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51. 发明申请

US20110295180A1 INTESTINAL BRAKE INDUCING INTRALUMINAL THERAPEUTIC SUBSTANCE ELUTING DEVICES AND METHODS 有权
标题翻译： INTESTINAL BRAKE INDING IN INTRALUMINAL THERAPEUTIC THEAPEUTIC TYSTURE ELDTING ELTERTING DEVICES AND METHODS
公开(公告)号：US20110295180A1
公开(公告)日：2011-12-01
申请号：US13105029
申请日：2011-05-11
申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Thomas W. Huitema , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Thomas W. Huitema , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
IPC分类号： A61F2/04
CPC分类号： A61F5/0076 , A61F2/04 , A61F5/0013 , A61F5/0026 , A61F5/0079 , A61F2002/045
摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.
摘要翻译：方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。在一个实施方案中，可植入系统包括将治疗物质递送到患者胃肠道内的目标位置的装置，以便开始肠促动作用，其将促进饱腹感，并刺激患者多余的体重减轻。

52. 发明申请

US20110295056A1 SYSTEMS AND METHODS FOR GASTRIC VOLUME REGULATION 审中-公开
标题翻译：用于胃体积调节的系统和方法
公开(公告)号：US20110295056A1
公开(公告)日：2011-12-01
申请号：US13104223
申请日：2011-05-10
申请人： Jeffrey L. Aldridge , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , John V. Hunt , Prasanna Malaviya , Jeffrey D. Messerly , Mark S. Ortiz , Mark D. Overmyer , Galen C. Robertson , Frederick E. Shelton, IV , Foster B. Stulen , Suzanne Thompson , James W. Voegele , Lauren S. Weaner , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , David C. Yates , Mark S. Zeiner
发明人： Jeffrey L. Aldridge , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , John V. Hunt , Prasanna Malaviya , Jeffrey D. Messerly , Mark S. Ortiz , Mark D. Overmyer , Galen C. Robertson , Frederick E. Shelton, IV , Foster B. Stulen , Suzanne Thompson , James W. Voegele , Lauren S. Weaner , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , David C. Yates , Mark S. Zeiner
IPC分类号： A61F2/04
CPC分类号： A61F5/0083 , A61B17/00234 , A61B17/064 , A61B17/12136 , A61B17/12159 , A61B17/1355 , A61B2017/00035 , A61B2017/00557 , A61B2017/00632 , A61B2017/00818 , A61B2017/00898 , A61B2017/1142 , A61F5/004 , A61F5/0056
摘要： Devices and methods for modifying stomach volume include the formation of intragastric slots for wrapping one or more portions of the fundus therethrough with minimal interference with nerves and vasculature flow. Intragastric space occupying devices expand with environmental changes brought about by natural conditions inherent to the digestive cycle such as with changes in pH. Extragastric volume occupying balloons are placed into folded stomach sections. The balloons are fluidly coupled to external gastric filling devices. In yet another set of embodiments, methods and devices provide adjustable gastric volume reduction fundal wraps. In one embodiment, a device is placed in the fundus for Nissen fundoplication and permits postoperative adjustment to reach desired weight loss. Intragastric and extragastric balloons are optionally incorporated.
摘要翻译：用于改变胃体积的装置和方法包括形成胃内狭槽，用于以最小的神经和脉管系统流动的干扰来包裹眼底的一个或多个部分。内部空间占据装置随着消化循环固有的自然条件（如pH变化）带来的环境变化而扩大。腹腔积气囊放置在折叠的胃部。气囊流体地联接到外部胃灌注装置。在另一组实施方案中，方法和装置提供可调节的胃体积减少基底包裹。在一个实施例中，将装置放置在眼底以进行尼森眼底切开术，并允许术后调整以达到期望的体重减轻。肠内和胃内气囊任选并入。

