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51. 发明授权

US07856270B2 Cardiac pacing using adjustable atrio-ventricular delays 有权
标题翻译：心脏起搏使用可调节的心房延迟
公开(公告)号：US07856270B2
公开(公告)日：2010-12-21
申请号：US11049181
申请日：2005-02-02
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1/365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

52. 发明授权

US07580745B2 Method and apparatus for using heart rate variability to control maximum tracking rate in pacing therapy 有权
标题翻译：心率变异性控制起搏治疗最大跟踪率的方法和装置
公开(公告)号：US07580745B2
公开(公告)日：2009-08-25
申请号：US11037723
申请日：2005-01-18
申请人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
发明人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/36592 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于调整心房跟踪起搏模式中的最大跟踪率。

53. 发明授权

US07013176B2 Method and apparatus for setting pacing parameters in cardiac resynchronization therapy 有权
标题翻译：心脏再同步治疗中设置起搏参数的方法和装置
公开(公告)号：US07013176B2
公开(公告)日：2006-03-14
申请号：US10352780
申请日：2003-01-28
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Lawrence Baumann
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Lawrence Baumann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and apparatus is disclosed for automatically setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way is the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes.
摘要翻译：公开了一种用于自动设置可植入心脏装置在输送心脏再同步治疗中使用的起搏参数的方法和装置。起搏参数的选择至少部分地基于固有心脏传导参数的测量。可以以这种方式选择的起搏参数是在心房跟踪和AV顺序起搏模式中使用的心房延迟间隔。

54. 发明授权

US06684103B2 Cardiac pacing using adjustable atrio-ventricular delays 有权
标题翻译：心脏起搏使用可调节的心房延迟
公开(公告)号：US06684103B2
公开(公告)日：2004-01-27
申请号：US10243811
申请日：2002-09-13
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

55. 发明授权

US08831724B2 Method and apparatus for using heart rate variability as a safety check in electrical therapies 有权
标题翻译：使用心率变异性作为电疗法安全检查的方法和装置
公开(公告)号：US08831724B2
公开(公告)日：2014-09-09
申请号：US12694124
申请日：2010-01-26
申请人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
发明人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/365 , A61N1/36592
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。

56. 发明授权

US06859665B2 Cardiac pacing using adjustable atrio-ventricular delays 有权
公开(公告)号：US06859665B2
公开(公告)日：2005-02-22
申请号：US10615202
申请日：2003-07-07
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

57. 发明授权

US07310554B2 Method and apparatus for adjustment of sequential biventricular pacing parameters 有权
标题翻译：用于调整顺序性双心室起搏参数的方法和装置
公开(公告)号：US07310554B2
公开(公告)日：2007-12-18
申请号：US10742630
申请日：2003-12-19
申请人： Andrew P. Kramer , Jiang Ding
发明人： Andrew P. Kramer , Jiang Ding
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and system are disclosed for setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The system may, in different embodiments, be implemented in programming of the implantable device and an external programmer in communication therewith or in the programming of the implantable device by itself. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way are the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes and the biventricular offset interval.
摘要翻译：公开了一种用于设置由可植入心脏装置用于输送心脏再同步治疗的起搏参数的方法和系统。在不同的实施例中，该系统可以在可植入装置和与之通信的外部编程器的编程中或在可植入装置自身的编程中实现。起搏参数的选择至少部分地基于固有心脏传导参数的测量。可以以这种方式选择的起搏参数是在心房跟踪和AV顺序起搏模式和双心室偏移间隔中使用的心房延迟间隔。

58. 发明授权

US06597951B2 Automatic selection from multiple cardiac optimization protocols 有权
公开(公告)号：US06597951B2
公开(公告)日：2003-07-22
申请号：US09995255
申请日：2001-11-27
申请人： Andrew P. Kramer , Veerichetty Kadhiresan , Jiang Ding , Lawrence Baumann , Scott Vanderlinde
发明人： Andrew P. Kramer , Veerichetty Kadhiresan , Jiang Ding , Lawrence Baumann , Scott Vanderlinde
IPC分类号： A61N1365
CPC分类号： A61N1/3627 , A61N1/3682
摘要： A method and system for setting the operating parameters of a cardiac rhythm management device in which a plurality of parameter optimization algorithms are available. A measured feature of an electrophysiological signal such as QRS width has been shown to be useful in selecting among certain parameter optimization algorithms.

59. 发明申请

US20120158088A1 METHOD AND APPARATUS FOR ADJUSTMENT OF SEQUENTIAL BIVENTRICULAR PACING PARAMETERS 有权
标题翻译：用于调整连续双歧杆菌参数的方法和装置
公开(公告)号：US20120158088A1
公开(公告)日：2012-06-21
申请号：US13406320
申请日：2012-02-27
申请人： Andrew P. Kramer , Jiang Ding
发明人： Andrew P. Kramer , Jiang Ding
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and system are disclosed for setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The system may, in different embodiments, be implemented in programming of the implantable device and an external programmer in communication therewith or in the programming of the implantable device by itself. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way are the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes and the biventricular offset interval.
摘要翻译：公开了一种用于设置由可植入心脏装置用于输送心脏再同步治疗的起搏参数的方法和系统。在不同的实施例中，该系统可以在可植入装置和与之通信的外部编程器的编程中或在可植入装置自身的编程中实现。起搏参数的选择至少部分地基于固有心脏传导参数的测量。可以以这种方式选择的起搏参数是在心房跟踪和AV顺序起搏模式和双心室偏移间隔中使用的心房延迟间隔。

60. 发明授权

US07822473B2 Resynchronization method and apparatus based on intrinsic atrial rate 有权
标题翻译：基于固有心房率的再同步方法和装置
公开(公告)号：US07822473B2
公开(公告)日：2010-10-26
申请号：US11676339
申请日：2007-02-19
申请人： Andrew P. Kramer , Veerichetty Kadhiresan , Jiang Ding , Lawrence Baumann , Scott Vanderlinde
发明人： Andrew P. Kramer , Veerichetty Kadhiresan , Jiang Ding , Lawrence Baumann , Scott Vanderlinde
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3682
摘要： A method and system for setting the operating parameters of a cardiac rhythm management device in which a plurality of parameter optimization algorithms are available. A measured feature of an electrophysiological signal such as QRS width has been shown to be useful in selecting among certain parameter optimization algorithms. In one embodiment, one or more resynchronization pacing parameters are set based on one or both of the feature extracted from an electrogram signal and the value of a resynchronization pacing parameter which tends to minimize the intrinsic atrial rate.
摘要翻译：一种用于设定多个参数优化算法可用的心律管理装置的操作参数的方法和系统。电生理信号（如QRS宽度）的测量特征已被证明可用于某些参数优化算法中的选择。在一个实施例中，基于从电描记信号提取的特征中的一个或两个以及倾向于使固有心房率最小化的再同步起搏参数的值来设置一个或多个再同步起搏参数。

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