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51. 发明申请

US20120235873A1 Radiating Element for Antenna 有权
标题翻译：天线辐射元件
公开(公告)号：US20120235873A1
公开(公告)日：2012-09-20
申请号：US13419140
申请日：2012-03-13
申请人： Zhonglin Wu , Lei Shi , Gang Cheng , Mulin Liu , Zhuofeng Gao
发明人： Zhonglin Wu , Lei Shi , Gang Cheng , Mulin Liu , Zhuofeng Gao
IPC分类号： H01Q1/38 , H01Q19/10
CPC分类号： H01Q21/26 , H01Q1/246 , H01Q9/285 , H01Q19/10
摘要： A radiating element includes a supporting element and a plurality of radiating units formed at one end of the supporting element. Each of the radiating units has a lower surface facing towards the supporting element and an upper surface facing away from the supporting element. The radiating element further includes a first and second dividing pieces symmetrically disposed on each of the radiating units. The radiating element also includes a loading element formed on the lower surface of each of the plurality of radiating units, wherein the loading element extends outward from the supporting element and along an edge of the radiating unit. Moreover, the radiating element includes an electrical connecting element for connecting the radiating units to a feeding cable, the electrical connecting element being lower than the upper surfaces of the radiating units.
摘要翻译：辐射元件包括支撑元件和形成在支撑元件的一端的多个辐射单元。每个辐射单元具有面向支撑元件的下表面和背离支撑元件的上表面。辐射元件还包括对称地设置在每个辐射单元上的第一和第二分割片。辐射元件还包括形成在多个辐射单元中的每一个的下表面上的加载元件，其中加载元件从支撑元件向外延伸并沿着辐射单元的边缘延伸。此外，辐射元件包括用于将辐射单元连接到馈电电缆的电连接元件，电连接元件低于辐射单元的上表面。

52. 发明授权

US08183383B2 Protein tyrosine phosphatase 1B inhibitor, preparation methods and uses thereof 失效
标题翻译：蛋白酪氨酸磷酸酶1B抑制剂，其制备方法和用途
公开(公告)号：US08183383B2
公开(公告)日：2012-05-22
申请号：US12530281
申请日：2008-02-26
申请人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
发明人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
IPC分类号： C07D277/30 , C07D263/34 , C07D233/00 , C07D233/61 , C07D417/10 , C07D413/10 , C07D401/10 , A61K31/445 , A61K31/44 , A61K31/425 , A61K31/42 , A61K31/415
CPC分类号： C07D277/30 , C07D417/12
摘要： PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.
摘要翻译：具有以下结构的PTP1B抑制剂（式I）。实验表明，这些抑制剂能有效抑制蛋白酪氨酸磷酸酶1B（PTP1B）的活性。它们可以用作胰岛素敏化剂。它们可用于预防，延迟或治疗与PTP1B介导的胰岛素拮抗相关的疾病，特别是II型糖尿病和肥胖症。本发明还提供了制备这些抑制剂的方法。

53. 发明授权

US08168791B2 Aminomethyl azaadamantane derivatives and methods of use thereof 有权
标题翻译：氨基甲基氮杂金刚烷衍生物及其使用方法
公开(公告)号：US08168791B2
公开(公告)日：2012-05-01
申请号：US12052093
申请日：2008-03-20
申请人： Lei Shi , Marc J. C. Scanio , William H. Bunnelle
发明人： Lei Shi , Marc J. C. Scanio , William H. Bunnelle
IPC分类号： C07D453/00
CPC分类号： C07D471/18
摘要： The invention relates to compounds that are substituted aminomethyl azaadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.
摘要翻译：本发明涉及取代的氨基甲基氮杂金刚烷衍生物的化合物，包含这些化合物的组合物，以及使用这些化合物和组合物的方法。

54. 发明授权

US08148408B2 Selective substituted pyridine ligands for neuronal nicotinic receptors 有权
标题翻译：用于神经元烟碱受体的选择性取代的吡啶配体
公开(公告)号：US08148408B2
公开(公告)日：2012-04-03
申请号：US12430468
申请日：2009-04-27
申请人： William H. Bunnelle , Lei Shi , Marc J. C. Scanio
发明人： William H. Bunnelle , Lei Shi , Marc J. C. Scanio
IPC分类号： A61K31/44
CPC分类号： C07D487/04
摘要： The present application describes selective ligands of formula (I) for neuronal nicotinic receptors (NNRs), more specifically for the α4β2 NNR subtype, compositions thereof, and methods of using the same, wherein X, R1, X, R2, R3, L1, m, n, p, and q are defined in the specification.
摘要翻译：本申请描述了用于神经元烟碱受体（NNR）的式（I）的选择性配体，更具体地涉及α4和bgr2NNR亚型，其组合物及其使用方法，其中X，R 1，X，R 2，R 3， L1，m，n，p和q在本说明书中定义。

