signaling. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment. Furthermore, the compounds, compositions including antagonists and methods of the present invention are further expected to have therapeutic effect upon conditions characterized by FgF-19 modulation.
摘要翻译：本发明涉及与PRO533蛋白质和编码这些多肽的核酸分子具有同源性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体，以及本发明多肽的制备方法发明。本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。预期这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生和/或自分泌信号传导。因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。此外，进一步预期本发明的化合物，包括拮抗剂和方法的组合物对于以FgF-19调节为特征的病症具有治疗作用。

52. 发明申请

US20090098603A1 POLYPEPTIDES SHARING SEQUENCE IDENTITY WITH A FIBROBLAST GROWTH FACTOR POLYPEPTIDE AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
标题翻译：多肽与纤维蛋白原生长因子多肽和核酸共编序列序列识别
公开(公告)号：US20090098603A1
公开(公告)日：2009-04-16
申请号：US12273334
申请日：2008-11-18
申请人： David BOTSTEIN , Audrey Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Margaret Ann Roy
发明人： David BOTSTEIN , Audrey Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Margaret Ann Roy
IPC分类号： C12P21/04 , C12N15/11 , C12N15/00 , C12N5/06 , C07K14/00 , C12N1/21 , C12N1/19
CPC分类号： C07K14/50 , C07K2317/24 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention. The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis and/or autocrine signaling. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment. Furthermore, the compounds, compositions including antagonists and methods of the present invention are further expected to have therapeutic effect upon conditions characterized by FgF-19 modulation.
摘要翻译：本发明涉及与PRO533蛋白质和编码这些多肽的核酸分子具有同源性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体，以及本发明多肽的制备方法发明。本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。预期这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生和/或自分泌信号传导。因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。此外，进一步预期本发明的化合物，包括拮抗剂和方法的组合物对于以FgF-19调节为特征的病症具有治疗作用。

53. 发明授权

US08350008B2 WISP polypeptides and nucleic acids encoding same 失效
公开(公告)号：US08350008B2
公开(公告)日：2013-01-08
申请号：US13117051
申请日：2011-05-26
申请人： David Botstein , Robert L. Cohen , Audrey D. Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Arnold J. Levine , Diane Pennica , Margaret Ann Roy , William I. Wood
发明人： David Botstein , Robert L. Cohen , Audrey D. Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Arnold J. Levine , Diane Pennica , Margaret Ann Roy , William I. Wood
IPC分类号： C12P21/08 , C07K16/00 , C07K16/18
CPC分类号： C07K14/47 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/30 , C07K16/32 , C07K2317/73 , C07K2317/74 , C12Q1/6886 , C12Q2600/136
摘要： Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.

54. 发明申请

US20110311540A1 WISP POLYPEPTIDES AND NUCLEIC ACIDS ENCODING SAME 失效
标题翻译： WISP多糖和核酸编码它们
公开(公告)号：US20110311540A1
公开(公告)日：2011-12-22
申请号：US13117051
申请日：2011-05-26
申请人： David Botstein , Robert L. Cohen , Audrey D. Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Arnold J. Levine , Diane Pennica , Margaret Ann Roy , William I. Wood
发明人： David Botstein , Robert L. Cohen , Audrey D. Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Arnold J. Levine , Diane Pennica , Margaret Ann Roy , William I. Wood
IPC分类号： A61K39/395 , C07K16/46 , A61P35/00 , C07K16/22
CPC分类号： C07K14/47 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/30 , C07K16/32 , C07K2317/73 , C07K2317/74 , C12Q1/6886 , C12Q2600/136
摘要： Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
摘要翻译：提供了Wnt-1诱导的分泌蛋白（WISP），其基因至少被Wnt-1诱导。还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。

55. 发明授权

US06387657B1 WISP polypeptides and nucleic acids encoding same 有权
标题翻译： WISP多肽和编码相同的核酸
公开(公告)号：US06387657B1
公开(公告)日：2002-05-14
申请号：US09182145
申请日：1998-10-29
申请人： David A. Botstein , Robert L. Cohen , Audrey D. Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Arnold J. Levine , Diane Pennica , Margaret Ann Roy , William I. Wood
发明人： David A. Botstein , Robert L. Cohen , Audrey D. Goddard , Austin L. Gurney , Kenneth J. Hillan , David A. Lawrence , Arnold J. Levine , Diane Pennica , Margaret Ann Roy , William I. Wood
IPC分类号： C12N1512
CPC分类号： C07K14/47 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/30 , C07K16/32 , C07K2317/73 , C07K2317/74 , C12Q1/6886 , C12Q2600/136
摘要： Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
摘要翻译：提供了Wnt-1诱导的分泌蛋白（WISP），其基因至少被Wnt-1诱导。还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。

