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51. 发明授权

US08377921B2 Compounds and compositions as protein kinase inhibitors 有权
公开(公告)号：US08377921B2
公开(公告)日：2013-02-19
申请号：US13172572
申请日：2011-06-29
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno
IPC分类号： A61K31/505 , A61K31/535 , A61K31/497
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.

52. 发明申请

US20110257155A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 有权
公开(公告)号：US20110257155A1
公开(公告)日：2011-10-20
申请号：US13172572
申请日：2011-06-29
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno
IPC分类号： A61K31/506 , A61K31/5377 , A61P35/00 , C12N9/99
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.

53. 发明授权

US08039479B2 Compounds and compositions as protein kinase inhibitors 有权
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US08039479B2
公开(公告)日：2011-10-18
申请号：US11943436
申请日：2007-11-20
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译：本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物，以及使用这些化合物的方法。例如，本发明的嘧啶和吡啶衍生物可用于治疗，改善或预防响应于间变性淋巴瘤激酶（ALK）活性，粘着斑激酶（FAK），ζ-链相关蛋白激酶70 （ZAP-70），胰岛素样生长因子（IGF-1R）或其组合。

54. 发明授权

US07708364B2 Ink-jet recording apparatus and data transfer apparatus 有权
标题翻译：喷墨记录装置和数据传送装置
公开(公告)号：US07708364B2
公开(公告)日：2010-05-04
申请号：US11809490
申请日：2007-06-01
申请人： Masakazu Mori , Hiroaki Arakawa , Tetsuo Uno
发明人： Masakazu Mori , Hiroaki Arakawa , Tetsuo Uno
IPC分类号： B41J29/38
CPC分类号： B41J2/0458 , B41J2/04541 , B41J2/0455
摘要： An ink-jet recording apparatus, including plural ink-jet head units which are daisy-chain-connected to a control section and eject ink; and the control section which sends serial driving data to the plural ink-jet head units, wherein each ink-jet head unit includes a head drive control section, which includes: a serial/parallel conversion section which converts the serial driving data inputted from a pre-ceding ink-jet head unit to parallel driving data, and sends the parallel driving data to a post-ceding ink-jet head unit; an identification information setting section which sets identification information for selecting a signal essential to drive the ink-jet head unit, a data extracting section which selects the signal essential to drive the ink-jet head unit, based on identification information, and a data processing section which conducts process for driving the ink-jet head unit, by the signal essential to drive the ink-jet head unit selected by the data extracting section.
摘要翻译：一种喷墨记录装置，包括与控制部分菊花链连接并喷射墨水的多个喷墨头单元; 以及将串行驱动数据发送到多个喷墨头单元的控制部，其中，每个喷墨头单元包括头驱动控制部，该头驱动控制部包括：串行/并行转换部，其将从预先喷墨头单元并行驱动数据，并将并行驱动数据发送到后置喷墨头单元; 识别信息设定部，其设定用于选择驱动喷墨头单元的必要信号的识别信息;数据提取部，其基于识别信息选择驱动喷墨头单元的必要信号;数据处理通过由数据提取部选择的驱动喷墨头单元的必要信号来进行驱动喷墨头单元的处理。

55. 发明授权

US07642255B2 Compounds and compositions as protein kinase inhibitors 失效
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US07642255B2
公开(公告)日：2010-01-05
申请号：US12099708
申请日：2008-04-08
申请人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Schiander Gray , Shuli You
发明人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Schiander Gray , Shuli You
IPC分类号： C07D413/14 , C07D471/04 , C07D487/04 , A61K31/535 , A61K31/497 , A61K31/519 , C07D251/12 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，Bmx，c-Raf，Csk，Fes，FGFR，Flt3，Ikk，IR，JNK，Lck，Mkk，PKC，PKD，Rsk，SAPK，Syk，Trk，BTK，Src，EGFR，IGF，Mek，Ros和Tie2 激酶。

56. 发明申请

US20090137804A1 Compounds and Compositions as Protein Kinase Inhibitors 有权
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US20090137804A1
公开(公告)日：2009-05-28
申请号：US11570983
申请日：2005-06-23
申请人： Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Taebo Sim , Tetsuo Uno , Guobao Zhang , Carole Pissot Soldermann , Werner Breitenstein , Guido Bold , Giorgio Caravatti , Pascal Furet , Vito Guagnano , Marc Lang , Paul W. Manley , Joseph Schoepfer , Carsten Spanka
发明人： Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Taebo Sim , Tetsuo Uno , Guobao Zhang , Carole Pissot Soldermann , Werner Breitenstein , Guido Bold , Giorgio Caravatti , Pascal Furet , Vito Guagnano , Marc Lang , Paul W. Manley , Joseph Schoepfer , Carsten Spanka
IPC分类号： A61K31/50 , C07D239/12 , A61P35/00
CPC分类号： C07D239/48 , C07D251/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
摘要翻译：本发明涉及式（I）化合物，其中取代基X1，R1，R2，R3和R4具有本发明说明书中阐述和解释的含义，制备这些化合物的方法，含有它们的药物组合物，其任选与一种或多种其它药学活性化合物组合用于治疗对蛋白激酶活性的抑制作出反应的疾病的用途，以及治疗这种疾病的方法。