55. 发明授权

US08147138B2 Power supply circuit for motherboard 失效
标题翻译：主板电源电路
公开(公告)号：US08147138B2
公开(公告)日：2012-04-03
申请号：US12185134
申请日：2008-08-04
申请人： Lei Shi
发明人： Lei Shi
IPC分类号： G06F1/26
CPC分类号： G06F1/26 , Y10T307/76
摘要： An exemplary power supply circuit for a motherboard includes a control circuit, a self-locking circuit, and an unlocking circuit. The control circuit is configured for receiving a working mode signal. The self-locking circuit is arranged to receive a power ok signal and a power supply on signal from a power supply, and is connected to the control circuit and a standby power. The unlocking circuit is connected to the control circuit, the self-locking circuit and the standby power, and is also arranged to receive the power ok signal. When the motherboard is placed in an energy-saving mode, the unlocking circuit unlocks the standby power from the motherboard when the computer is turned off to achieve energy savings.
摘要翻译：用于母板的示例性电源电路包括控制电路，自锁电路和解锁电路。控制电路被配置为接收工作模式信号。自锁电路被布置成从电源接收电源ok信号和电源接通信号，并且连接到控制电路和备用电源。解锁电路连接到控制电路，自锁电路和备用电源，并且还被布置成接收电源ok信号。当主板处于节能模式时，解锁电路在计算机关闭时解除主板上的备用电源以实现节能。

56. 发明授权

US08073679B2 Aligning hierarchial and sequential document trees to identify parallel data 失效
标题翻译：对齐分层和顺序文档树以识别并行数据
公开(公告)号：US08073679B2
公开(公告)日：2011-12-06
申请号：US12842177
申请日：2010-07-23
申请人： Ming Zhou , Cheng Niu , Lei Shi
发明人： Ming Zhou , Cheng Niu , Lei Shi
IPC分类号： G06F17/28 , G06F17/20
CPC分类号： G06F17/2827 , G06F17/30014 , G06F17/30882
摘要： A set of candidate parallel pages is identified based on trigger words in one or more pages downloaded from a given network location (such as a website). A set of document trees representing each of the candidate pages are aligned to identify translationally parallel content and hyperlinks. The parallel content is further fed into conventional sentence aligner for parallel sentences. And the parallel hyperlinks usually refer to other parallel documents, and lead to a recursive mining of parallel documents.
摘要翻译：基于从给定网络位置（诸如网站）下载的一个或多个页面中的触发词来识别一组候选并行页面。表示每个候选页面的一组文档树被对齐以识别平移的平行内容和超链接。将并行内容进一步馈送到常规句子对齐器中用于并行句子。并行超链接通常是指其他并行文档，并导致并行文档的递归挖掘。

57. 发明申请

US20110268803A1 LUNG TARGETING DUAL DRUG DELIVERY SYSTEM 有权
标题翻译： LUNG瞄准双药物递送系统
公开(公告)号：US20110268803A1
公开(公告)日：2011-11-03
申请号：US13080371
申请日：2011-04-05
申请人： Robert K. Prud'homme , Patrick J. Sinko , Howard A. Stone , Nathalie M. Pinkerton , Lei Shi , Jiandi Wan , Sherif Ibrahim , Dayuan Gao
发明人： Robert K. Prud'homme , Patrick J. Sinko , Howard A. Stone , Nathalie M. Pinkerton , Lei Shi , Jiandi Wan , Sherif Ibrahim , Dayuan Gao
IPC分类号： A61K9/107 , A61K47/32 , A61K31/437 , A61P35/00 , A61P11/06 , A61K9/00 , A61K47/36 , B82Y5/00
CPC分类号： A61K9/1641 , A61K9/0019 , A61K9/1635 , A61K9/1647 , A61K31/437 , A61K31/4745
摘要： The American Cancer Society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the United States of which 219,440 would be lung and bronchus related. The standard treatments for NSCLC include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer. National Cancer Institute assesses, however, that results of standard treatment are generally poor with only a 15 percent 5-year survival rate for combined cancer stages. Challenges facing the current chemotherapy drugs include excessive toxicity to healthy tissues and limited ability to prevent metastases. A dual drug delivery system described herein selectively targets the lung to deliver anti-cancer drugs and inhibit the formation of metastases.
摘要翻译：美国癌症协会估计，在2009年，美国将诊断出1,479,350例新的癌症病例，其中219,440例与肺和支气管有关。 NSCLC的标准治疗方法包括手术，化学疗法，放射线，激光和光动力疗法，均取决于癌症的各个阶段。然而，国家癌症研究所评估标准治疗结果普遍较差，联合癌症阶段的5年生存率只有15％。目前化疗药物面临的挑战包括对健康组织的过度毒性和预防转移的能力有限。本文描述的双重药物递送系统选择性地靶向肺以递送抗癌药物并抑制转移的形成。

