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51. 发明授权

US07914434B2 Endoscopic/percutaneous electronic radiation applicator and method of use 有权
标题翻译：内窥镜/经皮电子辐射施加器及其使用方法
公开(公告)号：US07914434B2
公开(公告)日：2011-03-29
申请号：US11481242
申请日：2006-07-03
申请人： Darius Francescatti , Paul A. Lovoi
发明人： Darius Francescatti , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61B1/005 , A61B1/015 , A61B1/12 , A61N5/1001 , A61N5/1002 , A61N5/1014
摘要： Treatment of lesions in any luminal or organ system of mammalian anatomy is performed using an electronic source of ionizing radiation and aided by an endoscopic or percutaneous approach.
摘要翻译：使用电离辐射源进行哺乳动物解剖结构的任何腔内或器官系统中的损伤的治疗，并通过内窥镜或经皮方法进行辅助治疗。

52. 发明授权

US07578780B2 Brachytherapy applicator for delivery and assessment of low-level ionizing radiation therapy and methods of use 有权
标题翻译：近距离放射治疗仪用于交付和评估低水平电离放射治疗和使用方法
公开(公告)号：US07578780B2
公开(公告)日：2009-08-25
申请号：US11324772
申请日：2005-12-31
申请人： Paul A. Lovoi
发明人： Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N5/1048 , A61N2005/1018
摘要： Applicators for ionizing radiation therapy and their methods of use are provided for expedient preparation of precise treatment plans and for quantitative assessment of therapy delivered to natural or surgically-created, intra-corporeal cavities or lumina. Feedback capability is provided for timely treatment control and for verification of treatment to plan using sensors on the applicators.
摘要翻译：提供用于电离辐射治疗的施用者及其使用方法，用于便利地准备精确的治疗计划和用于定量评估递送至天然或手术产生的，体内腔内或腔内的治疗。提供反馈能力以及时进行治疗控制和验证治疗计划，使用涂抹器上的传感器。

53. 发明申请

US20090112047A1 Brachytherapy apparatus and method for use with minimally invasive surgeries of the lung 有权
标题翻译：近距离放射治疗仪及其与微创手术相结合的方法
公开(公告)号：US20090112047A1
公开(公告)日：2009-04-30
申请号：US11978147
申请日：2007-10-26
申请人： Mark P. Carol , James E. Jervis , Paul A. Lovoi
发明人： Mark P. Carol , James E. Jervis , Paul A. Lovoi
IPC分类号： A61M36/04
CPC分类号： A61N5/1015 , A61B1/00082 , A61B1/00094 , A61B1/018 , A61B1/2676 , A61M1/0023 , A61N5/1002
摘要： Brachytherapy treatment of a patient's lung tissue following resection is effected using a balloon applicator which is inserted, normally through the same opening used for the surgery, through the chest wall and into the cavity. The lung and chest openings are closed around the applicator and generally sealed around the applicator. A suction port is provided, in a suction circuit of the applicator, to withdraw fluid from the pleural cavity, at intervals as needed, to assure that the lung can be inflated. Different embodiments of suction circuits are disclosed. A bronchial applicator and method are also disclosed.
摘要翻译：切除术后患者肺组织的近距离放射治疗使用气囊施放器进行，通常穿过用于手术的相同开口通过胸壁插入腔中。肺和胸部开口围绕涂抹器封闭，并且通常围绕敷贴器密封。在施用器的抽吸回路中设置吸入口，以便根据需要间隔地从胸膜腔中取出流体，以确保肺可以膨胀。公开了吸入电路的不同实施例。还公开了支气管施用器和方法。

