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51. 发明申请

US20110071194A1 Chemical Compounds 572 失效
标题翻译：化学化合物572
公开(公告)号：US20110071194A1
公开(公告)日：2011-03-24
申请号：US12959027
申请日：2010-12-02
申请人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
发明人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
IPC分类号： A61K31/4439 , C07D401/12 , A61P29/00 , A61P11/06
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译：式（I）化合物：本发明涉及新的吲唑基酯或酰胺衍生物，包含这些衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物

52. 发明申请

US20100016338A1 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents 审中-公开
标题翻译： 5 - [（3,3,3-三氟-2-羟基-1-芳基丙基）氨基] -1-芳基喹啉-2-酮，其制备方法及其作为抗炎剂
公开(公告)号：US20100016338A1
公开(公告)日：2010-01-21
申请号：US12505623
申请日：2009-07-20
申请人： Markus Berger , Hartmut Rehwinkel , Ekkehard May , Heike Schäcke
发明人： Markus Berger , Hartmut Rehwinkel , Ekkehard May , Heike Schäcke
IPC分类号： A61K31/4704 , C07D215/227 , C07D239/42 , C07D239/47 , C07D403/04 , A61P29/00 , A61K31/506
CPC分类号： C07D401/04 , A61K31/4704 , A61K31/506 , A61K45/06 , C07D215/38 , A61K2300/00
摘要： The present invention relates to compounds of formula I, processes and intermediates for their production and their use as anti-inflammatory agents.
摘要翻译：本发明涉及式I化合物，其制备方法和中间体及其作为抗炎剂的用途。

53. 发明申请

US20080207721A1 Chemical compounds 失效
标题翻译：化合物
公开(公告)号：US20080207721A1
公开(公告)日：2008-08-28
申请号：US11986555
申请日：2007-11-21
申请人： Markus Berger , Lena Bergstrom , Jan Dahmen , Anders Eriksson , Balint Gabos , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepisto , Stinabritt Nilsson , Camilla Taflin , Darren McKerrecher , Hartmut Rehwinkel
发明人： Markus Berger , Lena Bergstrom , Jan Dahmen , Anders Eriksson , Balint Gabos , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepisto , Stinabritt Nilsson , Camilla Taflin , Darren McKerrecher , Hartmut Rehwinkel
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Compounds of formula (I): or a pharmaceutically acceptable salt thereof, compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).
摘要翻译：式（I）化合物或其药学上可接受的盐，包含它们的组合物，其制备方法及其在药物治疗中的用途（例如调节温血动物中的糖皮质激素受体）。

54. 发明授权

US08692495B2 Roller mill and method for size reduction of ground material 有权
标题翻译：辊磨机和磨碎材料尺寸减小的方法
公开(公告)号：US08692495B2
公开(公告)日：2014-04-08
申请号：US13055183
申请日：2009-07-30
申请人： Markus Berger , Franz-Josef Zurhove , Ludger Kimmeyer , Carsten Sachse
发明人： Markus Berger , Franz-Josef Zurhove , Ludger Kimmeyer , Carsten Sachse
IPC分类号： H02P7/00
CPC分类号： B02C15/00 , B02C25/00
摘要： The invention relates to a roller mill having a grinding table, at least one grinding roller and at least two drives with a rotor winding for driving the roller mill and at least one adjustment device for adjusting the motor torque of at least one drive, the adjustment device being connected to the rotor winding of at least one drive in order to influence the rotor current.
摘要翻译：本发明涉及一种具有研磨台，至少一个研磨辊和至少两个具有用于驱动辊磨机的转子绕组和至少一个用于调节至少一个驱动器的电动机转矩的调节装置的驱动器的辊磨机，该调节装置装置连接到至少一个驱动器的转子绕组，以便影响转子电流。

