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51. 发明专利

PL217630B1 Pochodne azaspiroalkanów, kompozycja farmaceutyczna oraz zastosowanie związku 未知
公开(公告)号：PL217630B1
公开(公告)日：2014-08-29
申请号：PL38027504
申请日：2004-04-23
申请人： INCYTE CORP
发明人： YAO WENQING , ZHUO JINCONG , XU MEIZHONG , ZHANG FENGLEI , METCALF BRIAN
IPC分类号： C07D401/02 , A61K20060101 , A61K31/4188 , A61K31/424 , A61K31/428 , A61K31/4747 , A61K31/495 , C07D20060101 , C07D471/10 , C07D491/10 , C07D497/10

52. 发明专利

AU2012211351A1 Amido compounds and their use as pharmaceuticals 未知
公开(公告)号：AU2012211351A1
公开(公告)日：2012-08-23
申请号：AU2012211351
申请日：2012-08-03
申请人： INCYTE CORP
发明人： YAO WENQING , ZHUO JINCONG , XU MEIZHONG , ZHANG COLIN , METCALF BRIAN , HE CHUNHONG , QIAN DING-QUAN
IPC分类号： C07D221/00 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/263 , C07D209/08 , C07D209/44 , C07D209/52 , C07D209/62 , C07D209/70 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/70 , C07D213/38 , C07D217/06 , C07D221/20 , C07D223/02 , C07D223/04 , C07D231/04 , C07D295/185 , C07D333/34 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D491/20 , C07D495/04 , C07D498/20 , C07D513/10
摘要： INCY0016-500 The present invention relates to inhibitors of I 1 -P hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of I 1-p hydroxyl steroid dehydrogenase type I and/or diseases associated with aldosterone excess.

53. 发明专利

AU2011269788A1 Imidazo[1,2-b][1,2,4]triazines as c-Met inhibitors 未知
公开(公告)号：AU2011269788A1
公开(公告)日：2012-08-23
申请号：AU2011269788
申请日：2011-02-02
申请人： INCYTE CORP
发明人： ZHUO JINCONG , HE CHUNHONG , YAO WENQING
IPC分类号： C07D487/04 , A61K31/53 , A61P1/00 , A61P9/00 , A61P11/00 , A61P29/00 , A61P35/00 , A61P37/00
摘要： The present invention relates to imidazo[1,2-b][1,2,4]triazines that are inhibitors of c- Met and are useful in the treatment of c-Met associated diseases including cancer.

54. 发明专利

GEP20125565B LACTAM COMPOUNDS AND THEIR PHARMACEUTICAL USE 未知
公开(公告)号：GEP20125565B
公开(公告)日：2012-07-10
申请号：GEAP2005010125
申请日：2005-11-09
申请人： INCYTE CORP
发明人： METCALF BRIAN , YAO WENQING , XU MEIZHONG , ZHUO JINCONG , ZHANG COLIN , QIAN DING-QUAN , BURNS DAVID , HE CHUNHONG
IPC分类号： A61K31/52 , A61K31/4747 , A61K31/496 , C07D473/02 , C07D487/04
摘要： The invention relates to compounds of the general formula I, wherein substitutes have the values indicated in the description; pharmaceutical compositions comprising these compounds and use thereof for treatment of II type diabetes and other diseases.

55. 发明专利

NZ568446A Lactam compounds and methods of using the same as modulators of 11-beta hydroxyl steroid dehydrogenase 1 未知
公开(公告)号：NZ568446A
公开(公告)日：2011-12-22
申请号：NZ56844606
申请日：2006-12-04
申请人： INCYTE CORP
发明人： ZHUO JINCONG , YAO WENQING , QIAN DING-QUAN
IPC分类号： C07D471/10 , A61K31/4015 , A61K31/407 , A61K31/438
摘要： Disclosed herein is a 2,8-diazaspirl[4.5]decan-1-one compound of formula III, wherein the substituents are as defined with in the specification, processes for their preparation and compositions comprising said compounds. Such compounds are useful in the treatment of obesity, diabetes, glucose intolerance, insulin resistance, hyperglycemia, atherosclerosis, hypertension, hyperlipidemia, cognitive impairment, dementia, depression, glaucoma, cardiovascular disorders, osteoporosis, inflammation, metabolic syndrome, coronary heart disease, type 2 diabetes, hypercortisolemia, androgen excess, or polycystic ovary syndrome (PCOS).

56. 发明专利

UA94028C2 АМИДОСОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ 未知
公开(公告)号：UA94028C2
公开(公告)日：2011-04-11
申请号：UAA200700717
申请日：2005-06-23
申请人： INCYTE CORP
发明人： YAO WENQING , XU MEIZHONG , ZHANG COLIN , AGRIOS KONSTANTINOS , METCALF BRIAN , ZHUO JINCONG
IPC分类号： A61K31/495 , C07D295/092 , C07D409/06
摘要： Данноеизобретениекасаетсяингибиторов 11-β-гидроксистероиддегидрогеназытипа 1, антагонистовминералокортикоидногорецептора (MR), атакжеихфармацевтическихкомпозиций.Соединенияподанномуизобретениюмогутприменятьсяприлеченииразныхзаболеваний, связанныхс экспрессиейилиактивностью 11-β-гидроксистероиддегидрогеназытипа 1 и/илизаболеваний, связанныхс излишкомальдостерона.

