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51. 发明申请

US20100114210A1 IMPLANTABLE MEDICAL DEVICE LEAD CONNECTION ASSEMBLY 有权
标题翻译：可植入医疗设备引线连接组件
公开(公告)号：US20100114210A1
公开(公告)日：2010-05-06
申请号：US12363375
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause
IPC分类号： A61N1/375 , A61N1/39
CPC分类号： A61N1/3752 , H01R13/5224 , H01R24/58 , H01R2107/00 , H01R2201/12 , Y10S439/909
摘要： A lead connection assembly of an implantable medical device (IMD) may include at least two different types of electrical connectors. In some examples, the lead connection assembly may include first and second electrical connectors that have at least one of a different electrical contact arrangement, a different lead connection receptacle geometry or a different size than the first electrical connector. The first electrical connector may be electrically connected to a first therapy module that generates cardiac rhythm therapy that is delivered to a heart of a patient, and the second electrical connector may be electrically connected to a second therapy module that generates electrical stimulation that is delivered to a tissue site within the patient. The second electrical connector may be configured to be incompatible with a lead that delivers the cardiac rhythm therapy to the patient.
摘要翻译：可植入医疗装置（IMD）的引线连接组件可以包括至少两种不同类型的电连接器。在一些示例中，引线连接组件可以包括具有与第一电连接器不同的电接触布置，不同引线连接插座几何形状或不同尺寸中的至少一个的第一和第二电连接器。第一电连接器可以电连接到第一治疗模块，该第一治疗模块产生被递送到患者的心脏的心律疗法，并且第二电连接器可以电连接到产生电刺激的第二治疗模块，该电刺激被递送到患者内的组织部位。第二电连接器可以被配置为与将心律治疗递送给患者的引线不相容。

52. 发明申请

US20100114200A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114200A1
公开(公告)日：2010-05-06
申请号：US12362814
申请日：2009-01-30
申请人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke
发明人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke
IPC分类号： A61N1/37 , A61N1/362
CPC分类号： A61N1/08 , A61N1/36114 , A61N1/37 , A61N1/37258 , A61N1/37288
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

53. 发明申请

US20100114199A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114199A1
公开(公告)日：2010-05-06
申请号：US12362809
申请日：2009-01-30
申请人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke , Timothy Davis
发明人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke , Timothy Davis
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/36114 , A61N1/36185 , A61N1/3686 , A61N1/3688
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

54. 发明申请

US20100114197A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114197A1
公开(公告)日：2010-05-06
申请号：US12362773
申请日：2009-01-30
申请人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
发明人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3605 , A61N1/36114 , A61N1/36521 , A61N1/37 , A61N1/37258 , A61N1/37288
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

55. 发明申请

US20100114196A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114196A1
公开(公告)日：2010-05-06
申请号：US12362768
申请日：2009-01-30
申请人： John E. Burnes , Paul G. Krause , William T. Donofrio , James D. Reinke , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , Timothy Davis
发明人： John E. Burnes , Paul G. Krause , William T. Donofrio , James D. Reinke , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , Timothy Davis
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/3622 , A61N1/37247 , A61N1/37258 , A61N1/3962 , A61N2001/083
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

56. 发明申请

US20100114195A1 IMPLANTABLE MEDICAL DEVICE INCLUDING EXTRAVASCULAR CARDIAC STIMULATION AND NEUROSTIMULATION CAPABILITIES 审中-公开
标题翻译：包括超声心动图刺激和神经细胞功能的可植入医疗装置
公开(公告)号：US20100114195A1
公开(公告)日：2010-05-06
申请号：US12362662
申请日：2009-01-30
申请人： John E. Burnes , Chris Zillmer , Paul G. Krause , Gerald P. Arne , Timothy Davis , David J. Peichel , James D. Reinke , William T. Donofrio , Xiaohong Zhou
发明人： John E. Burnes , Chris Zillmer , Paul G. Krause , Gerald P. Arne , Timothy Davis , David J. Peichel , James D. Reinke , William T. Donofrio , Xiaohong Zhou
IPC分类号： A61N1/39 , A61N1/36 , A61N1/362
CPC分类号： A61N1/0504 , A61B5/046 , A61N1/0587 , A61N1/36114 , A61N1/3622 , A61N1/365 , A61N1/3962
摘要： An implantable medical device may deliver pacing, cardioversion, and/or defibrillation stimulation to a heart of a patient via extravascular electrodes and delivers electrical stimulation to a nonmyocardial tissue site to modulate the autonomic nervous system of the patient. The implantable medical device may include a cardiac therapy module that generates and delivers at least one of pacing, cardioversion, or defibrillation therapy to a patient via an extravascular electrode, and a neurostimulation therapy module that generates and delivers a neurostimulation signal to the patient via a neurostimulation electrode. The cardiac therapy module and neurostimulation therapy module may be disposed in a common housing of the medical device. In some examples, at least one common lead may electrically couple the neurostimulation electrode and the extravascular electrode to the neurostimulation and cardiac therapy modules, respectively.
摘要翻译：可植入医疗装置可以通过血管外电极向患者的心脏递送起搏，心脏复律和/或除颤刺激，并将电刺激递送至非心肌组织部位以调节患者的自主神经系统。可植入医疗装置可以包括心脏治疗模块，该心脏治疗模块通过血管外电极产生并向患者提供起搏，心脏复律或除颤疗法中的至少一种，以及神经刺激治疗模块，其通过以下方式产生并递送神经刺激信号给患者神经刺激电极。心脏治疗模块和神经刺激治疗模块可以设置在医疗装置的公共壳体中。在一些示例中，至少一个共同的引线可以将神经刺激电极和血管外电极分别电耦合到神经刺激和心脏治疗模块。