56. 发明授权

US07132283B2 PRO273 polypeptides 有权
标题翻译： PRO273多肽
公开(公告)号：US07132283B2
公开(公告)日：2006-11-07
申请号：US09999832
申请日：2001-10-24
申请人： Sherman Fong , Audrey Goddard , Kenneth J. Hillan , William I. Wood
发明人： Sherman Fong , Audrey Goddard , Kenneth J. Hillan , William I. Wood
IPC分类号： C12N5/16
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/4703 , C07K14/475 , C07K14/52 , C07K14/521 , C07K14/54 , C07K14/705 , C07K14/70503 , C07K14/70578 , C07K16/18 , C07K16/28 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N9/00 , C12N2799/026 , C12N2799/027 , G01N33/573 , G01N33/57484 , G01N33/68 , G01N2333/99 , G01N2800/042
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

57. 发明授权

US06972325B2 PRO273 polypeptides 有权
标题翻译： PRO273多肽
公开(公告)号：US06972325B2
公开(公告)日：2005-12-06
申请号：US09978189
申请日：2001-10-15
申请人： Sherman Fong , Audrey Goddard , Kenneth J. Hillan , William I. Wood
发明人： Sherman Fong , Audrey Goddard , Kenneth J. Hillan , William I. Wood
IPC分类号： C07K14/475 , C07K14/52
CPC分类号： C07K14/475 , C07K14/521
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

58. 发明授权

US07700571B2 Compositions and methods for liver growth and liver protection 有权
公开(公告)号：US07700571B2
公开(公告)日：2010-04-20
申请号：US10455470
申请日：2003-06-05
申请人： Napoleone Ferrara , Kenneth J. Hillan , Jennifer Le Couter
发明人： Napoleone Ferrara , Kenneth J. Hillan , Jennifer Le Couter
IPC分类号： A01N37/18 , A01N43/04 , C12N15/88 , C07K1/00 , C07H21/04
CPC分类号： A61K38/1866 , A61K48/00 , C12N2799/022
摘要： The present invention provides pharmaceutical compositions and methods for liver proliferation and protection. Specifically useful are VEGFR modulating agents capable of promoting liver growth. Disclosed compositions and methods may be useful for promoting proliferation or treating pathological conditions in other organs of significant biological functions.

59. 发明申请

US20090081660A1 Compositions and methods for the diagnosis and treatment of tumor 审中-公开
公开(公告)号：US20090081660A1
公开(公告)日：2009-03-26
申请号：US12079586
申请日：2008-03-26
申请人： Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth J. Hillan , Hartmut Koeppen , Heidi S. Phillips , Paul Polakis , Susan D. Spencer , Victoria Smith , P. Mickey Williams , Thomas D. Wu , Zemin Zhang
发明人： Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth J. Hillan , Hartmut Koeppen , Heidi S. Phillips , Paul Polakis , Susan D. Spencer , Victoria Smith , P. Mickey Williams , Thomas D. Wu , Zemin Zhang
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C07K16/18 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/40 , C07K2317/73 , G01N33/57407
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

60. 发明申请

US20090075279A1 Compositions and methods for the diagnosis and treatment of tumor 有权
公开(公告)号：US20090075279A1
公开(公告)日：2009-03-19
申请号：US12156180
申请日：2008-05-29
申请人： Gretchen Frantz , Kenneth J. Hillan , Heidi Phillips , Paul Polakis , Susan D. Spencer , P. Mickey Williams , Thomas D. Wu , Zemin Wang
发明人： Gretchen Frantz , Kenneth J. Hillan , Heidi Phillips , Paul Polakis , Susan D. Spencer , P. Mickey Williams , Thomas D. Wu , Zemin Wang
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： C07K14/4748 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/30 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

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