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51. 发明申请

US20060062425A1 Interactive atlas extracted from volume data 有权
标题翻译：从卷数据中提取的交互式地图集
公开(公告)号：US20060062425A1
公开(公告)日：2006-03-23
申请号：US11203792
申请日：2005-08-15
申请人： Hong Shen , Shuping Qing
发明人： Hong Shen , Shuping Qing
IPC分类号： G06K9/00
CPC分类号： G06T15/08 , G06T7/11 , G06T2200/08 , G06T2207/10081 , G06T2207/20128 , G06T2207/20156 , G06T2207/20161 , G06T2207/30008
摘要： A computer-implemented method for building an atlas includes providing a volume data for a plurality of bones, segmenting, individually, the plurality of bones from the volume data, storing locations of a plurality of voxels for each of the plurality of bones, wherein each of the plurality of bones is registered with a dedicated list of locations, wherein the locations are locations in a coordinate system of the volume data, selecting one or more of the plurality of bones, forming a selected structure, and rendering the selected structure in the coordinate system of the volume data according to the dedicated list of locations of each of the plurality of bones in the selected structure, wherein a rendering is displayed by a display.
摘要翻译：用于构建图集的计算机实现的方法包括提供用于多个骨骼的体数据，从体数据单独分割多个骨骼，存储多个骨骼中的每一个的多个体素的位置，其中每个将多个骨骼的专用列表登记在专用的位置列表中，其中，位置是体数据的坐标系中的位置，选择多个骨骼中的一个或多个，形成所选择的结构，并将所选择的结构呈现在根据所选择的结构中的多个骨骼中的每一个的位置的专用列表来体积数据的坐标系，其中通过显示显示呈现。

52. 发明申请

US20050111714A1 Method and system for patient identification in 3D digital medical images 失效
标题翻译： 3D数字医学图像中患者识别的方法和系统
公开(公告)号：US20050111714A1
公开(公告)日：2005-05-26
申请号：US10974313
申请日：2004-10-27
申请人： Hong Shen , Benjamin Odry , Shuping Qing
发明人： Hong Shen , Benjamin Odry , Shuping Qing
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0012 , A61B6/5294 , G06T2207/30061 , Y10S378/901
摘要： A method of identifying a patient from digital medical images includes providing a first digital image volume of an organ of a patient and a second digital image volume of the same organ, segmenting each slice of the first image volume and calculating a cross-sectional area of the organ in each slice to form a first area profile, segmenting each slice of the second image volume and calculating a cross-sectional area of the organ in each slice to form a second area profile, and comparing the first area profile with the second area profile to determine a correlation value for the two profiles. Based on the correlation value between the first area profile and the second area profile, it is determined whether the first digital image volume of the organ and the second digital image volume of the same organ came from the same patient.
摘要翻译：从数字医学图像识别患者的方法包括提供患者的器官的第一数字图像体积和同一器官的第二数字图像体积，分割第一图像体积的每个切片，并计算第一图像体积的横截面积每个切片中的器官以形成第一区域轮廓，分割第二图像体积的每个切片并计算每个切片中的器官的横截面面积以形成第二区域轮廓，并且将第一区域轮廓与第二区域配置文件以确定两个配置文件的相关值。基于第一区域轮廓和第二区域轮廓之间的相关值，确定器官的第一数字图像体积和同一器官的第二数字图像体积是否来自同一患者。

53. 发明申请

US20140275133A1 MINERALOCORTICOID RECEPTOR ANTAGONISTS 有权
标题翻译：矿物胆碱受体拮抗剂
公开(公告)号：US20140275133A1
公开(公告)日：2014-09-18
申请号：US14350930
申请日：2012-10-08
申请人： Hong Shen , Jason M. Cox , Hong Dong Chu
发明人： Hong Shen , Jason M. Cox , Hong Dong Chu
IPC分类号： C07D413/04 , C07D413/14 , A61K31/4245 , A61K31/422 , A61K31/506 , A61K31/454
CPC分类号： C07D413/04 , A61K31/422 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/506 , C07D263/44 , C07D413/14
摘要： The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof that are possible useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).
摘要翻译：本发明涉及可用于治疗醛固酮介导的疾病的式（I）化合物及其药学上可接受的盐。本发明还涉及制备式（I）化合物，其可能用于治疗上述疾病和为此目的制备药物的方法，以及包含式（I）化合物的药物组合物。