54. 发明申请

US20080306323A1 Everting gynecological brachytherapy applicator and method 失效
标题翻译：永乐妇科近距离放射治疗仪及方法
公开(公告)号：US20080306323A1
公开(公告)日：2008-12-11
申请号：US11811295
申请日：2007-06-07
申请人： James E. Jervis , Paul A. Lovoi
发明人： James E. Jervis , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： An everting applicator for brachytherapy of body cavities such as the vagina has a flexible sleeve secured to a distal mandrel, both the sleeve and the mandrel having internal lumens. The flexible sleeve has a diverging opening at its distal end, preferably bell-shaped or cone-shaped, such that when the open end is pushed against the mouth of a vagina, the sleeve will evert back upon itself, progressively unrolling to an inside out configuration wherein, fully inserted, the sleeve is fully everted back over the exterior surface of the mandrel. A radiation source, isotopic or electronic, is then inserted into the mandrel lumen to commence a therapeutic irradiation procedure of tissues of the vagina.
摘要翻译：用于诸如阴道的体腔近距离放射治疗的止痛器具有固定到远端心轴的柔性套管，套筒和心轴都具有内腔。柔性套管在其远端具有分叉的开口，优选为钟形或锥形，使得当开口端被推靠在阴道口时，套筒将自身退回，逐渐展开到内侧配置，其中，完全插入，套筒完全退回到心轴的外表面上。然后将辐射源，同位素或电子插入到心轴腔中，以开始阴道组织的治疗辐射程序。

55. 发明申请

US20080306322A1 Everting gynecological brachytherapy applicator 审中-公开
标题翻译：永远妇科近距离放射治疗仪
公开(公告)号：US20080306322A1
公开(公告)日：2008-12-11
申请号：US11811069
申请日：2007-06-07
申请人： James E. Jervis , Paul A. Lovoi
发明人： James E. Jervis , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： An everting applicator for brachytherapy of body cavities such as the vagina has a flexible sleeve secured to a distal mandrel, both the sleeve and the mandrel having internal lumens. The flexible sleeve has a diverging opening at its distal end, preferably bell-shaped or cone-shaped, such that when the open end is pushed against the mouth of a vagina, the sleeve will evert back upon itself, progressively unrolling to an inside out configuration wherein, fully inserted, the sleeve is fully everted back over the exterior surface of the mandrel. A radiation source, isotopic or electronic, is then inserted into the mandrel lumen to commence a therapeutic irradiation procedure of tissues of the vagina.
摘要翻译：用于诸如阴道的体腔近距离放射治疗的止痛器具有固定到远端心轴的柔性套管，套筒和心轴都具有内腔。柔性套管在其远端具有分叉的开口，优选为钟形或锥形，使得当开口端被推靠在阴道口时，套筒将自身退回，逐渐展开到内侧配置，其中，完全插入，套筒完全退回到心轴的外表面上。然后将辐射源，同位素或电子插入到心轴腔中，以开始阴道组织的治疗辐射程序。

56. 发明申请

US20080300443A1 Method for modifying skin distance from a brachytherapy balloon applicator 失效
标题翻译：从近距离放射治疗气球敷料器修改皮肤距离的方法
公开(公告)号：US20080300443A1
公开(公告)日：2008-12-04
申请号：US11810415
申请日：2007-06-04
申请人： Paul A. Lovoi
发明人： Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61B2018/00291 , A61N2005/1094
摘要： In brachytherapy radiation treatment, particularly on the breast following a tumor resection, adequate skin to balloon distance must be maintained, to avoid damage to the skin. Often the distance is too small in certain areas or at a single point. The disclosed procedures and devices are effective to manipulate the skin-to-balloon distance to increase that distance when necessary, using vacuum, friction or other means to grip, move and “bunch” the breast tissue from regions of larger balloon-skin distance to regions with inadequate balloon-skin distance. The apparatus can include a ring or ring shaped array that fits around the breast, larger than the balloon, a circular vacuum device, or a cup which is pushed over the breast to move tissue toward a thin tissue region. In many cases only a few millimeters of added distance are needed to meet minimum requirements so that the radiation procedure can commence.
摘要翻译：在近距离放射治疗中，特别是在肿瘤切除后的乳房上，必须保持适当的皮肤到气球距离，以避免损伤皮肤。通常距离在某些区域或单个点处太小。所公开的程序和装置有效地操纵皮肤到气球的距离以在必要时增加该距离，使用真空，摩擦或其它手段来将乳腺组织从更大的气球 - 皮肤距离区域夹持，移动和“束缚” 气球皮肤距离不足的区域。该装置可以包括围绕乳房，大于气囊，圆形真空装置或杯子的环或环形阵列，其被推到乳房上以朝向薄组织区域移动组织。在许多情况下，只需要几毫米的附加距离来满足最低要求，从而可以开始辐射程序。