53. 发明申请

US20100262080A1 SURGICAL ACCESS DEVICE HAVING REMOVABLE AND REPLACEABLE COMPONENTS 有权
标题翻译：具有可拆卸和可更换组件的外科手术设备
公开(公告)号：US20100262080A1
公开(公告)日：2010-10-14
申请号：US12420202
申请日：2009-04-08
申请人： Frederick E. Shelton, IV , Christopher W. Widenhouse
发明人： Frederick E. Shelton, IV , Christopher W. Widenhouse
IPC分类号： A61B17/34 , A61B1/32
CPC分类号： A61B17/3423 , A61B17/3498 , A61B2017/00477 , A61B2017/3445 , A61B2017/3447 , A61B2017/3466 , A61B2017/3482
摘要： Methods and devices are provided to improve access to a surgical site during surgical procedures. In one exemplary embodiment a surgical access device is provided having a cannula, a cannula base, and a retractor. The cannula base is configured to couple both to the retractor and the cannula to provide access to a surgical site. The cannula can be removably and replaceably coupled to the cannula base. Optionally, the cannula base can be removably and replaceably coupled to the retractor. As desired, the cannula can be decoupled from the cannula base, which can allow for an object to be removed from the surgical site and/or for the cannula, or another cannula to be attached to the cannula base that remains in place to maintain access to the surgical site. Exemplary methods for accessing a surgical site are also provided.
摘要翻译：提供了方法和装置，以改善在外科手术过程中进入手术部位。在一个示例性实施例中，提供具有插管，插管基座和牵开器的外科进入装置。套管基座构造成将两者联接到牵开器和套管以提供对手术部位的通路。套管可以可移除地和可更换地耦合到套管基座。任选地，套管基座可拆卸地且可更换地联接到牵开器。根据需要，套管可以与套管基座分离，这可以允许物体从外科手术部位和/或套管移除，或者另一套管连接到保持在适当位置的插管基座，以保持通路到手术部位。还提供了用于进入手术部位的示例性方法。

54. 发明申请

US20100261974A1 METHODS AND DEVICES FOR PROVIDING ACCESS INTO A BODY CAVITY 有权
标题翻译：用于提供进入体腔的方法和装置
公开(公告)号：US20100261974A1
公开(公告)日：2010-10-14
申请号：US12420146
申请日：2009-04-08
申请人： Frederick E. Shelton, IV , Christopher W. Widenhouse
发明人： Frederick E. Shelton, IV , Christopher W. Widenhouse
IPC分类号： A61B1/32
CPC分类号： A61B17/3423 , A61B17/3439 , A61B2017/00407 , A61B2017/3445 , A61B2017/3466
摘要： Methods and devices are provided for providing surgical access into a body cavity. In one embodiment, a surgical access device is provided that includes a proximal housing and a distal retractor. At least one stability thread can extend around a perimeter of at least a portion of the distal retractor. In some embodiments, the stability thread can be mechanically adjustable to change a diameter of the distal retractor.
摘要翻译：提供了用于提供进入体腔的外科手术的方法和装置。在一个实施例中，提供了一种外科进入装置，其包括近端壳体和远侧牵开器。至少一个稳定性螺纹可以围绕远端牵开器的至少一部分的周边延伸。在一些实施例中，稳定性螺纹可以机械地调节以改变远侧牵开器的直径。

55. 发明申请

US20100261970A1 RETRACTOR WITH FLEXIBLE SLEEVE 有权
标题翻译：带柔性套筒的拉杆
公开(公告)号：US20100261970A1
公开(公告)日：2010-10-14
申请号：US12420107
申请日：2009-04-08
申请人： Frederick E. Shelton, IV , Christopher W. Widenhouse
发明人： Frederick E. Shelton, IV , Christopher W. Widenhouse
IPC分类号： A61B1/32
CPC分类号： A61B17/3423 , A61B17/3462 , A61B2017/3447 , A61B2017/3464 , A61B2017/3466 , A61B2017/349
摘要： Devices and methods are disclosed for accessing a body cavity or other surgical site while providing optimal device length and improved tissue retraction, device retention and stability, and seal integrity. A surgical access device is disclosed that generally comprises an external seal housing having at least one working channel and that is coupled to a flexible and/or resilient retractor. The retractor can include a resilient ring at its distal circumference configured to be deformed to facilitate insertion through an incision and then to return to an undeformed state having a diameter greater than a diameter of the incision once within a body cavity. Various means of coupling the retractor to the housing are disclosed, as are various types of seals that can be included within the housing. “Low-profile” and “peel-away cannula” embodiments of the surgical access device are disclosed, along with methods of accessing a body cavity using such devices.
摘要翻译：公开了用于进入体腔或其他手术部位的装置和方法，同时提供最佳装置长度和改进的组织缩回，装置保持和稳定性以及密封完整性。公开了一种外科进入装置，其通常包括具有至少一个工作通道并且联接到柔性和/或弹性牵开器的外部密封壳体。牵开器可以包括在其远端圆周处的弹性环，该弹性环被构造为变形以便于通过切口插入，然后返回至直径大于切口直径的未变形状态。公开了将牵开器联接到壳体的各种装置，以及可以包括在壳体内的各种类型的密封件。公开了外科进入装置的“低轮廓”和“剥离插管”实施例，以及使用这种装置进入体腔的方法。