54. 发明申请

US20130299985A1 PROCESS FOR FABRICATING GALLIUM ARSENIDE DEVICES WITH COPPER CONTACT LAYER 有权
标题翻译：用铜箔接触层制造铝合金器件的工艺
公开(公告)号：US20130299985A1
公开(公告)日：2013-11-14
申请号：US13466792
申请日：2012-05-08
申请人： Hong Shen
发明人： Hong Shen
IPC分类号： H01L23/532 , H01L21/283
CPC分类号： H01L21/76898 , H01L21/561 , H01L21/6835 , H01L21/6836 , H01L23/4827 , H01L23/49513 , H01L24/97 , H01L2221/68327 , H01L2221/68331 , H01L2221/6834 , H01L2224/48091 , H01L2224/48227 , H01L2224/92247 , H01L2924/01029 , H01L2924/10253 , H01L2924/10329 , H01L2924/12042 , H01L2924/1305 , H01L2924/1306 , H01L2924/15311 , H01L2924/181 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： Systems, apparatuses, and methods related to the design, fabrication, and manufacture of gallium arsenide (GaAs) integrated circuits are disclosed. Copper can be used as the contact material for a GaAs integrated circuit. Metallization of the wafer and through-wafer vias can be achieved through copper plating processes disclosed herein. Various protocols can be employed during processing to avoid cross-contamination between copper-plated and non-copper-plated wafers. GaAs integrated circuits can be singulated, packaged, and incorporated into various electronic devices.
摘要翻译：公开了与砷化镓（GaAs）集成电路的设计，制造和制造相关的系统，装置和方法。铜可以用作GaAs集成电路的接触材料。通过本文公开的铜电镀工艺可以实现晶片和晶片通孔的金属化。在处理过程中可采用各种方案，以避免镀铜和非镀铜晶圆之间的交叉污染。 GaAs集成电路可以单片化，封装并结合到各种电子设备中。

55. 发明申请

US20130249095A1 GALLIUM ARSENIDE DEVICES WITH COPPER BACKSIDE FOR DIRECT DIE SOLDER ATTACH 审中-公开
标题翻译：具有铜背板的GALLIUM ARSENIDE设备用于直接DIE焊接附件
公开(公告)号：US20130249095A1
公开(公告)日：2013-09-26
申请号：US13429725
申请日：2012-03-26
申请人： Hong Shen
发明人： Hong Shen
IPC分类号： H01L23/48 , H01L21/50
CPC分类号： H01L23/481 , H01L21/561 , H01L21/6835 , H01L21/6836 , H01L23/49816 , H01L24/16 , H01L24/29 , H01L24/45 , H01L24/48 , H01L24/73 , H01L24/97 , H01L2221/68327 , H01L2221/68336 , H01L2221/6834 , H01L2221/68381 , H01L2224/0401 , H01L2224/05647 , H01L2224/13101 , H01L2224/16225 , H01L2224/29101 , H01L2224/2929 , H01L2224/32225 , H01L2224/45124 , H01L2224/45144 , H01L2224/45147 , H01L2224/48091 , H01L2224/48227 , H01L2224/48247 , H01L2224/48647 , H01L2224/48747 , H01L2224/48847 , H01L2224/73265 , H01L2224/83192 , H01L2224/85207 , H01L2224/97 , H01L2924/01047 , H01L2924/01327 , H01L2924/10253 , H01L2924/10329 , H01L2924/12042 , H01L2924/1305 , H01L2924/1306 , H01L2924/14 , H01L2924/15311 , H01L2924/181 , H01L2924/00014 , H01L2924/00 , H01L2924/014 , H01L2924/0665 , H01L2924/07811 , H01L2924/00015 , H01L2924/00012 , H01L2224/92247
摘要： Systems, apparatuses, and methods related to the design, fabrication, and manufacture of gallium arsenide (GaAs) integrated circuits are disclosed. Copper can be used as the contact material for a GaAs integrated circuit. Metallization of the wafer and through-wafer vias can be achieved through copper plating processes disclosed herein. Direct die solder (DDS) attach can be achieved by use of electroless nickel plating of the copper contact layer followed by a palladium flash. GaAs integrated circuits can be singulated, packaged, and incorporated into various electronic devices.
摘要翻译：公开了与砷化镓（GaAs）集成电路的设计，制造和制造相关的系统，装置和方法。铜可以用作GaAs集成电路的接触材料。通过本文公开的铜电镀工艺可以实现晶片和晶片通孔的金属化。可以通过使用铜接触层的无电镀镍，然后使用钯闪光来实现直接焊料（DDS）附着。 GaAs集成电路可以单片化，封装并结合到各种电子设备中。