55. 发明授权

US08128011B2 Method for comminuting material to be ground using a roller mill 有权
标题翻译：使用滚磨机粉碎待研磨材料的方法
公开(公告)号：US08128011B2
公开(公告)日：2012-03-06
申请号：US12525755
申请日：2008-02-04
申请人： Markus Berger , Ludwig Könning , Marco Völlink , Franz-Josef Zurhove
发明人： Markus Berger , Ludwig Könning , Marco Völlink , Franz-Josef Zurhove
IPC分类号： B02C25/00
CPC分类号： B02C15/00 , B02C25/00
摘要： The invention relates to a method for comminuting material to be ground having a roller mill which has a mill platen, at least one mill roller and at least two drives for driving the roller mill, with there being provided a power compensation control system for the drives which controls the power of the drives at a predetermined ratio relative to each other by the speed of at least one drive being controlled.
摘要翻译：本发明涉及一种用于粉碎被研磨材料的方法，该方法具有一个具有轧机压板，至少一个轧辊和至少两个用于驱动辊磨机的驱动器的辊磨机，其中为驱动器提供功率补偿控制系统其以至少一个被控制的驱动器的速度相对于彼此以预定比例控制驱动器的功率。

56. 发明申请

US20070088060A1 New effector conjugates, process for their production and their pharmaceutical use 失效
标题翻译：新的效应物缀合物，其生产过程及其药物用途
公开(公告)号：US20070088060A1
公开(公告)日：2007-04-19
申请号：US11509557
申请日：2006-08-25
申请人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
发明人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
IPC分类号： A61K31/427
CPC分类号： C07D493/04 , A61K47/6809 , A61K47/6851 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjugated to the recognition units. The pharmaceutical use of the conjugates for treating proliferative or angiogenesis-associated processes is described.
摘要翻译：描述了具有合适的生物分子（作为识别单元）的埃坡霉素和埃坡霉素衍生物（作为效应物）的缀合物。它们的生产通过与合适的接头反应的效应器进行，并且所生成的化合物与识别单元缀合。描述了缀合物用于治疗增殖或血管生成相关过程的药物用途。

57. 发明授权

US07129254B2 Effector conjugates, process for their production and their pharmaceutical use 失效
标题翻译：效应物缀合物，其制备方法及其药物用途
公开(公告)号：US07129254B2
公开(公告)日：2006-10-31
申请号：US10631011
申请日：2003-07-31
申请人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
发明人： Markus Berger , Gerhard Siemeister , Ulrich Klar , Jorg Willuda , Andreas Menrad , Klaus Bosslet
IPC分类号： A61K31/425 , A61K31/44 , C07D277/20 , C07D417/08
CPC分类号： C07D493/04 , A61K47/6809 , A61K47/6851 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjugated to the recognition units. The pharmaceutical use of the conjugates for treating proliferative or angiogenesis-associated processes is described.
摘要翻译：描述了具有合适的生物分子（作为识别单元）的埃坡霉素和埃坡霉素衍生物（作为效应物）的缀合物。它们的生产通过与合适的接头反应的效应器进行，并且所生成的化合物与识别单元缀合。描述了缀合物用于治疗增殖或血管生成相关过程的药物用途。

58. 发明授权

US07124978B2 Spiraling device 有权
标题翻译：螺旋装置
公开(公告)号：US07124978B2
公开(公告)日：2006-10-24
申请号：US10518851
申请日：2003-05-15
申请人： Markus Berger , Rainer Oehl , Klaus Binder
发明人： Markus Berger , Rainer Oehl , Klaus Binder
IPC分类号： B65H54/64
CPC分类号： B29C53/8016 , B29C70/16 , B65H49/32 , B65H59/16
摘要： A spiraling arrangement (1) for applying a spirally-shaped filament layer to an elongated carrier (2) which is drivable in the direction of the carrier longitudinal axis (X). The arrangement has a rotor (3), which is rotatable about the carrier longitudinal axis (X), and a plurality of filament bobbin carrier shafts (5) which extend in the direction of the carrier longitudinal axis (X). The carrier shafts (5) are arranged distributed on a circumscribed circle radius of the rotor (3) and are each configured to take up a plurality of filament bobbins (7). On one end face (6a) of the rotor (3), filament brake elements (10) are arranged distributed over the periphery and can be driven synchronously with respect to each other. The filaments (8) are taken off the filament bobbins (7) and are guided by filament guide elements (9) via the filament brake elements (10) and an annular comb (12), which encloses the carrier (2), onto the carrier (2).
摘要翻译：一种螺旋形布置（1），用于将螺旋状的细丝层施加到可沿着载体纵向轴线（X）的方向驱动的细长载体（2）。该装置具有绕托架纵向轴线X可转动的转子（3），以及沿托架纵向轴线（X）的方向延伸的多个长丝轴托架轴（5）。载体轴（5）分布在转子（3）的外接圆半径上，并且分别被构造成吸收多个长丝线轴（7）。在转子（3）的一个端面（6a）上，灯丝制动元件（10）布置成分布在周边上，并且可以相对于彼此同步地被驱动。灯丝（8）从灯丝筒（7）中取出，并经灯丝制动元件（10）和细丝引导元件（9）引导，环形梳（12）包围载体（2）载体（2）。