57. 发明申请

US20080214887A1 Brachytherapy apparatus and method using off-center radiation source 审中-公开
标题翻译：近距离放射治疗仪和使用偏心辐射源的方法
公开(公告)号：US20080214887A1
公开(公告)日：2008-09-04
申请号：US12082492
申请日：2008-04-10
申请人： Joseph A. Heanue , Paul A. Lovoi , Steve Axelrod , James E. Jervis
发明人： Joseph A. Heanue , Paul A. Lovoi , Steve Axelrod , James E. Jervis
IPC分类号： A61M36/04
CPC分类号： A61N5/1014 , A61M2025/1063 , A61N5/1015 , A61N5/1048 , A61N2005/1018
摘要： A brachytherapy applicator and method of use involve source guides that assume a desired curving, non-linear configuration. A flexible source catheter follows the shape of the source guides when inserted therein. Radiation dose received in various tissue areas can be better controlled using the invention, and the ratio of cavity surface dose to prescription depth dose can be lowered. With sequential manipulation of the source via movement of the catheter, the applicator can deliver radiotherapy to a treatment plan with local variation to prevent overdose, through either stepped or continuous movement of the source. Source guides can be fixed in position and arranged in bowed configuration around a generally central balloon axis, either attached to the balloon wall or not, and the series of off-center guides can be used to shape the dose delivered.
摘要翻译：近距离放射疗法施加器和使用方法包括采用期望的弯曲非线性构造的源引导件。当插入其中时，柔性源导管遵循源极引导件的形状。可以使用本发明更好地控制在各组织区域中接收的辐射剂量，并且可以降低腔表面剂量与处方深度剂量的比例。通过导管的运动对源进行顺序操作，施用器可以将放射治疗递送到具有局部变化的治疗计划，以通过源的逐步或连续运动来防止过量。源引导件可以被固定在适当位置并且围绕一般中心的气球轴线以弓形的形式布置，或者附接到球囊壁，并且可以使用一系列偏心导向器来调整所输送的剂量。

58. 发明申请

US20080167514A1 Gynecological brachytherapy applicator and system 有权
标题翻译：妇科近距离放射治疗仪和系统
公开(公告)号：US20080167514A1
公开(公告)日：2008-07-10
申请号：US12074468
申请日：2008-03-03
申请人： Alex Lim , Paul A. Lovoi , Heike Hausen , Daren L. Stewart
发明人： Alex Lim , Paul A. Lovoi , Heike Hausen , Daren L. Stewart
IPC分类号： A61M36/10
CPC分类号： A61N5/1016 , A61N5/1048 , A61N2005/1005
摘要： A vaginal brachytherapy applicator is versatile to different anatomies and more comfortable to the patient than prior applicators. An inflatable balloon on a shaft may be inelastic or elastic. In one embodiment the shaft is rotatable relative to the balloon for enabling a ring or band of dose delivery, for versatility in radiation placement. Alternatively, the source can be rotated and pulled back within a stationary shaft. An adjustment is provided for reducing the length of balloon that inflates, to accommodate different anatomies and positions. Although isotope radiation sources can be used in the applicator, an electronic source is preferred, and the system and method include procedures for using the applicator with an electronic source.
摘要翻译：阴道近距离放射治疗仪对于不同的解剖结构是多功能的，对于患者而言比以前的给药者更舒适。轴上的可膨胀气球可能是无弹性的或弹性的。在一个实施例中，轴可相对于球囊旋转，以实现用于辐射放置的多功能性的剂量递送环或带。或者，源可以在固定轴内旋转和拉回。提供了一种减小气囊膨胀长度的调整，以适应不同的解剖结构和位置。虽然同位素辐射源可以用于施用器中，但是电子源是优选的，并且该系统和方法包括使用具有电子源的施加器的程序。