56. 发明授权

US08415805B2 Etched wafers and methods of forming the same 有权
标题翻译：蚀刻晶片及其形成方法
公开(公告)号：US08415805B2
公开(公告)日：2013-04-09
申请号：US12971465
申请日：2010-12-17
申请人： Hong Shen
发明人： Hong Shen
IPC分类号： H01L23/48
CPC分类号： H01L21/76898 , H01L21/3081 , H01L21/6835 , H01L2221/68327 , H01L2221/6834 , H01L2221/68381
摘要： Etched wafers and methods of forming the same are disclosed. In one embodiment, a method of etching a wafer is provided. The method includes forming a metal hard mask on the wafer using electroless plating, patterning the metal hard mask, and etching a plurality of features on the wafer using an etcher. The plurality of featured are defined by the metal hard mask.
摘要翻译：公开了蚀刻的晶片及其形成方法。在一个实施例中，提供了蚀刻晶片的方法。该方法包括使用化学镀在晶片上形成金属硬掩模，图案化金属硬掩模，以及使用蚀刻器蚀刻晶片上的多个特征。多个特征由金属硬掩模定义。

57. 发明申请

US20120178750A1 Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment 审中-公开
标题翻译：烟酸受体激动剂，包含这些化合物的组合物和治疗方法
公开(公告)号：US20120178750A1
公开(公告)日：2012-07-12
申请号：US13423618
申请日：2012-03-19
申请人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
发明人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
IPC分类号： A61K31/4439 , A61K31/423 , A61K31/429 , A61K31/41 , A61K31/426 , A61K31/427 , A61K31/403 , A61K31/4375 , A61K31/437 , A61K31/538 , A61K31/4196 , A61P9/10 , A61P3/06 , A61P3/10 , A61P3/00 , A61K31/196
CPC分类号： C07D261/20 , C07C233/52 , C07C233/55 , C07C235/36 , C07C237/20 , C07C2601/10 , C07C2601/16 , C07D231/12 , C07D249/06 , C07D249/08 , C07D257/04 , C07D271/06 , C07D277/30 , C07D307/79 , C07D309/14 , C07D309/28 , C07D401/04 , C07D413/04 , C07D417/04 , C07D513/04
摘要： The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要翻译：本发明包括可用于治疗动脉粥样硬化，血脂异常等的式I化合物及其药学上可接受的盐和水合物。还包括药物组合物和使用方法。