57. 发明授权

US07711423B2 Algorithm for the automatic determination of optimal pacing intervals 失效
标题翻译：自动确定最佳起搏间隔的算法
公开(公告)号：US07711423B2
公开(公告)日：2010-05-04
申请号：US11135921
申请日：2005-05-24
申请人： John E. Burnes , David A. Igel , John C. Rueter , Yong K. Cho , Luc R. Mongeon , Harold E. Stone , Jodi Zilinski
发明人： John E. Burnes , David A. Igel , John C. Rueter , Yong K. Cho , Luc R. Mongeon , Harold E. Stone , Jodi Zilinski
IPC分类号： A61N1/362
CPC分类号： A61N1/36521
摘要： Impedance, e.g. sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change. Other methods vary the AA interval to maximize impedance change over the entire cardiac cycle or during the atrial cycle.
摘要翻译：阻抗，例如亚阈值阻抗是在选定心脏周期时间内心脏测量的，作为腔室扩张或收缩的量度。为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。另一实施例改变VV间隔以最大化阻抗变化。其他方法改变AA间隔以最大化整个心动周期或心房周期期间的阻抗变化。

58. 发明授权

US07706879B2 Apparatus and methods for automatic determination of a fusion pacing pre-excitation interval 有权
标题翻译：用于自动确定融合起搏预激间隔的装置和方法
公开(公告)号：US07706879B2
公开(公告)日：2010-04-27
申请号：US11742230
申请日：2007-04-30
申请人： John E. Burnes , Thomas J. Mullen , Aleksandra T. Sambelashvili
发明人： John E. Burnes , Thomas J. Mullen , Aleksandra T. Sambelashvili
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36542 , A61N1/36585 , A61N1/3682 , A61N1/3684
摘要： Automated adjustment of a pre-excitation interval (PEI) used to deliver hemodynamically efficient fusion pacing therapy.
摘要翻译：用于提供血液动力学有效的融合起搏治疗的预激发间隔（PEI）的自动调整。

59. 发明申请

US20090276022A1 TECHNIQUES FOR PLACING MEDICAL LEADS FOR ELECTRICAL STIMULATION OF NERVE TISSUE 审中-公开
公开(公告)号：US20090276022A1
公开(公告)日：2009-11-05
申请号：US12433773
申请日：2009-04-30
申请人： John E. Burnes , Kenneth C. Gardeski , Ruth N. Klepfer , Patrick E. Macaulay , Mary M. Morris , Avram Scheiner
发明人： John E. Burnes , Kenneth C. Gardeski , Ruth N. Klepfer , Patrick E. Macaulay , Mary M. Morris , Avram Scheiner
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.

60. 发明申请

US20090275999A1 EXTRA-CARDIAC IMPLANTABLE DEVICE WITH FUSION PACING CAPABILITY 审中-公开
公开(公告)号：US20090275999A1
公开(公告)日：2009-11-05
申请号：US12112833
申请日：2008-04-30
申请人： John E. Burnes , Becky L. Dolan
发明人： John E. Burnes , Becky L. Dolan
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3682
摘要： According to this disclosure, a non-transvenous pacing and, optionally defibrillation, therapy device is implanted subcutaneously and oriented to provide cardiac sensing from electrodes spaced from a heart and deliver pacing and/or defibrillation from one or more non-transvenous electrodes (e.g., an epicardial or pericardial electrode or electrode patch). A subject receiving a device according to this disclosure is monitored to confirm a relatively stable bundle branch block (i.e., delayed activation) of one ventricle. The subcutaneous device has electrodes disposed on the housing and/or having an electrode on a subcutaneous medical lead is oriented so that the pacing (and sensing) vector impinges mainly upon the one ventricle, and/or optionally an epicardial or pericardial lead is deployed to a last-to-depolarize ventricle (e.g., a left ventricle) so that single-ventricular pacing is delivered to achieve fusion depolarization of both ventricles.

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