59. 发明授权

US07351193B2 Treatment of age-related macular degeneration 有权
标题翻译：治疗年龄相关性黄斑变性
公开(公告)号：US07351193B2
公开(公告)日：2008-04-01
申请号：US11234824
申请日：2005-09-22
申请人： Michael Forman , Paul A. Lovoi , Peter C. Smith
发明人： Michael Forman , Paul A. Lovoi , Peter C. Smith
IPC分类号： A61N5/00
CPC分类号： A61N5/1001 , A61B2090/306 , A61F9/0079 , A61N5/0601 , A61N5/062 , A61N5/1017 , A61N2005/0651 , A61N2005/0659 , A61N2005/1022 , A61N2005/1098
摘要： Age-related macular degeneration is treated by radiation delivered from a miniature x-ray tube inserted via a catheter around the globe of the eye, to a position behind the macula. The process can employ an applicator with several parallel guides, inserted around the eye to receive the catheter with x-ray tube (or an isotope) at a matrix of different positions. Methods are described for properly locating the catheter and x-ray tube, using illumination on the catheter and viewing through the front of the eye, or sensors on the catheter and a scanned beam shone from the front of the eye. Fluorescent material excited by x-rays can also be used. Also described are methods and devices for immobilizing the probe once properly located in the eye, for standoff of the x-ray tube from the target tissue, and for achieving prescription radiation dose in the choroid while eliminating dose to adjacent tissues. The x-ray treatment can be enhanced using a radiosensitizing drug, and can be combined with PDT.
摘要翻译：年龄相关性黄斑变性通过从通过眼睛周围的导管插入的微型X射线管递送到黄斑后面的位置进行治疗。该过程可以使用具有多个平行引导件的施用器，其插入眼睛周围以在不同位置的基质处接收具有x射线管（或同位素）的导管。描述了用于适当地定位导管和X射线管的方法，使用导管上的照明和通过眼睛前方观察，或导管上的传感器以及从眼前方照射的扫描光束。也可以使用由X射线激发的荧光材料。还描述了一旦适当地定位在眼睛中来固定探针的方法和装置，用于X射线管与靶组织的间隔，并且用于在消除相邻组织的剂量的同时获得脉络膜中的处方辐射剂量。可以使用放射增敏药物来增强X射线治疗，并且可以与PDT组合。

60. 发明申请

US20080009659A1 Radiation therapy apparatus with selective shielding capability 有权
标题翻译：具有选择性屏蔽能力的放射治疗仪
公开(公告)号：US20080009659A1
公开(公告)日：2008-01-10
申请号：US11471277
申请日：2006-06-19
申请人： Peter C. Smith , Michael Klein , Heike Hausen , Paul A. Lovoi
发明人： Peter C. Smith , Michael Klein , Heike Hausen , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61B2017/22051 , A61B2090/0481 , A61N2005/1003 , A61N2005/1005 , A61N2005/1094
摘要： Brachytherapy applicators incorporate various forms of selective shielding devices for controlling the direction and intensity of radiation directed at a patient's tissue. In some forms the applicators include a retractable sheath, in some a series of retractable fingers. In other forms the applicator, having an inflatable balloon, has a shield which is retractable from a position adjacent to the balloon or retracted from the balloon, or a shield can itself be inflatable, separately or together with the balloon.
摘要翻译：近程放射治疗仪包括各种形式的选择性屏蔽装置，用于控制指向患者组织的辐射的方向和强度。在一些形式中，施用器包括可伸缩护套，在一些可伸缩的手指中。在其他形式中，具有可膨胀气囊的施用器具有可从邻近气囊的位置缩回或从球囊缩回的护罩，或者屏蔽件本身可以与气囊分开地或与气囊一起充气。

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