58. 发明申请

US20120153477A1 METHODS FOR METAL PLATING AND RELATED DEVICES 审中-公开
标题翻译：金属镀层及相关装置的方法
公开(公告)号：US20120153477A1
公开(公告)日：2012-06-21
申请号：US12972119
申请日：2010-12-17
申请人： Hong Shen
发明人： Hong Shen
IPC分类号： H01L23/532 , H01L21/768
CPC分类号： H01L23/5286 , C23C18/1651 , C23C18/1653 , C23C18/1879 , C23C18/32 , C23C18/38 , C23C18/42 , C23C18/50 , H01L21/288 , H01L21/76873 , H01L21/76874 , H01L21/76898 , H01L2221/1089 , H01L2924/0002 , H01L2924/00
摘要： Methods for plating metal over features of a semiconductor wafer and devices that can be formed by these methods are disclosed. One such method includes forming a barrier layer over the substrate using electroless plating and forming a copper layer over the barrier layer. In some implementations, the semiconductor wafer is a GaAs wafer. Alternatively or additionally, the feature over which metal is plated can be a through-wafer via. In some implementations, a seed layer over the barrier layer can be formed using electroless plating.
摘要翻译：公开了通过这些方法形成的可以形成半导体晶片的特征的金属镀覆方法和装置。一种这样的方法包括使用化学镀在衬底上形成阻挡层，并在阻挡层上形成铜层。在一些实施方案中，半导体晶片是GaAs晶片。或者或另外，金属镀覆的特征可以是贯通晶片通孔。在一些实施方案中，阻挡层上的种子层可以使用无电镀形成。

59. 发明授权

US08165376B2 System and method for automatic detection of rib metastasis in computed tomography volume 有权
标题翻译：计算机断层扫描体积自动检测肋骨转移的系统和方法
公开(公告)号：US08165376B2
公开(公告)日：2012-04-24
申请号：US11951382
申请日：2007-12-06
申请人： Hong Shen , Limin Ma
发明人： Hong Shen , Limin Ma
IPC分类号： G06K9/00 , G06K9/34
CPC分类号： G06T7/0012
摘要： A method and system for automatically detecting rib metastasis in a thoracic CT volume is disclosed. The ribs are segmented in said CT volume by recursive tracing. A series of cross-sectional images are then generated along a centerline of each rib. Cortical and trabecular bone structures are segmented in each of the cross-sectional images for each rib. Features are calculated for each cross-sectional image based on characteristics of the cortical and trabecular bone structures, and alterations are detected in the cross-sectional images based on the features. Rib metastasis is detected in a rib when an alteration is detected in a number of consecutive cross-sectional images along the centerline of the rib.
摘要翻译：公开了一种用于自动检测胸部CT体积的肋骨转移的方法和系统。肋骨通过递归跟踪在所述CT体积中分段。然后沿着每个肋的中心线产生一系列横截面图像。在每个肋骨的每个截面图像中分割皮质和小梁骨结构。基于皮质和小梁骨结构的特征为每个横截面图像计算特征，并且基于特征在截面图像中检测到变化。当沿着肋的中心线的多个连续横截面图像中检测到改变时，肋中检测到肋转移。

60. 发明授权

US07949171B2 System and method for tracing rib posterior in chest CT volumes 有权
标题翻译：胸部CT检查肋后路系统及方法
公开(公告)号：US07949171B2
公开(公告)日：2011-05-24
申请号：US11549723
申请日：2006-10-16
申请人： Shuping Qing , Hong Shen
发明人： Shuping Qing , Hong Shen
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/155
摘要： A method for tracing, rib posteriors includes providing an incomplete rib tracing comprising a digitized 3-dimensional representation of a rib and a digital image from which said rib tracing was extracted, initializing, a tracing direction for a remainder of said rib, detecting a plurality of ridge points in a sub-volume of said digital image about said initial tracing direction, and deforming a closed curve in a plane perpendicular to said tracing direction until a rib-edge contour is obtained, using said ridge points as constraints.
摘要翻译：一种用于跟踪的方法，肋部后部包括提供不完整的肋跟踪，其包括肋的数字化3维表示和从其提取所述肋跟踪的数字图像，初始化，所述肋的剩余部分的跟踪方向，检测多个在所述数字图像的子体积中的关于所述初始跟踪方向的脊点的脊点，并且使垂直于所述跟踪方向的平面中的闭合曲线变形，直到获得肋边缘轮廓，使用所述脊点作为约束。

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