56. 发明申请

US20100249521A1 Access Device Including Retractor And Insert 审中-公开
标题翻译：访问设备包括缩进和插入
公开(公告)号：US20100249521A1
公开(公告)日：2010-09-30
申请号：US12712406
申请日：2010-02-25
申请人： Frederick E. Shelton, IV , Christopher W. Widenhouse
发明人： Frederick E. Shelton, IV , Christopher W. Widenhouse
IPC分类号： A61B1/32
CPC分类号： A61B17/3423 , A61B17/0218 , A61B17/0293 , A61B17/3431 , A61B2017/0225 , A61B2017/3429 , A61B2017/3445 , A61B2017/3447 , A61B2017/3466
摘要： Various devices and methods are provided with respect to inserting multiple surgical instruments through a single surgical access device. A medical device including a flexible tissue retractor and a releasable insert having multiple instrument openings is disclosed. The insert can be in the form of an insert assembly including multiple components. A member operable to prevent over insertion of the insert with respect to a passageway of a retractor is provided.
摘要翻译：提供了通过单个外科手术进入装置插入多个外科器械的各种装置和方法。公开了一种包括柔性组织牵开器和具有多个仪器开口的可释放插入件的医疗装置。插入件可以是包括多个部件的插入组件的形式。提供了可操作以防止插入件相对于牵开器的通道过度插入的构件。

57. 发明授权

US07780685B2 Adhesive and mechanical fastener 有权
标题翻译：粘合剂和机械紧固件
公开(公告)号：US07780685B2
公开(公告)日：2010-08-24
申请号：US11558002
申请日：2006-11-09
申请人： John V. Hunt , Daniel W. Price , Mark S. Ortiz , Frederick E. Shelton, IV , Christopher W. Widenhouse , Ronald J. Kolata , James W. Voegele
发明人： John V. Hunt , Daniel W. Price , Mark S. Ortiz , Frederick E. Shelton, IV , Christopher W. Widenhouse , Ronald J. Kolata , James W. Voegele
IPC分类号： A61B17/08
CPC分类号： A61B17/0643 , A61B17/00491 , A61B2017/00893 , A61B2017/0641 , A61B2017/0647
摘要： Provided is a two-piece anastomosis fastener that can be used to join two tissue sections together in accordance with Natural Orifice Transendoscopic Surgery (NOTES). The fastener may be releasably attached to a fastener applying instrument for delivery in accordance with such procedures. The fastener includes a first member and a second member, where the clamp members are operably configured to fasten together to clamp and hold tissue, such as gastric tissue, in juxtaposition to establish an anastomosis. The first clamp member and the second clamp member are coupled with an adhesive.
摘要翻译：提供了一种两件式吻合紧固件，其可以根据天然瓣膜内窥镜手术（NOTES）用于将两个组织切片连接在一起。紧固件可以可释放地附接到紧固件应用工具以根据这种过程进行输送。紧固件包括第一构件和第二构件，其中夹紧构件可操作地构造成紧固在一起以夹紧并保持组织（例如胃组织）并置以建立吻合。第一夹紧构件和第二夹紧构件与粘合剂联接。

58. 发明申请

US20100113882A1 SURGICAL ACCESS PORT WITH MULTILAYERED TORTUOUS PATH SEAL 有权
标题翻译：手术通道与多层螺旋孔密封
公开(公告)号：US20100113882A1
公开(公告)日：2010-05-06
申请号：US12261672
申请日：2008-10-30
申请人： Christopher W. Widenhouse , Frederick E. Shelton, IV , Chris Cicenas
发明人： Christopher W. Widenhouse , Frederick E. Shelton, IV , Chris Cicenas
IPC分类号： A61B17/34
CPC分类号： A61B17/3423 , A61B17/3462 , A61B17/3498
摘要： A surgical access device includes a wound protector and an instrument seal. The instrument seal comprises a plurality of resilient membranes each having a plurality of parallel slits. The membranes are stacked relative one another to create a tortuous path preventing insufflatory gases from escaping through the instrument seal.
摘要翻译：外科进入装置包括伤口保护器和仪器密封件。仪器密封件包括多个具有多个平行狭缝的弹性膜。膜相对彼此堆叠以产生弯曲路径，防止吹入气体通过仪器密封件逸出。