57. 发明申请

US20070279449A1 Ink-jet recording apparatus and data transfer apparatus 有权
标题翻译：喷墨记录装置和数据传送装置
公开(公告)号：US20070279449A1
公开(公告)日：2007-12-06
申请号：US11809490
申请日：2007-06-01
申请人： Masakazu Mori , Hiroaki Arakawa , Tetsuo Uno
发明人： Masakazu Mori , Hiroaki Arakawa , Tetsuo Uno
IPC分类号： B41J29/38
CPC分类号： B41J2/0458 , B41J2/04541 , B41J2/0455
摘要： An ink-jet recording apparatus, including plural ink-jet head units which are daisy-chain-connected to a control section and eject ink; and the control section which sends serial driving data to the plural ink-jet head units, wherein each ink-jet head unit includes a head drive control section, which includes: a serial/parallel conversion section which converts the serial driving data inputted from a pre-ceding ink-jet head unit to parallel driving data, and sends the parallel driving data to a post-ceding ink-jet head unit; an identification information setting section which sets identification information for selecting a signal essential to drive the ink-jet head unit, a data extracting section which selects the signal essential to drive the ink-jet head unit, based on identification information, and a data processing section which conducts process for driving the ink-jet head unit, by the signal essential to drive the ink-jet head unit selected by the data extracting section.
摘要翻译：一种喷墨记录装置，包括与控制部分菊花链连接并喷射墨水的多个喷墨头单元; 以及将串行驱动数据发送到多个喷墨头单元的控制部，其中，每个喷墨头单元包括头驱动控制部，该头驱动控制部包括：串行/并行转换部，其将从预先喷墨头单元并行驱动数据，并将并行驱动数据发送到后置喷墨头单元; 识别信息设定部，其设定用于选择驱动喷墨头单元的必要信号的识别信息;数据提取部，其基于识别信息选择驱动喷墨头单元的必要信号;数据处理通过由数据提取部选择的驱动喷墨头单元的必要信号来进行驱动喷墨头单元的处理。

58. 发明授权

US06982092B2 Method of complexing a nucleic acid with a lipid-conjugated polyamide 失效
标题翻译：使核酸与脂质共轭聚酰胺络合的方法
公开(公告)号：US06982092B2
公开(公告)日：2006-01-03
申请号：US10448902
申请日：2003-05-30
申请人： Ronald N. Zuckermann , Chin-Yi Huang , John E. Murphy , Tetsuo Uno
发明人： Ronald N. Zuckermann , Chin-Yi Huang , John E. Murphy , Tetsuo Uno
IPC分类号： A61K9/127 , C07H21/04 , C07J9/00 , C08K5/21 , C11C3/00
CPC分类号： C12N15/87 , A61K47/645
摘要： In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.
摘要翻译：根据本发明，提供了脂质共轭聚酰胺化合物及其相关组合物和方法。本发明的脂质偶联的聚酰胺化合物特别可用作将生物活性剂递送到靶位点的载体。特别地，本发明化合物有利于促进将多核苷酸递送至细胞。本发明还提供了用于制备与递送载体复合的多核苷酸的稳定制剂的方法。

59. 发明授权

US06468986B1 Compositions and methods for polynucleotide delivery 失效
标题翻译：用于多核苷酸递送的组合物和方法
公开(公告)号：US06468986B1
公开(公告)日：2002-10-22
申请号：US09620925
申请日：2000-07-21
申请人： Ronald N. Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael A. Innis , John E. Murphy , Fred E. Cohen , Tetsuo Uno
发明人： Ronald N. Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael A. Innis , John E. Murphy , Fred E. Cohen , Tetsuo Uno
IPC分类号： A61K4800
CPC分类号： A61K38/2264 , A61K38/1816 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07K7/08 , C07K14/001 , C12N15/87 , C12N2810/858
摘要： This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
摘要翻译：本发明涉及用于增加多核苷酸进入细胞的摄取的组合物和方法。具体地，本发明涉及载体，靶向配体和聚阳离子剂。聚阳离子剂能够（1）增加多核苷酸进入细胞的频率，（2）缩合多核苷酸; 和（3）抑制多核苷酸的血清和/或核酸酶降解。

60. 发明授权

US5041283A Cosmetic composition 失效
标题翻译：化妆品组成
公开(公告)号：US5041283A
公开(公告)日：1991-08-20
申请号：US404409
申请日：1989-09-08
申请人： Katsumi Kita , Tetsuo Uno , Shinichi Masuda , Kazuyuki Yahagi , Kazuhiro Tashiro
发明人： Katsumi Kita , Tetsuo Uno , Shinichi Masuda , Kazuyuki Yahagi , Kazuhiro Tashiro
IPC分类号： C07C29/38 , A61K8/00 , A61K8/34 , A61Q5/00 , A61Q19/00 , C07C27/00 , C07C31/22 , C07C67/00
CPC分类号： A61K8/345 , A61Q19/00 , C07C31/22 , A61Q1/02 , A61Q1/06 , A61Q19/10 , A61Q5/00 , A61Q5/06 , A61Q5/12
摘要： A cosmetic composition comprising a long-chain alkyltrimethylol is disclosed. The alkyltrimethylol is represeneted by the formula (I): ##STR1## wherein R is a linear or branched, saturated or unsaturated alkyl group having 8-22 carbon atoms. The composition is applied to various types of cosmetic and exhibits superior extendibility when applied, imparts a non-sticky, fresh feeling upon use, and provides an excellent moisture-retaining effect.

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