58. 发明申请

US20110152306A1 AZA-BRIDGED RING-FUSED INDOLES AND INDOLINES 有权
标题翻译： AZA-BRIDGED环式熔断器和INDOLINES
公开(公告)号：US20110152306A1
公开(公告)日：2011-06-23
申请号：US12968103
申请日：2010-12-14
申请人： Lei Shi , William H. Bunnelle , Tao Li , Marc J. Scanio , Michael R. Schrimpf , Chih-Hing Lee
发明人： Lei Shi , William H. Bunnelle , Tao Li , Marc J. Scanio , Michael R. Schrimpf , Chih-Hing Lee
IPC分类号： A61K31/439 , C07D471/18 , A61K31/4709 , C07D487/08 , A61K31/4439 , A61P25/00 , A61P25/28 , A61P25/14
CPC分类号： C07D471/18 , A61K31/439 , A61K31/4439 , A61K31/4709 , C07D487/08
摘要： The present application relates to indole and indoline derivatives of formula (I) wherein a, R1, R2, R3, h, i, j, m, n, L, Q, and X are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions.
摘要翻译：本发明涉及式（I）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，h，i，j，m，n，L，Q和X如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法。

59. 发明申请

US20100286978A1 ALIGNING HIERARCHIAL AND SEQUENTIAL DOCUMENT TREES TO IDENTIFY PARALLEL DATA 失效
标题翻译：校准分类和序列文件来确定并行数据
公开(公告)号：US20100286978A1
公开(公告)日：2010-11-11
申请号：US12842177
申请日：2010-07-23
申请人： Ming Zhou , Cheng Niu , Lei Shi
发明人： Ming Zhou , Cheng Niu , Lei Shi
IPC分类号： G06F17/28
CPC分类号： G06F17/2827 , G06F17/30014 , G06F17/30882
摘要： A set of candidate parallel pages is identified based on trigger words in one or more pages downloaded from a given network location (such as a website). A set of document trees representing each of the candidate pages are aligned to identify translationally parallel content and hyperlinks. The parallel content is further fed into conventional sentence aligner for parallel sentences. And the parallel hyperlinks usually refer to other parallel documents, and lead to a recursive mining of parallel documents.
摘要翻译：基于从给定网络位置（诸如网站）下载的一个或多个页面中的触发词来识别一组候选并行页面。表示每个候选页面的一组文档树被对齐以识别平移的平行内容和超链接。将并行内容进一步馈送到常规句子对齐器中用于并行句子。并行超链接通常是指其他并行文档，并导致并行文档的递归挖掘。

60. 发明授权

US07805289B2 Aligning hierarchal and sequential document trees to identify parallel data 失效
标题翻译：对齐层次和顺序文档树以识别并行数据
公开(公告)号：US07805289B2
公开(公告)日：2010-09-28
申请号：US11483941
申请日：2006-07-10
申请人： Ming Zhou , Cheng Niu , Lei Shi
发明人： Ming Zhou , Cheng Niu , Lei Shi
IPC分类号： G06F17/28 , G06F17/20
CPC分类号： G06F17/2827 , G06F17/30014 , G06F17/30882
摘要： A set of candidate parallel pages is identified based on trigger words in one or more pages downloaded from a given network location (such as a website). A set of document trees representing each of the candidate pages are aligned to identify translationally parallel content and hyperlinks. The parallel content is further fed into conventional sentence aligner for parallel sentences. And the parallel hyperlinks usually refer to other parallel documents, and lead to a recursive mining of parallel documents.
摘要翻译：基于从给定网络位置（诸如网站）下载的一个或多个页面中的触发词来识别一组候选并行页面。表示每个候选页面的一组文档树被对齐以识别平移的平行内容和超链接。将并行内容进一步馈送到常规句子对齐器中用于并行句子。并行超链接通常是指其他并行文档，并导致并行文档的递归挖掘。

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