59. 发明授权

US09345793B2 Compounds for binding to the platelet specific glycoprotein IIB/IIIA and their use for imaging of thrombi 有权
标题翻译：用于结合血小板特异性糖蛋白IIB / IIIA的化合物及其用于血栓成像的用途
公开(公告)号：US09345793B2
公开(公告)日：2016-05-24
申请号：US14239065
申请日：2012-08-17
申请人： Markus Berger , Martin Kruger , Jessica Lohrke , Michael Reinhardt , Holger Siebeneicher
发明人： Markus Berger , Martin Kruger , Jessica Lohrke , Michael Reinhardt , Holger Siebeneicher
IPC分类号： A61K51/08 , C07D401/04 , C07D401/06 , C07K5/06
CPC分类号： A61K51/088 , A61J1/06 , A61K49/0433 , C07D211/60 , C07D401/04 , C07D401/06 , C07D401/14 , C07K5/06
摘要： The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.
摘要翻译：本发明涉及新的含氟化合物，其制备方法，合成中间体，它们作为诊断剂的用途，特别是用于血栓成像。本发明涉及正电子发射断层摄影（PET）剂和相关的前体试剂，以及用于在哺乳动物体内产生用于血栓成像的放射性物质的方法。更具体地，本发明涉及用于血栓成像的小的非肽，高亲和力，特异性结合的糖蛋白11b / IIIa拮抗剂。

60. 发明授权

US09194759B2 Flange for pressure measurement cells or pressure transfer means and method for manufacture of such flanges 有权
标题翻译：用于压力测量单元或压力传递装置的法兰和用于制造这种凸缘的方法
公开(公告)号：US09194759B2
公开(公告)日：2015-11-24
申请号：US13994208
申请日：2011-11-23
申请人： Markus Berger , Volker Frey , Dietmar Salg , Christoph Bollig
发明人： Markus Berger , Volker Frey , Dietmar Salg , Christoph Bollig
IPC分类号： G01L7/08 , G01L19/06 , B23K26/14 , B23K26/32 , B23K26/34 , B23K35/00 , B23K35/02 , G01L9/00
CPC分类号： G06F11/1415 , B23K26/142 , B23K26/144 , B23K26/32 , B23K26/322 , B23K26/342 , B23K26/346 , B23K35/004 , B23K35/007 , B23K35/0244 , B23K2101/20 , B23K2101/35 , B23K2103/04 , B23K2103/05 , B23K2103/08 , B23K2103/18 , B23K2103/26 , B23K2103/50 , G01L9/0048 , G01L19/06 , G01L19/0645 , Y10T29/5176
摘要： A flange for a corrosion resistant and nevertheless low cost flange for pressure measurement cells, or pressure transfer means, is composed essentially of a metal foundation of a standard material and is protected on the side facing a process medium by a there applied layer of a highly alloyed, special material.
摘要翻译：用于压力测量单元或压力传递装置的用于耐腐蚀且成本低廉的法兰的法兰基本上由标准材料的金属基底组成，并且在面向加工介质的一侧受到高应力层的保护合金，特殊材料。

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