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51. 发明申请

US20120277199A1 Modulation of Gel Temperature of Poloxamer-Containing Formulations 审中-公开
标题翻译：含泊洛沙唑的配方凝胶温度的调制
公开(公告)号：US20120277199A1
公开(公告)日：2012-11-01
申请号：US13500971
申请日：2010-10-19
申请人： Qiang Ye , Luis A. Dellamary , Fabrice Piu
发明人： Qiang Ye , Luis A. Dellamary , Fabrice Piu
IPC分类号： A61K31/573 , A61P35/00 , A61P11/00 , A61P27/16 , A61P37/06
CPC分类号： A61K9/0043 , A61K9/0046 , A61K9/06 , A61K31/496 , A61K31/506 , A61K31/573 , A61K38/18 , A61K47/10
摘要： Disclosed herein are methods for modulation of gel temperature of poloxamer-containing formulations. Also described herein are sustained release pharmaceutical formulations that gel upon contact with the body and are administered by direct application of these compositions and formulations onto or via perfusion into the targeted structure(s).
摘要翻译：本文公开了用于调节含泊洛沙姆的制剂的凝胶温度的方法。本文还描述了缓释药物制剂，其在与身体接触时凝胶化，并且通过将这些组合物和制剂直接施用到或通过灌注到目标结构中来施用。

52. 发明申请

US20110319377A1 Controlled Release Corticosteroid Compositions and Methods for the Treatment of Otic Disorders 有权
标题翻译：控制释放的皮质类固醇组合物和治疗眼病的方法
公开(公告)号：US20110319377A1
公开(公告)日：2011-12-29
申请号：US13190329
申请日：2011-07-25
申请人： Jay Lichter , Benedikt Vollrath , Andrew M. Trammel , Sergio G. Durón , Fabrice Piu , Luis A. Dellamary , Qiang Ye , Carl Lebel , Michael Christopher Scaife , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Andrew M. Trammel , Sergio G. Durón , Fabrice Piu , Luis A. Dellamary , Qiang Ye , Carl Lebel , Michael Christopher Scaife , Jeffrey P. Harris
IPC分类号： A61K31/573 , A61P27/16 , A61P29/00 , A61P37/06
CPC分类号： A61K9/0046 , A61K9/06 , A61K31/573 , A61K45/06 , A61K47/10
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译：本文公开了用类固醇，NSAID和/或腺苷三磷酸酶（“ATPase”）调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中，将甾体，NSAID和/或ATP酶组合物和制剂局部施用于患有耳科疾病的个体。

53. 发明申请

US20110319374A1 Controlled Release Corticosteroid Compositions and Methods for the Treatment of Otic Disorders 有权
公开(公告)号：US20110319374A1
公开(公告)日：2011-12-29
申请号：US13190327
申请日：2011-07-25
申请人： Jay Lichter , Benedikt Vollrath , Sergio G. Durón , Michael Christopher Scaife , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Carl Lebel , Andrew M. Trammel , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Sergio G. Durón , Michael Christopher Scaife , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Carl Lebel , Andrew M. Trammel , Jeffrey P. Harris
IPC分类号： A61K31/573 , A61P27/16
CPC分类号： A61K9/0046 , A61K9/06 , A61K31/573 , A61K45/06 , A61K47/10
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

54. 发明申请

US20100016218A1 CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 审中-公开
标题翻译：控制释放调节组合物和治疗情绪障碍的方法
公开(公告)号：US20100016218A1
公开(公告)日：2010-01-21
申请号：US12500486
申请日：2009-07-09
申请人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice PIU , Qiang Ye , Luis A. Dellamary , Michael Christopher Scaife , Andrew M. Trammel , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice PIU , Qiang Ye , Luis A. Dellamary , Michael Christopher Scaife , Andrew M. Trammel , Jeffrey P. Harris
IPC分类号： A61K38/22 , A61K38/16 , A61K47/32 , A61P27/02
CPC分类号： A61K38/1709 , A61K9/0046 , A61K9/06 , A61K9/14 , A61K38/005 , A61K38/162 , A61K38/1761 , A61K47/36 , C12N7/00 , C12N2740/16322
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with anti-apoptotic agent or pro-apoptotic agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
摘要翻译：本文公开的是通过将这些组合物和组合物直接施用于灌注或通过灌注至本发明的，通过将抗凋亡剂或促凋亡剂组合物和组合物局部施用于患有耳科疾病的个体来治疗耳部病症的组合物和方法，目标耳结构。

55. 发明授权

US07141236B2 Methods and compositions for delivering macromolecules to or via the respiratory tract 有权
标题翻译：将大分子递送到呼吸道或通过呼吸道递送的方法和组合物
公开(公告)号：US07141236B2
公开(公告)日：2006-11-28
申请号：US10132215
申请日：2002-04-26
申请人： Adrian I. Bot , Luis A. Dellamary , Dan J. Smith
发明人： Adrian I. Bot , Luis A. Dellamary , Dan J. Smith
IPC分类号： A61K9/00 , A61K9/12 , A61K9/127 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/1075 , A61K9/127 , A61K9/1617
摘要： Methods and compositions for delivering macromolecules to or via the respiratory tract, such that the macromolecules exhibit improved local and/or systemic bioavailability are provided. Such methods utilize lipid-based microstructures formed in combination with at least one bioactive macromolecule, which have a superior ability to rapidly release the bioactive macromolecule(s) thereby resulting in improved local and/or systemic bioavailability of the bioactive macromolecule(s). Such improved bioavailability is believed to be due, in part, to reduction of scavenging by bronchoalveolar macrophages and/or mucociliary clearance. Compositions with improved bioavailability are provided comprising a plurality of lipid-based microstructures formed in combination with at least one bioactive macromolecule, wherein the bioavailability of the bioactive macromolecule is improved by modifying the rate of release of the bioactive macromolecule from the microstructure thereby reducing scavenging by bronchoalveolar macrophages and/or mucociliary clearance.
摘要翻译：将大分子递送至呼吸道或经由呼吸道递送的方法和组合物，使得大分子表现出改善的局部和/或全身生物利用度。这种方法利用与至少一种生物活性大分子组合形成的基于脂质的微结构，其具有优异的快速释放生物活性大分子的能力，从而导致生物活性大分子的局部和/或全身生物利用度的改善。这种改善的生物利用度被认为是由于部分地由于支气管肺泡巨噬细胞的清除和/或粘膜纤毛清除的减少。提供具有改善的生物利用度的组合物，其包含与至少一种生物活性大分子组合形成的多个基于脂质的微结构，其中生物活性大分子的生物利用度通过改变生物活性大分子从微结构的释放速率来改善，从而通过支气管肺泡巨噬细胞和/或粘膜纤毛清除。

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