57. 发明专利

NZ551603A N-substituted piperidines and their use as pharmaceuticals 未知
公开(公告)号：NZ551603A
公开(公告)日：2010-11-26
申请号：NZ55160305
申请日：2005-06-23
申请人： INCYTE CORP
发明人： YAO WENQING , XU MEIZHONG , ZHANG COLIN , LI YANLONG , ZHUO JINCONG , METCALF BRIAN
IPC分类号： A61K31/445 , A61K31/451 , A61K31/47 , A61K31/495 , A61K31/505 , C07D211/32 , C07D211/34 , C07D211/78 , C07D211/96 , C07D401/04 , C07D401/12 , C07D401/14
摘要： Disclosed are inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds have formula I, wherein Cy is aryl, heteroaryl, cycloalkyl or heterocycloalkyl, L is absent or SO2, Q is cycloalkyl or heterocycloalkyl, and the remaining substituents are as defined in the specification. The compounds can be useful in the treatment of various diseases associated with expression or activity of 11-beta hydroxyl steroid dehydrogenase type I and/or diseases associated with aldosterone excess.

58. 发明专利

NZ551602A Amido compounds and their use as pharmaceuticals 未知
公开(公告)号：NZ551602A
公开(公告)日：2010-11-26
申请号：NZ55160205
申请日：2005-06-23
申请人： INCYTE CORP
发明人： YAO WENQING , XU MEIZHONG , ZHANG COLIN , ZHUO JINCONG , METCALF BRIAN , AGRIOS KONSTANTINOS
IPC分类号： A61K31/495 , C07D295/092 , C07D409/06
摘要： Disclosed are inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds have formulae IIIa and IIIb, wherein Cy is optionally substituted aryl or heteroaryl, R1 and R2 are optionally substituted alkyl, and the remaining substituents are as defined in the specification. The compounds can be useful in the treatment of various diseases associated with expression or activity of 11-beta hydroxyl steroid dehydrogenase type I and/or diseases associated with aldosterone excess.

59. 发明专利

HK1136489A1 IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS 未知
公开(公告)号：HK1136489A1
公开(公告)日：2010-07-02
申请号：HK10101978
申请日：2010-02-25
申请人： INCYTE CORP
发明人： ZHUO JINCONG , METCALF BRIAN , XU MEIZHONG , HE CHUNHONG , ZHANG COLIN , QIAN DING-QUAN , BURNS DAVID M , LI YUNLONG , YAO WENQING
IPC分类号： A61K20060101 , C07D20060101
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.

60. 发明专利

CO6150151A2 ESPIROCICLOS COMO INHIBIDORES DE LA 11-BETA HIDROXIESTEROIDE DESHIDROGENASA DE TIPO 1 未知
公开(公告)号：CO6150151A2
公开(公告)日：2010-04-20
申请号：CO09148800
申请日：2009-12-29
申请人： INCYTE CORP
发明人： YAO WENQING , ZHUO JINCONG , ZHANG COLIN
IPC分类号： C07D471/10
摘要： La presente invención se refiere a determinados compuestos espirocíclicos que son inhibidores de la 11-ß hidroxiesteroide deshidrogenasa de tipo 1 (11ßHSD1), a composiciones que los contienen y a métodos de uso de ellos para el tratamiento de diabetes, obesidad y otras enfermedades. 1.- Un compuesto caracterizado porque es:5-{3-Fluoro-4-[(5S)-2-(cis-4-hidroxiciclohexil)-1-oxo-2,7- diazaespiro[4.5]dec-7-il]fenil}-N,N-dimetilpiridin-2-carboxamida;o una de sus sales farmacéuticamente aceptables.2.- Un compuesto caracterizado porque es:5-{3-Fluoro-4-[(5S)-2-(cis-.4-hidroxiciclohexil)-1-oxo-2,7-diazaespiro[4,5]dec-7-iI]fenil}-N-metilpiridin-2-carboxamida;o una de sus sales farmacéuticamente aceptables.3.- Un compuesto caracterizado porque es:N-Etil-5-{3-fluoro -4-[(5S)-2-(cis-4-hidroxicicIohexil)-1-oxo-2,7-diazaespiro[4.5]dec-7-il]fenil)piridin-2-carboxamida;o una de sus sales farmacéuticamente aceptables.4.- Un compuesto caracterizado porque es:5-{3--cloro-4-[(5S)-2-(cis-4-hidroxiciclohexil)-1-oxo--2,7-diazaespiro[4 .5)dec-7-il)fenil}-N-etilpiridin-2-carboxamida;o una de sus sales farmacéuticamente aceptables.5.- Una composición farmacéutica caracterizada porque comprende un compuesto de acuerdo con cualquiera de las reivindicaciones 1 a 4 o una de sus sales farmacéuticamente aceptables y al menos un portador farmacéuticamente aceptable.6.- Un método de inhibición de la actividad de 11ßHSD1, caracterizado porque comprende poner en contacto dicha 11ßHSD1 con un compuesto de acuerdo con cualquiera de las reivindicaciones 1 a 4 o una de sus sales farmacéuticamente aceptables.7.- Un método de inhibición de la conversión de cortisona en cortisol en una célula, caracterizado porque comprende poner en contacto la célula con un compuesto de acuerdo con cualquiera de las reivindicaciones 1 a 4 o una de sus sales farmacéuticamente aceptables.

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