59. 发明申请

US20110282324A1 Multi-Chamber Therapeutic Cell Applicator Instrument 有权
标题翻译：多室治疗细胞施用仪器
公开(公告)号：US20110282324A1
公开(公告)日：2011-11-17
申请号：US12779400
申请日：2010-05-13
申请人： Takashi Kurokawa , Christopher W. Widenhouse , Agnieszka Seyda , Jeffrey S. Swayze , Foster B. Stulen , Mark H. Ransick , Richard W. Timm , Shailendra K. Parihar , Shelby L. Cook Kornbluth
发明人： Takashi Kurokawa , Christopher W. Widenhouse , Agnieszka Seyda , Jeffrey S. Swayze , Foster B. Stulen , Mark H. Ransick , Richard W. Timm , Shailendra K. Parihar , Shelby L. Cook Kornbluth
IPC分类号： A61M37/00 , A61M1/00
CPC分类号： A61B17/0057 , A61B10/0275 , A61B10/0283 , A61B17/00491 , A61B17/07207 , A61B17/12099 , A61B17/12186 , A61B2017/00495 , A61B2017/00641 , A61B2017/22067 , A61F5/0083 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/31586 , A61M25/10 , A61M2005/2414
摘要： A surgical device comprises a housing, a plurality of media reservoirs, an end effector, and a pumping device. Each media reservoir is configured to receive at least one component of a tissue repair composition. The end effector is configured for insertion into a lumen to deliver a tissue repair composition into that lumen. The end effector has at least one fluid conduit and at least one orifice in communication with the fluid conduit. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the plurality of media reservoirs through the fluid conduit of the end effector such that the tissue repair composition is expelled from the at least one orifice. The media reservoirs may contain medical fluid components such as viable cells and scaffold material to repair a fistula or address some other condition in a patient.
摘要翻译：手术装置包括壳体，多个介质容器，末端执行器和泵送装置。每个介质储存器构造成接收组织修复组合物的至少一个组分。末端执行器构造成用于插入内腔以将组织修复组合物递送到该内腔中。末端执行器具有至少一个流体导管和与流体导管连通的至少一个孔口。抽吸装置可操作以通过端部执行器的流体管道促使包含多个介质容器的内容物的至少一部分的组织修复组合物，使得组织修复组合物从至少一个孔排出。介质储存器可以包含医疗流体组分，例如活细胞和支架材料，以修复瘘管或解决患者中的一些其他状况。

60. 发明申请

US20120241491A1 EXPANDABLE TISSUE THICKNESS COMPENSATOR 有权
标题翻译：可膨胀组织厚度补偿器
公开(公告)号：US20120241491A1
公开(公告)日：2012-09-27
申请号：US13433098
申请日：2012-03-28
申请人： Jeffrey L. Aldridge , Chunlin Yang , Charles J. Scheib , Christopher W. Widenhouse , William B. Weisenburgh, II , John L. Stammen , Mark H. Ransick , Stephanie A. Mutchler , Gary W. Knight
发明人： Jeffrey L. Aldridge , Chunlin Yang , Charles J. Scheib , Christopher W. Widenhouse , William B. Weisenburgh, II , John L. Stammen , Mark H. Ransick , Stephanie A. Mutchler , Gary W. Knight
IPC分类号： A61B17/068
CPC分类号： A61B17/0643 , A61B17/00491 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B17/072 , A61B17/07207 , A61B17/07292 , A61B17/105 , A61B17/1155 , A61B17/2909 , A61B2017/00004 , A61B2017/00314 , A61B2017/00327 , A61B2017/00526 , A61B2017/0053 , A61B2017/00561 , A61B2017/00818 , A61B2017/00862 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2017/00938 , A61B2017/00942 , A61B2017/0641 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2908 , A61B2017/2919 , A61B2017/2923 , A61B2017/2927 , A61B2017/2933 , A61B2017/2936 , A61B2017/2937 , A61B2017/320052 , A61B2090/0807
摘要： A tissue thickness compensator may generally comprise a biocompatible material, a first component, and a second component, wherein the first component and second component form a reaction product to expand the tissue thickness compensator. The first component may comprise a first hydrogel precursor, the second component may comprise a second hydrogel precursor, and the reaction product may comprise a hydrogel. The reaction product may be formed in vivo and/or in situ by contacting the first component and the second component. The first component and/or second component may be encapsulated and configured to release the components when ruptured. The reaction product may comprise a fluid-swellable composition. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.
摘要翻译：组织厚度补偿器通常可以包括生物相容性材料，第一组分和第二组分，其中第一组分和第二组分形成用于扩展组织厚度补偿剂的反应产物。第一组分可以包含第一水凝胶前体，第二组分可以包含第二水凝胶前体，并且反应产物可以包含水凝胶。反应产物可以通过使第一组分和第二组分接触而在体内和/或原位形成。第一组分和/或第二组分可以被封装并构造成在破裂时释放组分。反应产物可以包含流体可溶胀组合物。还描述了包括组织厚度补偿器的制品以及制造和使用组织厚度补偿器的方法。

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